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A survey for Batrachochytrium salamandrivorans in Chinese amphibians

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Current Zoology 2014年第6期60卷 729-735页

作者： Wei ZHU Feng XU Changming BAI Xuan liU Supen WANG Xu GAO Shaofei YAN xianping li Zetian liU Yiming li Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences 19 Yuquan Road Beijing 100049 China Key Laboratory of Biogeography and Bioresource in Arid Land Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China Maricultural Organism Disease Control and Pathogenic Molecular Biology Laboratory Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Science Qingdao 266071 China

For the last decade, chytridiomycosis was considered to be caused by a single species of fungus, Batrachochytrium dendrobatidis （Bd）, but a second chytrid species, Batrachochytrium salamandrivorans （Bs）, was recently isolated from an in- fected Salamandra salamandra in the Netherlands. To date, Bs has only been found in the Netherlands. To assess whether Bs is present in China, we analyzed a total of 665 samples, including 425 wild samples, 41 preserved specimens, and 199 captive sam- pies, from 30 different species, including both urodeles and anurans. Our sample sites covered 15 provinces in China. All of the samples tested negative for Bs, resulting in a 95% confidence limit for a prevalence of 0.6%. The absence of Bs observed in this large-scale survey in China has significant implications for amphibian conservation and for border trade management strategies intended to control amphibian diseases. We strongly recommend the continued close monitoring of Bs to verify the status of this potentially devastating amphibian fungus in China .

关键词： Amphibian decline Asia Batrachochytrium salamandrivorans China Chytridiomycosis Batrachochytrium dendrobatidis.

Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats

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Food Science and Human Wellness 2024年第3期13卷 1258-1270页

作者： Qishan Wang Bin liu xianping li Junying Zhao Zongshen Zhang Weicang Qiao Xinyue Wei lijun Chen School of Bioengineering Dalian Polytechnic UniversityDalian 116034China National Engineering Research Center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd.Beijing 100163China Beijing Engineering Research Center of Dairy Beijing Sanyuan Foods Co.Ltd.Beijing 100163China

The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are ***,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral *** 3 months of FM(containing vitamin D,and casein phosphopeptides,1000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical *** results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid ***,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and ***,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen typeⅠN-propeptide,and decreased expression of the bone resorption marker C-telopiptide and tartrate-resistant acid phosphatase ***,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis.

关键词： Dairy products Calcium Vitamin D Bone turnover markers Gut microbiota Postmenopausal osteoporosis

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给比较教育专业研究生的十条建议

学位与研究生教育 2007年第12期 30-33页

作者：李现平中国人民解放军国防大学训练部教学研究室

作者以"过来人"的身份,根据自己的切身体会和深入思考,给比较教育专业研究生提出了十条建议,涉及读书、学习、研究、实践等诸多方面。

关键词：比较教育研究生研究方法

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飞机稳定尾旋的改出规律研究

南京航空航天大学学报 1999年第1期31卷 6-11页

作者：黎先平江西洪都航空工业集团有限责任公司飞机设计研究所

研究稳定尾旋的改出方法，即寻求一种操纵规律，可以使飞机从一种稳定状态（稳定尾旋）跳到另一处非失速稳定状态。从系统的全局稳定性观点出发，构造了李雅普诺夫函数，根据输入操纵每一时刻该函数增长速度最大条件，保证尾旋改出过程... 详细信息

研究稳定尾旋的改出方法，即寻求一种操纵规律，可以使飞机从一种稳定状态（稳定尾旋）跳到另一处非失速稳定状态。从系统的全局稳定性观点出发，构造了李雅普诺夫函数，根据输入操纵每一时刻该函数增长速度最大条件，保证尾旋改出过程中飞机振荡状态的频率接近其固有频率，从而求得飞机稳定尾旋的改出规律———振荡型改出操纵规律。本文用求解飞机运动的六自由度方程的方法计算出尾旋改出的时间历程，验证了用简单的三舵面回中难改出稳定尾旋或改出时间较长，而振荡型操纵规律可有效改出稳定尾旋。

关键词：稳定尾旋全局稳定性改出规律飞行力学

前缘角冰几何参数对翼型失速特性的影响分析研究

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西北工业大学学报 2023年第1期41卷 39-46页

作者：赵宾宾黎先平李杰张恒西北工业大学航空学院陕西西安710072 中国商飞上海飞机设计研究院上海201210

前缘角冰不规则凸起特征和几何随机性显著,分离流场特征复杂,导致翼型失速特性发生本质变化的致因机理和关键因素仍未完全明确。针对大型客机适航审定实际需求,基于典型翼型及结冰环境,构造了一族具备不同形貌特征、几何参数彼此关联的... 详细信息

前缘角冰不规则凸起特征和几何随机性显著,分离流场特征复杂,导致翼型失速特性发生本质变化的致因机理和关键因素仍未完全明确。针对大型客机适航审定实际需求,基于典型翼型及结冰环境,构造了一族具备不同形貌特征、几何参数彼此关联的角冰冰形。结合数值模拟方法系统分析了翼型失速特性及分离流场特征对冰形高度及角度变化的参数敏感性,归纳了冰形参数改变导致失速过程分离泡发展规律发生变化的本质影响机理,为大型客机的结冰适航取证验证工作提供了更为充分的理论依据。

关键词：前缘角冰翼型冰形参数失速特性

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断层带强度对采动应力影响的数值模拟

煤矿安全 2018年第12期49卷 208-211页

作者：李先平山东科技大学矿业与安全工程学院山东青岛266590

以工作面沿断层走向推进为工程背景,采用FLAC3D数值模拟软件,根据岩体强度指标GSI确定断层带弹性模量,并分析了不同断层带岩体强度指标GSI条件下,断层带对采动应力分布的影响。研究表明:工作面沿断层走向推进时,下盘工作面断层煤柱以及... 详细信息

以工作面沿断层走向推进为工程背景,采用FLAC3D数值模拟软件,根据岩体强度指标GSI确定断层带弹性模量,并分析了不同断层带岩体强度指标GSI条件下,断层带对采动应力分布的影响。研究表明:工作面沿断层走向推进时,下盘工作面断层煤柱以及工作面超前支承应力集中较上盘工作面回采时更高,断层对下盘工作面回采时采动应力分布的影响更明显。断层带岩体质量指标GSI值越小,断层煤柱以及工作面超前支承应力集中更明显,即断层岩体裂隙越发育对采动应力的阻隔作用越强。

关键词：断层岩体地质强度指标数值模拟采动应力弹性模量超前支承应力

Potential of A Yogurt Enriched with Synbiotics for Influenza Prevention and Treatment

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Food Science and Human Wellness 2024年

作者： liqiong Song Bin liu Yuangming Huang Junying Zhao xianping li Weicang Qiao Siqin He Hanyu Ma Yanpin liu Weicheng Nie lijun Chen Zhihing Ren National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases， National Institute for Communicable Disease Control and Prevention， Chinese Center for Disease Control and Prevention National Engineering Research Center of Dairy Health for Maternal and Child， Beijing Sanyuan Foods Co.Ltd. Beijing Engineering Research Center of Dairy， Beijing Technical Innovation Center of Human Milk Research， Beijing Sanyuan Foods Co.Ltd. Institute of Basic Theory for Chinese Medicine， China Academy of Chinese Medical Sciences Beijing University of Chinese Medicine Third Affiliated Hospital

Probiotics show anti-influenza activity， offering a potential variant-resistant alternative for infection prevention and control. In this study， we evaluated whether a specially formulated yogurt enriched with synbiotics (named yogurt 1 in this study) with seven probiotics and six prebiotics， has anti-influenza effects and its underlying mechanisms using a mouse model challenged with influenza virus H1N1 PR8 strain. The mice were treated with phosphate-buffered saline (negative control)， yogurt matrix， yogurt 1， and oseltamivir (positive control)， respectively. yogurt 1 treatment improved the survival of infected mice (from 0% to 30%)， alleviated pathological injuries in the lungs and colon， and reduced the viral load of influenza virus on days 3 and 7 post-infection. yogurt 1 also downregulated some inflammation-related signaling pathways and reduced the levels of proinflammatory cytokines or chemokines in the lungs or serum， including interleukin (IL)-1β， IL-6， tumor necrosis factor-α (TNF-α) and keratinocyte chemoattractant (KC). The levels of short-chain fatty acids in the cecal content were increased， the diversity of the intestinal flora was partially restored， and influenza-specific IgG and interferon-secreting lymphocytes were enhanced following yogurt 1 administration. Thus， yogurt 1， as a commercial and easily accessible dairy product， demonstrated a notable anti-influenza effect in mice by inhibiting viral proliferation， suppressing excessive inflammatory responses， and promoting influenza virus-specific adaptive humoral and cellular immune responses， demonstrating its potential for influenza epidemic prevention and control.

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Journal of Traditional Chinese Medical Sciences 2014年第1期1卷 20-27页

作者： Yin Zhang Yue liu xianping li Yuezhou Chen Hui Ye Xiaofeng li Zihan lin Zheng Wang Wei Huang Xia Ding Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine BeijingChina Dongfang Hospital Affiliated to Beijing University of Chinese Medicine BeijingChina Beijing University of Chinese Medicine BeijingChina China Academy of Chinese Medical Sciences BeijingChina Changping District Hospital of Integrative Medicine BeijingChina Quanzhou Hospital of Traditional Chinese Medicine QuanzhouChina

Objective:This study aimed to reveal the age-related changes in prevalence and symptom characteristics in kidney deficiency syndrome(KDS)with varied health ***:This cross-sectional observational study was conducted in6 *** queried participants aged 20e79 about their health,including symptoms if any,and completed questionnaires to collect participants ***,severity,and frequency of KDS and other relevant parameters were observed and *** analysis of countable variables,including prevalence,was performed by frequency analysis and c2 test and expressed as a composite *** analysis of quantitative scores of the severity and frequency of symptoms was performed by the rank-sum *** analysis of the correlation of KDS with potential contributing factors was performed by non-conditional binary logistic stepwise regression of numerical ***:Prevalence of KDS in healthy and unhealthy participants correlated with increasing age(P0.05).Age,health status,lower back pain,shin soreness or heel pain,tinnitus or deafness,hair loss or loose teeth,incomplete bladder emptying or incontinence,and sexual dysfunction or infertility were potenti

关键词： Kidney deficiency syndrome Aging Health Subhealth Chronic disease

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图书馆网站设计之浅论

现代情报 2008年第6期28卷 74-75,135页

作者：李显萍杨芳李铄吉林省经济管理干部学院吉林长春130000 吉林省科技信息研究所吉林长春130021

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