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Acceptor Engineering Produces Ultrafast Nonradiative Decay in NIR-Ⅱ Aza-BODIPY Nanoparticles for Efficient Osteosarcoma Photothermal Therapy via Concurrent Apoptosis and Pyroptosis

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Research 2024年第1期2024卷 625-635页

作者： Zhenxiong Shi Hua Bai Jiaxing Wu Xiaofei Miao Jia Gao xianning xu Yi Liu Jiamin Jiang Jiaqi Yang Jiaxin Zhang Tao Shao Bo Peng Huili Ma Dan Zhu Guojing Chen Wenbo Hu Lin Li Wei Huang Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Key Laboratory of Flexible Electronics(KLOFE)and IAM Nanjing Tech UniversityNanjing 211800China Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074China Department of Orthopedics Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China

Small-molecule photothermal agents(PTAs)with intense second near-infrared(NIR-Ⅱ,1,000 to 1,700 nm)absorption and high photothermal conversion efficiencies(PCEs)are promising candidates for treating deep-seated tumors such as *** date,the development of small-molecule NIR-Ⅱ PTAs has largely relied on fabricating donor–acceptor–donor(D–A–D/D′)structures and limited success has been ***,through acceptor engineering,a donor–acceptor–acceptor(D–A–A′)-structured NIR-Ⅱ aza-boron-dipyrromethene(aza-BODIPY)PTA(SW8)was readily developed for the 1,064-nm laser-mediated phototheranostic treatment of *** the donor groups to acceptor groups produced remarkable red-shifts of absorption maximums from first near-infrared(NIR-Ⅰ)regions(~808 nm)to NIR-Ⅱ ones(~1,064 nm)for aza-BODIPYs(SW1 to SW8).Furthermore,SW8 self-assembled into nanoparticles(SW8@NPs)with intense NIR-Ⅱ absorption and an ultrahigh PCE(75%,1,064 nm).This ultrahigh PCE primarily originated from an additional nonradiative decay pathway,which showed a 100-fold enhanced decay rate compared to that shown by conventional pathways such as internal conversion and vibrational ***,SW8@NPs performed highly efficient 1,064-nm laser-mediated NIR-Ⅱ photothermal therapy of osteosarcoma via concurrent apoptosis and *** work not only illustrates a remote approach for treating deep-seated tumors with high spatiotemporal control but also provides a new strategy for building high-performance small-molecule NIR-Ⅱ PTAs.

关键词： donor BODIPY intense

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A novelα-ketoamide reactivity-based two-photon fluorogenic probe for visualizing peroxynitrite in Parkinson's disease models

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创新光学健康科学杂志(英文) 2023年第4期16卷 79-89页

作者： Tao Shao xianning xu Lan Wang Yu Shen Jun Zhao Huizi Li Duoteng Zhang Wei Du Hua Bai Bo Peng Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics(IFE)and Xi'an Institute of Biomedical Materials&Engineering Northwestern Polytechnical University Xi'an 710072P.R.China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech) Nanjing 211816P.R.China Department of Outpatient PLA Rocket Force Characteristic Medical Center Beijing 100088 P.R.China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005FujianP.R.China

Peroxynitrite(ONOO^(-))contributes to oxidative stress and neurodegeneration in Parkinson's disease(PD).Developing a peroxynitrite probe would enable in situ visualization of the overwhelming ONOO^(-)flux and understanding of the ONOO^(-)stress-induced neuropathology of ***,a novelα-ketoamide-based fluorogenic probe(DFlu)was designed for ONOO^(-)monitoring in multiple PD *** results demonstrated that DFlu exhibits a fluorescence turn-on response to ONOO^(-)with high specificity and *** efficacy of DFlu for intracellular ONOO^(-)imaging was demonstrated *** results showed that DFlu can successfully visualize endogenous and exogenous ONOO^(-)in cells derived from chemical and biochemical *** importantly,the two-photon excitation ability of DFlu has been well demonstrated by monitoring exogenous/endogenous ONOO^(-)production and scavenging in live zebraflsh PD *** work provides a reliable and promisingα-ketoamide-based optical tool for identifying variations of ONOO^(-)in PD models.

关键词： α-Ketoamide two-photon fluorogenic probe bioimaging peroxynitrite Parkinson's disease.

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Recent Development in X-Ray Imaging Technology:Future and Challenges

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Research 2021年第1期2021卷 1565-1582页

作者： Xiangyu Ou xue Chen xianning xu Lili Xie Xiaofeng Chen Zhongzhu Hong Hua Bai Xiaowang Liu Qiushui Chen Lin Li Huanghao Yang MOE Key Laboratory for Analytical Science of Food Safety and Biology College of ChemistryFuzhou UniversityFuzhou 350108China Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’an 710072China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

X-ray imaging is a low-cost,powerful technology that has been extensively used in medical diagnosis and industrial nondestructive *** ability of X-rays to penetrate through the body presents great advances for noninvasive imaging of its internal *** particular,the technological importance of X-ray imaging has led to the rapid development of highperformance X-ray detectors and the associated imaging ***,we present an overview of the recent development of X-ray imaging-related technologies since the discovery of X-rays in the 1890s and discuss the fundamental mechanism of diverse X-ray imaging instruments,as well as their advantages and disadvantages on X-ray imaging *** also highlight various applications of advanced X-ray imaging in a diversity of *** further discuss future research directions and challenges in developing advanced next-generation materials that are crucial to the fabrication of flexible,low-dose,highresolution X-ray imaging detectors.

关键词： diagnosis directions instruments

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聚四氟乙烯在仪表防腐上的应用

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工程塑料应用 2005年第8期33卷 47-49页

作者：徐显宁董高峰衢州市巨化第二中学衢州324004 巨化工程有限公司仪表厂衢州324004

介绍聚四氟乙烯(PTFE)的性能,比较各种常用防腐材料的耐化学药品性能的优劣,给出PTFE在仪表防腐上的常用工艺,并介绍了PTFE在仪表防腐上的实际应用。

关键词：聚四氟乙烯仪表防腐问题 PTFE 耐化学药品性能内衬工艺外包工艺

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Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review

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Animal Nutrition 2024年第1期16卷 251-266页

作者： Pengju Wang Lv-hui Sun xu Wang Qinghua Wu Aimei Liu Hubei Key Laboratory of Diabetes and Angiopathy Medicine Research Institute Xianning Medical College Hubei University of Science and Technology Hubei Hongshan Laboratory College of Animal Science and Technology Huazhong Agricultural University National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural University College of Life Science Yangtze University

T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive toxicity, neurotoxicity, and nephrotoxicity in humans and animals. T-2 toxin is physicochemically stable and does not readily degrade during food and feed processing. Therefore, suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent issue. Protective agents against the organ toxicity of T-2 toxin have been recorded widely in the literature, but these protective agents and their molecular mechanisms of detoxification have not been comprehensively summarized. In this review, we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification effects. Targeting appropriate targets to antagonize T-2 toxin toxicity is also an important option. This review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future.

关键词： T-2 toxin Organ toxicity Protective agent Detoxification mechanism

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Glass-Ceramics with High Strength and High Transmittance Obtained by Multi-Factor Controlling

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 551-560页

作者：胡云坤 RAO Yu WANG Mingzhong xu Yinsheng XIA Mengling TAO Haizheng 陆平 School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China xianning CSG Photovoltaic Glass Co. Ltd.Xianning 437100China State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Jincheng Optical-mechanical Industry Research Institute Jincheng 048000China

The presence of Li_(2)Si_(2)O_(5) and LiAlSi_(4)O_(10) could effectively improve the elastic modulus and transmittance of lithium disilicate(LD)*** synergistically modulation of the crystal content and grain size,we obtained high strength and high transmittance of LD *** optimal sample had a high transmittance of 90.3%,the hardness was 7.72 GPa,the fracture toughness was 1.07 MPa·m^(1/2),and the elastic modulus was 103.1 GPa.

关键词： lithium disilicate glass-ceramics transmittance mechanical properties

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Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes:a bioinformatics analysis

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1411-1417页

作者： Cai-Han Yu Cai-Xia Wu Dai Li Lan-Lan Gong xu-Dong Lyu Jie Yang Department of Ophthalmology Xianning Central HospitalThe First Affiliated Hospital of Hubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Optometry Hubei University of Science and TechnologyXianning 430071Hubei ProvinceChina

AIM:To prevent neovascularization in diabetic retinopathy(DR)patients and partially control disease ***:Hypoxia-related differentially expressed genes(DEGs)were identified from the GSE60436 and GSE102485 datasets,followed by gene ontology(GO)functional annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** candidate drugs were screened using the CMap ***,a protein-protein interaction(PPI)network was constructed to identify hypoxia-related hub genes.A nomogram was generated using the rms R package,and the correlation of hub genes was analyzed using the Hmisc R *** clinical significance of hub genes was validated by comparing their expression levels between disease and normal groups and constructing receiver operating characteristic curve(ROC)***,a hypoxia-related miRNA-transcription factor(TF)-Hub gene network was constructed using the NetworkAnalyst online ***:Totally 48 hypoxia-related DEGs and screened 10 potential candidate drugs with interaction relationships to upregulated hypoxia-related genes were identified,such as ruxolitinib,meprylcaine,and *** addition,8 hub genes were also identified:glycogen phosphorylase muscle associated(PYGM),glyceraldehyde-3-phosphate dehydrogenase spermatogenic(GAPDHS),enolase 3(ENO3),aldolase fructose-bisphosphate C(ALDOC),phosphoglucomutase 2(PGM2),enolase 2(ENO2),phosphoglycerate mutase 2(PGAM2),and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3).Based on hub gene predictions,the miRNA-TF-Hub gene network revealed complex interactions between 163 miRNAs,77 TFs,and hub *** results of ROC showed that the except for GAPDHS,the area under curve(AUC)values of the other 7 hub genes were greater than 0.758,indicating their favorable diagnostic ***:PYGM,GAPDHS,ENO3,ALDOC,PGM2,ENO2,PGAM2,and PFKFB3 are hub genes in DR,and hypoxia-related hub genes exhibited favorable diagnostic perform

关键词： diabetic retinopathy hypoxia-related genes hub genes miRNA-TF-Hub gene drug prediction

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载脂蛋白E基因多态性及脂质代谢水平与胆囊结石形成的关系研究

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浙江医学 2024年第14期46卷 1513-1517页

作者：任爱群胡裕雯叶红于徐蓓蓓戴显宁叶毅温州市人民医院消化内科 325000 温州市人民医院神经内科 325000 温州市人民医院检验科 325000

目的探讨载脂蛋白(Apo)E基因多态性及脂质代谢水平与胆囊结石形成的关系。方法回顾性选取2022年6月至2023年6月在温州市人民医院诊断为胆囊结石的100例患者作为胆囊结石组,另选取同期在本院体检的100名健康者作为对照组。使用基因检测... 详细信息

目的探讨载脂蛋白(Apo)E基因多态性及脂质代谢水平与胆囊结石形成的关系。方法回顾性选取2022年6月至2023年6月在温州市人民医院诊断为胆囊结石的100例患者作为胆囊结石组,另选取同期在本院体检的100名健康者作为对照组。使用基因检测试剂盒进行多通道荧光定量分析Apo E基因多态性。比较两组Apo E基因型分布、等位基因频率分布以及血清TG、TC、HDL-C、LDL-C、非高密度脂蛋白胆固醇及脂蛋白水平差异。采用logistic回归分析胆囊结石形成的独立危险因素,采用ROC曲线评估危险因素对胆囊结石的预测效能。结果胆囊结石组患者TC、HDL-C、LDL-C水平均高于对照组(均P<0.05)。Apo E基因多态性分析显示,胆囊结石组ε2、ε4等位基因频率均高于对照组(均P<0.01)。胆囊结石组E2/3、E2/4、E3/4、E4/4及E2/4+E3/4+E4/4基因型频率均高于对照组(均P<0.01)。logistic回归分析显示,E2/3、E2/4及E3/4基因型、性别、HDL-C水平及吸烟史均是胆囊结石形成的独立危险因素(均P<0.05)。而E2/4、E3/4、TG、HDL-C可作为胆囊结石的预测指标,其联合预测的灵敏度为0.710,特异度为0.910,约登指数为0.620,截断值为0.600,AUC为0.880。结论胆囊结石患者存在Apo E基因多态性,且Apo E基因多态性、性别、HDL-C水平及吸烟史与胆囊结石的形成密切相关,E2/4、E3/4、TG、HDL-C可作为预测胆囊结石形成的潜在指标。

关键词：载脂蛋白E 基因多态性胆囊结石脂质代谢

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双重绩效反馈相关性对企业异质性创新战略抉择的影响研究

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中国软科学 2024年第4期 201-213页

作者：李奉书叶江峰徐朝辉徐莹婕安徽大学商学院安徽合肥230601 湖北科技学院经济与管理学院湖北咸宁437000 南开大学商学院天津300071

绩效反馈对组织创新的影响一直备受关注,然而历史绩效和行业绩效连续时期的反馈相关性对企业异质性创新战略抉择的影响机理尚未厘清。基于绩效反馈理论,以2010—2022年中国深沪A股高科技制造业上市公司为样本,探讨双重绩效反馈相关性对... 详细信息

绩效反馈对组织创新的影响一直备受关注,然而历史绩效和行业绩效连续时期的反馈相关性对企业异质性创新战略抉择的影响机理尚未厘清。基于绩效反馈理论,以2010—2022年中国深沪A股高科技制造业上市公司为样本,探讨双重绩效反馈相关性对企业异质性创新战略抉择的影响机理,以及高管股权激励的调节效应。研究结果显示,双重绩效反馈相关性与企业突破性创新呈U型关系,双重绩效反馈相关性与企业渐进性创新呈倒U型关系。高管股权激励强化了双重绩效反馈强相关与企业突破性创新之间的关系,也强化了弱相关与企业渐进性创新之间的关系。

关键词：双重绩效反馈相关性突破性创新渐进性创新高管股权激励绩效反馈理论

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新生儿脐血耳聋基因高通量筛查及分析

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中华新生儿科杂志（中英文） 2018年第2期33卷 89-93页

作者：戴显宁童郁许锴陈娟娟陈亥尚露梦温州市人民医院温州市妇幼保健院检验科 325000

目的分析新生儿遗传性耳聋基因的突变率，探讨开展新生儿遗传性耳聋基因普遍筛查的必要性及临床意义。方法前瞻性选择2015年5月至2017年5月我院出生的新生儿，生后留取脐带血，采用基因芯片技术进行常见4个耳聋基因筛查，并于出生48 h... 详细信息

目的分析新生儿遗传性耳聋基因的突变率，探讨开展新生儿遗传性耳聋基因普遍筛查的必要性及临床意义。方法前瞻性选择2015年5月至2017年5月我院出生的新生儿，生后留取脐带血，采用基因芯片技术进行常见4个耳聋基因筛查，并于出生48 h后进行新生儿听力筛查，42 d复查。采用χ2检验对基因筛查结果及42 d后听力筛查数据进行分析。结果共纳入2 615例新生儿，出生48 h后听力筛查通过2 455例，通过率为93.9%（2 455/2 615）。42 d后复查听力筛查通过143例，通过率为99.3%（2 598/2 615）。脐血耳聋基因突变107例，突变率4.1%。携带耳聋突变基因患儿听力筛查通过96例，通过率为89.7%（96/107）；未携带耳聋突变基因患儿听力筛查通过2 502例，通过率为99.8%（2 502/2 508）；携带耳聋突变基因患儿听力筛查通过率明显低于未携带者，差异有统计学意义（χ2＝160.199，P〈0.001）。107例耳聋基因突变患儿以GJB2基因突变最为常见（49例，45.8%），其次是SLC26A4（37例，34.6%）和mtDNA 12SrRNA（13例，12.1%），GJB3基因突变最少（8例，7.5%）。对17例42 d后听力复筛未通过的新生儿在3月龄时进行听力学诊断，最终确诊新生儿听力下降6例，其中耳聋基因突变导致听力下降5例。结论本组患儿耳聋基因突变以GJB2、SLC26A4突变为主，新生儿听力和基因联合筛查具有临床可行性，能发现暂无听力下降的耳聋基因携带者，有利于对其进行早期干预。

关键词：基因测定新生儿筛查听力检查胎血耳聋基因

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