Acceptor Engineering Produces Ultrafast Nonradiative Decay in NIR-Ⅱ Aza-BODIPY Nanoparticles for Efficient Osteosarcoma Photothermal Therapy via Concurrent Apoptosis and Pyroptosis

作     者：Zhenxiong Shi Hua Bai Jiaxing Wu Xiaofei Miao Jia Gao Xianning Xu Yi Liu Jiamin Jiang Jiaqi Yang Jiaxin Zhang Tao Shao Bo Peng Huili Ma Dan Zhu Guojing Chen Wenbo Hu Lin Li Wei Huang Zhenxiong Shi;Hua Bai;Jiaxing Wu;Xiaofei Miao;Jia Gao;Xianning Xu;Yi Liu;Jiamin Jiang;Jiaqi Yang;Jiaxin Zhang;Tao Shao;Bo Peng;Huili Ma;Dan Zhu;Guojing Chen;Wenbo Hu;Lin Li;Wei Huang

作者机构：Frontiers Science Center for Flexible ElectronicsXi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM)Nanjing University of Posts&TelecommunicationsNanjing 210023China Key Laboratory of Flexible Electronics(KLOFE)and IAMNanjing Tech UniversityNanjing 211800China Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical PhotonicsWuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074China Department of OrthopedicsXijing HospitalThe Fourth Military Medical UniversityXi’an 710032China The Institute of Flexible Electronics(IFEFuture Technologies)Xiamen UniversityXiamen 361005China 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2024年第2024卷第1期

页      面：625-635页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Key R&D Program of China(2020YFA0709900) the National Natural Science Foundation of China(62288102,22077101,62175201,and 22004099) the Joint Research Funds of Department of Science&Technology of Shaanxi Province and North-western Polytechnical University(2020GXLH-Z-008,2020GXLH-Z-021 and 2020GXLH-Z-023) the Open Project Program of Wuhan National Laboratory for Optoelectronics(Nos.2020WNLOKF023 and 2022WNLOKF009) The Natural Science Foundation of Ningbo(202003N4049 and 202003N4065) the Natural Science Foundation of Shaanxi Province(2022JM-130) 

主　　题：donor BODIPY intense 

摘      要：Small-molecule photothermal agents(PTAs)with intense second near-infrared(NIR-Ⅱ,1,000 to 1,700 nm)absorption and high photothermal conversion efficiencies(PCEs)are promising candidates for treating deep-seated tumors such as *** date,the development of small-molecule NIR-Ⅱ PTAs has largely relied on fabricating donor–acceptor–donor(D–A–D/D′)structures and limited success has been ***,through acceptor engineering,a donor–acceptor–acceptor(D–A–A′)-structured NIR-Ⅱ aza-boron-dipyrromethene(aza-BODIPY)PTA(SW8)was readily developed for the 1,064-nm laser-mediated phototheranostic treatment of *** the donor groups to acceptor groups produced remarkable red-shifts of absorption maximums from first near-infrared(NIR-Ⅰ)regions(~808 nm)to NIR-Ⅱ ones(~1,064 nm)for aza-BODIPYs(SW1 to SW8).Furthermore,SW8 self-assembled into nanoparticles(SW8@NPs)with intense NIR-Ⅱ absorption and an ultrahigh PCE(75%,1,064 nm).This ultrahigh PCE primarily originated from an additional nonradiative decay pathway,which showed a 100-fold enhanced decay rate compared to that shown by conventional pathways such as internal conversion and vibrational ***,SW8@NPs performed highly efficient 1,064-nm laser-mediated NIR-Ⅱ photothermal therapy of osteosarcoma via concurrent apoptosis and *** work not only illustrates a remote approach for treating deep-seated tumors with high spatiotemporal control but also provides a new strategy for building high-performance small-molecule NIR-Ⅱ PTAs.