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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang liu Yu-Chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming Zhang Hanyu Wu Qi Chen Jiaxin Yang Bonan liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

Micro-strain regulation strategy to stabilize perovskite lattice based on the categories and impact of strain on perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 578-604页

作者： Caixia Li Wenwu liu Shiji Da Lingbin Kong Fen Ran State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology

Photovoltaic metal halide perovskite solar cells(PSCs) convert light to electricity more efficiently than crystalline silicon cells, and the cost of materials used to make them is lower than that of silicon *** efficiency is not a core issue affecting the application of perovskite solar cells in special *** present, stability is the major technical encounters that hinders its further commercial development. Microstrain in PSCs is currently a significant factor responsible for the device's instability. Strain-induced ion migration is widely believed to accelerate perovskite degradation even when external stimuli are ***, it is imperative to study strain to enhance the stability of PSCs. This paper reviews recent developments to understand strain's origin and effect mechanisms on performance of PSCs, including ion migration,failure behavior, defect formation, and its effect on photoelectric properties, stability, and ***, several well-known strain management strategies are systematically introduced based on the strain effect mechanism and strain engineering on the film, providing more clues for further preparation with increased stability. The manipulation of external physical strain applied from films to entire devices has been extensively studied. Furthermore, recommendations for future research directions and chemical approaches have been provided. It is emphasized that strain engineering plays a crucial role in improving the efficiency and longevity of PSCs. Tensile strain causes rapid degradation, while moderate compressive strain and external strain control could improve properties and stability. Efforts should focus on controlling compressive strain to mitigate residual tensile strain and introducing it in a controlled manner. Future research endeavors may focus on exploring these pathways to improve the efficiency and lifespan of PSCs.

关键词： Halide perovskite solar cells Strain origins Strain effects Strain management

大健康产业背景下药食同源资源开发的现状与对策研究

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湖南中医药大学学报 2021年第5期41卷 815-820页

作者：胡思王超孙贵香刘仙菊李晨婷何清湖湖南中医药大学湖南长沙410208 湖南医药学院湖南怀化418000

随着“健康中国”战略的提出,大健康产业已成为当前拥有巨大潜力的朝阳产业。在大健康产业背景下药食同源资源因其独特的优势,具有重要的研究意义。综合论述药食同源资源在大健康产品、日化产品、天然食品添加剂、农业应用方面的开发现... 详细信息

随着“健康中国”战略的提出,大健康产业已成为当前拥有巨大潜力的朝阳产业。在大健康产业背景下药食同源资源因其独特的优势,具有重要的研究意义。综合论述药食同源资源在大健康产品、日化产品、天然食品添加剂、农业应用方面的开发现状以及当前开发中存在低水平重复开发、缺乏中医药特色与优势、产品质量不稳定的问题,提出了构建药食同源资源全值化利用产业链、结合中医食疗和现代科学理论、优化质量检测方法3种开发策略,以促进我国药食同源资源的研究与开发。

关键词：大健康产业药食同源现状对策

Effects of RapidEye Imagery's Red-edge Band and Vegetation Indices on Land Cover Classification in an Arid Region

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Chinese Geographical Science 2017年第5期27卷 827-835页

作者： LI xianju CHEN Gang liu Jingyi CHEN Weitao CHENG Xinwen LIAO Yiwei College of Computer Science and Hubei Key Laboratory of Intelligent Geo-Information Processing China University of GeosciencesWuhan 430074China College of Marine Science and Technology China University of GeosciencesWuhan 430074China Laboratory of Geographic Information and Spatial Analysis Department of Geography and PlanningQueen's UniversityKingston ON K7L3N6Canada Faculty of Information Engineering China University of GeosciencesWuhan 430074China School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhan 430074China

Land cover classification(LCC) in arid regions is of great significance to the assessment, prediction, and management of land desertification. Some studies have shown that the red-edge band of RapidE ye images was effective for vegetation identification and could improve LCC accuracy. However, there has been no investigation of the effects of RapidE ye images' red-edge band and vegetation indices on LCC in arid regions where there are spectrally similar land covers mixed with very high or low vegetation coverage information and bare land. This study focused on a typical inland arid desert region located in Dunhuang Basin of northwestern China. First, five feature sets including or excluding the red-edge band and vegetation indices were constructed. Then, a land cover classification system involving plant communities was developed. Finally, random forest algorithm-based models with different feature sets were utilized for LCC. The conclusions drawn were as follows: 1) the red-edge band showed slight contribution to LCC accuracy; 2) vegetation indices had a significant positive effect on LCC; 3) simultaneous addition of the red-edge band and vegetation indices achieved a significant overall accuracy improvement(3.46% from 86.67%). In general, vegetation indices had larger effect than the red-edge band, and simultaneous addition of them significantly increased the accuracy of LCC in arid regions.

关键词： arid region land cover classification RapidEye red-edge band vegetation indices random forest Dunhuang Basin

Modification strategies on nickel-based electrocatalysts for energyefficient anodic reactions

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Nano Research 2025年第1期18卷 50-75页

作者： Jingwen Yu Yunliang liu Naiyun liu Yaxi Li Yuanyuan Cheng Peng Cao Yixian liu Xinya Yuan Xinyue Zhang Haitao Li Institute for Energy Research School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China

Electrocatalytic chemical oxidation(ECO)is an energy-efficient anodic reaction alternative to the oxygen evolution reaction(OER).ECO lowers the reaction potential and yields higher-value fine chemicals at the *** catalyst material plays a crucial role in influencing and determining ECO *** catalyst performance encompasses aspects such as activity,stability,selectivity and *** electrocatalysts have garnered significant attention for their exceptional performance and widespread use in ECO *** modifying nickel-based electrocatalysts,the formation of NiOOH active centers can be *** such as adjusting size and morphology,doping,introducing defects and constructing heterojunctions are advantageous for enhancing *** the rapid advancements in related research fields,it is imperative to comprehend the mechanisms of nickel-based electrocatalysts in ECO and develop innovative *** article provides an overview of the modification strategies of nickel-based electrocatalysts,as well as their applications and mechanisms in ECO.

关键词： anodic reactions electrocatalytic chemical oxidation nickel-based electrocatalysts NiOOH modification strategies

The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis

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Neural Regeneration Research 2025年第5期20卷 1513-1520页

作者： Xueyun Shao Longfei He Yangyang liu Physical Education School Shenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Institute of Neuroscience ShenzhenGuangdong ProvinceChina

Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase brain-derived neurotrophic factor levels in children and adolescents, the effects of specific types of exercise on brain-derived neurotrophic factor levels are still controversial. To address this issue, we used meta-analytic methods to quantitatively evaluate, analyze, and integrate relevant studies. Our goals were to formulate general conclusions regarding the use of exercise interventions, explore the physiological mechanisms by which exercise improves brain health and cognitive ability in children and adolescents, and provide a reliable foundation for follow-up research. We used the Pub Med, Web of Science, Science Direct, Springer, Wiley Online Library, Weipu, Wanfang, and China National Knowledge Infrastructure databases to search for randomized controlled trials examining the influences of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents. The extracted data were analyzed using Review Manager 5.3. According to the inclusion criteria, we assessed randomized controlled trials in which the samples were mainly children and adolescents, and the outcome indicators were measured before and after the intervention. We excluded animal experiments, studies that lacked a control group, and those that did not report quantitative results. The mean difference(MD;before versus after intervention) was used to evaluate the effect of exercise on brain-derived neurotrophic factor levels in children and adolescents. Overall, 531 participants(60 children and 471 adolescents, 10.9–16.1 years) were included from 13 randomized controlled trials. Heterogeneity was evaluated using the Q statistic and I^(2) test provided by Review Manager software. The meta-analysis showed that there was no heterogeneity among the studies(P = 0.67,

关键词： adolescents brain-derived neurotrophic factor children exercise meta-analysis randomized controlled trials

The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng liu Chunhua Pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics