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Bacterial and cancerous cell membrane fused liposome coordinates with PD-L1 inhibitor for cancer immunotherapy

Nano Research 2024年第9期17卷 8389-8401页

作者： xianjin luo Chenglong Li Zhaofei Guo Hairui Wang Penghui He Yuanhao Zhao Yi Lin Chunting He Yingying Hou Yongshun Zhang Guangsheng Du Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610064China Pharmaceutical Biotechnology Department of PharmacyLMU MunichButenandt Strasse 5-13Munich 81377Germany Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China

Although tumor cell membranes with broad-spectrum antigens have been explored for cancer vaccines for decades,their relatively poor capacity to stimulate immune responses,especially cellular immune responses,has limited their ***,we presented a novel bacterial and cancerous cell membrane fusogenic liposome for co-delivering cell membrane-derived antigens and ***,a programmed death-ligand 1(PD-L1)inhibitor,JQ-1,was incorporated into the formulation to tackle the up-regulated PD-L1 expression of antigen-presenting cells(APCs)upon vaccination,thereby augmenting its anti-tumor *** fusogenic liposomes demonstrated significantly improved cellular uptake by APCs and effectively suppressed PD-L1 expression in bone marrow-derived dendritic cells(BMDCs)in *** subcutaneous vaccination,the nano-vaccines efficiently drained to the tumor-draining lymph nodes(TDLNs),and significantly inhibited PD-L1 expression of both dendritic cells(DCs)and macrophages within the TDLNs and *** a result,the liposomal vaccine induced robust innate and cellular immune responses and inhibited tumor growth in a colorectal carcinoma-burden mouse *** summary,the fabricated cell membrane-based fusogenic liposomes offer a safe,effective,and easily applicable strategy for tumor immunotherapy and hold potential for personalized cancer immunotherapy.

关键词： fusogenic liposome tumor cell membrane adjuvant programmed death-ligand 1(PD-L1)inhibitor tumor draining lymph nodes

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Design, synthesis, and antiviral properties of 2-aryl-1H- benzimidazole-4-carboxamide derivatives

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Frontiers of Chemical Science and Engineering 2009年第3期3卷 305-309页

作者： xianjin luo ZhonglüZHANG Yutian YANG Fei XUE Naiyun XIU Yuanbin SHE School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Schools of Life Science and Environmental Science Shanghai Normal UniversityShanghai 200234China Institute of Green Chemistry and Fine Chemicals Beijing University of TechnologyBeijing 100022China

A series of new benzimidazole derivatives were designed and *** chemical structures were testified by 1 H NMR,infrared spectroscopy(IR),mass spectrography(MS),and elemental *** potent antiviral properties indicated the prospect of new *** 13,16,18,19,21,22,and 23 were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B_(3) in VERO cells.

关键词： benzimidazole coxsackie virus B_(3) antiviral properties

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Regulable toehold lock for the effective control of strand displacement reaction sequence and circuit leakage

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Chinese Chemical Letters 2024年第7期35卷 372-376页

作者： Kuangdi luo Yang Qin Xuehao Zhang Hanxu Ji Heao Zhang Jiangtian Li xianjin Xiao Xinyu Wang Department of Breast Surgery Second Hospital of Jilin UniversityChangchun 130041China Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pancreatic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430023China

Strand displacement reaction enables the construction of enzyme-free DNA reaction networks,thus has been widely applied to DNA circuit and *** has the characteristics of high efficiency,universality and ***,the existing regulation tools cannot enable effective control of the reaction sequence,which undoubtedly limits the construction of complex nucleic acid ***,we developed a regulation tool,toehold lock,and achieved strict control of reaction sequence without loss of the main reaction signal ***,we applied the tool to scenarios such as seesaw circuits,AND/OR logic gates,and entropy-driven circuits,and respectively demonstrated its significant superiority compared to the original *** believe that the proposed toehold lock has greatly optimized the efficiency of DNA strand displacement-based networks,and we anticipate that the tool will be widely used in multiple fields.

关键词： DNA circuit Toehold lock DNA strand displacement Reaction sequence Seesaw circuit

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The Application of Bilayer Artificial Dermis Combined with VSD Technology in Chronic Wounds

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Journal of Biosciences and Medicines 2024年第3期12卷 238-244页

作者： xianjin Dong Huasong luo Traumatology Orthopedics The First Affiliated Hospital of Yangtze University Jingzhou China

Background: Bilayer artificial dermis promotes wound healing and offers a treatment option for chronic wounds. Aim: Examine the clinical efficacy of bilayer artificial dermis combined with Vacuum Sealing Drainage (VSD) technology in the treatment of chronic wounds. Method: From June 2021 to December 2023, our hospital treated 24 patients with chronic skin tissue wounds on their limbs using a novel tissue engineering product, the bilayer artificial dermis, in combination with VSD technology to repair the wounds. The bilayer artificial dermis protects subcutaneous tissue, blood vessels, nerves, muscles, and tendons, and also promotes the growth of granulation tissue and blood vessels to aid in wound healing when used in conjunction with VSD technology for wound dressing changes in chronic wounds. Results: In this study, 24 cases of chronic wounds with exposed bone or tendon larger than 1.0 cm2 were treated with a bilayer artificial skin combined with VSD dressing after wound debridement. The wounds were not suitable for immediate skin grafting. At 2 - 3 weeks post-treatment, good granulation tissue growth was observed. Subsequent procedures included thick skin grafting or wound dressing changes until complete wound healing. Patients were followed up on average for 3 months (range: 1 - 12 months) post-surgery. Comparative analysis of the appearance, function, skin color, elasticity, and sensation of the healed chronic wounds revealed superior outcomes compared to traditional skin fl repairs, resulting in significantly higher satisfaction levels among patients and their families. Conclusion: The application of bilayer artificial dermis combined with VSD technology for the repair of chronic wounds proves to be a viable method, yielding satisfactory therapeutic effects compared to traditional skin flap procedures.

关键词： Bilayer Artificial Dermis Vacuum Sealing Drainage (VSD) Chronic Wounds Wound Healing Application

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非电解质溶液扩散系数的理论研究评述

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化工学报 2006年第10期57卷 2263-2269页

作者：阎建民罗先金 R.Krishna 上海交通大学化学化工学院上海200240 阿姆斯特丹大学化工系

许多过程都涉及扩散控制的传质,相应的扩散速率计算对过程工程的精确量化具有重要意义.本文简述了扩散速率的理论表述模型,并着重介绍了非电解质溶液内扩散系数的理论分析计算途径.分子动力学模拟正处于发展中,并用于估算自扩散系数,但... 详细信息

许多过程都涉及扩散控制的传质,相应的扩散速率计算对过程工程的精确量化具有重要意义.本文简述了扩散速率的理论表述模型,并着重介绍了非电解质溶液内扩散系数的理论分析计算途径.分子动力学模拟正处于发展中,并用于估算自扩散系数,但进入实用化阶段尚需时日,唯象模型仍为最重要的理论计算手段.作为最常用的方法,由无限稀释浓度下的扩散系数以及合适的插值方法可计算特定浓度下的扩散系数;自由体积理论是半经验性模型,可以计算自扩散系数,并借助混合规则计算相互扩散系数;最后,对扩散系数的理论研究作了展望.

关键词：扩散系数唯象模型 Maxwell-Stefan方程

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Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives

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International Journal of Organic Chemistry 2013年第1期3卷 41-46页

作者： Dongping Shao Yanbing Yang Fei Xue xianjin luo Reyila Wubulikasimu Yuhuan Li Rongmei Gao Weidong Ye Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai China Zhejiang Medicine Co. Ltd. Xinchang Pharmaceutical Factory Xinchang China

A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.

关键词： 1 2 4-Triazole Anti-Enterovirus Coxsackie B Viruses

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干法赤泥堆场周边的安全影响区域分析

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轻金属 2021年第8期 10-13页

作者：罗先进杨小全贵阳铝镁设计研究院有限公司贵州贵阳550081

在铝冶炼企业高质量、低风险、健康有序的持续发展需要背景下,本文以赤泥的特性、及坝体和防洪设施作为重点分析对象,分析干法赤泥堆场的本质安全,并通过对周边环境的调查和了解,结合赤泥堆场的本质安全,分析其对周边环境安全的影响,为... 详细信息

在铝冶炼企业高质量、低风险、健康有序的持续发展需要背景下,本文以赤泥的特性、及坝体和防洪设施作为重点分析对象,分析干法赤泥堆场的本质安全,并通过对周边环境的调查和了解,结合赤泥堆场的本质安全,分析其对周边环境安全的影响,为企业进一步掌握赤泥堆场安全动态、以及下一步堆存规划和运行管理提供技术支撑。

关键词：干法赤泥堆场本质安全影响分析

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贵州都匀毛尖茶叶中微量元素测定与营养价值分析

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广东化工 2015年第1期42卷 104-105页

作者：罗先进息烽县环境监测站贵州贵阳551100

选用了都匀毛尖茶,用火焰原子吸收分光光度法对其中的微量元素Ca、Mg、Fe、Mn、Cu、Zn的含量进行了分析测定。结果表明,该方法简单,精密度和准确度高,标准曲线线性关系好(RCa=0.9991、RMg=0.0.9977、RFe=0.9970、RMn=0.9987、RCu=0.9990... 详细信息

选用了都匀毛尖茶,用火焰原子吸收分光光度法对其中的微量元素Ca、Mg、Fe、Mn、Cu、Zn的含量进行了分析测定。结果表明,该方法简单,精密度和准确度高,标准曲线线性关系好(RCa=0.9991、RMg=0.0.9977、RFe=0.9970、RMn=0.9987、RCu=0.9990、RZn=0.9985)。

关键词：火焰原子吸收光谱法都匀毛尖茶微量元素

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风电场数据中心Hadoop云平台作业调度算法研究

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计算机工程与应用 2015年第15期51卷 266-270页

作者：罗贤缙岳黎明甄成刚华北电力大学控制与计算机工程学院河北保定071000

风电场数据中心包含状态监测、数据采集等实时类作业和非实时类作业,采用C/S结构存在资源利用率不平衡、管理与维护成本高等缺点。设计了一种基于Hadoop云平台的数据中心架构;针对开源Hadoop平台现有FIFO调度器不能满足实时监测系统要求... 详细信息

风电场数据中心包含状态监测、数据采集等实时类作业和非实时类作业,采用C/S结构存在资源利用率不平衡、管理与维护成本高等缺点。设计了一种基于Hadoop云平台的数据中心架构;针对开源Hadoop平台现有FIFO调度器不能满足实时监测系统要求,在原有FIFO调度器的基础上,设计了一种双队列的作业调度器,综合考虑作业的截止时间和优先级来进行作业调度决策,实验结果表明,与FIFO调度器相比,双队列的作业调度器在集群负载较大时能够表现出较好的性能,保证实时类作业能够优先执行,为风电机组的安全运行提供保障。

关键词： Hadoop 云平台调度算法集群负载

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高职学生自我素质教育概念界定及其特性探析

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当代教育论坛 2014年第3期 96-101页

作者：罗先进曾玲芝湖南理工职业技术学院湖南理工职业技术学院经贸系

随着高职教育的不断发展,素质教育理念正逐渐贯穿于高职人才培养过程中。如何将高职学生培养成专业技能过硬、综合素质较高的实用型技术人才,是高职教育工作者不断研究和探讨的课题。文章试图从学生自身角度出发,通过梳理国内外有关素... 详细信息

随着高职教育的不断发展,素质教育理念正逐渐贯穿于高职人才培养过程中。如何将高职学生培养成专业技能过硬、综合素质较高的实用型技术人才,是高职教育工作者不断研究和探讨的课题。文章试图从学生自身角度出发,通过梳理国内外有关素质教育及自我教育的相关文献,提出自我素质教育概念,并对其内涵及特征进行深入分析,从而为高职院校更快、更好地实施素质教育提供一定的参考意见。

关键词：高职学生素质教育自我教育自我素质教育

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