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Comparative transcriptome analysis between rhesus macaques(Macaca mulatta) and crab-eating macaques(M. fascicularis)

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Zoological Research 2024年第2期45卷 299-310页

作者： Yu-Xiang Mao Yamei Li Zikun yang Ning Xu Shilong Zhang Xuankai Wang xiangyu yang Qiang Sun Yafei Mao Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science&Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Genetic Evolution&Animal Models Chinese Academy of SciencesKunmingYunnan 650201China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Zhiyuan College Shanghai Jiao Tong UniversityShanghai 200240China Center for Genomic Research International Institutes of MedicineFourth Affiliated HospitalZhejiang UniversityYiwuZhejiang 322000China

Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques(Macaca mulatta, MMU)and crab-eating macaques(M. fascicularis, MFA) serve as crucial nonhuman primate biomedical models with different phenotypes. To date, however, large-scale comparative transcriptome research between these two species has not yet been fully explored. Here, we conducted systematic comparisons utilizing newly sequenced RNA-seq data from84 samples(41 MFA samples and 43 MMU samples)encompassing 14 common tissues. Our findings revealed a small fraction of genes(3.7%) with differential expression between the two species, as well as 36.5% of genes with tissue-specific expression in both macaques. Comparison of gene expression between macaques and humans indicated that 22.6% of orthologous genes displayed differential expression in at least two tissues. Moreover,19.41% of genes that overlapped with macaque-specific structural variants showed differential expression between humans and macaques. Of these, the FAM220A gene exhibited elevated expression in humans compared to macaques due to lineage-specific duplication. In summary,this study presents a large-scale transcriptomic comparison between MMU and MFA and between macaques and humans. The discovery of gene expression variations not only enhances the biomedical utility of macaque models but also contributes to the wider field of primate genomics.

关键词： Crab-eating macaques Rhesus macaques Comparative transcriptomics Biomedical models Nonhuman primates RNA-seq Duplicated genes

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Intelligent overheating fault diagnosis for overhead transmission line using semantic segmentation

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High Voltage 2024年第2期9卷 309-318页

作者： xiangyu yang Youping Tu Zhikang Yuan Zhong Zheng Geng Chen Cong Wang Yan Xu Beijing Key Laboratory of High Voltage and EMC North China Electric Power UniversityBeijingChina College of Electronic and Information Engineering Tongji UniversityShanghaiChina

The strain clamps and leading wires are important components that connect conductors on overhead transmission lines and conduct current.During operation,poor contact between these components can cause abnormal overheating,leading to electric failures and threatening power system reliability.Recently,the use of unmanned aerial vehicles equipped with infrared thermal imagers for strain clamp and leading wire maintenance has become increasingly popular.Deep learning-based image recognition shows promising prospects for intelligent fault diagnosis of overheating faults.A pre-treatment method is proposed based on dynamic histogram equalisation to enhance the contrast of infrared images.The DeepLab v3+network,loss function,and existing networks with different backbones are compared.The DeepLab v3+network with ResNet101 and convolutional block attention module added,and the Focal Loss function achieved the highest performance with an average pixel accuracy of 0.614,an average intersection over union(AIoU)of 0.567,an F1 score of 0.644,and a frequency weighted intersection over union of 0.594 on the test set.The optimised Atrous rates has increased the AIoU by 12.91%.Moreover,an intelligent diagnosis scheme for evaluating the defect state of the strain clamps and leading wires is proposed and which achieves a diagnostic accuracy of 91.0%.

关键词： union fault diagnosis

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A Review of Contact Electrification at Diversified Interfaces and Related Applications on Triboelectric Nanogenerator

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Nano-Micro Letters 2024年第1期16卷 106-130页

作者： Jun Hu Mitsumasa Iwamoto xiangyu Chen CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Department of Physical Electronics Tokyo Institute of Technology2‑12‑1 S3‑33 O‑OkayamaMeguro‑KuTokyo 152‑8552Japan

The triboelectric nanogenerator(TENG)can effectively collect energy based on contact electrification(CE)at diverse interfaces,including solid–solid,liquid–solid,liquid–liquid,gas–solid,and gas–liquid.This enables energy harvesting from sources such as water,wind,and sound.In this review,we provide an overview of the coexistence of electron and ion transfer in the CE process.We elucidate the diverse dominant mechanisms observed at different interfaces and emphasize the interconnectedness and complementary nature of interface studies.The review also offers a comprehensive summary of the factors influencing charge transfer and the advancements in interfacial modification techniques.Additionally,we highlight the wide range of applications stemming from the distinctive characteristics of charge transfer at various interfaces.Finally,this review elucidates the future opportunities and challenges that interface CE may encounter.We anticipate that this review can offer valuable insights for future research on interface CE and facilitate the continued development and industrialization of TENG.

关键词： Contact electrification Interfaces Triboelectric nanogenerators Diversified applications

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Ion Channel Dysregulation Following Intracerebral Hemorrhage

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Neuroscience Bulletin 2024年第3期40卷 401-414页

作者： xiangyu Zhang Yan Zhang Qiuyang Su yang Liu Zhe Li V.Wee Yong Mengzhou Xue Department of Cerebrovascular Diseases The Second Afliated Hospital of Zhengzhou UniversityZhengzhou 450000China Academy of Medical Science Zhengzhou UniversityZhengzhou 450000China Hotchkiss Brain Institute and Department of Clinical Neurosciences University of CalgaryCalgaryAB T2N 1N4Canada

Injury to the brain after intracerebral hemorrhage(ICH)results from numerous complex cellular mechanisms.At present,effective therapy for ICH is limited and a better understanding of the mechanisms of brain injury is necessary to improve prognosis.There is increasing evidence that ion channel dysregulation occurs at multiple stages in primary and secondary brain injury following ICH.Ion channels such as TWIK-related K+channel 1,sulfonylurea 1 transient receptor potential melastatin 4 and glutamate-gated channels affect ion homeostasis in ICH.They in turn participate in the formation of brain edema,disruption of the blood-brain barrier,and the generation of neurotoxicity.In this review,we summarize the interaction between ions and ion channels,the effects of ion channel dysregulation,and we discuss some therapeutics based on ion-channel modulation following ICH.

关键词： Intracerebral hemorrhage Ion dyshomeostasis Sulfonylurea 1 transient receptor potential melastatin 4 TWIK-related K+channel 1 N-methyl-Daspartate receptor Transient receptor potential vanilloid 4

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Review of the application of in-situ sensing techniques to address the tea growth characteristics from leaf to field

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 1-11页

作者： Qiong Cao Chunjiang Zhao Ze Xu Ping Jiang Haibin yang xiangyu Meng Guijun yang Information Technology Research Center Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China College of Machnical and Electrical Engineering Hunan Agricultural UniversityChangsha 410125China Tea Research Institute of Chongqing Academy of Agricultural Sciences Chongqing 400000China

The tea plant is a valuable and evergreen crop that is extensively cultivated in China and many other countries.Currently,there is growing research interest in this plant.For the tea industry,it is crucial to develop rapid and non-invasive methods to evaluate tea plants in their natural environment.This article provides a comprehensive overview of non-invasive sensing techniques used for in-situ detection of tea plants.The topics covered include leaf,canopy,and field-level assessments,as well as statistical analysis techniques and characteristics specific to the research.Non-invasive testing technology is primarily used for monitoring and predicting tea pests and diseases,monitoring quality,and nutrients,determining tenderness and grade,identifying tea plant varieties,automatically detecting,and identifying tea buds,monitoring tea plant growth,and extracting tea garden areas through remote sensing.It also helps to evaluate planting suitability,assess disasters,and estimate yields.Additionally,the article examines the challenges and prospects of emerging techniques aimed at resolving the in-situ detection problem for tea plants.It can assist researchers and producers in comprehensively understanding the tea environment,quality characteristics,and growth process,thereby enhancing tea production quality,and fostering tea industry development.

关键词： non-destructive in-situ detection tea plants growth characteristics sensors

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The application of the strip-shaped cymba conchae orthosis in the nonsurgical correction of complex auricular deformity

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Journal of Otology 2024年第1期19卷 24-29页

作者： Huijuan Xu Shaoguang Ding Fei Zhang Zhifeng Zhang xiangyu Chen Mingyang Li Haitao yang Fugen Han Hongjian Liu Department of Otolaryngology Head and Neck Surgery People’s Hospital of Henan UniversityHenan Provincial People’s HospitalZhengzhouChina Department of Otolaryngology Head and Neck Surgery Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhouChina Department of Otolaryngology Head and Neck Surgery Henan Children’s HospitalZhengzhouChina Department of Otolaryngology Head and Neck Surgery The Third People’s Hospital of ZhengzhouZhengzhouChina Zheng Dong Mihuan Clinic ZhengzhouChina

Objective: This study aims to evaluate the efficacy and safety of using a strip-shaped cymba conchae orthosis for the nonsurgical correction of complex auricular deformities. Methods: Clinical data were collected from 2020 to 2021 for 6 patients who underwent correction using a stripshaped cymba conchae orthosis. The indications, corrective effects, and complications associated with use of the orthosis were analyzed. Results: There were four indications for treatment: cryptotia with helix adhesion;cryptotia with grade I microtia;cryptotia with excessive helix thickness;and auricular deformity beyond the treatment time window(≥6 months). Excellent corrective effects were observed in all 6 patients. Complications occurred in one patient, who recovered after symptomatic treatment. Conclusion: The use of a strip-shaped cymba conchae orthosis alone or combined with a U-shaped helix orthosis presents a feasible approach for correcting complex auricular deformities or deformities beyond the treatment time window in pediatric patients.

关键词： Cymba conchae Auricular deformity Cryptotia Nonsurgical correction Orthosis

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Toward understanding the microstructure characteristics,phase selection and magnetic properties of laser additive manufactured Nd-Fe-B permanent magnets

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International Journal of Extreme Manufacturing 2024年第1期6卷 277-294页

作者： Bo Yao Nan Kang xiangyu Li Dou Li Mohamed EL Mansori Jing Chen Haiou yang Hua Tan Xin Lin State Key Laboratory of Solidiffcation Processing Northwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Arts et Metiers Institute of Technology MSMPHESAM UniversitéF-51006 Chˆalons-en-ChampagneFrance Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Texas A&M Engineering Experiment Station Institute for Manufacturing SystemsCollege StationTX 77843United States of America

Nd-Fe-B permanent magnets play a crucial role in energy conversion and electronic devices.The essential magnetic properties of Nd-Fe-B magnets,particularly coercivity and remanent magnetization,are significantly infuenced by the phase characteristics and microstructure.In this work,Nd-Fe-B magnets were manufactured using vacuum induction melting(VIM),laser directed energy deposition(LDED)and laser powder bed fusion(LPBF)technologies.Themicrostructure evolution and phase selection of Nd-Fe-B magnets were then clarified in detail.The results indicated that the solidification velocity(V)and cooling rate(R)are key factors in the phase selection.In terms of the VIM-casting Nd-Fe-B magnet,a large volume fraction of theα-Fe soft magnetic phase(39.7 vol.%)and Nd2Fe17Bxmetastable phase(34.7 vol.%)areformed due to the low R(2.3×10-1?C s-1),whereas only a minor fraction of the Nd2Fe14B hard magnetic phase(5.15 vol.%)is presented.For the LDED-processed Nd-Fe-B deposit,although the Nd2Fe14B hard magnetic phase also had a low value(3.4 vol.%)as the values of V(10-2m s-1)and R(1.45×106?C s-1)in the LPBF process resulted in the substantial formation of the Nd2Fe14B hard magnetic phase(55.8 vol.%)directly from the liquid,while theα-Fe soft magnetic phase and Nd2Fe17Bxmetastable phase precipitation are suppressed in the LPBF-processed Nd-Fe-B magnet.Additionally,crystallographic texture analysis reveals that the LPBF-processedNd-Fe-B magnets exhibit isotropic magnetic characteristics.Consequently,the LPBF-processed Nd-Fe-B deposit,exhibiting a coercivity of 656 k A m-1,remanence of 0.79 T and maximum energy product of 71.5 k J m-3,achieved an acceptable magnetic performance,comparable to other additive manufacturing

关键词： laser additive manufacturing(LAM) Nd-Fe-B permanent magnets numerical simulation microstructure magnetic properties

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Current assessment and management of measurable residual disease in patients with acute lymphoblastic leukemia in the setting of CAR-T-cell therapy

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Chinese Medical Journal 2024年第2期137卷 140-151页

作者： Minghao Lin Xiaosu Zhao Yingjun Chang xiangyu Zhao Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China

Chimeric antigen receptor(CAR)-modified T-cell therapy has achieved remarkable success in the treatment of acute lymphoblastic leukemia(ALL).Measurable/minimal residual disease(MRD)monitoring plays a significant role in the prognostication and management of patients undergoing CAR-T-cell therapy.Common MRD detection methods include flow cytometry(FCM),polymerase chain reaction(PCR),and next-generation sequencing(NGS),and each method has advantages and limitations.It has been well documented that MRD positivity predicts a poor prognosis and even disease relapse.Thus,how to perform prognostic evaluations,stratify risk based on MRD status,and apply MRD monitoring to guide individual therapeutic decisions have important implications in clinical practice.This review assesses the common and novel MRD assessment methods.In addition,we emphasize the critical role of MRD as a prognostic biomarker and summarize the latest studies regarding MRD-directed combination therapy with CAR-T-cell therapy and allogeneic hematopoietic stem cell transplantation(allo-HSCT),as well as other therapeutic strategies to improve treatment effect.Furthermore,this review discusses current challenges and strategies for MRD detection in the setting of disease relapse after targeted therapy.

关键词： Measurable/minimal residual disease Acute lymphoblastic leukemia Chimeric antigen receptor-modified T-cell therapy Allogeneic hematopoietic stem cell transplantation Relapse

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Three-dimensional(3D)parametric measurements of individual gravels in the Gobi region using point cloud technique

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Journal of Arid Land 2024年第4期16卷 500-517页

作者： JING xiangyu HUANG Weiyi KAN Jiangming College of Engineering Beijing Forestry UniversityBeijing 100083China Key Laboratory of State Forestry Administration on Forestry Equipment and Automation Beijing 100083China

Gobi spans a large area of China,surpassing the combined expanse of mobile dunes and semi-fixed dunes.Its presence significantly influences the movement of sand and dust.However,the complex origins and diverse materials constituting the Gobi result in notable differences in saltation processes across various Gobi surfaces.It is challenging to describe these processes according to a uniform morphology.Therefore,it becomes imperative to articulate surface characteristics through parameters such as the three-dimensional(3D)size and shape of gravel.Collecting morphology information for Gobi gravels is essential for studying its genesis and sand saltation.To enhance the efficiency and information yield of gravel parameter measurements,this study conducted field experiments in the Gobi region across Dunhuang City,Guazhou County,and Yumen City(administrated by Jiuquan City),Gansu Province,China in March 2023.A research framework and methodology for measuring 3D parameters of gravel using point cloud were developed,alongside improved calculation formulas for 3D parameters including gravel grain size,volume,flatness,roundness,sphericity,and equivalent grain size.Leveraging multi-view geometry technology for 3D reconstruction allowed for establishing an optimal data acquisition scheme characterized by high point cloud reconstruction efficiency and clear quality.Additionally,the proposed methodology incorporated point cloud clustering,segmentation,and filtering techniques to isolate individual gravel point clouds.Advanced point cloud algorithms,including the Oriented Bounding Box(OBB),point cloud slicing method,and point cloud triangulation,were then deployed to calculate the 3D parameters of individual gravels.These systematic processes allow precise and detailed characterization of individual gravels.For gravel grain size and volume,the correlation coefficients between point cloud and manual measurements all exceeded 0.9000,confirming the feasibility of the proposed methodology for measuring 3D parameters of individual gr

关键词： Gobi gravels three-dimensional(3D)parameters point cloud 3D reconstruction Random Sample Consensus(RANSAC)algorithm Density-Based Spatial Clustering of Applications with Noise(DBSCAN)

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Multi-Objective Optimization of VBHF in Deep Drawing Based on the Improved QO-Jaya Algorithm

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 189-202页

作者： xiangyu Jiang Zhaoxi Hong Yixiong Feng Jianrong Tan State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province Zhejiang UniversityHangzhou 310027China Ningbo Innovation Center Zhejiang UniversityNingbo 315100China

Blank holder force(BHF)is a crucial parameter in deep drawing,having close relation with the forming quality of sheet metal.However,there are different BHFs maintaining the best forming effect in different stages of deep drawing.The variable blank holder force(VBHF)varying with the drawing stage can overcome this problem at an extent.The optimization of VBHF is to determine the optimal BHF in every deep drawing stage.In this paper,a new heuristic optimization algorithm named Jaya is introduced to solve the optimization efficiently.An improved“Quasi-oppositional”strategy is added to Jaya algorithm for improving population diversity.Meanwhile,an innovated stop criterion is added for better convergence.Firstly,the quality evaluation criteria for wrinkling and tearing are built.Secondly,the Kriging models are developed to approximate and quantify the relation between VBHF and forming defects under random sampling.Finally,the optimization models are established and solved by the improved QO-Jaya algorithm.A VBHF optimization example of component with complicated shape and thin wall is studied to prove the effectiveness of the improved Jaya algorithm.The optimization results are compared with that obtained by other algorithms based on the TOPSIS method.

关键词： Variable blank holder force Multi-objective optimization QO-Jaya algorithm Algorithm stop criterion

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