检索结果-南通市图书馆

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

基于时间卷积模型的GNSS多路径误差削弱

江西科学 2024年第1期42卷 142-147页

作者：李思辉刘超张开坤王向阳段伟孙景强安徽理工大学空间信息与测绘工程学院安徽淮南232001 南京市测绘勘察研究院股份有限公司南京210019 徐州矿务集团有限公司资产开发管理部江苏徐州221140

多路径误差是全球导航卫星系统(Global Navigation Satellite System,GNSS)短基线的主要误差源,考虑到GNSS多系统条件下,经典的恒星日滤波方法(Sidereal Filtering,SF)卫星的重访周期难以获取以及半天球模型(Multipath Hemispherical Map,MHM)需要大量数据支持的问题,引入了时间卷积网络模型(Time Convolutional Network,TCN),充分利用其对海量数据的深度挖掘能力,建立GNSS坐标序列中的多路径误差模型,并进行多路径误差的实时削弱。通过连续15 d的实验数据测试,结果表明,新方法克服了经典SF方法难以适用于多系统GNSS多路径误差的削弱,且仅需要1 d的训练样本,即可实现后续多天的多路径误差的实时削弱,其削弱效果明显优于MHM模型,表现出了良好的泛化能力。

关键词：全球导航卫星系统多路径误差时间卷积网络恒星日滤波半天球模型

维普期刊数据库博看期刊

Versatile subtypes of pericytes and their roles in spinal cord injury repair,bone development and repair

在线全文

学校读者我要写书评

暂无评论

Bone Research 2022年第2期10卷 253-264页

作者： Sipin Zhu Min Chen Yibo Ying Qiuji Wu Zhiyang Huang Wenfei Ni xiangyang wang Huazi Xu Samuel Bennett Jian Xiao Jiake Xu Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Molecular Pharmacology Research Centre School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhouZhejiang 325035China Molecular Laboratory School of Biomedical SciencesThe University of Western AustraliaPerthWA 6009Australia

Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit(NVU),pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, namely the PDGFR-β, Desmin, CD146, and NG2, each of which is involved with spinal cord injury(SCI) repair. In addition, pericytes may act as a stem cell source that is important for bone development and regeneration, whilst specific subtypes of pericyte could facilitate bone fracture and defect repair. One of the major challenges of pericyte biology is to determine the specific markers that would clearly distinguish the different subtypes of pericytes, and to develop efficient approaches to isolate and propagate pericytes. In this review, we discuss the biology and roles of pericytes, their markers for identification, and cell differentiation capacity with a focus on the potential application in the treatment of SCI and bone diseases in orthopedics.

关键词： CD146 pericyte injury

Surgical Treatment and Prognosis of Synchronous Double Primary Lung Cancer： a Report of 31 Cases

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Clinical Oncology 2005年第5期2卷 824-828页

作者： Feiyue Feng Dechao Zhang xiangyang Liu Yonggang wang Yousheng Mao Department of Thoracic Surgery Cancer Hospital/Institute Chinese Academy of Medical Sciences＆Peking Union Medical College Beijing 100021 China.

OBJECTIVE The concept of double primary lung cancer （DPLC） has been generally accepted. Recently, an increasing incidence of synchronous DPLC has been reported, while the diagnostic standard and treatment strategies remain to be improved. This study was conducted to investigate effective surgical treatment and prognosis of synchronous DPLC. METHODS From January 1983 to April 2004, 31 patients with synchronous DPLC were operated in our department. Clinical data, such as surgical pattern, postoperative complications, and survival status, of all these patients were reviewed retrospectively. RESULTS The 31 patients with synchronous DPLC accounted for 0.67% of all the 4,649 patients operated for primary lung cancer in our department during the same period. Both tumors of the synchronous DPLC were resected with Iobectomy or pneumonectomy in 12 patients, while among the other 19 patients at least 1 tumor was treated with partial pulmonary resection. The postoperative morbidity was 29%（9/31）, including 1 case of respiratory insufficiency, 3 cases of atelectasis, 2 cases of atrial fibrillation, 1 case of haemoptysis, 1 case of pleural effusion, and 1 case of wound fat necrosis. No deaths occurred during the operations or within 30 days postoperatively. The postoperative 1 -, 3-, and 5-year survival rates were 52%, 29%, and 20%, respectively. CONCLUSION The incidence of synchronous DPLC is low. An aggressive and reasonable surgical approach can achieve a satisfactory outcome in patients with synchronous DPLC. The postoperative morbidity is low. Some patients might achieve long-term survival.

关键词： synchronous double primary lung cancer surgery prognosis.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

采空区遗煤氧化自热隐患治理技术

中国高新科技 2024年第12期 21-23页

作者：曹文龙马小辉李文福刘咸富王向阳陕西彬长孟村矿业有限公司陕西咸阳712000

某煤矿工作面末采期间采空区断层附近遗煤量大,工作面停采时间长,推采速度慢,导致采空区遗煤氧化自热,CO快速升高。通过树立“安全第一、快速高效”指导思想,确定“堵漏风、降氧气、消高温、防反复”的总体技术思路,采用“注惰防爆、分... 详细信息

某煤矿工作面末采期间采空区断层附近遗煤量大,工作面停采时间长,推采速度慢,导致采空区遗煤氧化自热,CO快速升高。通过树立“安全第一、快速高效”指导思想,确定“堵漏风、降氧气、消高温、防反复”的总体技术思路,采用“注惰防爆、分区防治、注胶降温、控氧抑温”为主的技术措施,从而有效消除采空区遗煤氧化自热高温隐患,使煤矿工作面能够安全开采,为工作面回撤工作提供安全保障。

关键词：遗煤氧化自热高温隐患治理氧化

Effect of PKCα on the gene expression related with proliferation and activity of transcription factor AP-1

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1997年第23期42卷 1986-1989页

作者： wang xiangyang and LIU HuituKey Laboratory of Cell Proliferation and Regulation Biology, Department of Biology, Beijing Normal University, Beijing 100875, China Key Laboratory of Cell Proliferation and Regulation Biology Department of Biology Beijing Normal University Beijing China

PROTEIN kinase C (PKC) is a serine/thronine kinase, which plays a major role in cell sig-nalling, growth control and tumorigenesis. PKC is encoded by a multigene family, which havebeen identified as consisting of at least 12 members in mammalian tissues. PKC isoforms differin their biochemical properties, tissue-specific expression and intracellular localization. Thedifferences imply that the individual PKC isoforms have a distinct physiological function. Inorder to study the role of specific PKC subtype in cell proliferation and transformation, weconstructed the human embryonic lung cell (2BS) model stably overexpressing PKC_α andfound that the overexpression of PKC_α promoted the growth rate and caused the transform-

关键词： protein kinase Cα 2BS cell transcription factor AP-1.

孟村煤矿401103综放面采空区煤自燃“三带”研究

在线全文

学校读者我要写书评

暂无评论

中国高新科技 2024年第14期 21-23,26页

作者：李文福马小辉刘咸富王向阳曹文龙陕西彬长孟村矿业有限公司陕西咸阳712000

为预测孟村煤矿401103综放工作面采空区内的煤炭自燃情况,在工作面进行煤自燃发火“三带”观测,现场观测并收集氧气浓度等数据,分析采空区氧气浓度的分布规律。采用Fluent模拟软件进一步分析采空区的氧气浓度,确定孟村煤矿401103综放面... 详细信息

为预测孟村煤矿401103综放工作面采空区内的煤炭自燃情况,在工作面进行煤自燃发火“三带”观测,现场观测并收集氧气浓度等数据,分析采空区氧气浓度的分布规律。采用Fluent模拟软件进一步分析采空区的氧气浓度,确定孟村煤矿401103综放面采空区煤自燃发火“三带”分布规律及范围。结果表明,运输巷侧工作面氧化带范围为距离工作面6.5~58m,回风侧工作面氧化带范围为距离工作面7~56m,最大氧化带宽度为51.5m,结合煤层最短自燃发火期,计算得到工作面最小安全推进速度为2.5m/d,为孟村煤矿401103综放面采空区注氮、喷洒阻化剂、灌浆管释放口的布置提供依据,为该矿工作面采空区煤自燃预测提供参考。

关键词：自燃“三带” 采空区分布规律现场实测数值模拟

Engineered high-strength biohydrogel as a multifunctional platform to deliver nucleic acid for ameliorating intervertebral disc degeneration

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第7期25卷 107-121页

作者： Tao Chen Qiuping Qian Pooyan Makvandi Ehsan Nazarzadeh Zare Qizhu Chen Linjie Chen Zhiguang Zhang Hao Zhou Wenxian Zhou Hui wang xiangyang wang Yu Chen Yunlong Zhou Aimin Wu Department of Orthopaedics Key Laboratory of Orthopaedics of Zhejiang ProvinceThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang325000China Institute for Bioengineering School of EngineeringThe University of EdinburghEdinburghEH93FBUK School of Chemistry Damghan UniversityDamghan36716-45667Iran Wenzhou Medical University WenzhouZhejiang325000China Materdicine Lab School of Life SciencesShanghai UniversityShanghai200444China

Intervertebral disc degeneration(IVDD)is a leading cause of low back *** strategy of using functional materials to deliver nucleic acids provides a powerful tool for ameliorating ***,the immunogenicity of nucleic acid vectors and the poor mechanical properties of functional materials greatly limit their ***,antagomir-204-3p(AM)shows low immunogenicity and effectively inhibits the apoptosis of nucleus pulposus ***,a high-strength biohydrogel based on zinc-oxidized sodium alginate-gelatin(ZOG)is designed as a multifunctional nucleic acid delivery *** loaded with AM(ZOGA)exhibits great hygroscopicity,antibacterial activity,biocompatibility,and ***,ZOGA can be cross-linked with nucleus pulposus tissue to form a high-strength collagen network that improves the mechanical properties of the intervertebral disc(IVD).In addition,ZOGA provides an advantageous microenvironment for genetic expression in which AM can play an efficient role in maintaining the metabolic balance of the extracellular *** results of the radiological and histological analyses demonstrate that ZOGA restores the height of the IVD,retains moisture in the IVD,and maintains the tissue *** ZOGA platform shows the sustained release of nucleic acids and has the potential for application to ameliorate IVDD,opening a path for future studies related to IVD.

关键词： Intervertebral disc degeneration Hydrogel Nucleic acid MicroRNA Delivery Extracellular matrix

瑞舒伐他汀与阿托伐他汀对动脉钙化抑制作用的比较

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华实验外科杂志 2024年第9期41卷 1992-1995页

作者：聂斌张宽心潘漩屈世芳方宇林王向阳江汉大学附属医院武汉市第六医院老年外科武汉430015 武汉市第四医院华中科技大学同济医学院附属普爱医院口腔颌面外科武汉430030 华中科技大学同济医学院附属武汉中心医院胃肠外科武汉430015

目的探讨瑞舒伐他汀和阿托伐他汀对动脉中膜钙化的抑制作用差异与其对骨保护素(OPG)/核因子κB受体活化因子配体(RANKL)比值的影响.方法分别建立动脉中膜钙化的动物模型和细胞模型.6~8周龄体重180~200g雄性SD大鼠.使用华法林对大鼠灌... 详细信息

目的探讨瑞舒伐他汀和阿托伐他汀对动脉中膜钙化的抑制作用差异与其对骨保护素(OPG)/核因子κB受体活化因子配体(RANKL)比值的影响.方法分别建立动脉中膜钙化的动物模型和细胞模型.6~8周龄体重180~200g雄性SD大鼠.使用华法林对大鼠灌胃诱导大鼠主动脉钙化构建动脉中膜钙化的动物模型,使用维生素C和β-磷酸甘油诱导大鼠主动脉中膜平滑肌细胞(SMC)钙化构建钙化的细胞模型.将80只大鼠采用简单随机表法分为4组:正常对照组,钙化组、瑞舒伐他汀组和阿托伐他汀组,每组20只.瑞舒伐他汀组和阿托伐他汀组在使用上述物质的同时分别再加入瑞舒伐他汀和阿托伐他汀进行干预;使用分光光度计测定钙离子含量,考马斯亮蓝法测定碱性磷酸酶(ALP)活性,蛋白质印迹法(Western blot)判断骨钙素水平,实时荧光定量聚合酶链反应(Real-time PCR)来检测此过程中OPG、RANKL的表达.多组间比较采用单因素方差分析ANOVA,组间的比较使用独立样本t检验.结果动物模型中,瑞舒伐他汀组和阿托伐他汀组中的钙离子含量、ALP活性、骨钙素表达水平均低于钙化组[(0.94±0.09)mg/g比(1.44±0.10)mg/g、34.39±7.68 比 100.60±5.90、0.51±0.07 比 0.92±0.09,t=9.926、30.564、16.287,P<0.05;(1.30±0.29)mg/g 比(1.44±0.10)mg/g、61.47±4.04 比 100.60±5.90、0.74±0.06 比 0.92±0.09,t=2.092、24.463、7.528,P<0.05];瑞舒伐他汀组的钙离子含量、ALP活性、骨钙素表达水平均低于阿托伐他汀组[(0.94±0.09)mg/g 比(1.30±0.2)mg/g、34.39±7.68 比 61.47±4.04、0.51±0.07 比 0.74±0.06,t=5.152、13.946、10.887,P<0.05];瑞舒伐他汀组中动脉的 OPG/RANKL比值高于阿托伐他汀组(1.08±0.15比0.77±0.03,t=8.742,P<0.05).细胞模型中,瑞舒伐他汀组和阿托伐他汀组中的钙离子含量、ALP活性、骨钙素表达水平均低于钙化组[(69.83±3.77)μg/mg protein 比(133.00±4.50)μg/mgprotein、29.42±1.81 比99.94±3.83、0.49±0.06 比0.92±0.06,t=48.156、74.403、22.931,P<0.05;(99.03±2.93)μg/mg protein 比(133.00±4.50)μg/mgprotein、61.14±2.13 比 99.94±3.83、0.79±0.07 比 0.92±0.06,t=28.326、39.633、6.610,P<0.05];瑞舒伐他汀组的钙离子含量、ALP活性、骨钙素表达水平均低于阿托伐他汀组[(69.83±3.77)μg/mg protein 比(99.03±2.93)μg/mg protein、29.42±1.81 比 61.14±2.13、0.49±0.06 比 0.79±0.07,t=27.363、50.747、15.246,P<0.05];瑞舒伐他汀组中细胞的 OPG/RANKL 比值高于阿托伐他汀组(1.08±0.09比0.78±0.12,t=9.034,P<0.05).结论瑞舒伐他汀比阿托伐他汀具有更明显的抑制钙化作用,其机制可能与其上调OPG/RANKL比值的能力更强有关.

关键词：动脉钙化阿托伐他汀瑞舒伐他汀

Stability Investigation and Improvement for DC Cascade Systems with Simplified Impedance-based Stability Criterion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第3期10卷 1044-1052页

作者： Junbin Fang Zhikang Shuai Yang Li Zhibing wang xiangyang Wu Xia Shen Z.John Shen College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Renewable Energy Department of China Electric Power Research Institute Beijing 100192China Department of Electrical and Computer Engineering Illinois Institute of TechnologyChicagoIL 60616USA IEEE

In DC distributed power systems(DPSs),the complex impedance interactions possibly lead to DC bus voltage oscillation or *** previous research,the stability analysis of DPSs is implemented based on mathematical analysis in control *** specific mechanisms of the instability of the cascade system have not been intuitively *** this paper,the stability analysis of DPSs based on the traditional Nyquist criterion is simplified to the resonance analysis of the seriesconnected port impedance(Z=R+jX)of source and load *** reveals that the essential reason for impedance instability of a DC cascade system is that the negative damping characteristic(R<0)of the port the overall impedance amplifies the internal resonance source at reactance zero-crossing *** simplified stability criterion for DC cascade systems can be concluded as:in the negative damping frequency ranges(R<0),there exists no zero-crossing point of the reactance component(i.e.,X=0).According to the proposed stability criterion,the oscillation modes of cascade systems are classified.A typical one is the internal impedance instability excited by the negative damping,and the other one is that the external disturbance amplified by negativity in a low stability ***,the impedance reshaping method for stability improvement of the system can be further *** validity of the simplified criterion is verified theoretically and experimentally by a positive damping reshaping method.

关键词： DC cascaded system,impedance model impedance reconstruction stability criterion