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Optical detection of acetylcholine esterase based on CdTe quantum dots

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Chinese Science Bulletin 2013年第21期58卷 2622-2627页

作者： CHEN ZhenZhen ren xiangling TANG FangQiong Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

In this study, we have constructed a simple, sensitive and rapid biosensor for detection of acetylcholine esterase (AChE) based on CdTe quantum dots (QDs). The detection limit of AChE by one-step enzyme reaction based on the thiolglycolic acid (TGA) stabilized QDs (TGA-QDs) was 10 U/L and the linear range was 10-100 and 100-1200 U/L, respectively. The detection limit of AChE by two-step enzyme reaction based on the 3-mercaptopropionic acid (MGA) stabilized QDs (MGA-QDs) was found to be 20 U/L and the linear range was 100-2500 U/L. The experimental conditions of biosensors were optimized, and the detection mechanism was studied. We also detected AChE in serum samples based on TGA-QDs or MGA-QDs. The linear range was 10-140 and 50-1000 U/L, respectively. The excellent performance of this novel biosensor demonstrated that this strategy has prodigious potential to be applied in practice detection of AChE.

关键词：乙酰胆碱酯酶量子点光学检测 CdTe 生物传感器传感器检测 TGA AChE

Metal-Organic Frameworks-Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo

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Chinese Journal of Chemistry 2021年第2期39卷 473-487页

作者： Meijia Liu xiangling ren Xianwei Meng Hongbo Li Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing100081 China Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190 China

Metal-organic frameworks(MOFs)as a class of porous functional materials have attracted more and more attention for biomedical *** date,MOFs have been developed for bioimaging based on a series of advantages such as the large surface areas,high porosity,fluorescence functionalities and good *** is worth noting that organic or inorganic fluorescent materials such as fluorescent dyes,quantum dots,metal nanoclusters and nanosheets can combine MOFs or be encapsulated in MOFs to form fluorescent nanocomposites for excellent imaging ***,excellent imaging capabilities are of great significance in living cells and in vivo for detection,diagnosis and cancer *** this review,we focus on the recent research of the bioimaging in living cells and in vivo based on various MOF-based nanocomposites and their potential biological clinical applications.

关键词： Metal-organic frameworks Fluorescent material Nanostructures Fluorescence Bioimaging

Preparation and enhanced properties of ZrMOF@CdTe nanoparticles with high-density quantum dots

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Frontiers of Materials Science 2020年第2期14卷 155-162页

作者： Xin LIU xiangling ren Longfei TAN Wenna GUO Zhongbing HUANG Xianwei MENG College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

ZrMOF@CdTe nanoparticles(NPs)with high fluorescence were synthe-sized by hydrothermal *** morphology,particle size distribution,compositions,fluorescence properties and stability of the synthesized ZrMOF@CdTe were analyzed via the characterization by TEM,ICP-AES and fluorescence spectrophotometry,and the effects of the reaction time and pH value on the fluorescent property of ZrMOF@CdTe NPs were *** results show that ZrMOFs could maintain its morphology and structure well during the process of loading CdTe quantum *** the increase of the loading reaction time,the red-shifted emission peaks of ZrMOF@CdTe NPs appear,and their fluorescence gradually changes from green to red *** the increase of the pH value and temperature of the hydrothermal reaction,the fluorescence of ZrMOF@CdTe NPs was also consistent with the red-shifted *** fluorescent property of ZrMOF@CdTe NPs could be remained for more than 3 ***,ZrMOF@CdTe NPs synthesized by the hydrothermal method have the characteristics of simple operation,adjustable fluorescent color and high stability,and the potential application in the fields of biological detection and sensing is expected.

关键词： hydrothermal synthesis ZrMOF@CdTe nanoparticles quantum dots metal-organic framework

Enhanced antibacterial activity of silica nanorattles with ZnO combination nanoparticles against methicillin-resistant Staphylococcus aureus

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Science Bulletin 2017年第17期62卷 1207-1215页

作者： Qianqian Chai Qiong wu Tianlong Liu Longfei Tan Changhui Fu xiangling ren Yue Yang Xianwei Meng Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academyof SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Silica nanorattles(SNs) with zinc oxide(ZnO) combination nanoparticles are reported to inhibit methicillin-resistant Staphylococcus aureus(MRSA) for the first time. SNs loaded with ZnO nanoparticles,which can produce free radicals, can cause severe damage to bacteria. ZnO nanoparticles not only provide free radicals in the combined nanostructures, which can inhibit the growth of bacteria, but also form nanorough surfaces with an irregular distribution of spikes on the SNs, which can enhance their adhesion to bacteria. Nanorough silica shell surfaces maintain the high activity and stability of small-sized ZnO nanoparticles and gather ZnO nanoparticles together to enhance production, which improves the efficiency of free radicals against the cytomembranes of bacterial cells. The enhanced adhesion of ZnO@SN nanoparticles to MRSA cells shortens the effective touching distance between free radicals and MRSA, which also improves antibacterial activity. As we expected, the ZnO@SN nanoparticles exhibit a better antibacterial effect than free ZnO nanoparticles against MRSA in vitro and in vivo. We also demonstrate that SNs loaded with ZnO nanoparticles can accelerate wound healing in MRSA skin inflammation models. This method of multilevel functionalization will be potentially applicable to the antibacterial field.

关键词： Silica nanorattles ZnO nanoparticles Methicillin-resistant Staphylococcus aureus(MRSA) Rough surface Reactive oxygen species

Preparation and properties of covalent organic framework nanoparticles with high drug loading

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Frontiers of Materials Science 2021年第3期15卷 465-470页

作者： Jian ZOU xiangling ren Longfei TAN Zhongbing HUANG Li GOU Xianwei MENG College of Biomedical Engineering Sichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

With the rapid development of nanotechnology,nano-drug carrier systems in biomedicine have received extensive attention from *** adsorbing or coating the drug in/on a nano-sized carrier,this system improves the drug’s stability and selectivity in the body,reducing the toxicity and side effects of the *** these carrier systems have broad application prospects in the field of biomedicine.A common nano-drug carrier system includes inorganic nano-carriers,organic nano-carriers,and metal *** nano-carriers have the advantages of good stability,controllable size,larger specific surface area,and unique photothermal electromagnetic properties.

关键词： coating stability loading

Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2

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Chinese Chemical Letters 2021年第10期32卷 3087-3089页

作者： xiangling ren Xinyuan Huang Qiong Wu Longfei Tan Changhui Fu Yi Chen Xianwei Meng Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Tumor cells usually show abnormally high glycolysis rate to maintain the dynamic balance of *** growth of tumor cells can be affected by inhibiting the activity of pyruvate kinase(especially M2-type isozyme,PKM2),the rate limiting enzyme of *** is helpful to the treatment of ***,metal organic frameworks(MOFs) were found to inhibit the activity of *** ZIF-8 was synthesized by standing and ultrasonic method,*** ZIF-8 has the performance of inhibiting *** research showed that the inhibition ability was attributed to zinc ion in ***,the IC_(50) of ZIF-8 on PKM2 was one percent of that of zinc *** novel enzyme inhibitor is expected to be used in cancer therapy.

关键词： Metal organic frameworks Pyruvate kinase Glycolysis Lactate dehydrogenase Inhibition

Superoxide dismutase mimetic ability of Mn-doped ZnS QDs

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Chinese Chemical Letters 2018年第12期29卷 1865-1868页

作者： xiangling ren Mingqian Wang Xing He Zheng Li Jing Zhang Wei Zhang Xudong Chen Hong ren Xianwei Meng Laboratory of Controllable Preparation and Application of Nanomaterials Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China First Affiliated Hospital of Southern University of Science and Technology Shenzhen People's Hospital&Shenzhen Interventional Medical Engineering Research and Development CenterShenzhen 518020China Beijing University of Chemical Technology Beijing 100029China Beijing Technology&Business University Beijing Higher Institution Engineering Research Center of Food Additives and IngredientsBeijing Key Laboratory of Flavor ChemistryBeijing Laboratory for Food Quality and SafetyBeijing 100048China University of Chinese Academy of Sciences Beijing 100049China

Superoxide dismutase(SOD) is an important antioxidant enzyme in the body. SOD has special physiological activity and is the primary substance for scavenging free radicals in living ***, the expensive and complex extraction processes, low SOD yield, as well as difficult to store at room temperature have seriously hindered its application pace. Herein, the enzyme mimetic function of Mn-doped ZnS quantum dots(QDs) was discovered. The improved Marklund and McCord method both showed that Mn-doped ZnS QDs possess intrinsic SOD-like activity. The effects of temperature and pH on the mimetic enzyme activity of Mn-doped ZnS QDs have been investigated compared with SOD *** low cost and easy to synthesize white Mn-doped ZnS QDs with good biocompatibility are expected to be used as a new type of SOD nanozymes in the biology-relevant fields.

关键词： Mn-doped ZnS QDs Superoxide dismutase Nanozymes Marklund method Pyrogallol

11-Mercaptoundecanoic acid functionalized gold nanoclusters as fluorescent probes for the sensitive detection of Cu^(2＋) and Fe^(3＋) ions

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Chinese Chemical Letters 2017年第9期28卷 1901-1904页

作者： Zhiqun Bai xiangling ren Zhen Gong Chenxi Hao Yongmei Chen Pingyu Wan Xianwei Meng National Fundamental Research Laboratory of New Hazardous Chemicals Beijing University of Chemical Technology Beijing 100029 China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of Sciences Beijing 100190 China

Metal ions are physiologically essential,but excessive metal ions may cause severe risk to plants and ***,we prepared gold nanoclusters（Au NCs） protected by 11-mercaptoundecanoic acid（11-MUA）,which have excellent fluorescence properties for the detection of metal *** results showed that the copper ions（Cu^（2＋）） and iron ions（Fe^（3＋）） in the solution have obvious quenching effect on the fluorescence intensity of Au *** detection range of Fe^（3＋） was 0.8-4.5 mmol/L（R^2= 0.992） and 4.5-11.0 mmol/L（R^2= 0.997）.And Cu^（2＋） has a lower linear range（0.1-1.0 mmol/L,R2= 0.993）.When EDTA was added into the reaction system,it was observed that the quenching effect of Cu^（2＋） and Fe^（3＋）on Au NCs showed different ***,the effect of metal ions on the fluorescence of Au NCs was *** selective detection of Cu（2＋） was achieved by EDTA masking of Fe^（3＋）.In addition,we realized the metal ions detection application of Au NCs in the serum

关键词： Gold nanoclusters Copper ions Iron ions Detection

Toxicity and bio-distribution of carbon dots after single inhalation exposure in vivo

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Chinese Chemical Letters 2018年第6期29卷 895-898页

作者： Yue Yang xiangling ren Zhenning Sun Changhui Fu Tianlong Liu Xianwei Meng Zili Wang College of Animal Science and Technology Southwest University Chongqing 400716 China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China College of Veterinary Medicine China Agricultural University Beijing 100193 China

Because of the advantages of excellent light stability, carbon dots（CDs） are considered to be a promising agent in the bio-marker application. Nevertheless, there are many unresolved issues with the toxicity of CDs in vitro and in vivo. In the study, CDs were synthesized by citric acid and ethylenediamine into deionized water, then the inhalation toxicity and bio-distribution of CDs in vivo were systematically assessed. The results showed that CDs caused animals death at higher dosages and induced injury in the lung and liver including inflammation and necrosis after single inhalation exposure at 5, 2 and 1 mg/kg dosages of the CDs. We also found that the injury increase with a dose-dependent and time-dependent manner. Fluorescent examination and TEM results showed that CDs mainly located at the lung and *** the fluorescent intensity increase with a time-dependent manner. This study provides a theoretical basis of the respiratory toxicity of CDs, and provides a basis for the use of CDs as a bio-marker.

关键词： Carbon dots Toxicity Bio-distribution Inhalation Fluorescent intensity