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Proteomic study of vitreous in proliferative diabetic retinopathy patients after treatment with aflibercept:a quantitative analysis based on 4D label-free technique

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 676-685页

作者： Ting-Ting Feng xiang Gao An-Ran Liang Bo-Wen Zhao Guang-hui He Song Chen Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalTianjin 300020China Key Laboratory of Ophthalmology Anyang Eye HospitalAnyang 455000Henan ProvinceChina Department of Ophthalmology Jining No.1 People’s HospitalJining 272011Shandong ProvinceChina

AIM:To identify different metabolites,proteins and related pathways to elucidate the causes of proliferative diabetic retinopathy(PDR)and resistance to anti-vascular endothelial growth factor(VEGF)drugs,and to provide biomarkers for the diagnosis and treatment of ***:Vitreous specimens from patients with diabetic retinopathy were collected and analyzed by Liquid Chromatography-Mass Spectrometry(LC-MS/MS)analyses based on 4D label-free *** differentially expressed proteins(DEPs),Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway representation and protein interactions were ***:A total of 12 samples were *** proteomics results showed that a total of 58 proteins were identified as DEPs,of which 47 proteins were up-regulated and 11 proteins were *** found that C1q and tumor necrosis factor related protein 5(C1QTNF5),Clusterin(CLU),tissue inhibitor of metal protease 1(TIMP1)and signal regulatory protein alpha(SIRPα)can all be specifically regulated after aflibercept *** functional analysis showed that some DEPs are related to changes in inflammatory regulatory pathways caused by *** addition,protein-protein interaction(PPI)network evaluation revealed that TIMP1 plays a central role in neural *** addition,CD47/SIRPαmay become a key target to resolve anti-VEGF drug resistance in ***:Proteomic analysis is an approach of choice to explore the molecular mechanisms of *** data show that multiple proteins are differentially changed in PDR patients after intravitreal injection of aflibercept,among which C1QTNF5,CLU,TIMP1 and SIRPαmay become targets for future treatment of PDR and resolution of anti-VEGF resistance.

关键词： vitreous proliferative diabetic retinopathy proteome 4D label-free

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A quadrivalent norovirus vaccine based on a chimpanzee adenovirus vector induces potent immunity in mice

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Virologica Sinica 2024年第4期39卷 675-684页

作者： Yihua Jiang Lingjin Sun Nan Qiao xiang wang Caihong Zhu Man Xing hui Liu Ping Zhou Dongming Zhou Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin300070China Shanghai Public Health Clinical Center Fudan UniversityShanghai201508China R&D Centre Chengdu Kanghua Biological Products Co.LtdChengdu610000China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai200031China

Norovirus(NoV)infection is a major cause of gastroenteritis *** virus poses great challenges in developing vaccines with broad immune protection due to its genetic and antigenic *** date,there are no approved NoV vaccines for clinical ***,we aimed to develop a broad-acting quadrivalent NoV vaccine based on a chimpanzee adenovirus vector,AdC68,carrying the major capsid protein(VP1)of noroviral GI and GII *** to intramuscular(i.m.),intranasal(i.n.),or other prime-boost immunization regimens(i.m.t i.m.,i.m.t i.n.,i.n.t i.m.),AdC68-GI.1-GII.3(E1)-GII.4-GII.17(E3),administered via i.n.t *** higher titers of serum IgG antibodies and higher IgA antibodies in bronchoalveolar lavage fluid(BALF)and saliva against the four homologous VP1s in *** also significantly stimulated the production of blocking antibodies against the four *** response to re-stimulation with virus-like particles(VLP)-GI.1,VLP-GII.3,VLP-GII.4,and VLP-GII.17,the quadrivalent vaccine administered according to the i.n.t *** effectively triggered specific cell-mediated immune responses,primarily characterized by IFN-γ***,the preparation of this novel quadrivalent NoV vaccine requires only a single recombinant adenovirus to provide broad preventive immunity against the major GI/GII epidemic strains,making it a promising vaccine candidate for further development.

关键词： Norovirus(NoV) Quadrivalent vaccine Adenovirus vector

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MoS2 as a cocatalyst applied in advanced oxidation processes for enhancing degradation of organic pollutants: a review

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Tungsten 2024年第3期6卷 473-487页

作者： Ming-Hao Fan Cong-hui wang xiang Yu Jun Ding Ao-Qi Xiao Yue Li Wei-Ya Huang School of Material Science and Engineering Henan Polytechnic University School of Chemical and Printing-Dyeing Engineering Henan International Joint Laboratory of Rare Earth Composite Materials Henan University of Engineering School of Chemistry and Chemical Engineering Jiangxi University of Science and Technology Department of Chemical and Environmental Engineering University of Cincinnati

Fenton technology,as a typical advanced oxidation processes（AOPs）,can generate reactive oxygen species（ROS） of strong oxidation capacity to degrade organic pollutants,which has attracted wide ***,it is accompanied by the slow Fe3+/Fe2+cycle rate,easy to generate iron sludge and so ***,it has been proven that the inorganic cocatalysts represented by MoS2can effectively solve the above ***,MoS2can accelerate the activation of peroxy mono sulfate（PMS） and peroxodisulfate（PDS） by Fe2+.In this paper,MoS2as the cocatalyst in H2O2+Fe2+,PMS+Fe2+and PDS+Fe2+were comprehensively ***,the cycling processes of Fe3+/Fe2+in different systems,the cocatalytic effect of MoS2by the exposed active sites,the ROS generation mechanism as well as the microscopic mechanism during the reaction were elaborated *** results indicate that the reductive active sites on the surface of MoS2can promote the regeneration of Fe2+through the cycle between Fe3+/Fe2+and Mo4+/Mo5+/Mo6+.Thus,ROS such as ·OH,SO4·-and1O2with strong oxidizing property can be produced to improve the degradation efficiency of organic *** last,the challenges and developments of MoS2cocatalysts in AOPs for practical applications were *** review contributes to a deeper understanding of the cocatalytic effect of two-dimensional metal sulfides in AOPs and facilitates their industrial application.

关键词： Cocatalyst Fenton reaction Degradation of organic pollutant Molybdenum disufide Reactive oxygen species

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Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8^(+)T Cell Immunity against Tumor

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Research 2024年第3期2023卷 433-444页

作者： Anze Yu Jinfei Fu Zheng Yin hui Yan xiang Xiao Dawei Zou Xiaolong Zhang Xiongbing Zu Xian C.Li Wenhao Chen Immunobiology and Transplant Science Center Department of SurgeryHouston Methodist Research Institute and Institute for Academic MedicineHouston Methodist HospitalHoustonTXUSA Department of Urology First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Systems Medicine and Bioengineering Department Houston Methodist Neal Cancer CenterHoustonTXUSA Department of Radiology Houston Methodist HospitalWeill Cornell MedicineHoustonTXUSA Department of Urology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Surgery Weill Cornell MedicineCornell UniversityNew YorkNYUSA.

T-cell-based immunotherapy is gaining momentum in cancer treatment;however,our comprehension of the transcriptional regulation governing T cell antitumor activity remains *** objective of this study was to explore the function of interferon regulatory factor 4(IRF4)in antitumor CD8^(+)T cells using the TRAMP-C1 prostate cancer and B16F10 melanoma *** achieve this,we generated an Irf4^(GFP-DTR) mouse strain and discovered that CD8^(+)tumor-infiltrating lymphocytes(TILs)expressing high levels of *** exhibited a more differentiated PD-1high cell *** administering diphtheria toxin to tumor-bearing Irf4^(GFP-DTR) mice,we partially depleted ***^(+)TILs and observed an accelerated tumor *** specifically explore the function of IRF4 in antitumor CD8^(+)T cells,we conducted 3 adoptive cell therapy(ACT)***,depleting ***^(+)CD8^(+)TILs derived from ACT significantly accelerated tumor growth,emphasizing their crucial role in controlling tumor ***,deleting the Irf4 gene in antitumor CD8^(+)T cells used for ACT led to a reduction in the frequency and effector differentiation of CD8^(+)TILs,completely abolishing the antitumor effects of ***,we performed a temporal deletion of the Irf4 gene in antitumor CD8^(+)T cells during ACT,starting from 20 days after tumor implantation,which significantly compromised tumor ***,sustained expression of IRF4 is essential for maintaining CD8^(+)T cell immunity in the melanoma model,and these findings carry noteworthy implications for the advancement of more potent immunotherapies for solid tumors.

关键词： sustained immunity implantation

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Inter-layer interference for multi-layered tight gas reservoir in the absence and presence of movable water

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Petroleum Science 2024年第3期21卷 1751-1764页

作者： Tao Zhang Bin-Rui wang Yu-Long Zhao Lie-hui Zhang xiang-Yang Qiao Lei Zhang Jing-Jing Guo Hung Vo Thanh National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu60500SichuanChina Shaanxi Yanchang Petroleum(Group)Corp.Ltd. Xian710075ShaanxiChina Waseda Research Institute for Science and Engineering Waseda UniversityTokyoJapan

Due to the dissimilarity among different producing layers,the influences of inter-layer interference on the production performance of a multi-layer gas reservoir are ***,systematic studies of inter-layer interference for tight gas reservoirs are really limited,especially for those reservoirs in the presence of *** this work,five types of possible inter-layer interferences,including both absence and presence of water,are identified for commingled production of tight gas ***,a series of reservoir-scale and pore-scale numerical simulations are conducted to quantify the degree of influence of each type of *** field evidence from the Yan'an tight gas reservoir(Ordos Basin,China)is found to support the simulation ***,suggestions are proposed to mitigate the potential inter-layer *** results indicate that,in the absence of water,commingled production is favorable in two situations:when there is a difference in physical properties and when there is a difference in the pressure system of each *** reservoirs with a multi-pressure system,the backflow phenomenon,which significantly influences the production performance,only occurs under extreme conditions(such as very low production rates or well shut-in periods).When water is introduced into the multi-layer system,inter-layer interference becomes nearly *** both the gas-rich layer and water-rich layer for commingled production is not desirable,as it can trigger water invasion from the water-rich layer into the gas-rich *** gas-rich layer might also be interfered with by water from the neighboring unperforated water-rich layer,where the water might break the barrier(eg weak joint surface,cement in fractures)between the two layers and migrate into the gas-rich ***,the gas-rich layer could possibly be interfered with by water that accumulates at the bottom of the wellbore due to gravitational diff

关键词： Tight gas Comingled production Interference Two-phase flow Water blocking

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Clinical characteristics of testicular torsion and factors influencing testicular salvage in children:A 12-year study in tertiary center

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World Journal of Clinical Cases 2024年第7期12卷 1251-1259页

作者： xiang-hui Gang Yuan-Yuan Duan Bin Zhang Zheng-Gan Jiang Rong Zhang Jun Chen xiang-Yu Teng Duo-Bing Zhang Department of Urology Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of Ultrasound Diagnosis Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of Urology The Second Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Testicular torsion is the most common acute scrotum worldwide and mainly occurs in children and *** have demonstrated that the duration of symptoms and torsion grade lead to different outcomes in children diagnosed with testicular *** To predict the possibility of testicular salvage(TS)in patients with testicular torsion in a tertiary *** We reviewed the charts of 75 pediatric patients with acute testicular torsion during a 12-year period from November 2011 to July 2023 at the Suzhou Hospital of Anhui Medical *** and multivariate logistic regression analyses were used to determine independent predictors of testicular *** data included clinical findings,physical examinations,laboratory data,color Doppler ultrasound findings,operating results,age,presenting institution status,and follow-up *** Our study included 75 *** was possible in 57.3%of all patients;testicular torsion occurred mostly in winter,and teenagers aged 11-15 years old accounted for 60%.Univariate logistic regression analyses revealed that younger age(P=0.09),body mass index(P=0.004),torsion angle(P=0.013),red blood cell count(P=0.03),neutrophil-to-lymphocyte ratio(P=0.009),and initial presenting institution(P<0.001)were associated with *** multivariate analysis,only the initial presenting institution predicted TS(P<0.05).CONCLUSION The initial presenting institution has a predictive value for predicting TS in patients with testicular *** with scrotal pain should be admitted to a tertiary hospital as soon as possible.

关键词： Testicular torsion Testicular salvage Pediatrics Predictors Case report

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Advances in the research of intestinal fungi in Crohn's disease

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World Journal of Gastroenterology 2024年第39期30卷 4318-4323页

作者： Mo-Wei Kong Yang Yu Peng wang Ying wan Yu Gao Chun-xiang Zhang Department of Cardiology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of General Surgery Xinqiao HospitalArmy Medical UniversityChongqing 400037China School of Basic Medical Sciences Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Endocrinology Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina

This article reviews of the original research published by Wu et al in the World Journal of Gastroenterology,delving into the pivotal role of the gut microbiota in the pathogenesis of Crohn's disease(CD).Insights were gained from fecal microbiota transplantation(FMT)in mouse models,revealing the intricate interplay between the gut microbiota,mesenteric adipose tissue(MAT),and creeping *** study uncovered the characteristics of inflammation and fibrosis in the MAT and intestinal tissues of patients with CD;moreover,through the FMT mouse model,it observed the impact of samples from healthy patients and those with CD on *** pathogenesis of CD is complex,and its etiology remains unclear;however,it is widely believed that gut microbiota dysbiosis plays a significant ***,with the development and application of next-generation sequen-cing technology,research on the role of fungi in the pathogenesis and chronicity of CD has *** editorial serves as a supplement to the research by Wu et al who discussed advances related to the study of fungi in CD.

关键词： Intestinal microbiota Crohn's disease pathogenesis Fecal microbiota trans-plantation Mesenteric adipose tissue Gut fungal dynamics

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Removal of rubidium from brine by an integrated film of sulfonated polysulfone/graphene/potassium copper ferricyanide

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Chinese Journal of Chemical Engineering 2024年第5期69卷 112-121页

作者： Huanxi Xu Peihua Lin Pei-Jun Liu Hai-Gang Liu hui-Bin Guo Chao-xiang Wu Ming Fang Xu Zhang Guan-Ping Jin Anhui Province Engineering Research Center of Flexible and Intelligent Materials School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China Chemical Design and Research Institute Co. LTD of Qinghai ProvinceQinghai Engineering and Technology Research Center of Fine ChemicalXining 810008China

A novel integrated film of sulfonated polysulfone/graphene/potassium copper ferricyanide(KCuFC/SPSG)was used for selectively extracting rubidium ion(Rb^(+))from *** form KCuFC/SPSG,the precursor film of sulfonated polysulfone/graphene(SPSG)was synthesized by phase conversion process,which was alternately immersed in 0.1 mol·L^(-1)CuSO_(4)/K_(4)[Fe(CN)_(6)]by in-situ adsorption coupled co-precipitation *** data such as nuclear magnetic resonance spectrometer,Fourier transform infrared spectroscope,X-ray photoelectron spectroscope,X-ray diffraction,scanning electron microscope,and energy dispersive spectroscopy all verified that abundant KCuFC were uniformly located on the *** resulting KCuFC/SPSG was used in film separation *** the solution was fed into the system,the Rb^(+)could be selectively adsorption by KCuFC/*** the saturation adsorption,0.5 mol·L^(-1)NH_(4)Cl/HCl was fed into the film cell,Rb^(+)could be quickly desorbed by ion-exchange between Rb^(+)and NH_(4)^(+)in the lattice of *** purpose of separating and recovering Rb^(+)from the brine can be achieved after the repeated *** effects of pH,adsorption time,and interferential ions on the adsorption capacity of Rb^(+)were investigated by batch *** adsorption behavior fits the pseudo-second order kinetic process,while KCuFC has a higher adsorption capacity(Langmuir maximum sorption 165.4 mg·g^(-1)).In addition,KCuFC/SPSG shows excellent selectivity for Rb^(+)even in complex brine ***/SPSG could maintain 93.5%extraction efficiency after five adsorption/desorption cycles.

关键词： Rubidium extraction Potassium copper ferricyanide Sulfonated polysulfone Graphene oxide Adsorption

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RIOK1 synergizes with TRIP13 by regulating the E2F-Rb signaling pathway to promote the proliferation of esophageal cancer cells

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Genes & Diseases 2024年第3期11卷 55-58页

作者： Chengyu Li Deyuan Pan wan Lin Danxia Deng Yingxin Zhou hui Zhao Feng Pan Liyan Xu Enmin Li Lin Long The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area Department of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology Institute of Oncologic PathologyShantou University Medical CollegeShantouGuangdong 515041China Institute of Basic Medical Science Cancer Research CenterShantou University Medical CollegeShantouGuangdong 515041China Clinical Research Center Shantou Central HospitalShantouGuangdong 515041China

Esophageal cancer is one of the leading causes of cancer death in the world,with approximately half of the new cases occurring in China every year.^(1)Esophageal squamous cell carcinoma(ESCC)is the main subtype,accounting for more than 90%,and the five-year survival rate is less than 10%.Using large-scale genome analysis,many driver mutations and key pathways associated with ESCC have been ***,these genomic signatures have not improved the clinical management of EscC patients,or established effective targeted therapy.^(2)Esophageal cancer still lacks representative molecular markers.

关键词： cancer esophageal Esophageal

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Applying dynamic light scattering to investigate the self-assembly process of DNA nanostructures

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Chinese Chemical Letters 2024年第3期35卷 316-320页

作者： Wei Yuan Gui-Zhi Dong hui Ning xiang-xiang Guan Jia-Feng Cheng Zi-Wei Shi Xiu-Ji Du Si-Wen Meng Dong-Sheng Liu Yuan-Chen Dong CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Dandong Bettersize Instruments Ltd. Dandong 118000China Key Laboratory of Organic Optoelectronics&Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Department of Chemistry Renmin University of ChinaBeijing 100872China

Understanding the dynamic assembly process of DNA nanostructures is important for developing novel strategy to design and construct functional *** this work,temperature-controlled dynamic light scattering(DLS)strategy has been applied to study the global assembly process of DNA origami and DNA *** the temperature dependent size and intensity profiles,the self-assembly process of various DNA nanostructures with different morphologies have been well-studied and the temperature transition ranges could be *** advantage of the DLS information,rapid preparation of the DNA origami and the brick assembly has been realized through a constant temperature *** results demonstrate that the DLS-based strategy provides a convenient and robust tool to study the dynamic process of forming hieratical DNA structures,which will benefit understanding the mechanism of self-assembly of DNA nanostructures.

关键词： Dynamic light scattering Self-assembly process DNA nanostructures Temperature transition ranges Rapid preparation

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