A quadrivalent norovirus vaccine based on a chimpanzee adenovirus vector induces potent immunity in mice
作者机构：Department of Pathogen BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin300070China Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China R&D CentreChengdu Kanghua Biological Products Co.LtdChengdu610000China Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai200031China
出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)
年 卷 期：2024年第39卷第4期
页 面：675-684页
核心收录：
基 金：supported by the National Natural Science Foundation of China(82241065,32070926)to D.Z the Sichuan Science and Technology Program(2023JDRC0090)to H.L
主 题：Norovirus(NoV) Quadrivalent vaccine Adenovirus vector
摘 要：Norovirus(NoV)infection is a major cause of gastroenteritis *** virus poses great challenges in developing vaccines with broad immune protection due to its genetic and antigenic *** date,there are no approved NoV vaccines for clinical ***,we aimed to develop a broad-acting quadrivalent NoV vaccine based on a chimpanzee adenovirus vector,AdC68,carrying the major capsid protein(VP1)of noroviral GI and GII *** to intramuscular(i.m.),intranasal(i.n.),or other prime-boost immunization regimens(i.m.t i.m.,i.m.t i.n.,i.n.t i.m.),AdC68-GI.1-GII.3(E1)-GII.4-GII.17(E3),administered via i.n.t *** higher titers of serum IgG antibodies and higher IgA antibodies in bronchoalveolar lavage fluid(BALF)and saliva against the four homologous VP1s in *** also significantly stimulated the production of blocking antibodies against the four *** response to re-stimulation with virus-like particles(VLP)-GI.1,VLP-GII.3,VLP-GII.4,and VLP-GII.17,the quadrivalent vaccine administered according to the i.n.t *** effectively triggered specific cell-mediated immune responses,primarily characterized by IFN-γ***,the preparation of this novel quadrivalent NoV vaccine requires only a single recombinant adenovirus to provide broad preventive immunity against the major GI/GII epidemic strains,making it a promising vaccine candidate for further development.
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