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Usefulness of interferon-γrelease assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province,China

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Infectious Diseases of Poverty 2017年第1期6卷 1074-1078页

作者： Lei Ji Yong-Liang Lou Zhong-Xiu Wu Jin-Qin Jiang Xing-Li Fan Li-Fang Wang Xiao-xiang Liu Peng Du Jie yan Ai-hua Sun Department of Basic Medicine Hangzhou Medical CollegeHangzhou 310053ZhejiangPeople’s Republic of China School of Laboratory Medical Science and Life Science Wenzhou Medical UniversityWenzhou 325035ZhejiangPeople’s Republic of China Zhejiang Blood Center Hangzhou 310006ZhejiangPeople’s Republic of China Division of Basic Medical Microbiology State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesFirst Affiliated Hospital of Zhejiang UniversityHangzhou 310003ZhejiangPeople’s Republic of China Department of Medical Microbiology and Parasitology College of MedicineZhejiang UniversityHangzhou 310058ZhejiangPeople’s Republic of China

Background:Quick diagnosis of smear-negative pulmonary tuberculosis(TB)and extra-pulmonary TB are urgently needed in clinical *** research aims to investigate the usefulness of the interferon-γrelease assay(IGRA)for the diagnosis of smear-negative pulmonary and extra-pulmonary ***:We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients(including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients),113 extra-pulmonary TB patients,81 patients with other pulmonary diseases and 100 healthy *** samples for the TB-Ab test and the TB-IGRA were collected,processed,and interpreted according to the manufacturer’s ***:The detection ratio of smear-positive pulmonary TB patients and smear-negative pulmonary TB patients were 90.8%(109 of 120)and 89.6%(241 of 269),*** was no statistically significant difference of its performance between these two sample sets(P>0.05).The detection ratio of positive TB patients and extra-pulmonary TB patients were 90.0%(350 of 389)and 87.6%(99 of 113),respectively,which was not significantly different(P>0.05).Conclusions:In this work,the total detection ratio using TB-IGRA was 89.4%,therefore TB-IGRA has diagnostic values in smear-negative pulmonary TB and extra-pulmonary TB diagnosis.

关键词： Interferon-gamma release assay Smear-negative pulmonary TB Extra-pulmonary TB

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Preparation, Characterization and Nematicidal Activity of Lansiumamide B Nano-Capsules

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Journal of Integrative Agriculture 2012年第7期11卷 1151-1158页

作者： YIN yan-hua GUO Qing-ming HAN Yun WANG Ling-jing WAN Shu-qing Key Laboratory of Natural Pesticide&Chemical-Biology of Education Ministry/South China Agricultural University Guangzhou 510642P.R.China

In this study, nano-capsules of lansiumamide B （NCLB） was prepared by the microemulsion polymerization method to improve the nematicidal efficacy of lansiumamide B （LB）. An optimal formulation was gained by orthogonal experiment design based on the encapsulation efficiency （E, %） value. The optimized NCLB were spherical and uniform under transmission electron microscopy （TEM）. The mean particle size, zeta potential and E, were （38.50~0.64） nm, （-70.5~0.76） mV and （95.13± 1.16）%, respectively. The release profile indicated that the accumulated release of LB in NCLB reached up to 82% within 96 h. Effects of NCLB against Bursaphelenehus xylophilus and J2 ofMeloidogyne incognita were reported in this paper. The nematicidal activity of NCLB has been remarkably increased, with LCs0 values of 2.1407 mg L-1 and 19.3608 mg L-1, respectively, at 24 h after treatment. The disease progression and the average number of root knots of Ipomoea aquatica were 1.50 and 7.25, respectively, in the treatment of NCLB, at concentration of 200 mg L-1 significantly lower than the treatment of LB and ethoprophos. Compared to control, the treatments of NCLB, LB and ethoprophos leaded the disease progression to drop 68.42, 36.84 and 26.32%, respectively, and caused the average number of root knots to fall 83.94, 78.03 and 63.66%. These results suggested that NCLB, as a novel nematicides formulation, performed more efficient and longer effective maintenance against plant parasitic nematodes.

关键词： lansiumamide B nano-capsules structure characterization nematicidal activity

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Post-silking nitrogen accumulation and remobilization are associated with green leaf persistence and plant density in maize

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Journal of Integrative Agriculture 2019年第8期18卷 1882-1892页

作者： ZHANG Li-li ZHOU xiang-li FAN Ye FU Jun HOU Peng yanG Hai-long QI hua Agronomy College Shenyang Agricultural University Shenyang 110866 P.R.China Dandong Academy of Agricultural Sciences Fengcheng 118109 P.R.China College of Life Sciences Northwest A&F University Yangling 712100 P.R.China Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China

Stay green(SG) maize was found to have higher grain yield and post-silking nitrogen(N) uptake(PostN) compared with a non-stay green(NSG) hybrid. To understand the effects of plant density on grain yield(GY) and N efficiency in modern maize hybrids, we compared two modern hybrids(SG hybrid DY508 and NSG hybrid NH101) with similar maturity ratings at three plant densities(45 000, 60 000, and 75 000 pl ha^–1) in 2014 and 2015. GY, leaf senescence, dry matter(DM) accumulation,N accumulation, PostN, and post-silking N remobilization(RemN) were analyzed. DY508 and NH101 had similar GY, but DY508 had higher thousand kernel weight(TKW) and lower kernel number(KN) than NH101. Plant density significantly increased GY in the two hybrids. On average, over the two years, plant density improved GY in DY508 and NH101 by 18.5 and 11.1%, respectively, but there were no differences in total dry matter(TDM) and post-silking DM(PostDM) between the two hybrids. Plant density improved leaf N, stem N, and grain N at the silking and maturity stages in 2014 and 2015. DY508 was lower in harvest index(HI), nitrogen harvest index(NHI), and grain N concentration(GNC) than NH101. Grain N in DY508 was 2.61 kg ha^–1 less than in NH101, and this was caused by lower GNC and leaf RemN. On the average, DY508 was 1.62 kg ha^–1 less in leaf remobilized N(leaf RemN) than NH101, but was similar in stem remobilized N(stem RemN;2.47 kg ha^–1 vs. 3.41 kg ha^–1). Maize hybrid DY508 shows delayed leaf senescence in the upper and bottom canopy layers in the later stages of growth. The present study provides evidence that the NH101, which has rapid leaf senescence at the late grain-filling stage, has gained equivalent GY and higher leaf RemN, and was more efficient in N utilization.

关键词： maize N remobilization post-silking N uptake stay green plant density

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Systematic Synthesis on Pathological Models of CCCII and Modified CCCII

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Journal of Electronic Science and Technology 2018年第2期16卷 163-168页

作者： Yong-An Li yan-hua Xi Zhan-Ting Fan Yu-Ye Zhang Ji-Xia Wu School of Physics and Electronic Engineering Xianyang Normal UniversityXianyang 712000

According to the equivalent view for the terminal current-voltage constraint relationship between pathological elements and the various second-generation current-controlled convegors （CCCIIs）, four patholo- gical models for the CCCII are first derived by means of the nodal admittance matrix expansion in this paper. Moreover, 48 new pathological models for the modified CCCII are also synthesized. The derived pathological models for the various CCCIIs are expected to be useful in circuit analysis and synthesis.

关键词： Modified second-generation currentcontrolled conveyor pathological elements secondgeneration current-controlled conveyor systematic synthesis

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Antisense-Mediated Depletion of Tomato Chloroplast Omega-3 Fatty Acid Desaturase Enhances Thermal Tolerance

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Journal of Integrative Plant Biology 2006年第9期48卷 1096-1107页

作者： Xun-yan Liu Jing-hua yang Bin Li Xiu-Mei yang Qing-Wei Meng College of Life Sciences Key Laboratory of Crop Biology of Shandong Province Shandong Agricultural University Tai＇an 271018 China Department of Horticulture Zhejiang University Hangzhou 310029 China

A chloroplast-localized tomato （Lycopersicon esculentum Mill.） ω-3 fatty acid desaturase gene （LeFADT） was isolated and characterized with regard to its sequence, response to various temperatures, and function in antisense transgenic tomato plants. The deduced amino acid sequence had four histidine-rich regions, of which three regions were highly conserved throughout the whole ω-3 fatty acid desaturasegene family. Southern blotting analysis showed that LeFAD7was encoded by a single copy gene and had two homologous genes in the tomato genome. Northern blot showed that LeFAD7 was expressed in all organs and was especially abundant in leaf tissue. Meanwhile, expression of LeFAD7 was induced by chilling stress （4 ℃）, but was inhibited by high temperature （45 ℃）, in leaves. Transgenic tomato plants were produced by integration of the antisense LeFAD7DNA under the control of a CaMV35S promoter into the genome. Antisense transgenic plants with lower 18 ： 3 content could maintain a higher maximal photochemical efficiency （Fv/Fm） and O2 evolution rate than wild-type plants. These results suggested that silence of the LeFAD7 gene alleviated high-temperature stress. There was also a correlation between the low content of 18 ： 3 resulting from silence of the LeFAD7 gene and tolerance to high-temperature stress.

关键词： chloroplast-localized ω-3 fatty acid desaturase gene expression thermal tolerance tomato (Lycopersicon esculentum) tomato transformation

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Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C

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World Journal of Gastroenterology 2010年第35期16卷 4460-4466页

作者： Bing-Shui Xiu Xiao-yan Feng Jing He Guo-hua Wang He-Qiu Zhang Xiao-Guo Song Kun Chen Shi-Gan Ling Cui-Xia Zhu xiang-Ying Zhang Lai Wei Hui-Ying Rao Institute of Basic Medical Sciences Academy of Military Medical Sciences Beijing 100850 China National Institute for Control of Pharma-ceutical and Biological Products Beijing 100050 China Hepatology Institute People Hospital Peking University Beijing 100044China

AIM:To evaluate the presence and cross-reactive anti-bodies against hypervariable region 1(HVR1) in hepatitis C virus(HCV) infected patients and its relationship with the progression of the ***:Sixteen representative HVR1 proteins selected from a unique set of 1600 natural sequences were used to semiquantitate the cross-reactivity of HVR1 antibodies in the sera of HCV ***-five chronic HCV patients including 23 with asymptomatic mild hepatitis,18 with chronic hepatitis and 16 with liver cirrhosis patients were ***:The degree of the cross-reactivity of anti-HVR1 antibodies in 23 patients with mild asymptomatic hepatitis was 3.09 ± 2.68,which was signif icantly lower than in those with chronic hepatitis(5.44 ± 3.93,P < 0.05) and liver cirrhosis(7.44 ± 3.90,P < 0.01).No correlation was observed between the broadness of the cross-reactivity anti-HVR1 antibodies and patient's age,infection time,serum alanine aminotransferase activity,or serum HCV-RNA *** was the breath of cross-reactivity rather than the presence of anti-HVR1 antibody in HCV sera that was associated with the progression of liver ***:The broadly cross-reactive HVR1 antibodies generated in natural HCV patients can not neutralize the virus,which results in persistent infection in patients with chronic hepatitis.

关键词： Hepatitis C virus Hypervariable region 1 Cross-reactivity

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水系混合电池正极材料Li_(3)V_(2-x)Cox(PO_(4))_(3)制备及其电化学性能

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吉首大学学报（自然科学版） 2024年第4期45卷 67-75页

作者：王伟皮圣东王诚孙焱熊利芝向延鸿吉首大学物理与机电工程学院湖南吉首416000 吉首大学药学院湖南吉首416000

以偏钒酸铵、二水醋酸锂、磷酸二氢铵为原料,以四水乙酸钴为Co元素掺杂源,采用冷冻干燥辅助溶胶凝胶法制备Co元素掺杂的磷酸钒锂前驱体,再采用分段煅烧方法获得Li_(3)V_(2-x)Co_(x)(PO_(4))_(3)(x=0,0.01,0.02,0.04,0.06)材料,在此基础... 详细信息

以偏钒酸铵、二水醋酸锂、磷酸二氢铵为原料,以四水乙酸钴为Co元素掺杂源,采用冷冻干燥辅助溶胶凝胶法制备Co元素掺杂的磷酸钒锂前驱体,再采用分段煅烧方法获得Li_(3)V_(2-x)Co_(x)(PO_(4))_(3)(x=0,0.01,0.02,0.04,0.06)材料,在此基础上,进一步探究Co元素掺杂对材料结构和电化学性能的影响.结果表明,采用冷冻干燥辅助溶胶凝胶法能够获得结晶度良好的单斜结构晶体,适量Co元素掺杂没有改变磷酸钒锂的晶体结构;采用冷冻干燥辅助溶胶凝胶法合成的正极材料均呈微孔结构,适量Co元素掺杂有助于增加材料微孔数量,以获得颗粒尺寸更均匀的材料;随着Co元素掺杂量的增加,材料的离子扩散速率、充放电性能、循环倍率性能均呈现出先提高后降低的规律,电荷转移阻抗呈现出先减小后增大的规律;当x=0.04时,磷酸钒锂正极材料的电化学性能最佳,离子扩散速率高达8.99×10^(-13)cm^(2)/s,电荷转移阻抗低至233.6Ω,且在2C倍率下,首次放电比容量由未掺杂的53.4 mAh/g提升至81.7 mAh/g,2C倍率循环50次后放电比容量保持率为91.11%,与未掺杂样品相比,提升了13.54%.

关键词：水系混合电池正极材料磷酸钒锂冷冻干燥掺杂

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Identification of active compound combination contributing to anti-inflammatory activity of Xiao-Cheng-Qi Decoction via human intestinal bacterial metabolism

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Chinese Journal of Natural Medicines 2018年第7期16卷 513-524页

作者： LIU Xing-yan LI Li LI Xue-Qing YU Bo-yang LIU Ji-hua Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University State Key Laboratory of Natural Medicines China Pharmaceutical University

Human intestinal bacteria play an important role in the metabolism of herbal medicines, leading to the variations in their pharmacological profile. The present study aimed to investigate the metabolism of Xiao-Cheng-Qi decoction(XCQD) by human intestinal bacteria and to discover active component combination(ACC) contributing to the anti-inflammatory activity of XCQD. The water extract of XCQD was anaerobically incubated with human intestinal bacteria suspensions for 48 h at 37 °C. A liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry(LC-Q-TOF/MS) method was performed for identification of the metabolites. In addition, the anti-inflammatory effects of XCQD and biotransformed XCQD(XCQD-BT) were evaluated in vitro with cytokines in RAW264.7 cells induced by lipopolysaccharide(LPS). A total of 51 compounds were identified in XCQD and XCQD-BT. Among them, 20 metabolites were proven to be transformed by human intestinal bacteria. Significantly, a combination of 14 compounds was identified as ACC from XCQD-BT, which was as effective as XCQD in cell models of inflammation. In conclusion, this study provided an applicable method, based on intestinal bacterial metabolism, for identifying combinatory compounds responsible for a certain pharmacological activity of herbal medicines.

关键词： Xiao-Cheng-Qi decoction Human intestinal bacteria Metabolism Anti-inflammatory LC-Q-TOF/MS

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Laboratory Testing of Magnetic Tracers for Soil Erosion Measurement

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Pedosphere 2011年第3期21卷 328-338页

作者： HU Guo-Qing DONG Yuan- Jie WANG Hui QIU Xian-Kui WANG yan-hua College of Resources and Environment Shandong Agricultural University Tai'an 271018 (China)

Soil erosion, which includes soil detachment, transport, and deposition, is one of the important dynamic land surface processes. The magnetic tracer method is a useful method for studying soil erosion processes. In this study, five types of magnetic tracers were made with fine soil, fly ash, cement, bentonite, and magnetic powder （reduced iron powder） using the method of disk granulation. The tracers were uniformly mixed with soil and tested in the laboratory using simulated rainfall and inflow experiments to simulate the interrill and rill components of soil erosion, in order to select one or more tracers which could be used to study detachment and deposition by the erosive forces of raindrops and surface flow of water on a slope. The results showed that the five types of magnetic tracers with high magnetic susceptibility and a wide range of sizes had a range of 0.99-1.29 gcm-3 in bulk density. In the interrill and rill experiments, the tracers FC1 and FC2 which consisted of fly ash and cement at ratios of 1：1 and 2：1, respectively, were transported in phase with soil particles since the magnetic susceptibility of sediment approximated that of the soil which was uneroded and the slopes of the regression equations between the detachment of sediment and magnetic tracers FC1 and FC2 were very close to the expected value of 20, which was the original soil/tracer ratio. The detachment and deposition on slopes could be accurately reflected by the magnetic susceptibility differences. The change in magnetic susceptibility depended on whether deposition or detachment occurred. However, the tracer FS which consisted of fine soil and the tracers FB1 and FB2 which consisted of fly ash and bentonite at ratios of 1：1 and 2：1, respectively, were all unsuitable for soil erosion study since there was no consistent relationship between sediment and tracer detachment for increasing amounts of runoff. Therefore, the tracers FC1 and FC2 could be used to study soil erosion by water.

关键词： magnetic susceptibility interrill erosion rill erosion runoff sediment

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成型方式对应力吸收层沥青混合料性能的影响

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建材世界 2024年第1期45卷 61-64页

作者：石学文李鹏飞彭俊华李想林振华磨炼同湖北楚天智能交通股份有限公司武汉430000 河南省豫南高速投资有限公司信阳465550 武汉理工大学硅酸盐建筑材料国家重点实验室武汉430070

开展了旋转压实与马歇尔击实成型对应力吸收层沥青混合料体积和力学性能的影响分析。试验结果表明,应力吸收层配合比设计中可用马歇尔击实50次代替旋转压实50次成型试件,旋转压实试件与马歇尔试件的劈裂抗拉强度、贯入应力均具有良好相... 详细信息

开展了旋转压实与马歇尔击实成型对应力吸收层沥青混合料体积和力学性能的影响分析。试验结果表明,应力吸收层配合比设计中可用马歇尔击实50次代替旋转压实50次成型试件,旋转压实试件与马歇尔试件的劈裂抗拉强度、贯入应力均具有良好相关性,换算系数分别为1.347和0.910。提出了基于马歇尔击实方法的应力吸收层设计要求,可更好地进行配合比设计和工地现场质量控制。

关键词：应力吸收层旋转压实马歇尔击实贯入试验劈裂抗拉强度

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