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Rare Metals 2024年第10期43卷 5152-5163页

作者： Dong-Wei Ma Jing-Sheng Lu xiang-xin cao Yan-Wei Cheng Gang Wang Zi-Qian Zhang Bo-Cheng Chen Ning Lin Qing Chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance, toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***, Zn-based MOF-zeolitic imidazole framework-90(ZIF-90) was selected as the drug delivery carrier, with the cancer therapeutic drug mercaptopurine(6-MP) and glucose oxidase(GOD) as the drug models, hyaluronic acid(HA) was used for protection and targeted delivery, which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA). This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome. Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity, which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Cancer treatment Combination therapy Drug delivery Metal-organic framework Reduced toxicity

FOREST LANDSCAPE PATTERN DYNAMICS OF LUONINGCOUNTY IN HENAN PROVINCE AND ITS DRIVING FORCES

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Chinese Geographical Science 2003年第3期13卷 247-253页

作者： DING Sheng-yan, QIAN Le-xiang, cao xin-xiang, LI Shuang, LI Hao-min(College of Environment & Planning, Henan University, Kaifeng 475001, P. R. China) College of Environment & Planning Henan University Kaifeng P. R. China

With the help of ARC/INFOR and ERDAS software, based on the information from forest resources distribution maps and TM images, four indices were chosen to analyze spatial pattern changes of forest landscape of Luoning County, Henan Province from 1983 to 1999. The results showed that: 1) The number and total area of patches were rapidly increased with time changes. The fragmentation degree of the landscape was increasing greatly. 2) The area of some forest patch types, especially shrub forest, economic forest, Populus spp. forest, Quercus spp. forest, sparse forest, deserted grassland etc. had been greatly changed. 3) The fragemation degree of each forest patch type became greater from 1983 to 1999. 4) The transition probabilities of deserted forest, economic forest, Pi-nus tabulaeformis forest, Populus spp. forest exceed 85%,Robinia pseuoacacia forest, deserted grassland, 65% and Quercus spp. forest, non-forest, shrub forest had smaller ones, which were 26.5%, 29.1% and 45.3%, respectively. The main transition trends of various patches were non-forest and Quercus spp. forest. During the course of transition, the types that 50% of area was remained were Quercus spp. forest, non-forest and shrub forest. According to above analyses, the main driving forces, such as the management policies, market economy factors and influences of human activities etc. were brought out.

关键词： forest landscape pattern driving forces luoning county

Diversification of interfaces triggered hydrogen storage properties enhancement

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Rare Metals 2024年第5期43卷 2324-2330页

作者： Jia-xin Zhang xin Ding Rui-Run Chen xiang-Feng Ma Wen-Chao cao Yong Zhang Jing-Jie Guo National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

Dual effects of grain refinement and alloying are achieved and the mechanism of"diverse interfaces reinforcement"for hydrogen storage Mg alloys is first *** interface reinforced Mg-Y-Zn-Al alloy for hydrogen storage is *** work figures out that the adventurous Al-rich phase exhibits an ordered face-centered cubic(FCC)structure with composition of(31±2)at%Y-(28±1)at%Zn-(41±3)at%Al,i.e.,Y_(3)Zn_(3)Al_(4),and an incoherent interface between Y3Zn3Al4phase and Mg substrate is observed.

关键词： hydrogen alloying alloy

Dysfunction of synaptic endocytic trafficking in Parkinson's disease

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Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： xin Yi Ng Mian cao Programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of Physiology National University of SingaporeSingaporeSingapore

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's ***,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"***,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease *** will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK

关键词： autophagy auxilin/PARK19 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway Parkinson's disease synaptic vesicle recycling synaptojanin1/PARK20

Experimental and numerical demonstration of hierarchical time-delay reservoir computing based on cascaded VCSELs with feedback and multiple injections

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Science China(Information Sciences) 2024年第2期67卷 279-290页

作者： xingxing GUO Shuiying xiang xingyu cao Biling GU State Key Laboratory of Integrated Service Networks Xidian University State Key Discipline Laboratory of Wide Bandgap Semiconductor Technology School of MicroelectronicsXidian University

In this paper, we propose and demonstrate experimentally and numerically a hierarchical timedelay optical reservoir computing(RC) system based on cascaded vertical-cavity surface-emitting lasers(VCSELs) with feedback and multiple injections. The prediction performance characteristics of the hierarchical time-delay RC system based on cascaded VCSELs under different reservoir layers are ***, the prediction performance of the hierarchical time-delay RC system is first improved and saturates as the number of reservoir layers increases. Besides, the impacts of key factors on predicting the hierarchical time-delay RC system are also analyzed in detail experimentally and numerically. This proposed hierarchical time-delay RC system based on VCSELs is useful for the further development of RC systems and may be beneficial to improve the ability of RC systems to solve more complex problems.

关键词： vertical-cavity surface-emitting laser reservoir computing neuromorphic photonics time-delay system information processing

Numerical study of the influence of the atmospheric pressure on the thermal environment in the passenger cabin

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Building Simulation 2024年第2期17卷 253-265页

作者： xin Su Yu Guo Zhengwei Long Yi cao Tianjin Key Lab.of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin300072China Shanghai Aircraft Design and Research Institute Jinke RoadPudong DistrictShanghai201210China

The cabin air pressure remains lower than the horizontal atmospheric pressure when the airplane is in *** pressure is one of the parameters that must be taken into consideration while studying the thermal environment of an airplane *** are still no reference values for aircraft cabins despite the fact that numerous studies on low pressure heat transfer have demonstrated the connection between convective heat transfer coefficient(CHTC)and air *** this paper,a correction method for CHTC under low pressure conditions was established by using the dummy heat dissipation in the low-pressure cabin *** this basis,a thermal environment simulation model was developed,then was applied to the simulation of a seven-row aircraft cabin containing 42 passengers,and the CHTC and heat loss of dummy surface in the cabin were ***,the results of PMV calculated by using heat dissipation and air parameters at sampling points were *** results show that the modified CHTC can accurately reflect the cabin thermal environment under low pressure conditions,and the correction of CHTC can be realized by adjusting the turbulent Prandtl number,which is nonlinear correlated with the *** simulation results of the thermal environment in the seven-row cabin show that the CHTC changes by about 42%before and after *** air pressure decreases during take-off,which reduces the average CHTC of the crew surface from 5.09 W/(m^(2)·K)to 4.56 W/(m^(2)·K),but the air temperature rises by about 0.2°C as a *** deviation of PMV results calculated by using simulated heat loss data and using air parameters of measuring points in space is up to 0.5,but the latter is representative for calculating the thermal comfort level of the whole cabin.

关键词： low pressure aircraft cabin simulation heat dissipation convective heat transfer coefficient

Adaptive 5G-and-beyond network-enabled interpretable federated learning enhanced by neuroevolution

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Science China(Information Sciences) 2024年第7期67卷 107-132页

作者： Bin cao Jianwei ZHAO xin LIU Yun LI State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of Technology School of Artificial Intelligence Hebei University of Technology School of Economics and Management Hebei University of Technology Industrial Artificial Intelligence Centre Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of China

Mobile telemedicine systems based on the next-generation communication will significantly enhance deep fusion of network automation and federated learning(FL), but data privacy is a paramount issue in sectors like healthcare. This work hence considers FL augments 5G-and-beyond networks by training deep learning(DL) models without the need to exchange raw data. The substantial communication loads imposed on by extensive parameters involved in DL models are managed through adaptive scheduling mechanisms effectively. To address the opaque nature of DL models and to improve the interpretability of FL models, we introduce a convolutional fuzzy rough neural network specifically designed for medical image processing. We also develop a multiobjective memetic evolutionary algorithm to streamline and optimize the neural network architectures. Our comprehensive FL framework integrates smart scheduling, interpretable fuzzy rough logic,and neuroevolution. This framework is shown to improve communication efficiency, increase interpretability of diagnosis with protected privacy, and generate low-complexity neural architectures.

关键词： 5G-and-beyond network interpretable federated learning mobile telemedicine system fuzzy rough set theory neuroevolution

Graphene oxide/Al_(2)O_(3)-based diffusive memristor cells:enabling robust crossbar arrays for multidisciplinary applications

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Rare Metals 2024年第8期43卷 3997-4005页

作者： Chen Liu Jun-Cheng Jin Yi-Ke Xiao xin-xin Wang Ping-Yuan Yan Yan-Qiang cao Li-Yong Jiang Chuan-xiang Sheng Ye-Feng Yu School of Microelectronics Nanjing University of Science and TechnologyNanjing 210094China School of Science Nanjing University of Science and TechnologyNanjing210094China School of Information Science and Technology Fudan UniversityShanghai 200433China

A memristor crossbar array (MCA) has emerged as a cutting-edge platform for advanced memory and neuromorphic computing hardware,offering unrivaled bit-level storage density.A diffusive memristor cell (DMC) is particularly well-suited for MCA integration due to its inherent threshold switching characteristics as a selector,effectively addressing current sneak path *** DMC's potential is acknowledged,it necessitates furtherexploration of their practical applicability.

关键词： crossbar arrays offering

Experiments and numerical study on heat transfer of moist silica aerogel composites at high temperatures

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Energy Storage and Saving 2024年第2期3卷 73-86页

作者： Dong Li Zhan-Wei cao xiang-Qian Xie xin Chen Ya-Ling He Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an710049China Science and Technology on Space Physics Laboratory China Academy of Launch Vehicle TechnologyBeijing100076China

Silica aerogel composites have promising applications in high-temperature heat storage ***,the impact of high temperatures and moisture on their insulation performance remains *** reveal the influences of high temperature and moisture absorption property on the heat transfer of silica aerogel composites,an experimental and numerical study was conducted to explore the micromorphology,thermophysical parameters,moisture absorption characteristics,and temperature *** service temperature limit of the silica aerogel composite has been *** have conducted for the thermal conductivity,specific heat capacity,thermal diffusivity,specific surface area,density,porosity,and pore size distribution of the heated silica aerogel composite(at temperatures of 600,800,1,000,1,100 and 1,200℃).The moisture absorption characteristic curve at 20℃ has been *** testing of silica aerogel composites under varying heating temperatures and moisture content has been ***,a numerical method has been developed to calculate the temperature curve of moist silica aerogel *** insulation performance of silica aerogel composite with varying moisture contents depends on the game between thermal conductivity and latent *** with the negative effect of the moisture content on insulation performance,the positive influence of moisture evaporation and heat absorption is dominant in situations involving temperatures higher than the phase transition temperature.

关键词： Heat storage insulation Silica aerogel composite Thermal protection Lattice Boltzmann model

Characteristic Study of Self-Powered Sensors Based on Native Protein Composite Film

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Energy & Environmental Materials 2024年第1期7卷 222-228页

作者： Jiehui Xue Huijing xiang Yanrong Zhang Jun Yang Xia cao Zhonglin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Resources Environment and MaterialsSchool of PhysicsScience and TechnologyCenter on Nanoenergy ResearchGuangxi UniversityNanning 530004China Center for Green Innovation School of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China Research Centre of Information Technology Shenzhen Institute of Information TechnologyShenzhen 518172China School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Georgia Institute of TechnologyAtlanta GA 30332-0245USA

Flexible electronic sensors composed of flexible film and conductive materials play an increasingly important role in wearable and internet information *** has received more and more attention and made some progress over the ***,it is still a great challenge to prepare biocompatible and highly transparent conductive *** white is a pure natural protein-rich *** cellulose has a good compatibility and high transparency,which is an ideal material for flexible ***,we overcome the problem of poor mechanical flexibility and electrical conductivity of protein,and develop a high transparency and good flexibility hydroxypropylmethyl cellulose/egg white protein composite membrane-based triboelectric nanogenerator('X'-TENG).The experimental results show that the flexible pressure sensor based on'X'-TENG has a high sensitivity,fast response speed,and low detection *** can even be used as a touch/pressure sensing artificial electronic *** can also be made into an intelligent waffle keyboard for recording and tracking users of the *** strategy may provide a new way to easily build flexible electronic sensors and move toward practical applications.

关键词： flexible sensors intelligent sensing natural protein-rich material triboelectric nanogenerators