检索结果-南通市图书馆

Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2393-2414页

作者： Bo LIN xiang-xiang HE Song-chao xia Hua-qiang xiaO Yu-liang ZHAO Khashayar KHANLARI School of Mechanical Engineering Guizhou UniversityGuiyang 550025China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China Centro Nacional de Investigaciones Metalúrgicas(CENIM) C.S.I.C.Avda.de Gregorio del Amo 8Madrid 28040Spain Department of Chemical&Biotechnological Engineering Universitéde SherbrookeQuébecQC J1K 2R1Canada

Effects of ultrasonic vibration(UV)and mechanical vibration(MV)on the Mn-rich phase modification and mechanical properties of Al−12Si−4Cu−1Ni−1Mg−2Mn piston alloys were *** results show that the UV and UV+MV treatments can significantly refine and fragmentize the *** addition,UV treatment can significantly passivate the primary Mn-rich Al15Mn3Si2 *** formation mechanisms of refinement and passivation of the grains and non-dendrite particles were *** with the gravity die-cast alloys,the UV and UV+MV treated alloys exhibit improved tensile and creep resistance at room and elevated *** results can be attributed to the refinement of theα(Al)grains and the secondary intermetallics,the increased proportion of refined heat-resistant precipitates,and the formation of nano-sized Si *** ultimate tensile strength of the UV treated alloys at 350℃ exceeds that of commercial piston *** indicates the high application potential of the developed piston alloys in density diesel engines.

关键词： Al−Si piston alloys Mn-rich phases mechanical properties ultrasonic vibration mechanical vibration

盐肤木AGAMOUS同源基因的克隆及其功能分析

在线全文

学校读者我要写书评

暂无评论

林业科学 2024年第6期60卷 94-101页

作者：王芳岚项明张霞顾磊刘文陈发菊三峡区域植物遗传与种质创新重点实验室(三峡大学)生物技术研究中心三峡大学宜昌443002

【目的】AGAMOUS(AG)基因在控制雌蕊、雄蕊的发育中起着重要作用。对盐肤木中AG同源基因的克隆与功能分析,有利于明确AG基因在盐肤木花器官发育中的功能,并为进一步探索盐肤木花性别分化机制提供参考。【方法】基于实验室已有的转录组... 详细信息

【目的】AGAMOUS(AG)基因在控制雌蕊、雄蕊的发育中起着重要作用。对盐肤木中AG同源基因的克隆与功能分析,有利于明确AG基因在盐肤木花器官发育中的功能,并为进一步探索盐肤木花性别分化机制提供参考。【方法】基于实验室已有的转录组数据并结合RACE技术,从盐肤木花中克隆获得盐肤木AG同源基因,并对其编码的蛋白进行结构和系统进化分析;通过实时定量PCR技术分析盐肤木AG同源基因在雌、雄及两性花的不同花期中的表达特征;构建盐肤木AG同源基因的过表达载体,采用花序浸染法进行拟南芥遗传转化,获得T2代转基因植株,观察转基因植株表型。【结果】在盐肤木克隆获得了AG同源基因的2个可变剪接转录本,分别为RcAG和第6个外显子缺失的Rcag。RcAG包含729 bp的开放阅读框,编码242个氨基酸;Rcag包含687 bp的开放阅读框,编码228个氨基酸。系统进化树分析结果表明,RcAG与其同科植物杧果和阿月浑子的AG同源蛋白亲缘关系较近。qRT-PCR分析表明,在盐肤木不同发育阶段的雌、雄及两性花中,RcAG和Rcag呈现丰度持续升高的趋势,且在盐肤木雄花中,RcAG和Rcag的丰度要极显著高于雌花及两性花。过表达拟南芥表型观察发现,过表达RcAG导致拟南芥花瓣和雄蕊缺失,萼片尖端柱头化,萼片基部边缘出现胚珠结构,而过表达Rcag的拟南芥出现花瓣数量增多和雄蕊数量减少。【结论】Rcag可能由于K区42 bp碱基的缺失丧失AG基因的正常功能,与RcAG相互竞争,共同调控盐肤木雌、雄蕊的发育。这一结果为进一步探索RcAG和Rcag在盐肤木性别分化中的作用奠定基础。

关键词：盐肤木可变剪接 RcAG Rcag 功能分析

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu xiang xia Ning Xu Wen Sun Jianjun Du Jiangli Fan xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

胃癌患者EBV感染情况及对预后的影响

世界华人消化杂志 2024年第7期32卷 509-516页

作者：向霞李小英浙江省长兴县中医院消化内科浙江省湖州市313100 浙江省长兴县中医院肿瘤科浙江省湖州市313100

背景胃癌是威胁人类生命健康的主要恶性肿瘤之一,人类疱疹病毒(Epstein-Barr virus,EBV)是一种致癌病毒,主要感染上皮细胞、B细胞,与多种肿瘤的发生发展密切相关.本研究尝试探究胃癌患者EBV感染情况及对预后的影响.目的研究胃癌患者EBV... 详细信息

背景胃癌是威胁人类生命健康的主要恶性肿瘤之一,人类疱疹病毒(Epstein-Barr virus,EBV)是一种致癌病毒,主要感染上皮细胞、B细胞,与多种肿瘤的发生发展密切相关.本研究尝试探究胃癌患者EBV感染情况及对预后的影响.目的研究胃癌患者EBV感染情况及对预后的影响.方法选取2020-01/2022-12本院300例胃癌患者作为研究组,另选同期同年龄段150例胃部良性肿瘤(胃息肉)患者作为对照组.比较研究组和对照组临床资料、EBV感染阳性率,分析EBV感染与胃癌临床特征的相关性,分析胃癌预后不良的影响因素,根据影响因素构建预测预后不良的列线图模型,分析列线图模型的预测价值.结果研究组EBV感染阳性率(10.67%)高于对照组(1.33%)(P<0.05);Lauren分型混合型胃癌患者EBV感染阳性率(21.05%)高于肠型(7.19%)、弥漫型(7.50%)、未分型(0.00%)患者,程序性死亡分子1(programmed death-1,PD-1)阳性胃癌患者EBV感染阳性率(19.61%)高于PD-1阴性患者(6.06%),程序性死亡配体1(programmed death receptor 1,PD-L1)阳性胃癌患者EBV感染阳性率(21.13%)高于PD-L1阴性患者(7.42%)(P<0.05);研究组预后不良患者年龄、TNM分期Ⅲ-Ⅳ期占比、浸润深度T3+T4占比、淋巴结转移占比、分化程度低分化占比、PD-1阳性率、PD-L1阳性率、EBV感染阳性率高于预后良好患者(P<0.05);年龄、TNM分期Ⅲ-Ⅳ期、浸润深度T3+T4、淋巴结转移、分化程度低分化、PD-1阳性、PD-L1阳性、EBV感染阳性均为胃癌预后不良的独立危险因素(P<0.05);根据影响因素构建预测预后不良的列线图模型,该模型预测胃癌患者预后不良的曲线下面积为0.924(95%CI:0.892-0.956),具有较高预测效能,且预测预后不良的校准度、临床效用良好.结论胃癌患者具有较高EBV感染阳性率,EBV感染与Lauren分型、PD-1/PD-L1信号通路有关,且是胃癌预后不良的影响因素.

关键词：胃癌人类疱疹病毒临床特征相关性预后

Influence of thermomechanical treatment on recrystallization and softening resistance of Cu-6.5Fe-0.3Mg alloy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2024年第9期34卷 2900-2917页

作者： Zhen-xia LIU Da-wei YUAN Xin LUO Lan-hao wang Jin-shui CHEN Hui-ming CHEN xiang-peng xiaO Bin YANG College of Advanced Copper Industry Jiangxi University of Science and TechnologyYingtan 335000China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China

The recrystallization and softening resistance of a Cu-6.5Fe-0.3Mg(mass fraction,%)alloy prepared by Process 1(cold rolling heat treatment)and Process 2(hot/cold rolling heat treatment)were studied using Vickers hardness tests,tensile tests,scanning electron microscopy and transmission electron *** softening temperature,hardness and tensile strength of the alloy prepared by Process 2 were 110°C,HV 15 and 114 MPa higher,respectively,than those of the alloy prepared by Process 1 after aging at 300°*** recrystallization activation energy of the alloys prepared by Process 1 and Process 2 were 72.83 and 98.11 kJ/mol,*** pinning effects of the precipitates of the two alloys on grain boundaries and dislocations were basically the *** softening mechanism was mainly attributed to the loss of dislocation *** higher Fe fiber density inhibited the average free migration path of dislocations and grain boundary migration in the alloy,which was the main reason for higher softening temperature of the alloy prepared by Process 2.

关键词： Cu−6.5Fe−0.3Mg alloy hot rolling recrystallization activation energy softening mechanism dislocation strengthening

Protective Effect of Naringenin on Acute Myocardial Ischemia-reperfusion Injury in Rats

在线全文

学校读者我要写书评

暂无评论

Medicinal Plant 2024年第3期15卷 50-52页

作者： xia ZHANG Ping ZHOU Juan LI Zhaojun xiang Qianqian LUO Qing DENG Department of Neurosurgery Taihe Hospital of Shiyan CityHubei University of MedicineShiyan 442000China Gynecology and Obstetrics Taihe HospitalHubei University of MedicineShiyan 442000China

[Objectives]To investigate the protective mechanism of naringenin on acute myocardial ischemia-reperfusion injury(AMI-RI)in Sprague-Dawley(SD)rats.[Methods]A total of 32 SD rats with AMI-RI model construction were randomly divided into AMI-RI model control group and citrus pigment A/B/C groups(n=8).The naringenin A,B,and C groups were administrated 20,40 and 80 mg/(kg•d)for 10 *** AMI group served as the negative control and was not *** the conclusion of the treatment regimen,a sample of intraventricular blood was collected for the purpose of measuring lactate dehydrogenase(LDH),glutathione peroxidase(GLH-PX),nitric oxide(NO),and superoxide dismutase(SOD)***,myocardial tissue was identified within the ischemic *** content of malondialdehyde(MDA)was determined by inducing nitric oxide synthase(iNOS)and endodermal nitric oxide synthase(eNOS)positive cells in the left anterior descending coronary artery.[Results]Following citrus treatment,the contents of GLH-PX and SOD in ventricular blood of the citrus B group were found to be significantly elevated,while the contents of NO and LDH in myocardial MDA and ventricle were observed to be significantly *** number of eNOS-positive cells was significantly increased,while the number of iNOS-positive cells was significantly *** difference was statistically significant when compared with the AMI-RI group(P<0.05).The changes observed in the above indicators in the citrus C group were more pronounced than those observed in the citrus B *** difference between the citrus C and the B group was statistically significant(P<0.05),indicating that this effect is concentration dependent.[Conclusions]In addition to its ability to inhibit myocardial lipid peroxidation during AMI-RI by increasing SOD activity,naringenin may also affect the synthesis and release of NO by regulating eNOS and iNOS,thereby achieving protection against *** effect is enhanced as the dose of the drug inc

关键词： Rat Naringenin Acute myocardial ischemia-reperfusion Lipid peroxidation Inducible/endothelial nitric oxide synthase

Chinese Society of Cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第5期67卷 913-939页

作者： Chinese Society of Cardiology,Chinese Medical Association,Writing Group Jiangang Jiang Hongyang Shu Dao Wen wang Rutai Hui Chenze Li xiao Ran Hong wang Jing Zhang Shaoping Nie Guanglin Cui Dingcheng xiang Qun Shao Shengyong Xu Discussion experts:Ning Zhou Yuming Li Wei Gao Yuguo Chen Yuan Bian Guoping wang Liming xia Yan wang Chunxia Zhao Zhiren Zhang Yuhua Zhao Jianan wang Shaoliang Chen Hong Jiang Jing Chen xianjin Du Mao Chen Yinxian Sun Sheng Li Hu Ding Xueping Ma Hesong Zeng Li Lin Shenghua Zhou Likun Ma Ling Tao Juan Chen Yiwu Zhou xiaomei Guo 不详 Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Zhongnan Hospital of Wuhan University Wuhan 430062China Fuwai Huazhong Cardiovascular Hospital Zhengzhou 450003China Beijing Anzhen Hospital Capital Medical UniversityBeijing 100029China Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010China Harbin Medical University Cancer Hospital Harbin 150081China Union Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Taida Hospital Tianjin 300457China Peking University Third Hospital Beijing 100191China Qilu Hospital of Shandong University Jinan 250012China Kanghua Hospital DongguanGuangzhou 523080China Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003China Nanjing First Hospital Nanjing Medical UniversityNanjing 210006China Renmin Hospital of Wuhan University Wuhan 430060Wuhan West China Hospital Sichuan UniversityChengdu 610044China First Hospital of China Medical University Shenyang 110002China General Hospital of Ningxia Medical University Yinchuan 750003China The Second xiangya Hospital Central South UniversityChangsha 410012China The First Affiliated Hospital of USTC University of Science and Technology of ChinaHefei 230002China The First Affiliated Hospital of Air Force Medical University Xi’an 710032China Central Hospital of Wuhan City Wuhan 430014China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China

Fulminant myocarditis is an acute diffuse inflammatory disease of *** is characterized by acute onset,rapid progress and high risk of *** pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory *** to China’s practical experience,the adoption of the“life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core)can significantly improve the survival rate and long-term *** emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.

关键词： fulminant myocarditis guidelines life support-based comprehensive treatment regimen diagnosis treatment cytokine storm overactivation of immunity

Unlocking the potential of bispecific ADCs for targeted cancer therapy

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2024年第4期18卷 597-621页

作者： Hongye Zeng Wenjing Ning Xue Liu Wenxin Luo Ningshao xia State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsNational Innovation Platform for Industry-Education Integration in Vaccine Researchthe Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical SciencesXiamen UniversityXiamen361102China

Antibody–drug conjugates(ADCs)are biologically targeted drugs composed of antibodies and cytotoxic drugs connected by *** innovative compounds enable precise drug delivery to tumor cells,minimizing harm to normal tissues and offering excellent prospects for cancer ***,monoclonal antibody-based ADCs still present challenges,especially in terms of balancing efficacy and *** antibodies are alternatives to monoclonal antibodies and exhibit superior internalization and selectivity,producing ADCs with increased safety and therapeutic *** this review,we present available evidence and future prospects regarding the use of bispecific ADCs for cancer treatment,including a comprehensive overview of bispecific ADCs that are currently in clinical *** offer insights into the future development of bispecific ADCs to provide novel strategies for cancer treatment.

关键词： antibody-drug conjugate bispecific antibody bispecific ADC cancer

共同富裕视阈下劳动收入份额对代际收入流动的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

上海经济研究 2024年第8期 43-56页

作者：张霞李向虹中南财经政法大学经济学院 430070

共同富裕是社会主义的本质要求,代际流动是实现共同富裕的重要途径之一。然而,居民财富的代际传递会对代际收入流动产生显著影响,当财富分配差距过大时容易导致阶层固化、阻碍共同富裕目标的实现。提高劳动收入份额能否影响代际收入流... 详细信息

共同富裕是社会主义的本质要求,代际流动是实现共同富裕的重要途径之一。然而,居民财富的代际传递会对代际收入流动产生显著影响,当财富分配差距过大时容易导致阶层固化、阻碍共同富裕目标的实现。提高劳动收入份额能否影响代际收入流动、从而促进阶层跃升?影响机制如何?本文采用中国家庭追踪调查(CFPS)和国家统计局的相关数据,构建固定效应模型研究了劳动收入份额对代际收入流动的影响。结果表明:提高劳动收入份额可以显著促进代际收入流动;实现途径主要是通过提升家庭的人力资本、积累财富资本和拓展社会资本。此外,该效应在无组织参与、女性子女、低职业声望父代和农村个体等群体中更加显著。本研究表明,提高劳动收入份额是促进代际流动、实现共同富裕的重要政策手段。

关键词：劳动收入份额代际收入流动人力资本财富资本社会资本

The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2024年第1期27卷 1-10页

作者： Zhuo Chen Meng-Wei Yao xiang Ao Qing-Jia Gong Yi Yang Jin-xia Liu Qi-Zhou Lian xiang Xu Ling-Jing Zuo Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing400042China College of Basic Medical Sciences Army Medical UniversityChongqing400038China Department of Orthopedics 953 Hospital of PLAShigatse Branch of Xinqiao HospitalArmy Medical UniversityShigatse857000Tibet Autonomous RegionChina Department of Rheumatology and Immunology Daping HospitalArmy Medical UniversityChongqing400042China Department of Obstetrics and Gynecology Chongqing People's HospitalChongqing401121China Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Department of Nuclear Medicine The First People's Hospital of Yunnan provinceAffiliated Hospital of Kunming University of Science and TechnologyKunming650034China

Programmed cell death 1 ligand 1(PD-L1)is an important immunosuppressive molecule,which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell *** PD-L1 expression disorder plays an important role in the occurrence,development,and treatment of sepsis or other inflammatory diseases,and has become an important target for the treatment of these *** stem cells(MSCs)are a kind of pluripotent stem cells with multiple differentiation *** recent years,MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune ***,PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various *** this review,we will summarize the main regulatory mechanism of PD-L1 expression,and discuss various biological functions of PD-L1 in the immune regulation of MSCs.

关键词： PD-L1 MSCs Immunomodulation