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Development and validation of a nomogram to predict allograft survival after pediatric liver transplantation

World Journal of Pediatrics 2024年第3期20卷 239-249页

作者： Guang-xiang Gu Shu-Ting pan Yi-Chen Fan Chen Chen qiang Xia Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineNo.160 Pujian RoadPudong New DistrictShanghai 200128China Department of Liver Transplantation Sun Yet-Sen Memorial HospitalSun Yat-Sen UniversityNo.107 Yanjiang West RoadGuangzhou 510080China Clinical Center for Investigation Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Background Liver transplantation is the main treatment for cholestatic liver disease and some metabolic liver diseases in children.However,no accurate prediction model to determine the survival probability of grafts prior to surgery exists.This study aimed to develop an effective prognostic model for allograft survival after pediatric liver transplantation.Methods This retrospective cohort study included 2032 patients who underwent pediatric liver transplantation between January 1,2006,and January 1,2020.A nomogram was developed using Cox regression and validated based on bootstrap sampling.Predictive and discriminatory accuracies were determined using the concordance index and visualized using calibration curves;net benefits were calculated for model comparison.An online Shiny application was developed for easy access to the model.Results Multivariable analysis demonstrated that preoperative diagnosis,recipient age,body weight,graft type,preoperative total bilirubin,interleukin-1β,portal venous blood flow direction,spleen thickness,and the presence of heart disease and cholangitis were independent factors for survival,all of which were selected in the nomogram.Calibration of the nomogram indicated that the 1-,3-,and 5-year predicted survival rates agreed with the actual survival rate.The concordance indices for graft survival at 1,3,and 5 years were 0.776,0.757,and 0.753,respectively,which were significantly higher than those of the Pediatric End-Stage Liver Disease and Child-Pugh scoring systems.The allograft dysfunction risk of a recipient could be easily predicted using the following URL:https://aspelt.***.io/ASPELT/l Conclusion The allograft survival after pediatric liver transplantation(ASPELT)score model can effectively predict the graft survival rate after liver transplantation in children,providing a simple and convenient evaluation method for clinicians and patients.

关键词： Allograft survival Nomogram Pediatric liver transplantation

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Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1147-1164页

作者： Yan Guo pan xiang Xiaojiao Sun Wei Liu Jiafeng Zhou Bin Yin Lin Hou Boqin qiang Huiliang Li Pengcheng Shu Xiaozhong Peng Department of Molecular Biology and Biochemistry Institute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina State Key Laboratory of Common Mechanism Research for Major Diseases Beijing 100005China Wolfson Institute for Biomedical Research University College LondonGower StreetLondon WC1E 6BTUK Chinese Institute for Brain Research Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100005China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits,and this process requires the proper recruitment of adaptor molecules to selectively activate downstream pathways.Here,we identified that DOK6,a member of the Dok(downstream of tyrosine kinases)family,is required for the maintenance of peripheral axons,and that loss of Dok6 can cause typical peripheral neuropathy symptoms in mice,manifested as impaired sensory,abnormal posture,paw deformities,blocked nerve conduction,and dysmyelination.Furthermore,Dok6 is highly expressed in peripheral neurons but not in Schwann cells,and genetic deletion of Dok6 in peripheral neurons led to typical peripheral myelin outfolding,axon destruction,and hindered retrograde axonal transport.Specifically,DOK6 acts as an adaptor protein for selectivitymediated neurotrophic signal transduction and retrograde transport for TrkC and Ret but not for TrkA and TrkB.DOK6 interacts with certain proteins in the trafficking machinery and controls their phosphorylation,including MAP1B,Tau and Dynein for axonal transport,and specifically activates the downstream ERK1/2 kinase pathway to maintain axonal survival and homeostasis.This finding provides new clues to potential insights into the pathogenesis and treatment of hereditary peripheral neuropathies and other degenerative diseases.

关键词： impaired restrain peripheral

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Continuous Orbit Equivalence of Semigroup Actions

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1581-1598页

作者： xiang Qi qiang Cheng Jun HOU School of Mathematical Science Yangzhou UniversityYangzhou 225002P.R.China

We introduce notions of continuous orbit equivalence and its one-sided version for countable left Ore semigroup actions on compact spaces by surjective local homeomorphisms,and characterize them in terms of the corresponding transformation groupoids and their operator algebras.In particular,we show that two essentially free semigroup actions on totally disconnected compact spaces are continuously orbit equivalent if and only if there is a canonical abelian subalgebra preserving C^(∗)-isomorphism between the associated transformation groupoid C^(∗)-algebras.We also give some examples of orbit equivalence,consider the special case of semigroup actions by homeomorphisms and relate continuous orbit equivalence of semigroup actions to that of the associated group actions.

关键词： Semigroup action continuous one-sided orbit equivalence continuous orbit equivalence groupoid C^(∗)-algebras

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Quantized bound states around a vortex in anisotropic superconductors

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 146-155页

作者： Ke xiang Da Wang qiang-Hua Wang National Laboratory of Solid State Microstructures&School of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

The bound states around a vortex in anisotropic superconductors is a longstanding yet important issue.In this work,we develop a variational theory on the basis of the Andreev approximation to obtain the energy levels and wave functions of the low-energy quantized bound states in superconductors with anisotropic pairing on arbitrary Fermi surface.In the case of circular Fermi surface,the effective Schr¨odinger equation yielding the bound state energies gets back to the theory proposed by Volovik and Kopnin many years ago.Our generalization here enables us to prove the equidistant energy spectrum inside a vortex in a broader class of superconductors.More importantly,we are now able to obtain the wave functions of these bound states by projecting the quasiclassical wave function on the eigenmodes of the effective Schr¨odinger equation,going beyond the quasiclassical Eilenberger results,which,as we find,are sensitive to the scattering rate.For the case of isotropic Fermi surface,the spatial profile of the low-energy local density of states is dominated near the vortex center and elongates along the gap antinode directions,in addition to the ubiquitous Friedel oscillation arising from the quantum inteference neglected in the Eilenberger theory.Moreover,as a consequence of the pairing anisotropy,the quantized wave functions develop a peculiar distribution of winding number,which reduces stepwise towards the vortex center.Our work provides a flexible way to study the vortex bound states in the future.

关键词： vortex bound state anisotropic superconductor Andreev approximation

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Semi-Varying Coefficient panel Data Model with Technical Indicators Predicts Stock Returns in Financial Market

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Journal of Systems Science & Complexity 2024年第4期37卷 1638-1652页

作者： HU Xuemei pan Ying LI xiang School of Mathematics and Statistics Chongqing Technology and Business University Chongqing Key Laboratory of Social Economy and Applied Statistics Research Center for Economy of Upper Reaches of the Yangtse River Chongqing Technology and Business University

Accurately predicting stock returns is a conundrum in financial market. Solving this conundrum can bring huge economic benefits for investors and also attract the attention of all circles of people. In this paper the authors combine semi-varying coefficient model with technical analysis and statistical learning, and propose semi-varying coefficient panel data model with individual effects to explore the dynamic relations between the stock returns from five companies: CVX, DFS, EMN, LYB,and MET and five technical indicators: CCI, EMV, MOM, ln ATR, ln RSI as well as closing price(ln CP), combine semi-parametric fixed effects estimator, semi-parametric random effects estimator with the testing procedure to distinguish fixed effects(FE) from random effects(RE), and finally apply the estimated dynamic relations and the testing set to predict stock returns in December 2020 for the five companies. The proposed method can accommodate the varying relationship and the interactive relationship between the different technical indicators, and further enhance the prediction accuracy to stock returns.

关键词： Fixed effects random effects semi-varying coefficient panel data model stock returns technical indicators

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Synthesis and Antibacterial Activity of Selenium-functionalized Poly(ε-caprolactone)

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Chinese Journal of Polymer Science 2022年第1期40卷 67-74页

作者： Ying-Ying Li Dong Xing xiang-qiang pan Jian Zhu Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsDepartment of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

A selenium-functionalizedε-caprolactone was synthesized by introducing a phenyl selenide group at the 7-position.A polymer was obtained through the ring-opening polymerization of this monomer in a base/thiourea binary organocatalytic system.A living polymerization process was achieved under mild conditions.The resulting polymers had a controlled molecular weight with a narrow molecular weight distributions and high end-group fidelity.Random copolymers could be obtained by copolymerizing this monomer withε-caprolactone.The thermal degradation temperature of the obtained copolymers decreased with the increasing molar ratio of selenide functionalized monomer in copolymers,while the glass transition temperature increased.In addition,the phenyl selenide side group could be further modified to a polyselenonium salt,which resulted in a polymer with good antibacterial properties.The survival rate of E.coli and S.aureus was only 9%with a polymer concentration of 62.5μg/mL.

关键词： Selenium-containing polyester Polycations Antibacterial activity Degradable

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Iron–doped bismuth oxybromides as visible-light-responsive Fenton catalysts for the degradation of atrazine in aqueous phases

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Journal of Environmental Sciences 2024年第3期137卷 321-332页

作者： Yong-Li Cai Yu-Hang Xu Ji-Zun xiang Zhi-qiang Zhang Qiu-xiang He Ya-Feng Li Jian Lü Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116China

Pesticides and its degradation products,being well–known residues in soil,have recently been detected in many water bodies as pollutants of emerging concerns,and thus there is a contemporary demand to develop viable and cost–effective techniques for the removal of related organic pollutants in aqueous phases.Herein,a visible-light-responsive Fenton system was constructed with iron–doped bismuth oxybromides(Fe–BiOBr)as the catalysts.Taking the advantage of sustainable Fe(Ⅲ)/Fe(Ⅱ)conversion and optimized H_(2)O_(2)utilization,the optimal Fe–BiOBr–2 catalyst showed an excellent atrazine removal efficiency of 97.61%in 120 min,which is superior than the traditional homogeneous Fenton and the majority of heterogeneous processes documented in the literature.In this photo–Fenton system,hydroxyl(·OH)and superoxide(·O_(2)^(-))radicals were dominant active species contributed to the oxidative degradation of atrazine.Due to the production of various active radicals,five degradation pathways were proposed based on the identification of intermediates and degradation products.Overall,this work not only demonstrates a fundamental insight into creating highly efficient and atom economic photo-Fenton systems,but also provides a complementary strategy for the treatment of organic pollutants in water.

关键词： Bismuth oxybromide Photo–Fenton Atrazine Catalytic degradation

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Genetically modified non-human primate models for research on neurodegenerative diseases

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Zoological Research 2024年第2期45卷 263-274页

作者： Ming-Tian pan Han Zhang Xiao-Jiang Li xiang-Yu Guo Guangdong Key Laboratory of Non-human Primate Research Guangdong-Hongkong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China

Neurodegenerative diseases(NDs)are a group of debilitating neurological disorders that primarily affect elderly populations and include Alzheimer's disease(AD),Parkinson's disease(PD),Huntington's disease(HD),and amyotrophic lateral sclerosis(ALS).Currently,there are no therapies available that can delay,stop,or reverse the pathological progression of NDs in clinical settings.As the population ages,NDs are imposing a huge burden on public health systems and affected families.Animal models are important tools for preclinical investigations to understand disease pathogenesis and test potential treatments.While numerous rodent models of NDs have been developed to enhance our understanding of disease mechanisms,the limited success of translating findings from animal models to clinical practice suggests that there is still a need to bridge this translation gap.Old World nonhuman primates(NHPs),such as rhesus,cynomolgus,and vervet monkeys,are phylogenetically,physiologically,biochemically,and behaviorally most relevant to humans.This is particularly evident in the similarity of the structure and function of their central nervous systems,rendering such species uniquely valuable for neuroscience research.Recently,the development of several genetically modified NHP models of NDs has successfully recapitulated key pathologies and revealed novel mechanisms.This review focuses on the efficacy of NHPs in modeling NDs and the novel pathological insights gained,as well as the challenges associated with the generation of such models and the complexities involved in their subsequent analysis.

关键词： Neurodegeneration Non-human primate Macaque monkey Animal model Gene modification

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Suspected coexistence of perianal necrotizing sweet syndrome in chronic myelomonocytic leukemia:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1176-1183页

作者： Ke-qiang Yu Hui-xiang Li Jing Wu Clinical Medicine School Chengdu University of Chinese MedicineChengdu 610072Sichuan ProvinceChina Institute of Integrated Traditional Chinese and Western Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Chronic myelomonocytic leukemia(CMML)complicated with Sweet syndrome(SS)is a rare hematological neoplasm.However,cases of concomitant development of perianal necrotizing SS(NSS)have not been reported.CASE SUMMARY We report a case of a 49-year-old male patient who underwent sequential procedures for hemorrhoids and perianal abscess.He developed postoperative incision infection and was referred to the department where the authors work.Initially,perianal necrotizing fasciitis secondary to incision infection after perianal abscess surgery was suspected.Despite receiving antibiotic therapy and undergoing surgical debridement,deeper necrotic areas formed in the patient’s perianal wounds,accompanied by persistent high fever.Blood and fungal cultures yielded negative results.The final diagnosis was corrected to be CMML with suspected concomitant perianal NSS.CONCLUSION CMML with perianal NSS is a rare condition,often misdiagnosed as perianal abscess or perianal necrotizing fasciitis.Conventional antibiotic therapy and surgical debridement are ineffective in managing this condition.

关键词： Chronic myelomonocytic leukemia Sweet syndrome Necrotizing fasciitis Perianal abscess Case report

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Synthesis of Sulfur/Selenium-containing Polyester with Recyclability and Controllable Hydrophilicity and Glass Transition Temperature

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Chinese Journal of Polymer Science 2023年第12期41卷 1836-1845,I0004,I0005页

作者： Wen-Jing Li xiang-qiang pan Jian Zhu Zheng-Biao Zhang Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

We present a ring-opening polymerization of bridged cyclic lactone utilizing alcohol as the initiator and organic base as the catalyst.Bridged γ-butyrolactone monomers(PhSGBL and PhSeGBL)were synthesized efficiently from commercially available 3-cyclohexene-1-carboxylic acid.Due to the ring strain of the bridged structure,ring-opening polymerization of this type of γ-butyrolactone derivative was successfully carried out under mild conditions,e.g.,using ethylene glycol as the initiator and a commercial catalyst[1,5,7-triazabicyclo[4.4.0 dec-5-ene(TBD)]]as the catalyst at 30℃.The obtained polymer could be degraded to its monomer for recycling in the presence of ZnCl_(2) as a catalyst.PhSGBL and PhSeGBL could also be copolymerized with ε-caprolactone to tune the glass transition temperature.Additionally,the hydrophilicity of the obtained sulfur-containing polymers could be adjusted by selectively oxidizing the thioether side group to sulfone/sulfoxide,which offered a way to tune the hydrophilicity of polyester.On the other hand,the obtained selenium-containing compound could be degraded in the presence of m-CPBA(3-chloroperbenzoic acid),which offered potential application in sustained drug release.

关键词： Ring-opening polymerization Polyester Closed-loop recycling Selective oxidation

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