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Allergy march of Chinese children with infantile allergic symptoms: a prospective multi-center study

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World Journal of Pediatrics 2017年第4期13卷 335-340页

作者： Qi Gao Yi-Xin Ren Yong-Ge Liu Lin Ma xiao-Hong Gu Wei-Xi Zhang Li Liu xiao-Jia Zhai Li xiang Kun-Ling Shen Allergy Department Beijing Children's HospitalCapital Medical University Dermatology Department Beijing Children's HospitalCapital Medical University Pediatric Department People's Hospital of Wuxi CityJiangsu Province Respiratory Medicine Department Yuying Children's Hospital Affiliated to Wenzhou Medical College Pediatric Department the First Hospital of Jilin University Pediatric Department Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University National Clinical Medical Research Center for Respiratory Diseases China

Background:Allergy march refers to progression of allergic diseases from infantile food allergy to the development of asthma and allergic rhinitis (AR).Evidence come mostly from studies in European *** study aimed to investigate allergy march in Chinese children with infantile food protein allergy (FPA) with a special focus on the effect of different formula ***:From 2008 to 2010,153 infants diagnosed with FPA were recruited in five tertiary hospitals across *** were randomly treated with amino-acid-based formula or soy-protein-based formula for a period of 3 ***-term follow-up was performed when they reached early school age,using questionnaires,physical examinations,and serum-specific immunoglobulin ***:The overall follow-up rate was 73.20%.In patients who reached their early school years,the prevalence of physician-diagnosed AR and asthma were 43.75% and 23.21%,*** 40% of the subjects remained positive for food sensitizations upon ***-six subjects receiving aeroallergen screening tests in infancy all proved negative,but upon follow-up,65.57% were sensitized to aeroallergens (P=0.005).No significant difference between the effects of amino-acid-based formula and soy-protein-based formula on children's allergy march was ***:A high proportion (47.32%) of Chinese infants with early allergic symptoms developed respiratory allergies by their early school *** food-sensitized infants outgrew their condition several years later,but then aeroallergen sensitization often ***-acid-based formula showed no advantages over soy protein-based formula with respect to arresting the allergy march.

关键词： allergic rhinitis allergy march asthma atopic dermatitis infant

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声空化核效应实验的中子探测系统

原子能科学技术 2011年第5期45卷 606-610页

作者：李欣年范祥祥黄敏方晓明钱梦騄程茜上海大学射线应用研究所上海201800 同济大学声学研究所上海200092

设计建立了用于声空化核效应的中子测量系统,该系统由ST-451液闪探测器和BF3正比计数管组成,各中子谱仪的仪器精度<2.42%,并导出BF3正比计数管的中子探测灵敏度计算式。利用高压倍加器氘离子轰击D-Ti靶产生的2.45MeV中子,对BF3计数管进... 详细信息

设计建立了用于声空化核效应的中子测量系统,该系统由ST-451液闪探测器和BF3正比计数管组成,各中子谱仪的仪器精度<2.42%,并导出BF3正比计数管的中子探测灵敏度计算式。利用高压倍加器氘离子轰击D-Ti靶产生的2.45MeV中子,对BF3计数管进行探测灵敏度标定。利用BF3正比计数管测量声空化核效应实验的声核中子,由此估算有效中子发生率为7.0×104～8.0×105 s-1。

关键词：声空化核效应声核中子 BF3正比计数管中子探测灵敏度

Immunological Evaluation of a Novel Mycobacterium tuberculosis Antigen Rv0674

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Biomedical and Environmental Sciences 2019年第6期32卷 427-437页

作者： xiao Tong Yang LIU Hai Can LI xiao Qin HUANG Ming xiang LI Gui Lian LI Na YAN Yu Han LUO Qiao WANG Xue Zhi LI Ma Chao WAN Kang Lin State Key Laboratory for Infectious Diseases Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Key Laboratory of Laboratory Medicine Ministry of Education College of Laboratory Medicine and Life Sciences Wenzhou Medical University Wenzhou 325035 Zhejiang China Clinical laboratory Fuzhou Pulmonary Hospital Fuzhou 350008 Fujian China The first hospital of Changsha Changsha 410005 Hunan China Key laboratory of Translational Medicine of Guangdong Center for Tuberculosis Control of Guangdong Province Guangzhou 510630 Guangdong China

Objective This study aimed to characterize the diagnostic and vaccine potential of a novel Mycobacterium tuberculosisantigen Rv0674. Methods To evaluate thediagnostic potential and antigenicity of Rv0674, IgG was evaluated using ELISA and interferon (IFN)-γ was done by using ELISpot assay among TB patients and healthy donors. For immunogenicity evaluation, BALB/c mice were immunized with Rv0674. Cytokine production was determined by cytokine release assay using an ELISA kit, and the antibodies were tested using ELISA. Results The results of serum Elisa tests showed that Rv0674 specific immunoglobulin G (IgG) response was higher in TB patients than negative controls. And Rv0674 had good performance in serological test with sensitivity and specificity of 77.1% and 81.1%, respectively. While it shows poor sensitivity and specificity of 26.23% and 79.69% for IFN-γ tests. In BALB/c mice, Rv0674 adjuvant by DDA/PolyI:C could also induce a high level of IFN-γ, interleukin-2 and interleukin-6 as well as a high IgG titer in both high-and low-dose groups indicating that Rv0674 is essential in humoral and cellular immunity. Moreover, the cytokine profile and IgG isotypecharacterized Rv0674 as a Th1/Th2-mixed-type protective immunity with the predominance of Th1 cytokines. Conclusion Rv0674 may be a good potential candidate for the development of TB serological diagnosis and a new TB vaccine.

关键词： Antigen Immunologic diagnosis Mycobacterium tuberculosis Rv0674 Vaccine

Research advances in the study of Pistacia chinensis Bunge, a superior tree species for biomass energy

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Forestry Studies in China 2007年第2期9卷 164-168页

作者： Li Hong-lin Zhang Zhi-xiang Lin Shan-zhi Li xiao-xu College of Biological Sciences and Biotechnology Beijing Forestry University Beijing 100083 P. R. China

As a renewable energy, biomass energy has aroused wide attention and studies of this issue have become a hot topic throughout the world. Pistacia chinensis Bunge （Anacardiaceae） is a superior species for biomass energy with high oil content in seeds and wide geographic distribution. It is a dioeciously, deciduous arbor, flowering from March to April and bearing fruits from September to November. The classification, regional distribution and biological characteristics ofP chinensis are stated in this paper, then, research advances in the growth, breeding and physiology of this species are summarized. The problems in present studies are broached. Finally, a future direction for research is proposed.

关键词： Pistacia chinensis Bunge biomass energy of forest

The ARTS of p53-dependent mitochondrial apoptosis

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Journal of Molecular Cell Biology 2022年第10期14卷 11-18页

作者： qian Hao Jiaxiang Chen Hua Lu xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Physiology Medical College of Nanchang UniversityNanchang 330006China Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology Nanchang UniversityNanchang 330006China Department of Biochemistry&Molecular Biology and Tulane Cancer Center Tulane University School of MedicineNew OrleansLA 70112USA Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China

The tumor-suppressive activity of p53 is largely attributed to its ability to induce cell death,including apoptosis,through transcription-dependent and transcription-independent *** the one hand,nuclear p53 transcriptionally activates the expression of a myriad of pro-apoptotic BCL-2 family genes,such as NOXA,PUMA,BID,BAD,BIK,BAX,etc.,whereas it inactivates the expression of anti-apoptotic BCL-2,BCL-XL,and MCL1,leading to mitochondrial *** the other hand,cytoplasmic p53 also promotes mitochondrial apoptosis by directly associating with multiple BCL-2 family proteins in the ***-related protein in TGF-βsignaling pathway(ARTS),a mitochondria-localized pro-apoptotic protein encoded by an alternative spliced variant of the SEPT4 gene,triggers apoptosis by facilitating proteasomal degradation of BCL-2 and XIAP upon pro-apoptotic *** recently identified SEPT4/ARTS as a new p53 target gene in response to genotoxic *** in turn binds to p53,drives its mitochondrial localization,and enhances the interaction between p53 and BCL-XL,thereby promoting mitochondrial *** review will illustrate the mechanisms of p53-induced mitochondrial apoptosis,offer some recently discovered new insights into the functions of ARTS in regulating mitochondrial cell death,and discuss the clinical significance of ARTS in cancer and non-cancer diseases.

关键词： p53 ARTS SEPT4 BCL-2 family apoptosis cancer therapy

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石墨负极材料烧结辊道炉自动上下料系统设计

工业炉 2024年第4期46卷 42-45+61页

作者：芦靖宇何易鹏肖路向玉印杨金权易忠帆湖南烁科智能热工装备有限公司中国电子科技集团公司第四十八研究所

针对锂电池石墨负极材料采用辊道炉烧结生产时，存在石墨物料特性差异大、烧结后物料硬度高、现场温度高、粉尘大、环境恶劣等诸多难点，设计了一种配套辊道炉烧结生产的全自动上下料系统。该系统的设计融入了高硬度物料辅助卸料技术、... 详细信息

针对锂电池石墨负极材料采用辊道炉烧结生产时，存在石墨物料特性差异大、烧结后物料硬度高、现场温度高、粉尘大、环境恶劣等诸多难点，设计了一种配套辊道炉烧结生产的全自动上下料系统。该系统的设计融入了高硬度物料辅助卸料技术、复杂物料自适应装钵技术和适应复杂工况的高稳定技术等，能够很好地解决锂电池石墨负极材料烧结生产中的各种难题，提高负极材料产业链关键工艺装备自动化的技术性、稳定性，突破锂电池负极材料生产工艺装备的技术瓶颈，促进锂电池负极材料产业的发展。

关键词：石墨负极材料辊道炉上下料系统全自动化

Effect of astragaloside Ⅳ on lipid and glucose metabolism in acute myocardial infarction through PPARγ pathway

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中国药理学与毒理学杂志 2019年第9期33卷 680-681页

作者： ZHANG qian WANG xiao-ping WANG Yong LI Chun WANG Wei Beijing University of Chinese Medicine Beijing 100029China

OBJECTIVE To investigate the effects of astragaloside IV(which can be extracted from the traditional Chinese medicine Astragalus membranaceus)on lipid and glucose metabolism in acute myocardial infarction(AMI).METHODS Model of heart failure(HF)after AMI was established with ligation of left anterior descending artery on Sprague-Dawley(SD)*** rats were divided into three groups:sham,model and astragaloside IV treatment ***-eight days after treatment(astragaloside IV,20 mg·kg-1 daily),hematoxylin-eosin(HE)staining was applied to visualize cardiomyocyte morphological *** performance liquid chromatography(HPLC)was performed to assess the contents of adenosine phosphates in *** emission tomography and computed tomography(PET-CT)was conducted to evaluate the cardiac glucose *** of key molecules such as peroxisome proliferatoractivated receptor γ(PPARγ),sterol carrier protein 2(SCP2)and long chain acyl CoA dehydrogenase(ACADL)were measured by Western blotting and ***-glucose deprivation-reperfusion(OGD/R)-induced H9C2 injury cardiomyocyte model was adopted for potential mechanism research in *** Treatment with astragaloside Ⅳ rescued hearts from structural and functional damages as well as inflammatory *** of adenosine triphosphate(ATP)and energy charge(EC)in astragaloside IV group were also up-regulated compared to model *** results demonstrated that critical enzymes both in lipid metabolism and glucose metabolism compro mised in model group compared to sham ***,astragalosideⅣcould up-regulate critical enzymes including ACADL and SCP2 in lipid metabolism accompanying with promoting effect on molecules in glycolysis *** on upstreaming signaling pathway demonstrated that astragaloside Ⅳ could dramatically increase the expres sions of PPARγ.In vitro study suggested the efficacy of astragalosideⅣcould be blocked by T0070907,a selec

关键词： acute myocardial infarction astragalosideⅣ lipid and glucose metabolism PPARγpathway

Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB

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Chinese Journal of Natural Medicines 2015年第4期13卷 283-289页

作者： ZHANG xiao-Hong XU Xian-xiang XU Tao School of Biomedical Science Huaqiao University

This study investigated effects of Ginsenoside Ro （Ro） on interleukin-1β （IL-1β）-induced apoptosis and inflammation in rat chondrocytes. The rat chondrocytes were co-treated with IL-1β （10 ***^-1） and Ro （50, 100 and 200 μmol.L^-1） for 48 h. Chondrocytes viability was detected by the MTT assay and Annexin V-FITC/PI dual staining assay. Caspase 3 activity was measured by using caspase 3 colorimetric assay kit. Apoptosis related proteins Bax, Bad, Bcl-XL, PCNA, p53 and phospho-p53, along with inflammation related protein MMP 3, MMP 9 and COX-2, and the expression of phospho-NF-κ3 p65 were assayed by western blotting analyses. Ro could improve IL-1β-induced chondrocytes viability. Ro could suppress IL-1β-induced apoptosis by inhibiting levels of Bax and Bad, decreasing p53 phosphorylation and promoting the expression of Bcl-XL and PCNA. Ro inhibited caspase 3 activity. IL-1β-induced inflammation and matrix degration were also alleviated by Ro with down-regulating the expression of MMP 3, MMP 9 and COX-2. Moreover, Ro inhibited NF-κ3 p65 phosphorylation induced by 1L-1β. In conclusion, these results suggested Ro exerted anti-apoptosis and anti-inflammation in IL-1β-induced rat chondrocytes, which might be related to NF-κ3 signal pathway. Therefore, we propose that Ro might be a potential novel drug for the treatment ofosteoarthritis.

关键词： Ginsenoside Ro Cbondrocytes Apoptosis Inflammation NF-κB

Preparation and characterization of FPGX hydrogel dosimeters

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Nuclear Science and Techniques 2010年第1期21卷 60-62页

作者： xiao Ruijia Yang Liming Chen Jie qian qiang Rong Liang Cao Fangqi Luo Wenyun Dong xiaoqing Zha Yuanzi Wu Guohua School of Environmental and Chemical Engineering Shanghai University Shanghai 200444 China Department of Radiation Oncology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China

A three dimensional Fricke-(PVA-glutaraldehyde)-xylenol orange (FPGX) hydrogel dosimeter was prepared by chemical crosslinking *** determination was performed by measuring the absorbance change of the dosimeter before and after irradiation using UV-Vis spectrophotometer at 585 *** dose response of the FPGX hydrogel dosimeter related to absorbance change was linear,when it was irradiated by X-ray in the range of 0~2 *** stability of the dosimeter before and after irradiation was evaluated by studying the change of absorbance with time.

关键词：剂量计水凝胶制备紫外可见分光光度计 X射线照射表征化学交联法聚乙烯醇