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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu xiang Li Shen Du ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑Yuan Yu Jing Wu Guang Yin fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei fan Yi He Pan Chen ming Zhou Bo xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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均匀设计优化复方槲皮素乳膏基质处方

中国新药杂志 2016年第20期25卷 2365-2368页

作者：魏传梅孙绍伟薄明香樊其忠高培民滨州医学院附属医院药学部滨州256603

目的:研究复方槲皮素乳膏的最佳基质处方组成。方法:以油相、乳化剂、二甲亚砜(DMSO)、盐酸的用量为考察因素,以外观性状、粒度、均匀性、稳定性、酸碱性的综合评分为指标,采用均匀设计试验筛选处方并验证。结果:复方槲皮素乳膏的最佳... 详细信息

目的:研究复方槲皮素乳膏的最佳基质处方组成。方法:以油相、乳化剂、二甲亚砜(DMSO)、盐酸的用量为考察因素,以外观性状、粒度、均匀性、稳定性、酸碱性的综合评分为指标,采用均匀设计试验筛选处方并验证。结果:复方槲皮素乳膏的最佳基质处方组成为:每100 g成品含白凡士林21.2 g、十八醇6.5 g、单硬脂酸甘油酯6.9 g、十二烷基硫酸钠1.2 g、DMSO 2.4 g。结论:按此处方制备的复方槲皮素乳膏具有外观细腻均匀、易涂抹、稳定性好的特点,符合《中华人民共和国药典》2010年版乳膏项下有关规定。

关键词：复方槲皮素乳膏均匀设计基质处方

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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新型农村集体经济促进农民共同富裕的演进逻辑和创新路径

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西北农林科技大学学报（社会科学版） 2025年第1期25卷 69-77页

作者：樊晓燕蒋明西安交通大学马克思主义学院西安710049 西安理工大学马克思主义学院西安710048

新型农村集体经济具有市场性和社区性,农民共同富裕强调发展性和共享性两个维度的目标,二者在基本原则的人民性、实现途径的互助性和目标指向的全面性上相契合,这是构建新型农村集体经济促进农民共同富裕理论分析框架的基础。理论发展... 详细信息

新型农村集体经济具有市场性和社区性,农民共同富裕强调发展性和共享性两个维度的目标,二者在基本原则的人民性、实现途径的互助性和目标指向的全面性上相契合,这是构建新型农村集体经济促进农民共同富裕理论分析框架的基础。理论发展、实践探索和现实需求是揭示新型农村集体经济促进农民共同富裕内在逻辑演进的三个方面:理论逻辑是坚持公有制基础上农村集体经济制度的理论创新;历史逻辑是中国特色农业农村现代化的发展历程;现实逻辑是发展新型农村集体经济对乡村全面振兴的重大意义。由此从产权制度、分配制度和基层治理制度创新的整体视角提出新型农村集体经济促进农民共同富裕的创新路径。坚持以人民为中心的发展理念,发挥新型农村集体经济的战略作用,探索新型农村集体经济的发展规律是新型农村集体经济促进农民共同富裕需要坚持的重要原则。

关键词：新型农村集体经济农民共同富裕制度创新

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai xiang Wen-Hui Wei Shu-Hui fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Admissibility for Linear Estimator of Parameter on Growth Curve Model with Respect to Linear Constraint

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Acta Mathematicae Applicatae Sinica 2009年第1期25卷 171-176页

作者： ming-xiang Cao fan-chao Kong Department of Mathematics Hefei Teachers College Heifei 230061 China Department of Mathematics Anhui University Hefei 230038 China

By using the vector-method of matrix, we study Growth Curve Model with respect to linear constraint. Under matrix loss function and vector loss function, we obtain necessary and sufficient conditions for admissibility... 详细信息

关键词： Growth curve model linear estimators admissibility

General Admissibility for Linear Estimators in a General Multivariate Linear Model under Balanced Loss Function

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Acta Mathematica Sinica,English Series 2013年第9期29卷 1823-1832页

作者： ming xiang CAO fan Chao KONG Department of Mathematics Hefei Normal University School of Mathematics Anhui University

A generalization of Zellner’s balanced loss function is proposed. General admissibility in a general multivariate linear model is investigated under the generalized balanced loss function. And the sufficient and necessary conditions for linear estimators to be generally admissible in classes of homogeneous and nonhomogeneous linear estimators are given, respectively.

关键词： Balanced loss function linear estimators general optimality general admissibility