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Real-time in-situ monitoring of chiral changes during a reaction at single-molecule level

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Science China Chemistry 2024年第2期67卷 422-423页

作者： min Tan dong xiang Institute of Modern Optics and Center of Single-Molecule Science Tianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyNankai UniversityTianjin300350China School of Materials Science and Engineering Smart Sensing Interdisciplinary Science CenterNankai UniversityTianjin300350China TongLu FeiRan Garment–Nankai University Joint Laboratory Nankai UniversityTianjin300350China

Molecular chirality is a widespread phenomenon in nature,playing a critical role in various fields such as chemistry [1],life sciences [2], and materials science [3], and has therefore attracted significant attention and research by scholars [4–6].However, the chirality in chemical reactions is often dynamic, making real-time monitoring of chiral changes during chemical reactions at the single-molecule level extremely challenging.

关键词： chiral chirality critical

Effect of different bottom blowing elements on stirring characteristics of molten bath in converter

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Journal of Iron and Steel Research(International) 2024年第2期31卷 368-376页

作者： ming Lv Shuang-ping Chen Hong-min Guo Yi-jie Hao xiang-dong Xing School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina Shaanxi Longmen Steel Company Hancheng715405ShaanxiChina

The bottom blowing element is the key equipment to ensure the bottom blowing effect of the *** types of bottom blowing elements,dispersive type(D1),double circular seam(D2)and straight cylinder type(D3),were built,and the effects of bottom blowing element type on molten bath flow,wall erosion and furnace bottom erosion were *** was found that when the bottom blowing elements of dispersive type(D1)and double circular seam(D2)were used,the dead zone area in the lower part of the molten bath was smaller,and the high-speed zone area was larger;therefore,the stirring effect on the bottom melt was *** the straight cylinder type(D3)bottom blowing element was used,the gas penetrated the molten bath at a faster rate to reach the surface of molten bath and failed to disperse in the bottom molten bath,and the wall shear stress near the nozzle outlet was *** argon was blown by three different bottom blowing elements,the area of the wall shear stress greater than 3 Pa was 4.8,5.6 and 8.7 cm2,respectively,within 0.2 m of the bottom blowing nozzle outlet.

关键词： Converter steelmaking Bottom blowing element Molten bath stirring Wall erosion

Coordination for a Closed-loop Supply Chain with Recycling Platform Considering Dynamic Setting

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 425-451页

作者： Zehua xiang Ting Ji Lingfeng dong School of Management Zhejiang UniversityHangzhou310058China School of Business Hangzhou City UniversityHangzhou310015China Alibaba Business College Hangzhou Normal UniversityHangzhou311121China

This paper presents a dynamic closed-loop supply chain(CLSC)model,incorporating a manufacturer,a retailer,and an internet recycling platform(IRP),utilizing differential game theory while considering the forgetting effect of *** model encompasses factors such as the quality level of used products and Big Data marketing(BDM),comparing optimal equilibriums under decentralized and cooperative decision *** effectively coordinate the dynamic CLSC at each time point,we propose a revenue-sharing and cost-sharing(RSCS)combined *** addition to ensuring reasonable sharing of revenues and costs,this contract allows the manufacturer to flexibly adjust wholesale prices for final products and transfer prices for used products in order to distribute profits appropriately and achieve Pareto optimality within the CLSC ***,our results indicate that there exists a threshold for Big Data marketing efficiency;high-efficiency BDM not only facilitates increased recycling on Internet platforms but also reduces unit recycling costs for ***,when implementing the combined contract,Big Data marketing efficiency does not impact the transfer price paid by manufacturers to Internet recycling platforms.

关键词： Big Data marketing differential game closed-loop supply chain coordination internet recycling platform

Natural products inspired[3+2]cycloaddition enables efficient construction of hydroxylated tetrahydrofuran acetals and concise syntheses of lignans

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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： dong-Yue Cai Weiming Shi Zhao-Hui Jin Zhi-xiang Yu Jin-Xin Zhao Jian-min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

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Clinical practice of sepsis-induced immunosuppression:Current immunotherapy and future options

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Chinese Journal of Traumatology 2024年第2期27卷 63-70页

作者： Fei Pei Bin Gu Shu-min Miao xiang-dong Guan Jian-Feng Wu Department of Critical Care Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Guangdong Clinical Research Center for Critical Care Medicine Guangzhou510080China

Sepsis is a potentially fatal condition characterized by the failure of one or more organs due to a disordered host response to *** development of sepsis is closely linked to immune *** a result,immunotherapy has gained traction as a promising approach to sepsis treatment,as it holds the potential to reverse immunosuppression and restore immune balance,thereby improving the prognosis of septic ***,due to the highly heterogeneous nature of sepsis,it is crucial to carefully select the appropriate patient population for *** review summarizes the current and evolved treatments for sepsis-induced immunosuppression to enhance clinicians'understanding and practical application of immunotherapy in the management of sepsis.

关键词： Sepsis Sepsis-induced immunosuppression Immunotherapy Enrichment Classifier

Fabrication of micro-nano patterned materials mimicking the topological structure of extracellular matrix for biomedical applications

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Nano Research 2024年第5期17卷 4244-4258页

作者： Yifeng Nie dong Han xiang Li CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

With the advent of tissue engineering and biomedicine,the creation of extracellular matrix(ECM)biomaterials for in vitro applications has become a prominent and promising *** ECM materials provide physical,biochemical,and mechanical properties that guide cellular behaviors,such as proliferation,differentiation,migration,and *** micro-and nano-patterned materials have a unique surface topology and low energy replication process that directly affect cellular biological behaviors at the interface,the fabrication of micro-nano pattern biomaterials and the regulation of surface physical and chemical properties are of great significance in the fields of cell regulation,tissue engineering,and regenerative ***,we provide a comprehensive review of the progress in the fabrication and application of patterned materials based on the coupling of mechanical action at the micro-and nano-meter scale,including photolithography,micro-contact printing,electron beam lithography,electrospinning,and 3D printing ***,a summary of the fabrication process,underlying principles,as well as the advantages and disadvantages of various technologies are *** also discuss the influence of material properties on the fabrication of micro-and nano-patterns.

关键词： micro/nano hybrid materials patterning fabrication techniques extracellular matrix substrate-cell interaction biomedical engineering

Weighted Composition Operators That Preserve Frames On Weighted Hardy Spaces

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1645-1654页

作者： Ya Li dong Rui Liu Guo xiang Lu School of Mathematical Sciences and LPMC Nankai UniversityTianjin300071P.R.China School of Statistics and Mathematics Zhongnan University of Economics and LawWuhan430073P.R.China

In this paper, we characterize weighted composition operators that preserve frames on the weighted Hardy spaces in the unit disk. In particular, we obtain the symbol properties of the bounded invertible weighted composition operators. Moreover, we establish the equivalence between bounded invertible operators and frame-preserving operators. Furthermore, we show that weighted composition operator preserves frames if and only if it preserves the Riesz bases property. Additionally,we investigate the weighted composition operators that preserve tight or normalized tight frames on the Dirichlet space.

关键词： Weighted composition operators Weighted Hardy spaces frames invertible

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A probabilistic model based on the peak-over-threshold approach for risk assessment of airport controllers’performance

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Journal of Safety Science and Resilience 2024年第1期5卷 110-118页

作者： Lili Zu Yijie Lu min dong College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Engineering and Applied Science George Washington UniversityWashington DC 20052USA College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Airport tower control plays an instrumental role in ensuring airport ***,obtaining objective,quantitative safety evaluations is challenging due to the unavailability of pertinent human operation *** study introduces a probabilistic model that combines aircraft dynamics and the peak-over-threshold(POT)approach to assess the safety performance of airport *** applied the POT approach to model reaction times extracted from a radiotelephony dataset via a voice event detection *** model couples the risks of tower control and aircraft operation to analyze the influence of human *** data from radiotele-phony communications and the Base of Aircraft Data(BADA)database,we compared risk levels across *** findings revealed heightened airport control risks under low demand(0.374)compared to typical conditions(0.197).Furthermore,the risks associated with coupling under low demand exceeded those under typical de-mand,with the final approach stage presenting the highest risk(4.929×107).Our model underscores the significance of human factors and the implications of mental disconnects between pilots and controllers for safety ***,these consistent findings affirm the reliability of our probabilistic model as an evaluative tool for evaluating the safety performance of airport tower *** results also illuminate the path toward quantitative real-time safety evaluations for airport controllers within the *** recommend that airport regulators focus on the performance of airport controllers,particularly during the final approach stage.

关键词： Safety evaluation Performance Probabilistic model Task demand Airport controller

Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

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Current Medical Science 2024年第3期44卷 475-484页

作者： min-shan LI xiang-hong WANG Heng WANG Department of Otolaryngology-Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute of Allergy and Clinical Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Clinical Research Center for Nasal Inflammatory Diseases Wuhan430030China

Proton-activated G protein-coupled receptors(GPCRs),initially discovered by Ludwig in 2003,are widely distributed in various *** receptors have been found to modulate the immune system in several inflammatory diseases,including inflammatory bowel disease,atopic dermatitis,and ***-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular *** detection triggers downstream signaling pathways within the cells,ultimately influencing the function of immune *** this review,we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

关键词： proton-activated G protein-coupled receptors inflammation immunomodulation disease