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Facet-dependent transformation and toxicity of nanoscale zinc oxide in the synthetic saliva

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Journal of Environmental Sciences 2024年第5期139卷 170-181页

作者： xiang Zhang Yunpeng huang Jikun Wang jie Tang YangMei Nali Zhu Zhigang Li Lingxiangyu Li YaweiWang School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Chemistry University of PennsylvaniaPhiladelphia 19104USA

The nanoscale zinc oxide(n-ZnO)was used in food packages due to its superior antibac terial activity,resulting in potential intake of n-ZnO through the digestive system,wherein n-ZnO interacted with *** recent,facet engineering,a technique for controlling the exposed facets,was applied to n-ZnO,whereas risk of n-ZnO with specific exposed facets in saliva was *** nanoflakes(ZnO-0001)and nanoneedles(ZnO-1010)with the pri mary exposed facets of{0001}and{1010}respectively were prepared in this study,investigat ing stability and toxicity of ZnO-0001 and ZnO-1010 in synthetic *** ZnO-0001 and ZnO-1010 partially transformed into amorphous Zn_(3)(PO_(4))_(2)within 1 hr in the saliva even containing orgnaic components,forming a ZnO-Zn_(3)(PO_(4))_(2)core-shell *** less,ZnO-1010 relative to ZnO-0001 would likely transform into Zn_(3)(PO_(4))_(2),being attributed to superior dissolution of{1010}facet due to its lower vacancy formation energy(1.15 eV than{0001}facet(3.90 eV)).The toxicity of n-ZnO to Caco-2 cells was also dependent on the primary exposed facet;ZnO-0001 caused cell toxicity through oxidative stress,whereas ZnO-1010 resulted in lower cells viability than ZnO-0001 through oxidative stress and mem brane *** functional theory calculations illustrated that·O_(2)^(-)was formed and released on{1010}facet,yet O_(2)^(2-)instead of·O_(2)^(-)was generated on{0001}facet,leading to low oxidative stress from *** findings demonstrated that stability and toxicity of n-ZnO were dependent on the primary exposed facet,improving our understanding o health risk of nanomaterials.

关键词： The exposed facet Nanoscale ZnO Chemical transformation Synthetic salica Nanotoxicity

Post-acute ischemic stroke hyperglycemia aggravates destruction of the blood-brain barrier

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Neural Regeneration Research 2024年第6期19卷 1344-1350页

作者： Tianqi Xu Jianhong Yang Yao Xu Xiaofeng Wang xiang Gao jie Sun Chenhui Zhou Yi huang Department of Neurology The First Affiliated Hospital of Ningbo University Department of General Surgery The First Affiliated Hospital of Ningbo University Department of Neurosurgery The First Affiliated Hospital of Ningbo University Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province

Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation, which is associated with blood-brain barrier disruption. Brain microvascular endothelial cells are a major component of the blood-brain barrier. Intercellular mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial dysfunction. In this study, we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells, and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial cells. We found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial cells. However, post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial dysfunction. We established an in vitro brain microvascular endothelial cell model of the blood-brain barrier. We found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain barrier. In a clinical study, we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic transformation. We found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic transformation. These findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.

关键词： acute ischemic stroke blood-brain barrier brain microvascular endothelial cells mitochondrial transfer stress hyperglycemia

Weak type(1, 1) of the Riesz transform on some direct product manifolds with exponential volume growth

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Science China Mathematics 2024年第7期67卷 1599-1622页

作者： Hong-Quan Li jie-xiang Zhu School of Mathematical Sciences Fudan UniversityShanghai200433China Center for Applied Mathematics Tianjin UniversityTianjin300072China

In this paper, we are concerned with the Riesz transform on the direct product manifold H^(n)× M,where H^(n) is the n-dimensional real hyperbolic space, and M is a connected complete non-compact Riemannian manifold satisfying the volume doubling property and generalized Gaussian or sub-Gaussian upper estimates for the heat kernel. We establish its weak type(1, 1) property. In addition, we obtain the weak type(1, 1) of the heat maximal operator in the same setting. Our arguments also work for a large class of direct product manifolds with exponential volume growth. Particularly, we provide a simpler proof of weak type(1, 1) boundedness of some operators considered in the work of Li et al.(2016).

关键词： Riesz transform heat kernel direct product real hyperbolic space

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On Hamiltonian Property of Cayley Digraphs

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 547-556页

作者： Fang DUAN Qiong-xiang huang School of Mathematics Science Xinjiang Normal UniversityUrumqi 830017China College of Mathematics and Systems Science Xinjiang UniversityUrumqi 830017China

Let G be a finite group generated by S and C(G,S) the Cayley digraphs of G with connection set *** this paper,we give some sufficient conditions for the existence of hamiltonian circuit in C(G,S),where G=Zm×H is a semiproduct of Zmby a subgroup H of *** particular,if m is a prime,then the Cayley digraph of G has a hamiltonian circuit unless G=Zm×*** addition,we introduce a new digraph operation,called φ-semiproduct of Γ1by Γ2and denoted by Γ1×Γ_φΓ2,in terms of mapping φ:V(Γ2)→{1,-1}.Furthermore we prove that C(Zm,{a})×_φ C(H,S) is also a Cayley digraph if φ is a homomorphism from H to{1,-1} ≤ Zm~*,which produces some classes of Cayley digraphs that have hamiltonian circuits.

关键词： Cayley digraphs hamiltonian circuit external semidirect product

Geochemistry and origins of hydrogen-containing natural gases in deep Songliao Basin,China:Insights from continental scientific drilling

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Petroleum Science 2024年第2期21卷 741-751页

作者： Shuang-Biao Han Chao-Han xiang Xin Du Lin-Feng Xie jie huang Cheng-Shan Wang College of Geoscience and Surveying Engineering China University of Mining and TechnologyBeijing100083China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing100083China

The different reservoirs in deep Songliao Basin have non-homogeneous lithologies and include multiple layers with a high content of hydrogen *** gas composition and stable isotope characteristics vary significantly,but the origin analysis of different gas types has previously been *** on the geochemical parameters of gas samples from different depths and the analysis of geological settings,this research covers the diverse origins of natural gas in different *** gas components are mainly methane with a small amount of C_(2+),and non-hydrocarbon gases,including nitrogen(N_(2)),hydrogen(H_(2)),carbon dioxide(CO_(2)),and helium(He).At greater depth,the carbon isotope of methane becomes heavier,and the hydrogen isotope points to a lacustrine sedimentary *** increasing depth,the origins of N_(2)and CO_(2)change gradually from a mixture of organic and inorganic to *** origins of hydrogen gas are complex and include organic sources,water radiolysis,water-rock(Fe^(2+)-containing minerals)reactions,and *** shales of Denglouku and Shahezi Formations,as source rocks,provide the premise for generation and occurrence of organic ***,the deep faults and fluid activities in Basement Formation control the generation and migration of mantle-derived *** discovery of a high content of H_(2)in study area not only reveals the organic and inorganic association of natural-gas generation,but also provides a scientific basis for the exploration of deep hydrogen-rich gas.

关键词： Gas compositions Stable isotopes Gas origins Hydrogen gas Songliao Basin

Meta-analysis of transarterial chemoembolization combined with cryoablation vs transarterial chemoembolization alone for≥5 cm hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2793-2803页

作者： jie-Fei Cheng Qiu-Lian Sun Ling Tang Xin-Jian Xu xiang-Zhong huang Department of Radiology The Fifth People’s Hospital of TaizhouTaizhou 225300Jiangsu ProvinceChina Department of Radiology The Fifth People’s Hospital of SuzhouSuzhou 215100Jiangsu ProvinceChina Department of Radiology The Fourth People’s Hospital of TaizhouTaizhou 225300Jiangsu ProvinceChina Department of Interventional Radiology Jiangyin People HospitalJiangyin 214400Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)ranks sixth globally in cancer incidence and third in mortality ***,over 70% of HCC patients forego the opportunity for curative surgery or liver transplantation due to inadequate physical examinations,poor physical condition,and limited organ availability upon *** guidelines endorse transarterial chemoembolization(TACE)as the frontline treatment for intermediate to advanced-stage ***(CRA)is an emerging local ablative therapy increasingly used in HCC *** studies suggest that combining CRA with TACE offers complementary and synergistic effects,potentially improving long-term survival ***,the superiority of combined TACE+CRA therapy over TACE alone for HCC lesions equal to or exceeding 5 cm requires further *** To compare the efficacy and safety of TACE combined with CRA vs TACE alone in the treatment of HCC with a diameter of≥5 *** PubMed,EMBASE,Cochrane Library,CNKI,Wanfang,and VIP databases were searched to retrieve all relevant studies on TACE and CRA up to July ***-analysis was performed using RevMan 5.3 *** After screening according to the inclusion and exclusion criteria,6 articles were included,including 2 randomized controlled trials and 4 nonrandomized controlled trials,with a total of 575 patients included in the *** results showed that the objective response rate[odds ratio(OR)=2.56,95%confidence interval(CI):1.66-3.96,P<0.0001],disease control rate(OR=3.03,95%CI:1.88-4.89,P<0.00001),1-year survival rate(OR=3.79,95%CI:2.50-5.76,P<0.00001),2-year survival rate(OR=2.34,95%CI:1.43-3.85,P=0.0008),and 3-year survival rate(OR=3.34,95%CI:1.61-6.94,P=0.001)were all superior to those of the control group;the postoperative decrease in alpha-fetoprotein value(OR=295.53,95%CI:250.22-340.85,P<0.0001),the postoperative increase in CD4 value(OR=10.59,95%CI:8.78-12.40,P<0.00001),and the postoperative decrease in

关键词： Hepatic cancer Cryoablation Chemoembolization Transarterial chemoembolization Meta analysis

Aberrant protamination in sperm correlates to anomalous nuclear and cytoplasmic architectures in infertile males with sperm dysmorphology

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Asian Journal of Andrology 2024年第2期26卷 183-188页

作者： Huan Jiang Chu-jie huang Department of Reproductive Endocrinology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)Shenzhen 518172China Institute of Reproductive Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

Aberrant sperm protamination is linked to sperm dysmorphology and nuclear chromatin ***,its effects on sperm cytoplasmic maturation remain largely *** relationships of protamines,sperm morphology,DNA damage,and cytoplasmic remodeling were illustrated in this study to provide fresh perspectives on the mechanisms of male infertility.A total of 205 infertile males were allocated into 5 groups according to the percentage of spermatozoa exhibiting abnormal morphology within their *** concentration,motility,abnormal sperm morphology,cytoplasmic droplets(CDs),and excess residual cytoplasm(ERC)were analyzed according to the World Health Organization manual(2010).Sperm nuclear vacuoles(NVs)were determined by propidium iodide(PI)*** protamine expressions(P1 and P2)were detected by western *** damage was measured by acridine orange test(AOT)to calculate the proportion of sperm with single-strand DNA breaks(SSBs).Our data showed that sperm concentration and motility in infertile males significantly decreased with the severity of abnormal sperm morphology(both P<0.01).P1 level,P1/P2 ratio,and SSB rate increased with the severity of sperm dysmorphology,whilst the P2 level decreased(all P

关键词： abnormal sperm morphology excess residual cytoplasm male infertility protamines sperm DNA damage sperm nuclear vacuoles

Multi-agent reinforcement learning behavioral control for nonlinear second-order systems

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Frontiers of Information Technology & Electronic Engineering 2024年第6期25卷 869-886页

作者： Zhenyi ZHANG jie huang Congjie PAN College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China G+Industrial Internet Institute Fuzhou UniversityFuzhou 350108China

Reinforcement learning behavioral control(RLBC)is limited to an individual agent without any swarm mission,because it models the behavior priority learning as a Markov decision *** this paper,a novel multi-agent reinforcement learning behavioral control(MARLBC)method is proposed to overcome such limitations by implementing joint ***,a multi-agent reinforcement learning mission supervisor(MARLMS)is designed for a group of nonlinear second-order systems to assign the behavior priorities at the decision *** modeling behavior priority switching as a cooperative Markov game,the MARLMS learns an optimal joint behavior priority to reduce dependence on human intelligence and high-performance computing *** the control layer,a group of second-order reinforcement learning controllers are designed to learn the optimal control policies to track position and velocity signals *** particular,input saturation constraints are strictly implemented via designing a group of adaptive *** simulation results show that the proposed MARLBC has a lower switching frequency and control cost than finite-time and fixed-time behavioral control and RLBC methods.

关键词： Reinforcement learning Behavioral control Second-order systems Mission supervisor

Ultrahigh-brightness 50 MeV electron beam generation from laser wakefield acceleration in a weakly nonlinear regime

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Matter and Radiation at Extremes 2024年第3期9卷 4-10页

作者： Zhongtao xiang Changhai Yu Zhiyong Qin Xuhui Jiao Jiahui Cheng Qiaoxuan Zhou Gatie Axi Jianghua jie Ya huang Jintan Cai Jiansheng Liu Department of Physics Shanghai Normal UniversityShanghai 200234China

We propose an efficient scheme to produce ultrahigh-brightness tens of MeV electron beams by designing a density-tailored plasma to induce a wakefield in the weakly nonlinear regime with a moderate laser energy of 120 *** this scheme,the second bucket of the wakefield can have a much lower phase velocity at the steep plasma density down-ramp than the first bucket and can be exploited to implement longitudinal electron injection at a lower laser intensity,leading to the generation of bright electron beams with ultralow emittance together with low energy ***-dimensional particle-in-cell simulations are carried out and demonstrate that high-quality electron beams with a peak energy of 50 MeV,ultralow emittance of28 nm rad,energy spread of 1%,charge of 4.4 pC,and short duration less than 5 fs can be obtained within a 1-mm-long tailored plasma density,resulting in an ultrahigh six-dimensional brightness B6D,n of2×1017 A/m2/0.1%.By changing the density parameters,tunable bright electron beams with peak energies ranging from 5 to 70 MeV,a small emittance of B0.1 mm mrad,and a low energy spread at a few-percent level can be *** bright MeV-class electron beams have a variety of potential applications,for example,as ultrafast electron probes for diffraction and imaging,in laboratory astrophysics,in coherent radiation source generation,and as injectors for GeV particle accelerators.

关键词： weakly nonlinear acceleration