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Evaluation of pelvic lymph node coverage of conventional radiotherapy fields based on bony landmarks in Chinese cervical cancer patients using CT simulation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第9期10卷 683-688页

作者： xiang zhang hua YU Department of Gynecologic Oncology Zhejiang Cancer Hospital Hangzhou 310022 China

Objective： To evaluate the pelvic lymph node coverage of conventional pelvic fields based on bony landmarks in Chinese patients with cervical cancer by using computed tomography （CT） simulation images to contour pelvic vessels as substitutes for lymph nodes location. Methods： A retrospective review of CT simulation images and conventional pelvic radiation planning data sets was performed in 100 patients with cervical cancer at the International Federation of Gynecology and Obstetrics （FIGO） Stage liB to IIIB in our hospital. Pelvic arteries were contoured on CT simulation images, and the outlines of conventional pelvic fields were drawn as defined by the gynecologic oncology group （GOG） after hiding the contours. The distances between the following vessel contours and field borders were measured： D1, the superior border of the anterior/posterior （AP） field and the bifurcation of abdominal aorta; D2, the ipsilateral border of the AP field and the distal end of external iliac artery; and D3, the anterior border of the lateral （LAT） field and the distal end of the external iliac artery. The distances were recorded as positive values if the measuring point was within the conventional pelvic fields, or they were recorded as negative values. Lymph nodes coverage was considered adequate when D1≥0 mm, D2〉17 mm or D3≥7 mm. Results： All patients had at least 1 inadequate margin, 97 patients （97.0%） had 2, and 22 patients （22.0%） had all the 3. On the AP field, 95 patients （95%） had the measuring point, the bifurcation of the abdominal aorta, out of the field （D1〈0 mm）, and all the patients had a distance less than 17.0 mm between the distal end of the external iliac artery and ipsilateral border （D2〈1 7.0 mm）. On the LAT field, 24 patients （24%） had a distance less than 7.0 mm between the distal end of the external iliac artery and anterior border （D3〈7.0 mm）. Conclusion： We observed that conventional pelvic fields based on bony landmarks provided inadequate coverage of pelvi

关键词： Cervical cancer Radiotherapy planning Computed tomography (CT) simulation Lymph nodes

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Research progress of third-order optical nonlinearity of chalcogenide glasses

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Chinese Physics B 2018年第8期27卷 53-61页

作者： Xiao-Yu zhang Fei-Fei Chen xiang-hua zhang Wei Ji Laboratory of Infrared Materials and Devices The Research Institute of Advanced TechnologiesNingbo UniversityNingbo 315211Ch＆a Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Ningbo UniversityNingbo 315211China Faculty of Science Ningbo UniversityNingbo 315211China Laboratory of Glasses and Ceramics UMR 6226 CNRS-University of Rennes 1Rennes Cedex 135042France Department of Physics National University of Singapore2 Science Drive 3117551Singapore

Chalcogenide glasses （ChGs） are a promising candidate for applications in nonlinear photonic devices. In this paper, we review the research progress of the third-order optical nonlinearity （TONL） of ChGs from the following three aspects： chemical composition, excitation condition, and post processing. The deficiencies in previous studies and further research of the TONL property of ChGs are also discussed.

关键词： chalcogenide glasses nonlinear optics optical property

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Experimental and numerical investigation of mid-infrared laser in Pr^(3+)-doped chalcogenide fiber

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Chinese Physics B 2019年第2期28卷 257-263页

作者： hua Chen Ke-Lun Xia Zi-Jun Liu Xun-Si Wang xiang-hua zhang Yin-Sheng Xu Shi-Xun Dai Laboratory of Infrared Materials and Devices Advanced Technology Research InstituteNingbo University Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Laboratory of Glasses and Ceramics UMR CNRS 6226University of Rennes 1

We report on a chalcogenide glass fiber doped with Pr^(3+) that can be used for commercialized 1.5-μm and 2-μm laser excitations by emitting broadband 3 μm–5.5 μm fluorescence, which is extruded into a preform and then drawn into a step-index fiber. The spectroscopic properties of the fiber and glass are reported, and the mid-infrared fiber lasers are also numerically investigated. Cascade lasing is employed to increase the inversion population of the upper laser level. The particle swarm approach is applied to optimize the fiber laser parameters. The output power can reach 1.28 W at 4.89-μm wavelength, with a pump power of 5 W, excitation wavelength at 2.04 μm, Pr^(3+) ion concentration at 4.22 × 10^(25) ions/m^3,fiber length at 0.94 m, and fiber background loss at 3 dB/m.

关键词： mid-infrared fiber laser chalcogenide glass fiber rare earth doped glass fiber laser modelling

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Self-powered broadband kesterite photodetector with ultrahigh specific detectivity for weak light applications

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SusMat 2023年第5期3卷 682-696页

作者： Guang-Xing Liang Chuan-Hao Li Jun Zhao Yi Fu Zi-Xuan Yu Zhuang-Hao Zheng Zheng-hua Su Ping Fan xiang-hua zhang Jing-Ting Luo Liming Ding Shuo Chen Shenzhen Key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenChina Institut des Sciences Chimiques de Rennes Universite de RennesRennesFrance Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijingChina

Kesterite Cu_(2)ZnSn(S,Se)_(4)(CZTSSe)is a promising candidate for photodetector(PD)applications thanks to its excellent optoelectronic *** this work,a green solution-processed spin coating and selenization-processed thermodynamic or kinetic growth of high-quality narrow bandgap kesterite CZTSSe thin film is developed.A self-powered CZTSSe/CdS thin-film PD is then successfully *** optimization of light absorber and heterojunction interface,especially tailoring the defect and carrier kinetics,it can achieve broadband response from300 to 1300 nm,accompaniedwith a high responsivity of 1.37A/W,specific detectivity(D*)up to 4.0×10^(14)Jones under 5 nW/cm^(2),a linear dynamic range(LDR)of 126 dB,and a maximum Ilight/Idark ratio of 1.3×10^(8)within the LDR,and ultrafast response speed(rise/decay time of 16 ns/85 ns),representing the leading-level performance to date,which is superior to those of commercial andwell-researched ***,an imaging system with a 905nm laser is built for weak light response evaluation,and can respond to 718 pW weak light and infrared imaging at a wavelength as low as 5 nW/*** has also been employed for photoplethysmography detection of pulsating signals at both the finger and wrist,presenting obvious arterial blood volume changes,demonstrating great application potential in broadband and weak light photodetection scenarios.

关键词： detectivity kesterite photodetector thin film weak light detection

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Expression of RUNX2 and MDM21 in rats with periodontitis under chronic intermittent hypoxia

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 759-763页

作者： Kun Li Su-Ge Dong hua-xiang zhang Shu Zhou Li Ma Qiong-Qiong Yu Zhi-Yong Jiang Qiang-Fu Hu Dan Zhou Department of Stomatology the Fifth Affiliated Hospital of Zhengzhou University Department of Periodontics Wuhan University Stomatological Hospital Department of Anesthesiology the Fifth Affiliated Hospital of Zhengzhou University Department of Cardiac Surgery the Fifth Affiliated Hospital of Zhengzhou University

Objective: To discuss the expression of RUNX2 and MDM21 in rats with periodontitis under the chronic intermittent hypoxia. Methods: A total of 32 SD healthy rats were randomly divided into four groups, with 8 rats in each group. The molecular biological techniques of immunohistochemistry, RT-PCR and Western blotting were employed to detect the effect of different hypoxia time(0, 6, 12, 24 and 48 h) and different concentrations of hypoxia(0.000, 0.001, 0.010, 0.060 and 0.100 ppm) on the expression of RUNX2 and MDM21 in rats of four groups. Results: The expression of RUNX2 and MDM21 in each group was significantly higher than the one at other concentrations when the concentration was 0.010 ppm, with the statistical difference(P periodontitis group> chronic intermittent hypoxia group > compound group under the action with the concentration of 0.010 ppm for 12 h, but there was no significant difference for the comparison among groups(P>0.05). Conclusions: The condition of chronic intermittent hypoxia can reduce the expression of RUNX2 and MDM21 in rats with periodontitis and aggravate the damage of periodontal bone.

关键词： Chronic intermittent hypoxia RUNX2 MDM21 Periodontitis

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Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats

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Chinese Herbal Medicines 2019年第1期11卷 45-51页

作者： Wei-ting Wang Chun-hua Hao Shao-xiang zhang xiang-hua zhang Feng Guo Shuang-yong Sun Rui zhang Zhuan-you Zhao Li-da Tang State Key Laboratory of Pharmacokinetics and Pharmacodynamics Tianjin Institute of Pharmaceutical Research Kunming Hospital of Traditional Chinese Medicine Kunming Institute of Nephrology

Objective: To identify the therapeutic effect and possible mechanisms of Chinese medicine Sanqi Tongshuan Tablets(SQTS) on sequelae post-stroke in ***: The rat cerebral ischemia sequelae post-stroke models were successfully induced by blocking the middle cerebral artery with electric coagulator after the seventh week and balance beam test ≤ 4. The rats were then received with SQTS(0.5, 1, and 2 g/kg) and Naodesheng(NDS, 1.24 g/kg), Vinpocetine(VP,1.55 mg/kg) for 30 d. The beam-walking test and shuttle test were performed before and after 10, 20, and 30 d of administration. In addition, histopathology changes and GAP-43, GFAP were measured by H&E staining and ***: The model displayed signs of brain damage on motor function, learning and memory function and histopathology. After 30 d of treatment, SQTS at different doses(0.5, 1.0, and 2.0 g/kg) restored the beam-walking scores by 21.7%(P > 0.05), 30.4%(P > 0.05), and 39.1%(P 0.05), 50.0%(P > 0.05), and 75.0%(P < 0.05), respectively. On the other hand, the histological changes were less severe and the GAP-43 expression increased in hippocampal CA1 and cortical ***: SQTS showed therapeutic benefits on sequelae post-stroke in rats, which might be through the pathway of regeneration or neuroplasticity.

关键词： learning and memory motor function rats Sanqi Tongshuan Tablets Sequelae post-strokes

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秦岭造山带武关杂岩石榴黑云片岩的变质作用P-T轨迹与构造意义

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岩石学报 2017年第8期33卷 2563-2574页

作者：江媛媛向华张泽明地质过程与矿产资源国家重点实验室、中国地质大学地球科学与资源学院北京100083 中国地质科学院地质研究所北京100037

秦岭造山带是华北板块与华南板块长期汇聚的产物。该造山带以商南-丹凤缝合带为界分为早古生代的北秦岭造山带和晚古生代-中生代的南秦岭造山带。武关杂岩位于南秦岭造山带的北缘,被认为是一套形成于弧前盆地的杂岩,原岩沉积时代为泥盆... 详细信息

秦岭造山带是华北板块与华南板块长期汇聚的产物。该造山带以商南-丹凤缝合带为界分为早古生代的北秦岭造山带和晚古生代-中生代的南秦岭造山带。武关杂岩位于南秦岭造山带的北缘,被认为是一套形成于弧前盆地的杂岩,原岩沉积时代为泥盆纪-早石炭纪,经历了晚石炭纪变质作用。本文对武关杂岩的石榴黑云片岩进行了岩石学研究。该岩石主要由斜长石、石榴石、黑云母和石英组成,含少量白云母、金红石和钛铁矿。变斑晶石榴石具有明显的生长成分环带,其核部以MgO含量增加和MnO降低为特征,幔部FeO含量逐渐增加,MgO、CaO和MnO逐渐减少,而在边部CaO明显升高,MgO、FeO和MnO含量不同程度降低。相平衡模拟和温压计计算结果表明,石榴黑云片岩具有复杂的顺时针P-T轨迹,早期进变质阶段(M1)为升温升压过程,峰期条件为~695℃和~8.3kbar,变质矿物组合为石榴石(核)和所含的黑云母、斜长石、石英及钛铁矿包裹体;中期退变质阶段(M2)是降温降压过程,达到~615℃和~6.2kbar变质条件,变质矿物组合是石榴石(幔)和包含的黑云母、斜长石、石英、白云母和钛铁矿包裹体;晚期是以近等温升压为特征的进变质过程(M3),达到~620℃和~9.1kbar条件,变质矿物组合为石榴石(边)和基质矿物黑云母、斜长石、石英、白云母和金红石。M1和M2阶段的构造了一个"发夹状"的顺时针P-T轨迹,为俯冲带变质作用典型特征,表明岩石经历了早期俯冲和后来的折返过程。而以显著增压为特征的晚期进变质作用(M3)很可能表明岩石经历了又一期俯冲作用。因此,本研究表明武关杂岩中的石榴黑云片岩很可能处于俯冲通道之中,经历了多旋回俯冲与折返过程。

关键词：石榴石成分环带相平衡模拟 P-T轨迹武关杂岩秦岭造山带

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远红外Ge-Ga-Te-Ag硫系玻璃性能研究（英文）

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光子学报 2015年第11期44卷 25-29页

作者：程辞王训四徐铁峰祝清德廖方兴孙礼红潘章豪刘硕戴世勋沈祥 xiang-hua zhang 宁波大学高等技术研究院红外材料及器件实验室浙江宁波315211 Laboratory of Glasses and Ceramics UMR6226 CNRS-University of Rennes 1

采用传统的熔融-淬冷法制备了一系列的（Ge15Ga10Te75）100-x（Ag）x硫系玻璃样品.通过X射线衍射、差式扫描量热法、傅里叶红外光谱仪等测试了玻璃样品的热学及光学性能.结果表明该玻璃具有良好的非晶态特性和热稳定性,玻璃开始析晶温... 详细信息

采用传统的熔融-淬冷法制备了一系列的（Ge15Ga10Te75）100-x（Ag）x硫系玻璃样品.通过X射线衍射、差式扫描量热法、傅里叶红外光谱仪等测试了玻璃样品的热学及光学性能.结果表明该玻璃具有良好的非晶态特性和热稳定性,玻璃开始析晶温度和玻璃转变温度的差值都超过了100℃.随着Ag含量的增加,玻璃的吸收截止边产生了红移.通过提纯,Ge-Ga-Te-Ag玻璃在1.8-20μm有着较宽且平坦的红外光学窗口.Ge-Ga-Te-Ag玻璃组分的优良性质使其在红外领域具有广阔的应用前景.

关键词：远红外光学性质热稳定性硫系玻璃红外光学窗口

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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting xiang xiangxin Xing Xuyun hua Yuwen zhang Xin Xue Jiajia Wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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Predictive factors for the success of “one-off” ablation in single hepatocellular carcinoma patients who underwent percutaneous radiofrequency ablation

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Hepatoma Research 2016年第1期2卷 47-52页

作者： Jian-Yun Long Jing Li Jie Cao Liang huang xiang-hua zhang Jin-Kai Liu Yi-Qun Yan Department of Hepatic Surgery I Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

Aim:To investigate the technique’s effectiveness and evaluate the risk factors affecting the success of“one-off”percutaneous ultrasound-guided radiofrequency ablation(RFA)for single hepatocellular carcinoma(HCC).Methods:A total of 462 consecutive patients who received RFA from February 2010 to December 2013 at a single center(Eastern Hepatobiliary Surgery Hospital,Shanghai,China)were enrolled in the *** patients were followed up for at least 6 ***,this study adopted a new terminology named“one-off”ablation which is defined as achieving complete necrosis and no local residual or recurrent tumor within 6 months after single-session *** incidence of“one-off”RFA was observed and the attributing risk factors were analyzed.A multivariate analysis was conducted to determine the independent predictive factors for the success of“one-off”***:The technique’s effectiveness was 90.0%(416/462).After 6 months,281 patients achieved“one-off”ablation,while 181 patients *** univariate analysis,tumor size≤3 cm and tumor further from organs were found to be significantly correlated with“one-off”complete ablation(P=0.003,and P=0.010,respectively).On multivariate analysis using a logistic regression,tumor size≤3 cm[odds ratio(OR),0.534;95%confidence interval(CI):0.346-0.825,P=0.005]and tumor further from organs(OR,0.593;95%CI:0.387-0.909,P=0.017)remained ***:Tumor size and tumor location are the predictive factors for the success of“one-off”ablation in patients with single HCC.

关键词： Hepatocellular carcinoma radiofrequency ablation tumor location tumor size

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