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Journal of Genetics and Genomics 2017年第8期44卷 371-374页

作者： xiang-hong ou Qing-Yuan Sun Reproductive Medicine Center The 2nd People＇s Hospital of Guangdong Province Guangzhou 510317 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing I00101 China University of Chinese Academy of Sciences Beijing 100101 China

The mitochondrion which contains its own double-stranded circular DNA is a semi-independent organelle that plays critical roles in cell activity. Mitochondrial DNA （mtDNA） is maternally inherited through several mechanisms that have been proposed （Luo et al., 2013） and, if mitochondrial mutations are inherited to the offspring, it is possible to cause mitochondrial diseases such as neuropathy, cardiomyopathy, myopathy, and liver failure.

关键词： mtDNA Mitochondrial replacement techniques or therapies to improve embryo development and to prevent mitochondrial disease transmission

Why is oocyte aneuploidy increased with maternal aging?

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Journal of Genetics and Genomics 2020年第11期47卷 659-671页

作者： Jun-Yu Ma Sen Li Lei-Ning Chen Heide Schatten xiang-hong ou Qing-Yuan Sun Fertility Preservation Lab Reproductive Medicine CenterGuangdong Second Provincial General HospitalGuangzhou510317China Department of Veterinary Pathobiology University of MissouriColumbiaMO 65211USA State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China

One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy,which is increased with maternal *** possible causes of oocyte aneuploidy in aged women have been proposed,including cross-over formation defect,cohesin loss,spindle deformation,spindle assembly checkpoint malfunction,microtubule-kinetochore attachment failure,kinetochore mis-orientation,mitochondria dysfunction-induced increases in reactive oxygen species,protein over-acetylation,and DNA ***,it still needs to be answered if these aneuploidization factors have inherent relations,and how to prevent chromosome aneuploidy in aged ***,oocyte aneuploidy has been found to be weakly associated with higher homocysteine concentrations,obesity,ionizing radiation and even *** this review,we summarize the research progress and present an integrated view of oocyte aneuploidization.

关键词： Aging Oocyte Aneuploidy Cohesin SAC Spindle Mitochondria Meiosis DNA damage

Adsorption of tetrodotoxin by flexible shape-memory polymers synthesized from silica-stabilized Pickering high internal phase emulsion

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第10期22卷 805-818页

作者： hong-xiang ou Chen-xia GONG hong-lai XUE Dong-sheng ZHou Kai-jia LI Shu-cheng LIU School of Environmental and Safety Engineering Changzhou UniversityChangzhou 213164China Institute of Public Safety and Emergency Management Changzhou UniversityChangzhou 213164China School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China

Flexible shape-memory polymers were synthesized by Pickering high internal phase emulsion(HIPE)polymerization and used to adsorb and separate tetrodotoxin(TTX)from an aqueous ***_(2)nanoparticles were used to stabilize the Pickering oil-in-water(O/W)*** introduced imidazolium-modified bromobutyl rubber(IBR)with excellent mechanical properties and high viscosity into the emulsion system as the shape-memory *** properties,such as shape memory and morphology,were characterized by various methods,and batches of static adsorption experiments were conducted to analyze the adsorption performance of SiO_(2)@IBR on *** characterization revealed that the SiO_(2)@IBR had a porous structure and good shape ***,the combination of SiO_(2)particles and IBR prevented shedding of SiO_(2)and enhanced the mechanical and adsorption properties of SiO_(2)@*** results of the adsorption experiments indicated that the SiO_(2)@IBR had good adsorption of *** the Langmuir and Freundlich models fitted the isothermal adsorption experiment *** TTX adsorption capacity of SiO_(2)@IBR was about 290.44 mg/g at 308 *** fitting results of the pseudo-first-order and pseudosecond-order kinetic models showed that the adsorption process involved both chemical bonding and physical *** 10 adsorption and desorption experiments,the adsorption capacity of SiO_(2)@IBR decreased less than 0.03%,indicating that it had good adsorption and regeneration performance.

关键词： Tetrodotoxin(TTX) SiO_(2) Imidazolium-modified bromobutyl rubber(IBR) Pickering high internal phase emulsion(HIPE) Adsorption

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Shedding light on neurons:optical approaches for neuromodulation

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National Science Review 2022年第10期9卷 34-54页

作者： Shan Jiang xiang Wu Nicholas J.Rommelfanger Zihao ou Guosong hong Department of Materials Science and Engineering Stanford University Wu Tsai Neurosciences Institute Stanford University Department of Applied Physics Stanford University

Today’ s optical neuromodulation techniques are rapidly evolving,benefiting from advances in photonics,genetics and materials *** this review,we provide an up-to-date overview of the latest optical approaches for *** begin with the physical principles and constraints underlying the interaction between light and neural *** then present advances in optical neurotechnologies in seven modules:conventional optical fibers,multifunctional fibers,optical waveguides,light-emitting diodes,upconversion nanoparticles,optical neuromodulation based on the secondary effects of light,and unconventional light sources facilitated by ultrasound and magnetic *** conclude our review with an outlo ok on new methods and mechanisms that afford optical neuromodulation with minimal invasiveness and footprint.

关键词： optical neuromodulation optogenetics neural interfaces

在低卵巢储备患者中灵活的促性腺激素拮抗剂方案优于标准拮抗剂方案

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生殖与避孕 2015年第9期35卷 601-605页

作者：欧湘红陈雷宁王保平陈海霞李瑾刘怡潼靖涛广东省第二人民医院生殖医学中心广州510006

目的:评估灵活、低剂量促性腺激素释放激素拮抗剂(Gn RH-A)方案和标准的Gn RH-A方案在卵巢储备功能减退患者体外受精-胚胎移植(IVF-ET)/卵胞质单精子注射(ICSI)的超促排卵过程中的应用价值。方法:回顾性分析108例卵巢储备功能减退患者IV... 详细信息

目的:评估灵活、低剂量促性腺激素释放激素拮抗剂(Gn RH-A)方案和标准的Gn RH-A方案在卵巢储备功能减退患者体外受精-胚胎移植(IVF-ET)/卵胞质单精子注射(ICSI)的超促排卵过程中的应用价值。方法:回顾性分析108例卵巢储备功能减退患者IVF-ET周期,其中58例使用灵活而低剂量Gn RH-A方案(A组),50例使用标准Gn RH-A方案(B组)。比较各组实验室指标和临床结局。结果:A组Gn RH-A使用天数、剂量均少于B组(P0.05)。结论:与标准Gn RH-A方案相比,灵活而低剂量的Gn RH-A使用方案可获得更多的优质胚胎并降低Gn RH-A的使用总剂量和天数,提高累积临床妊娠率和胚胎着床率。

关键词：体外受精-胚胎移植(IVF—ET) 促性腺激素释放激素拮抗剂(GnRH—A) 卵巢低反应累积妊娠率

Nonlinear Bifurcation and Post-buckling Analysis of Cylindrical Composite Stiffened Laminates Based on Weak Form Quadrature Element Method

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Acta Mechanica Solida Sinica 2023年第6期36卷 817-836页

作者： xiang ou Xiaohu Yao Run Zhang School of Civil Engineering and Transportation South China University of TechnologyGuangzhouGuangdongChina

This paper presents a weak form quadrature element formulation in the analysis of nonlinear bifurcation and post-buckling of cylindrical composite stiffened laminates subjected to transverse loads.A total Lagrangian updating scheme is used in combination with arc-length method,and the branch-switching method is adopted to identify the whole post-buckling procedure of the *** formulation of the shell model and beam model are based on the basic concept of *** coincidence of discrete nodes and integration points in quadrature element endows it with compactness and conciseness in the nonlinear buckling analysis of the cylindrical stiffened *** numerical examples are firstly presented to verify the effectiveness and accuracy of present *** studies on the effects of the height-to-breadth ratio,lamination schemes,positions,distribution,number of the stiffeners on the bifurcation and post-buckling behavior are performed.

关键词： Cylindrical composite stiffened laminates Weak form quadrature element formulation Nonlinear bifurcation bucking Post-buckling analysis

An Accelerated Stochastic Mirror Descent Method

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Journal of the Operations Research Society of China 2024年第3期12卷 549-571页

作者： Bo-ou Jiang Ya-xiang Yuan LSEC ICMSECAMSSChinese Academy of SciencesBeijing100190China Department of Mathematics University of Chinese Academy of SciencesBeijing100049China

Driven by large-scale optimization problems arising from machine learning,the development of stochastic optimization methods has witnessed a huge *** types of methods have been developed based on vanilla stochastic gradient descent ***,for most algorithms,convergence rate in stochastic setting cannot simply match that in deterministic *** understanding the gap between deterministic and stochastic optimization is the main goal of this ***,we are interested in Nesterov acceleration of gradient-based *** our study,we focus on acceleration of stochastic mirror descent method with implicit regularization *** that the problem objective is smooth and convex or strongly convex,our analysis prescribes the method parameters which ensure fast convergence of the estimation error and satisfied numerical performance.

关键词： Large-scale optimization Variance reduction Mirror descent Acceleration Independent sampling Importance sampling

Is traumatic meniscal lesion associated with acute fracture morphology changes of tibia plateau? A series of arthroscopic analysis of 67 patients

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World Journal of Clinical Cases 2021年第1期9卷 81-90页

作者： Yan-Dong Chen Shu-xiang Chen hong-Guang Liu xiang-Sheng Zhao Wen-Huan ou Huan-Xi Li hong-Xing Huang 3^rd Institute of Clinical Medicine Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Joint Trauma Jiangmen Wuyi Hospital of Traditional Chinese MedicineAffiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan UniversityJiangmen 529031Guangdong ProvinceChina Department of Radiology Jiangmen Wuyi Hospital of Traditional Chinese MedicineJiangmen 529031Guangdong ProvinceChina Science and Education Section The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378Guangdong ProvinceChina

BACKGRouND Computed tomography(CT)has become a routine preoperative examination for tibial plateau fractures(TPFs).Assessing the location of the fragment and intercondylar eminence fracture can provide clinicians with valuable information;however,the evaluation of traumatic meniscal lesion(TML)and arthroscopic management are *** To predict TML by three-dimensional skeletal anatomy changes in unilateral TPF and bilateral TPF on preoperative thin layer *** Acute fracture of tibial plateau patients undergoing arthroscopic surgery between December 2017 and December 2019 were included in this retrospective *** type,zone,and location of TMLs were diagnosed based on the operation records and/or arthroscopic *** of three-dimensional fracture morphology included the following:Frontal fragment width of plateau,sagittal fragment subsiding distance(FSD),sagittal fracture line distance,sagittal posterior tibial slope,and transversal area ratio of fragment area)on preoperative CT three-dimensional *** correlation of TML with skeletal values was calculated according to unicondylar TPFs and bicondylar *** A total of 67 patients were enrolled in this study,among which 30 patients had TMLs,lateral/medial(23/7).FSD was a particularly positive factor to predict TML,with odds ratio of 2.31(1.26-5.63).On sagittal view of CT,FSD degree of 8 mm and posterior tibial slope exceeding 11.74°implied enhanced risk of TML in bicondylar *** coronal view,once fragment width of plateau surpassed 3 cm,incidence of TML reached 100%.On transverse view,area ratio of fragment as enhanced risk of 5.5%and FSD>4.3 mm for predicting TML were observed in unicondylar *** TML can be predicted by different parameters on preoperative CT views according to unicondylar fractures and bicondylar TPFs.

关键词： Traumatic meniscal lesion Knee Three-dimensional computerized tomography Posterior tibial slope Unicondylar fracture Bicondylar fracture

Receptor-like Kinases in Root Development:Current Progress and Future Directions

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Molecular Plant 2021年第1期14卷 166-185页

作者： Yang ou hong Kui Jia Li Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou 730000China

Cell-to-cell and cell-to-environment communications are critical to the growth and development of *** surface-localized receptor-like kinases(RLKs)are mainly involved in sensing various extracellular signals to initiate their corresponding cellular *** important vegetative organs for higher plants to adapt to a terrestrial living situation,roots play a critical role for the survival of *** has been demonstrated that RLKs control many biological processes during root growth and *** this review,we summarize several key regulatory processes during Arabidopsis root developm ent in which RLKs play critical *** also put forward a number of relevant questions that are required to be explored in future studies.

关键词： receptor-like kinase root development Arabidopsis