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Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 273-286页

作者： Di Pan Hao-Nan Liu Peng-fei Qu Xiao Ma Lu-Yao Ma Xiao-Xiao Chen Yu-Qin Wang Xiao-Bing Qin Zheng-xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human *** to challenges in early diagnosis,most patients lose the opportunity for radical treatment when ***,recent advancements in cancer immunotherapy provide new directions for the treatment of *** instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with ***,tumor cells can evade the immune system through various *** the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer *** review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC.

关键词： Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy Adverse reactions

Hepatitis B surface antigen-negative but hepatitis B envelope antigen-positive false occult hepatitis B virus infection:A case report

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World Journal of Hepatology 2024年第10期16卷 1199-1207页

作者： Shu-Sheng Yang fei Fu Qian-Kun Xuan Zhou-xiang Zhang Zhi-Jun Li Guang-Bo Li Xiao-Yu Yu Department of Laboratory Medicine Shanghai East HospitalTongji University School of MedicineShanghai 200123China Department of Obstetrics and Gynecology Shanghai East HospitalTongji University School of MedicineShanghai 200123China

BACKGROUND Occult hepatitis B infection(OBI)is characterized by the detection of hepatitis B virus(HBV)DNA in serum(usually HBV DNA<200 IU/mL)or the liver but negativity for hepatitis B surface antigen(HBsAg).The diagnosis of OBI relies on the sensitivity of assays used in the detection of HBV DNA and *** assays with inadequate sensitivity or inability to detect HBV S variants may lead to misdiagnosis of OBI in people with overt HBV *** SUMMARY We report a HBsAg-negative but hepatitis B envelope antigen-positive patient who had a significant HBV DNA *** patient was initially diagnosed as having ***,sequence analysis revealed a unique insertion of amino acid residues at positions 120-124 in the S protein,which affects the formation of a disulfide bond that is associated with the formation of a *** is well known that there is an overlap between the S protein and Pol *** found that this new insertion site occurred in polymerase/reverse transcriptase domain,indi-cating that this insertion might be involved in HBV *** patient was finally diagnosed with a false *** An insertion of amino acid residues at positions 120-124 of the S protein affects the formation of immunodominant epitopes and results in negative HBsAg levels.

关键词： Occult hepatitis B infection Hepatitis B virus Hepatitis B surface antigen Hepatitis B envelope antigen Immunodominant epitopes Case report

Ordered mesoporous nanofibers mimicking vascular bundles for lithium metal batteries

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National Science Review 2024年第5期11卷 291-302页

作者： Xiaohang Zhu mengmeng Liu Fanxing Bu Xin-Yang Yue xiang fei Yong-Ning Zhou Anqi Ju Jianping Yang Pengpeng Qiu Qi Xiao Chao Lin Wan Jiang Lianjun Wang Xiaopeng Li Wei Luo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Institute of Functional Materials College of Materials Science and Engineering Donghua University Institute for Conservation of Cultural Heritage Shanghai University Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong University Department of Materials Science Fudan University

Hierarchical self-assembly with long-range order above centimeters widely exists in nature. Mimicking similar structures to promote reaction kinetics of electrochemical energy devices is of immense interest, yet remains challenging. Here, we report a bottom-up self-assembly approach to constructing ordered mesoporous nanofibers with a structure resembling vascular bundles via electrospinning. The synthesis involves self-assembling polystyrene（PS） homopolymer, amphiphilic diblock copolymer, and precursors into supramolecular micelles. Elongational dynamics of viscoelastic micelle solution together with fast solvent evaporation during electrospinning cause simultaneous close packing and uniaxial stretching of micelles, consequently producing polymer nanofibers consisting of oriented micelles. The method is versatile for the fabrication of large-scale ordered mesoporous nanofibers with adjustable pore diameter and various compositions such as carbon, SiO2, TiO2and WO3. The aligned longitudinal mesopores connected side-by-side by tiny pores offer highly exposed active sites and expedite electron/ion transport. The assembled electrodes deliver outstanding performance for lithium metal batteries.

关键词： ordered mesoporous nanofibers electrospinning oriented micelles lithium metal batteries

MACS-W:A modified optical clearing agent for imaging 3D cell cultures

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 24-34页

作者： xiang Zhong Chao Gao Hui Li Yuening He Peng fei Zaozao Chen Zhongze Gu Dan Zhu Tingting Yu Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China School of Optical and Electronic Infrmation Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University NanjingJiangsu 210096P.R.China Institute of Biomaterials and Medical Devices Southeast University Suzhou Jiangsu 215163P.R.China

Three-dimensional(3D)cell cultures have contributed to a variety of biological research fields by filling the gap between monolayers and animal *** modern optical sectioning microscopic methods make it possible to probe the complexity of 3D cell cultures but are limited by the inherent *** tissue optical clearing methods have emerged as powerful tools for investigating whole-mount tissues in 3D,they often have limitations,such as being too harsh for fragile 3D cell cultures,requiring complex handling protocols,or inducing tissue deformation with shrinkage or *** address this issue,we proposed a modified optical clearing method for 3D cell cultures,called MACS-W,which is simple,highly efficient,and *** our evaluation of MACS-W,we found that it exhibits excellent clearing capability in just 10 min,with minimal deformation,and helps drug evaluation on tumor *** summary,MACS-W is a fast,minimally-deformative and fluorescence compatible clearing method that has the potential to be widely used in the studies of 3D cell cultures.

关键词： Tissue optical clearing 3D cell cultures imaging

Epidemiological characteristics of tuberculosis incidence and its macro-influence factors in Chinese mainland during 2014-2021

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Infectious Diseases of Poverty 2024年第3期13卷 43-57页

作者： Le-le Deng fei Zhao Zhuo-wei Li Wei-wei Zhang Guang-xue He xiang Ren National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Pharmacy Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical ScienceBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication EvaluationBeijing 100730China Miyun District Center for Disease Control and Prevention Beijing 101500China School Of Public Health Binzhon Medical UniversityYantai 264000China Division of Infectious Disease Key Laboratory of Surveillance and Early-Warning On Infectious DiseaseChinese Center for Disease Control and PreventionBeijing 102206China

Background Tuberculosis(TB)remains a pressing public health issue,posing a significant threat to individuals'well-being and *** study delves into the TB incidence in Chinese mainland during 2014-2021,aiming to gain deeper insights into their epidemiological characteristics and explore macro-level factors to enhance control and *** TB incidence data in Chinese mainland from 2014 to 2021 were sourced from the National Notifiable Disease Reporting System(NNDRS).A two-stage distributed lag nonlinear model(DLNM)was constructed to evaluate the lag and non-linearity of daily average temperature(℃,Atemp),average relative humidity(%,ARH),average wind speed(m/s,AWS),sunshine duration(h,SD)and precipitation(mm,PRE)on the TB incidence.A spatial panel data model was used to assess the impact of demographic,medical and health resource,and economic factors on TB *** A total of 6,587,439 TB cases were reported in Chinese mainland during 2014-2021,with an average annual incidence rate of 59.17/100,*** TB incidence decreased from 67.05/100,000 in 2014 to 46.40/100,000 in 2021,notably declining from 2018 to 2021(APC=-8.87%,95%CI:-11.97,-6.85%).TB incidence rates were higher among males,farmers,and individuals aged 65 years and *** analysis revealed a significant cluster in Xinjiang,Qinghai,and Xizang from March 2017 to June 2019(RR=3.94,P71.73%),low sunshine duration(<6.18 h)increased the risk of TB incidence,while extreme low wind speed(<2.79 m/s)decreased the *** spatial Durbin model showed positive associations between TB incidence rates and sex ratio(β=1.98),number of beds in medical and health institutions per 10

关键词： Tuberculosis Surveillance Epidemiological characteristics Incidence Influence factor Distributed lag nonlinear model(DLNM) Spatial panel model China

Serum Microcystin-LR Levels Linked with Risk of Inflammatory Bowel Disease:A Matched Case-Control Study in China

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Environment & Health 2024年第7期2卷 453-464页

作者： Xuejie Chen Wenya Liu Yangjie Liao Xin xiang Yue Yang Li Tian xiang Gao Qian Cao Hong Guo Kang Chao Fengmei Song Rongbei Liu Ying Li Shuyu Ye Jiangang Wang fei Yang Xiaoyan Wang Department of Gastroenterology Third Xiangya HospitalCentral South UniversityChangsha410013China Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang421001China Hunan Provincial Key Laboratory of Clinical Epidemiology Xiangya School of Public HealthCentral South UniversityChangsha410078China Department of Gastroenterology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou510510China Department of Gastroenterology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou310018China Department of Gastroenterology Chongqing General HospitalUniversity of Chinese Academy of SciencesChongqing401121China

Microcystin-LR(MC-LR),the most prevalent and diverse cyanotoxin produced by harmful cyanobacterial blooms,has been linked to gastrointestinal ***,we conducted a case-control study across four regions in China to investigate this *** bowel disease(IBD)cases(219)were matched with healthy controls(438)based on age and gender and conditional logistic regression models and Restricted cubic splines were used to evaluate the association between MC-LR exposure and IBD *** used quantitative real-time polymerase chain reaction to measure the expression levels of inflammatory *** levels of protein expression in the colorectum were determined using Western blotting(WB).Compared to the lowest quartile of serum MC-LR levels,the adjusted odds ratios and 95%confidence intervals(CI)for the highest quartiles of serum MC-LR levels were 5.51(2.70,11.21).The RCS was shown the association between serum MC-LR levels and IBD risk was nonlinear(Pnonlinear<0.001).In the animal experiments,MC-LR resulted in colorectal injury via the PI3K/AKT signaling *** study provides the evidence that serum MC-LR exposure is significantly associated with the risk of IBD in *** study results indicate that MC-LR probably causes IBD via the PI3K/AKT signaling pathway.

关键词： Microcystin-LR IBD Nonlinearity Case-Control Study Restricted Cubic Splines

Clinical practice of sepsis-induced immunosuppression:Current immunotherapy and future options

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Chinese Journal of Traumatology 2024年第2期27卷 63-70页

作者： fei Pei Bin Gu Shu-Min Miao xiang-Dong Guan Jian-Feng Wu Department of Critical Care Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Guangdong Clinical Research Center for Critical Care Medicine Guangzhou510080China

Sepsis is a potentially fatal condition characterized by the failure of one or more organs due to a disordered host response to *** development of sepsis is closely linked to immune *** a result,immunotherapy has gained traction as a promising approach to sepsis treatment,as it holds the potential to reverse immunosuppression and restore immune balance,thereby improving the prognosis of septic ***,due to the highly heterogeneous nature of sepsis,it is crucial to carefully select the appropriate patient population for *** review summarizes the current and evolved treatments for sepsis-induced immunosuppression to enhance clinicians'understanding and practical application of immunotherapy in the management of sepsis.

关键词： Sepsis Sepsis-induced immunosuppression Immunotherapy Enrichment Classifier

计算偏振彩色傅里叶叠层成像:散射光场偏振特性的复用技术

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物理学报 2024年第12期73卷 180-189页

作者：相萌何飘王天宇袁琳邓凯刘飞邵晓鹏西安电子科技大学光电工程学院西安710071 西安市计算成像重点实验室西安710071 中国科学院空间精密测量技术重点实验室西安710119 西安电子科技大学杭州研究院杭州311200

针对目前透过散射介质成像技术中宽谱导致目标信息被淹没于背景干扰中,且散射对波长的敏感性使得频谱信息混叠产生的色彩畸变严重,无法实现彩色超分辨率成像的问题,提出了基于散射光场偏振信息复用的计算偏振彩色傅里叶叠层成像技术.该... 详细信息

针对目前透过散射介质成像技术中宽谱导致目标信息被淹没于背景干扰中,且散射对波长的敏感性使得频谱信息混叠产生的色彩畸变严重,无法实现彩色超分辨率成像的问题,提出了基于散射光场偏振信息复用的计算偏振彩色傅里叶叠层成像技术.该技术深入地分析散射场的强度及偏振分布特性,综合利用散射场中目标与背景干扰的偏振信息差异性和唯一性表征,结合光场的偏振共模抑制特性和偏振的波长相关性,分通道实现宽谱散射场中的背景干扰信息和目标信息的有效分离.此外,深度挖掘散射光场中频谱信息的差异性,利用傅里叶叠层技术实现散射光场频谱信息拼接,进而获得透过散射介质的彩色高分辨率成像效果.实验结果表明,该方法不仅能够实现透过散射介质的超分辨率重建,而且偏振信息的复用对于谱宽造成的信号混叠有明显的抑制作用,大幅提升了重建图像的信噪比和对比度,抑制了色彩畸变,在未来的透过散射介质成像具有良好的应用前景.

关键词：散射偏振超分辨率傅里叶叠层计算成像

Measurement Research Based on Bayesian Structural Equation Cognitive Model

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1163-1177页

作者： Shuixian fei Sanzhi Shi Jixin Li Jiali Zheng Xinyi Yu Yifan Huang xiang Li School of Mathematics and Statistics Changchun University of Science and Technology Changchun China

The Bayesian structural equation model integrates the principles of Bayesian statistics, providing a more flexible and comprehensive modeling framework. In exploring complex relationships between variables, handling uncertainty, and dealing with missing data, the Bayesian structural equation model demonstrates unique advantages. Therefore, Bayesian methods are used in this paper to establish a structural equation model of innovative talent cognition, with the measurement of college students’ cognition of innovative talent being studied. An in-depth analysis is conducted on the effects of innovative self-efficacy, social resources, innovative personality traits, and school education, aiming to explore the factors influencing college students’ innovative talent. The results indicate that innovative self-efficacy plays a key role in perception, social resources are significantly positively correlated with the perception of innovative talents, innovative personality tendencies and school education are positively correlated with the perception of innovative talents, but the impact is not significant.

关键词： Bayesian Structural Equation Model Innovative Talents Measure of Cognition Innovative Self-Efficacy Social Resources