Serum Microcystin-LR Levels Linked with Risk of Inflammatory Bowel Disease:A Matched Case-Control Study in China

作     者：Xuejie Chen Wenya Liu Yangjie Liao Xin Xiang Yue Yang Li Tian Xiang Gao Qian Cao Hong Guo Kang Chao Fengmei Song Rongbei Liu Ying Li Shuyu Ye Jiangang Wang Fei Yang Xiaoyan Wang 

作者机构：Department of GastroenterologyThird Xiangya HospitalCentral South UniversityChangsha410013China Hunan Province Key Laboratory of Typical Environmental Pollution and Health HazardsSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang421001China Hunan Provincial Key Laboratory of Clinical EpidemiologyXiangya School of Public HealthCentral South UniversityChangsha410078China Department of Gastroenterologythe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou510510China Department of GastroenterologySir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou310018China Department of GastroenterologyChongqing General HospitalUniversity of Chinese Academy of SciencesChongqing401121China 

出 版 物：《Environment & Health》 (环境与健康（英文）)

年 卷 期：2024年第2卷第7期

页      面：453-464页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：National Natural Science Foundation of China(U23A20492) Hunan Province Key Research and Development Projects(2022SK2089) Huxiang Youth Talent Program(2021RC3107) 

主　　题：Microcystin-LR IBD Nonlinearity Case-Control Study Restricted Cubic Splines 

摘      要：Microcystin-LR(MC-LR),the most prevalent and diverse cyanotoxin produced by harmful cyanobacterial blooms,has been linked to gastrointestinal ***,we conducted a case-control study across four regions in China to investigate this *** bowel disease(IBD)cases(219)were matched with healthy controls(438)based on age and gender and conditional logistic regression models and Restricted cubic splines were used to evaluate the association between MC-LR exposure and IBD *** used quantitative real-time polymerase chain reaction to measure the expression levels of inflammatory *** levels of protein expression in the colorectum were determined using Western blotting(WB).Compared to the lowest quartile of serum MC-LR levels,the adjusted odds ratios and 95%confidence intervals(CI)for the highest quartiles of serum MC-LR levels were 5.51(2.70,11.21).The RCS was shown the association between serum MC-LR levels and IBD risk was nonlinear(Pnonlinear0.001).In the animal experiments,MC-LR resulted in colorectal injury via the PI3K/AKT signaling *** study provides the evidence that serum MC-LR exposure is significantly associated with the risk of IBD in *** study results indicate that MC-LR probably causes IBD via the PI3K/AKT signaling pathway.