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Evaluation of the efficacy of neoadjuvant chemotherapy for intermediate and advanced breast cancer by 3.0T MR and ultrasound combined with tumour markers

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Clinical Research Communications 2024年第3期7卷 53-60页

作者： Bao-Jun Pan Chun-Lei Sun Yu-Hua Liu Guo-Zheng Tan Chun-Yun Liu Hai-Jie Xu Qing-Yu Meng Ji-Xuan Liu xiang-dong wei Wen-Ming Cao Thyroid and mammary department Shandong Changle People’s HospitalWeifang 262400China. Gynecology Department Pingshan District Central HospitalShenzhen 518122China.

Objective:To evaluate the efficacy of neoadjuvant chemotherapy before and after neoadjuvant chemotherapy for intermediate and advanced breast cancer using 3.0T MR and ultrasound in combination with tumour markers(CEA,CA-153,CA125),and to provide therapeutic references for the clinicians,so as to better satisfy the needs of treatment for intermediate and advanced breast cancer ***:The team collected 30 patients who were diagnosed with intermediate and advanced breast cancer by biopsy and received neoadjuvant chemotherapy,and divided them into sensitive and insensitive groups according to the MP grading of postoperative pathological *** team retrospectively analysed the changes in the values of serum CEA,CA-153,and CA 125 before and after the neoadjuvant chemotherapy,the changes in the average ADC of the lesions before and after the observation by MRI,and the changes in the volume and size of lesions before and after the observation by ultrasonography to assess the effects of neoadjuvant chemotherapy individually,and the results of neoadjuvant chemotherapy were evaluated *** effect of neoadjuvant chemotherapy was assessed *** of the above was evaluated independently,and the accuracy of each item was calculated by comparing the evaluation results with the pathological examination results,and the accuracy of the single item was compared with the accuracy of the three combined tests to determine whether the combined evaluation was more ***:All three examination and testing methods can achieve high accuracy,and the combined evaluation of the three is more accurate than the evaluation of the single way,and the difference is statistically significant(P<0.05).Conclusion:In neoadjuvant chemotherapy for breast cancer patients,the combined assessment of MR,CDFI and tumour markers can more comprehensively and accurately assess the effect of ADC,and more accurately guide the clinical treatment and determine the progn

关键词： breast cancer neoadjuvant chemotherapy MR ultrasound tumour markers

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社会主义核心价值观引领当代青年偶像崇拜研究

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齐齐哈尔大学学报（哲学社会科学版） 2024年第7期 42-47,52页

作者：李宝林董翔薇齐齐哈尔大学马克思主义学院黑龙江齐齐哈尔161006

当代青年偶像崇拜呈现出多元、多维的丰富样态。作为一把双刃剑,对人民领袖、烈士英模、科技精英、民族企业家、体育冠军等优质偶像的崇拜能激发广大青年积极向上,而对负面人物、娱乐明星、成功人士的功利化崇拜等则使会青年的成长成才... 详细信息

当代青年偶像崇拜呈现出多元、多维的丰富样态。作为一把双刃剑,对人民领袖、烈士英模、科技精英、民族企业家、体育冠军等优质偶像的崇拜能激发广大青年积极向上,而对负面人物、娱乐明星、成功人士的功利化崇拜等则使会青年的成长成才偏离正确轨道。当代青年是未来国家建设的生力军,他们的人生选择关乎中华民族伟大复兴。在提炼当代青年偶像崇拜内容、梳理其类型、结合其特点基础上,具体阐述了社会主义核心价值观对提升当代青年偶像崇拜境界、约束其行为、端正其价值取向的引领作用,进而从正反两方面分析当代青年偶像崇拜的表现及不良青年偶像崇拜产生的原因,最后探讨了以社会主义核心价值观引领当代青年偶像崇拜的路径在于:聚合青年偶像崇拜的多元主体进行综合治理,发挥偶像和粉丝自我教育、社会各界、学校、传媒、家庭的合力作用。

关键词：社会主义核心价值观当代青年偶像崇拜

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新时代高校劳动教育的价值意蕴及路径探析

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齐齐哈尔高等师范专科学校学报 2024年第2期 129-131页

作者：朱圣楠董翔薇齐齐哈尔大学黑龙江齐齐哈尔161000

习近平总书记强调:“教育要同生产劳动和社会实践相结合,培养德智体美劳全面发展的社会主义建设者和接班人。”劳动教育作为中国特色社会主义教育制度的重要内容,是中国特色社会主义教育制度的重要组成部分,也是落实立德树人根本任务的... 详细信息

习近平总书记强调:“教育要同生产劳动和社会实践相结合,培养德智体美劳全面发展的社会主义建设者和接班人。”劳动教育作为中国特色社会主义教育制度的重要内容,是中国特色社会主义教育制度的重要组成部分,也是落实立德树人根本任务的关键环节。但目前高校劳动教育还存在着一系列问题,诸如劳动教育观念淡薄、缺乏完整的劳动教育体系等。基于此,本文提出了新时代高校劳动教育价值意蕴及路径探析,以期为促进新时代高校劳动教育健康发展提供参考。

关键词：劳动教育价值意蕴路径探析

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电潜离心泵内流场及外特性的数值模拟分析

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计算机仿真 2024年第2期41卷 120-126页

作者：薛晓雨董祥伟孟繁琪李增亮中国石油大学(华东)机电工程学院山东青岛266580

针对目前油田使用的两种不同叶导轮结构的电潜离心泵,包括传统径向流泵和聚驱用混向流泵,采用计算流体动力学(CFD)研究方法,建立电泵内流场的数值仿真,在流量80~200m^(3)/d范围内,研究泵输送不同运动黏度为1~40mm^(2)/s介质时特性差异... 详细信息

针对目前油田使用的两种不同叶导轮结构的电潜离心泵,包括传统径向流泵和聚驱用混向流泵,采用计算流体动力学(CFD)研究方法,建立电泵内流场的数值仿真,在流量80~200m^(3)/d范围内,研究泵输送不同运动黏度为1~40mm^(2)/s介质时特性差异。在介质黏度为1和40mm^(2)/s,流量为80~180m^(3)/d工况下,使用FLUENT软件选用标准k-ε湍流模型和SIMPLE算法进行求解,分析两种泵在不同工况下的内部流场变化规律,通过流场分析探究叶轮结构对泵外特性的影响机制。仿真得到泵的扬程、效率曲线,发现泵性能出现变化的工况点与叶轮内流场分析结果相对应,并根据泵叶轮的内流场分布和泵的性能曲线分析两种泵所适用的工况。结果表明,径向流泵适用于大流量和高黏度工况,混向流泵适用于较低流量和中低黏度工况,为不同工况下泵的选择及泵的优化提供理论依据。

关键词：潜油电泵叶轮数值模拟计算流体力学介质黏度

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Applying dynamic light scattering to investigate the self-assembly process of DNA nanostructures

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Chinese Chemical Letters 2024年第3期35卷 316-320页

作者： wei Yuan Gui-Zhi dong Hui Ning xiang-xiang Guan Jia-Feng Cheng Zi-wei Shi Xiu-Ji Du Si-Wen Meng dong-Sheng Liu Yuan-Chen dong CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Dandong Bettersize Instruments Ltd. Dandong 118000China Key Laboratory of Organic Optoelectronics&Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Department of Chemistry Renmin University of ChinaBeijing 100872China

Understanding the dynamic assembly process of DNA nanostructures is important for developing novel strategy to design and construct functional *** this work,temperature-controlled dynamic light scattering(DLS)strategy has been applied to study the global assembly process of DNA origami and DNA *** the temperature dependent size and intensity profiles,the self-assembly process of various DNA nanostructures with different morphologies have been well-studied and the temperature transition ranges could be *** advantage of the DLS information,rapid preparation of the DNA origami and the brick assembly has been realized through a constant temperature *** results demonstrate that the DLS-based strategy provides a convenient and robust tool to study the dynamic process of forming hieratical DNA structures,which will benefit understanding the mechanism of self-assembly of DNA nanostructures.

关键词： Dynamic light scattering Self-assembly process DNA nanostructures Temperature transition ranges Rapid preparation

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Precise Planar-Twisted Molecular Engineering to Construct Semiconducting Polymers with Balanced Absorption and Quantum Yield for Efficient Phototheranostics

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Research 2024年第2期2023卷 227-238页

作者： xiang Su Zhirong Bao wei Xie Deliang Wang Ting Han dong Wang Ben Zhong Tang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Materials Chemistry Huzhou UniversityHuzhou 313000China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdong 518172China

Semiconducting polymers(SPs)have shown great feasibility as candidates for near-infrared-II(NIR-Ⅱ)fluorescence imaging-navigated photothermal therapy due to their strong light-harvesting ability and flexible ***,the fluorescence signal of traditional SPs tends to quench in their aggregate states owing to the strongπ-πstacking,which can lead to the radiative decay pathway shutting *** address this issue,aggregation-induced emission effect has been used as a rational tactic to boost the aggregate-state fluorescence of NIR-Ⅱ*** this contribution,we developed a precise molecular engineering tactic based on the block copolymerizations that integrate planar and twisted segments into one conjugated polymer backbone,providing great flexibility in tuning the photophysical properties and photothermal conversion capacity of *** monomers featured with twisted and planar architectures,respectively,were tactfully incorporated via a ternary copolymerization approach to produce a series of new *** optimal copolymer(SP2)synchronously shows desirable absorption ability and good NIR-Ⅱquantum yield on the premise of maintaining typical aggregation-induced emission characteristics,resulting in balanced NIR-Ⅱfluorescence brightness and photothermal ***-dispersible nanoparticles fabricated from the optimal SP2 show efficient photothermal therapeutic effects both in vitro and in *** in vivo investigation reveals the distinguished NIR-Ⅱfluorescence imaging performance of SP2 nanoparticles and their photothermal ablation toward tumor with prominent tumor accumulation ability and excellent biocompatibility.

关键词： property. conducting twisted

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Highly homogeneous zero-index metamaterials make devices more compact and perform better

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Light(Science & Applications) 2024年第5期13卷 806-807页

作者： wei-xiang Jiang State Key Laboratory of Millimeter Waves School of Information Science and EngineeringSoutheast University210096 NanjingChina

A highly homogeneous microwave zero-index metamaterial based on high-permittivity SrTiO3 ceramics is demonstrated to realize the small-aperture high-directivity *** a novel technique is a remarkable step forward to de... 详细信息

关键词： ceramics SrTiO3 Highly

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Remote copper-catalyzed enantioselective substitution of yne-thiophene carbonates

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Science China Chemistry 2024年第4期67卷 1175-1180页

作者： Hao-dong Qian xiang Li Tingrui Yin wei-Feng Qian Chunhui Zhao Cuiju Zhu Hao Xu CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology of Ministry of EducationInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Here,we describe a strategy for the copper-catalyzed asymmetric heteroarylation of yne-thiophene carbonates with indoles via remote *** key to the success of this strategy lies in the design of the alkynyl group at the ortho-position of the heterocycle thiophene,enabling the formation of a triarylmethane moiety via very remote ***,the concept of remote copper-catalyzed asymmetric transformation extends not only to yne-allylic esters but also to yne-aryl *** reaction readily provides a diverse array of chiral triarylmethanes with high efficiency,enantioselectivity,and excellent functional group ***,facile follow-up transformations underscore their potential utility in the synthesis of various enantioenriched building *** mechanistic studies support the plausibility of the remote substitution pathway.

关键词： remote substitution copper catalyst asymmetric catalysis triaryl methanes

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Computed tomography-based radiomics to predict early recurrence of hepatocellular carcinoma post-hepatectomy in patients background on cirrhosis

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World Journal of Gastroenterology 2024年第15期30卷 2128-2142页

作者： Gui-xiang Qian Zi-Ling Xu Yong-Hai Li Jian-Lin Lu xiang-Yi Bu Ming-Tong wei wei-dong Jia Department of Hepatic Surgery Anhui Provincial HospitalThe First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Hepatic Surgery Anhui Provincial Hospital Affiliated to Anhui Medical UniversityAnhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Anorectal Surgery the First People’s Hospital of HefeiHefei 230001Anhui ProvinceChina

BACKGROUND The prognosis for hepatocellular carcinoma(HCC)in the presence of cirrhosis is unfavourable,primarily attributable to the high incidence of *** To develop a machine learning model for predicting early recurrence(ER)of posthepatectomy HCC in patients with cirrhosis and to stratify patients’overall survival(OS)based on the predicted risk of *** In this retrospective study,214 HCC patients with cirrhosis who underwent curative hepatectomy were *** feature selection was conducted using the least absolute shrinkage and selection operator and recursive feature elimination ***-radiologic features were selected through univariate and multivariate logistic regression *** machine learning methods were used for model comparison,aiming to identify the optimal *** model’s performance was evaluated using the receiver operating characteristic curve[area under the curve(AUC)],calibration,and decision curve ***,the Kaplan-Meier(K-M)curve was used to evaluate the stratification effect of the model on patient *** Within this study,the most effective predictive performance for ER of post-hepatectomy HCC in the background of cirrhosis was demonstrated by a model that integrated radiomics features and clinical-radiologic *** the training cohort,this model attained an AUC of 0.844,while in the validation cohort,it achieved a value of *** K-M curves illustrated that the combined model not only facilitated risk stratification but also exhibited significant discriminatory ability concerning patients’*** The combined model,integrating both radiomics and clinical-radiologic characteristics,exhibited excellent performance in HCC with *** K-M curves assessing OS revealed statistically significant differences.

关键词： Machine learning Radiomics Hepatocellular carcinoma Cirrhosis Early recurrence Overall survival Computed tomography Prognosis Risk factor Delta-radiomics

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Improved Approximation Schemes for Early Work Scheduling on Identical Parallel Machines with a Common Due Date

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Journal of the Operations Research Society of China 2024年第2期12卷 341-350页

作者： wei-dong Li School of Mathematics and Statistics Yunnan UniversityKunming650504YunnanChina

We study the early work scheduling problem on identical parallel machines in order to maximize the total early work,i.e.,the parts of non-preemptive jobs that are executed before a common due *** preprocessing and constructing an auxiliary instance which has several good properties,for any desired accuracy,we propose an efficient polynomial time approximation scheme with running time O(f(1/ε)n),where n is the number of jobs and f(1/ε)is exponential in 1/ε,and a fully polynomial time approximation scheme with running time O(1/ε^(2m+1)+n)when the number of machines is fixed.

关键词： Scheduling Early work Polynomial time approximation scheme:Effcient polynomial time approximation scheme-Fully polynomial time approximation scheme

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