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Bifurcation in most probable phase portraits for a bistable kinetic model with coupling Gaussian and non-Gaussian noises

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Applied Mathematics and Mechanics(English Edition) 2021年第12期42卷 1759-1770页

作者： Mengjiao hua Yu wu Department of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang UniversityHangzhou 310027China Soft Matter Research Center Zhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

The phenomenon of stochastic bifurcation driven by the correlated non-Gaussian colored noise and the Gaussian white noise is investigated by the qualitative changes of steady states with the most probable phase *** arrive at the Markovian approximation of the original non-Markovian stochastic process and derive the general approximate Fokker-Planck equation(FPE),we deal with the non-Gaussian colored noise and then adopt the unified colored noise approximation(UCNA).Subsequently,the theoretical equation concerning the most probable steady states is obtained by the maximum of the stationary probability density function(SPDF).The parameter of the uncorrelated additive noise intensity does enter the governing equation as a non-Markovian effect,which is in contrast to that of the uncorrelated Gaussian white noise case,where the parameter is absent from the governing equation,i.e.,the most probable steady states are mainly controlled by the uncorrelated multiplicative ***,in comparison with the deterministic counterpart,some peculiar bifurcation behaviors with regard to the most probable steady states induced by the correlation time of non-Gaussian colored noise,the noise intensity,and the non-Gaussian noise deviation parameter are ***,the symmetry of the stochastic bifurcation diagrams is destroyed when the correlation between noises is ***,the feasibility and accuracy of the analytical predictions are verified compared with those of the Monte Carlo(MC)simulations of the original system.

关键词： stochastic bifurcation non-Gaussian colored noise most probable steady state Fokker-Planck equation(FPE) Monte Carlo(MC)simulation

OsELF3 Is Involved in Circadian Clock Regulation for Promoting Flowering under Long-Day Conditions in Rice

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Molecular Plant 2013年第1期6卷 202-215页

作者： Ying Yang Qiang Peng Guo-Xing Chen xiang-hua Li Chang-Yin wu National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan430070 China

Heading date is a critical trait that determines cropping seasons and regional adaptability in rice （Oryza sativa）. Research efforts during the last decade have identified some important photoperiod pathway genes that are conserved between Arabidopsis and rice. In this study, we identified a novel gene, Oryza sativa ELF3 （OsELF3）, which is a putative homolog of the ELF3 gene in Arabidopsis thaliana. OsELF3 was required for the control of heading date under long-day conditions. Its Tos17-tagging mutants exhibited a delayed heading date phenotype only under long-day, but not short-day, conditions. OsELF3 was highly expressed in leaf blades, and the OsELF3 protein was localized in the nucleolus. An obvious diurnal rhythm of OsELF3 transcript level was observed, with a trough in the early day and a peak in the late night in wild-type plants. However, this expression pattern was disrupted in oself3 mutants. Further inves- tigations showed that the expression of OsGI and Ghd7 was up-regulated in the oself3 mutant, indicating that OsELF3 acts as a negative regulator upstream of OsGI and Ghd7 in the flowering-time control under long-day conditions. The rhythmic expression of circadian clock-related genes, including some OsPRR members, was obviously affected in oself3 mutants. Our results indicated that OsELF3 acts as a floral activator in the long-day photoperiodic pathway via its cross- talk with the circadian clock in rice.

关键词： heading date photoperiod pathway circadian clock rice.

A new shortcut synthesis route for (±) raphidecursinol

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Chinese Chemical Letters 2010年第2期21卷 127-130页

作者： hua Jie Yuan Yao Yao Cheng Shan Qian xiang Xiao Yong wu Key Laboratory of Drug Targeting of Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China

The new shortcut synthesis route of(±)raphidecursinol 1,a racemic 8,4′-oxyneolignan compound,can be more easily achieved by the synthesis route,starting from readily available inexpensive 3,4,5-trimethoxybenzaldehyd... 详细信息

关键词： 8,4'-Oxyneolignan Raphidecursinol Racemic compound

Hardware Implementation and Simulations of Joint Coding and Modulation Diversity MIMO-OFDM Scheme

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Journal of Harbin Institute of Technology(New Series) 2013年第3期20卷 27-34页

作者： xiang Gao Zhan-Ji wu Long-Fei hua Jun-Peng Liu School of Information and Communication Engineering Beijing University of Posts and Telecommunications

This paper presents an efficient Joint Coding and Modulation Diversity ( JCMD ) scheme. The proposed scheme applied modulation diversity technique to MIMO-OFDM system which can effectively use time, frequency and space diversity combined with channel coding. In fading channel,the proposed scheme not only achieves high spectral efficiency,but also greatly enhances the reliability of wireless transmission. The self- developed hardware prototype system proves that the proposed scheme can be realized and has high reliability. Compared with traditional MIMO-OFDM scheme based on bit-interleaved coded modulation ( BICM) ,software and hardware simulation results show that the proposed scheme with the optimal rotational angle can obtain a significant performance advantage both for precoded and non-precoded system in the condition of non-perfect channel knowledge and non-ideal synchronization.

关键词： multiple input multiple output ( MIMO) orthogonal frequency division multiplexing ( OFDM) modulation diversity channel estimation

Development of antibody-drug conjugates in cancer:Overview and prospects

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Cancer Communications 2024年第1期44卷 3-22页

作者： Dan-Yun Ruan Hao-xiang wu Qi Meng Rui-hua Xu Department of Clinical Research Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhouGuangdongP.R.China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhouGuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhouGuangdongP.R.China

In recent years,remarkable breakthroughs have been reported on antibody-drug conjugates(ADCs),with 15 ADCs successfully entering the market over the past *** substantial development has positioned ADCs as one of the fastest-growing domains in the realm of anticancer drugs,demonstrating their efficacy in treating awide array of ***,there is still an unmet clin-ical need forwider application,better efficacy,and fewer side effects of *** ADC generally comprises an antibody,a linker and a payload,and the combina-tion has profound effects on drug structure,pharmacokinetic profile and ***,optimization of the key components provides an opportunity to develop ADCs with higher potency and fewer side *** this review,we comprehen-sively reviewed the current development and the prospects of ADC,provided an analysis of marketed ADCs and the ongoing pipelines globally as well as in China,highlighted several ADC platforms and technologies specific to different pharmaceutical enterprises and biotech companies,and also discussed the new related technologies,possibility of next-generation ADCs and the directions of clinical research.

关键词： companies breakthrough payload

ON THE CELL ENTROPY INEQUALITY FOR THE FULLY DISCRETE RELAXING SCHEMES

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Journal of Computational Mathematics 2001年第5期19卷 511-518页

作者： hua-zhong Tang hua-mo wu School of Mathematical Sciences Peking UniversityBeijing 100871China LSEC JCMSECAcademy of Mathematics and Systems SciencesChinese Academy of SciencesBeijing 100080China

Presents a study on the cell entropy inequality for two classes of fully discrete relaxing schemes approximating scalar conservation laws. Main advantage of the schemes; Review of the construction of the relaxing syst... 详细信息

关键词： the relaxing schemes entropy inequality conservation laws

ON THE CONVERGENCE OF IMPLICIT DIFFERENCE SCHEMES FOR HYPERBOLIC CONSERVATION LAWS

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Journal of Computational Mathematics 2002年第2期20卷 121-128页

作者： hua-zhong Tang hua-mo wu School of Mathematical Sciences Peking UniversityBeijing 100871China LSEC ICMSECAcademy of Mathematics and System SciencesChinese Academy of SciencesBeijing 100080China

Discusses the treatment of implicit difference approximations to hyperbolic conservation laws with non-convex flux. Information on weighted implicit difference schemes; Convergence of difference scheme; Establishment ... 详细信息

关键词： conservation laws weighted implicit schemes entropy solution

A New Cobalt(Ⅱ)Polymer Based on 1-Butylben-zimidazole and Terephthalate Mixed-ligands:Crystal Structure and Weak Interactions

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1033-1038页

作者： WANG Jian-hua ZHENG Zhan-Ying wu Xiu-Mei WANG Xiu-Guang GUO Jian-hua LIU Qing-xiang Tianjin Key Laboratory of Structure and Performance for Functional Molecule College of Chemistry and Life Science Tianjin Normal University Tianjin 300387 China State Key Laboratory of Element-organic Chemistry Nankai University Tianjin 300071 China

A new cobalt（Ⅱ） polymer with quasi-rectangular cavities, [Co（L）2（TP）·H2O]n 1 （L=1-butylbenzimidazole, TP = terephthalate ion） has been prepared by means of self-assembly of 1-butylbenzimidazole, terephthalic acid and Co（NO3）2·6H2O. The structure of 1 was characterized by X-ray diffraction analysis. In the crystal packing, 2-D supramolecular layers are formed via π-π stacking interactions. The fluorescence emission spectra of L and 1 are described.

关键词： benzimidazole terephthalic acid cobalt,π-π interactions

Modeling of Strain-Induced Precipitation Kinetics and Evolution of Austenite Grains in Nb Microalloyed Steels

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Journal of Iron and Steel Research International 2008年第3期15卷 65-69页

作者： ZHOU Xiao-guang LIU Zhen-yu YUAN xiang-qian wu Di WANG Guo-dong LIU xiang-hua State Key Laboratory of Rolling Technology and Automation Northeastern University Shenyang 110004 Liaoning China

Considering the effect of strain and chemical composition onprecipitation behavior, new models for the start and end time of Nb（C,N） precipitation in austenite under the conditions of different temperatures and strains have been investigated for Nb microalloyed steel. The value of n in the precipitation kinetic equation has been determined by using the available experimental data in literature, which indicated that n is a constant and independent of temperature. The values of the start and end time of the predicted precipitation are compared with the experimental values. Calculated results are in good agreement with the experimental results. Also, the evolution of austenite grains before ferrite transformation is simulated by taking the effect of precipitation into consideration. The measured austenite grain size is in good agreement with predicted one prior to ferrite transformation.

关键词： strain-induced precipitation start time precipitation static recrystallization grain size