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Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update

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Journal of Nutritional Oncology 2022年第2期7卷 64-74页

作者： Hong Xia Xu Chun hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun hua Wang Jing wu Ying He Jia Jun Yang Cong hua Xie Fu xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi hua Chen Zhi Kang Chen Ming hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen xiang hua wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong wu Min Weng Qing hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Department of Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer Center of the First Hospital of Jilin University Changchun 130021Jilin China Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina Department of Gastrointestinal Surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Surgery The First Affiliated Hospital of SunYat-Sen UniversityGuangzhou 510080GuangdongChina Department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Nutrition and Metabolism of Oncology The First Affiliated Hospital of University of Science and Technology of ChinaAnhui Provincial Cancer HospitalHefei 230031AnhuiChina Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina Department of Gastrointestinal Surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunming 650032YunnanChina Department of Clinical Nutrition The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006ZhejiangChina Department of Clinical Nutrition Chongqing General HospitalChongqing 400014China Department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Department of Oncology Xingtai Peo

Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of *** Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since *** is an extension to the previous 2013-2020 study *** study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of *** and study design This is an observational,multi-centered,hospital-based prospective cohort *** collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital ***-up will be conducted for 1-20 years after *** primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of *** factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of

关键词： Cancer Malnutrition Nutritional status Nutritional assessment Survival Patient-Generated Subjective Global Assessment

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硬脂酸-直链淀粉复合物的制备工艺的研究

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食品科技 2011年第4期36卷 207-210页

作者：林若慧柴向华吴克刚张文广东工业大学轻工化工学院广州510006

选取高直链玉米淀粉,采用HCl/KOH沉淀法制备直链淀粉-硬脂酸复合物,并实验探讨了在不同酸度、结晶温度、保温时间和直链淀粉与脂质的比例下复合物的包埋效果。通过酸水解法测定复合物中的脂肪含量、脂质利用率,并用直接干燥法测定复合... 详细信息

选取高直链玉米淀粉,采用HCl/KOH沉淀法制备直链淀粉-硬脂酸复合物,并实验探讨了在不同酸度、结晶温度、保温时间和直链淀粉与脂质的比例下复合物的包埋效果。通过酸水解法测定复合物中的脂肪含量、脂质利用率,并用直接干燥法测定复合物的含水量,从而得出复合物的干基产率,分析确定制备硬脂酸-直链淀粉复合物的最佳工艺条件。结果表明,制备硬脂酸-直链淀粉复合物最佳的工艺条件为:0.1mol/LHCl的添加量为12mL,结晶温度为60℃,保温时间为0.5h,直链淀粉与脂质比例为10:1。

关键词：高直链玉米淀粉直链淀粉硬脂酸硬脂酸-直链淀粉复合物

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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng wu Wen-Jia Chen Xin-Ning Yu hua-Tao wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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妊娠期和哺乳期女性免疫抑制药的使用

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临床药物治疗杂志 2012年第1期10卷 56-62页

作者：孙闻嘉薛静吴华香浙江大学医学院附属第二医院风湿免疫科杭州市310009

妊娠期和哺乳期女性是多种炎症疾病的高发人群,如类风湿关节炎、系统性红斑狼疮、炎性肠病等。目前治疗炎症疾病的主要药物包括糖皮质激素、免疫抑制药以及近年来迅速发展的生物制剂。但是关于这类药物用于妊娠期及哺乳期女性的利弊,通... 详细信息

妊娠期和哺乳期女性是多种炎症疾病的高发人群,如类风湿关节炎、系统性红斑狼疮、炎性肠病等。目前治疗炎症疾病的主要药物包括糖皮质激素、免疫抑制药以及近年来迅速发展的生物制剂。但是关于这类药物用于妊娠期及哺乳期女性的利弊,通常是经验性的,多数缺乏随机对照研究。本文在回顾文献的基础上对妊娠及哺乳期女性激素及免疫抑制药使用的相关内容进行了综述。

关键词：妊娠期哺乳期激素免疫抑制药生物制剂炎症疾病

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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小儿肾活检中TEMNO针自动活检术与Tru-Cut针穿刺法比较

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实用儿科临床杂志 2008年第13期23卷 1047-1047,1052页

作者：程向华吴竟芝李威陈奎生商丘市妇幼保健院病理科河南商丘476000 郑州大学医学院病理教研室郑州450003

目的比较小儿肾脏活检TEMNO针自动活检术与Tru-Cut针穿刺法的优缺点。方法选择2003年7月-2007年7月本院儿科住院的178例肾脏疾病患儿。应用TEMNO针自动活检术取材98例(TEMNO针组),Tru-Cut针穿刺法取材80例(Tru-Cut针组),比较二组取材成... 详细信息

目的比较小儿肾脏活检TEMNO针自动活检术与Tru-Cut针穿刺法的优缺点。方法选择2003年7月-2007年7月本院儿科住院的178例肾脏疾病患儿。应用TEMNO针自动活检术取材98例(TEMNO针组),Tru-Cut针穿刺法取材80例(Tru-Cut针组),比较二组取材成功率、满意度、并发症种类及发生率、安全性及损伤性。结果***针组取材成功率97.96%,满意度94.9%;Tru-Cut针组分别为91.25%、86.25%,二组比较均有显著性差异(χ2=9.499,11.023 Pa<0.01)。TEMNO针组取材肾组织(2.4±0.6)条,最长一条肾组织肾小球(15±7)个;Tru-Cut针组分别为(1.6±0.4)条、(12±6)个,二组比较均有显著性差异(t=19.376,18.641 Pa<0.01)。***针组并发症发生率为33.67%;Tru-Cut针组为81.25%,二组比较有显著性差异(χ2=7.206P<0.01)。其中TEMNO针组一过性镜下血尿27.55%、肉眼血尿4.08%、被膜下出血2.04%,Tru-Cut针组分别为43.75%、30.0%及7.5%。结论TEMNO针自动活检术安全、可靠,使难度很高的小儿肾活检技术变得轻便快捷,初学者易掌握,且效果稳定。

关键词：活体组织学诊断肾脏儿童

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Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report

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World Journal of Clinical Cases 2025年第6期13卷 41-47页

作者： Kuan-hua Chen Ming-Yuan Kang Yi-Ting Chang Sheng-Yang huang Yung-Szu wu Center for Cardiovascular Disease Taichung Veterans General HospitalTaichung 407219TaiwanChina Department of Anesthesiology Taichung Veterans General HospitalTaichung 407219TaiwanChina Division of Pediatric Surgery Department of SurgeryTaichung Veterans General HospitalTaichung 407219TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Post-Baccalaureate Medicine National Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side *** case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA *** SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain *** patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without *** preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular *** Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.

关键词： Abdominal aortic aneurysm Postoperative pain management Rectus sheath block Surgical anesthesia Opioid-sparing techniques Case report

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A video structural similarity quality metric based on a joint spatial-temporal visual attention model

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第12期10卷 1696-1704页

作者： hua ZHANG xiang TIAN Yao-wu CHEN Institute of Advanced Digital Technology and Instrumentation Zhejiang University Hangzhou 310027 China

Objective video quality assessment plays a very important role in multimedia signal processing. Several extensions of the structural similarity （SSIM） index could not predict the quality of the video sequence effectively. In this paper we propose a structural similarity quality metric for videos based on a spatial-temporal visual attention model. This model acquires the motion attended region and the distortion attended region by computing the motion features and the distortion contrast. It mimics the visual attention shifting between the two attended regions and takes the burst of error into account by introducing the non-linear weighting fimctions to give a much higher weighting factor to the extremely damaged frames. The proposed metric based on the model renders the final object quality rating of the whole video sequence and is validated using the 50 Hz video sequences of Video Quality Experts Group Phase I test database.

关键词： Quality assessment Structural similarity (SSIM) index Attended region Visual attention shift

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Strengthening-toughening methods and mechanisms of Mg-Li alloy:a review

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Rare Metals 2022年第4期41卷 1176-1188页

作者： xiang Peng Wen-Cai Liu Guo-hua wu National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Magnesium-lithium(Mg-Li) alloy,as the lightest metal structure material,has unparalleled market prospects in aerospace,weapons and equipment,electronic technology,transportation,and many other ***,it is hard to balance the superlight and high strength of Mg-Li alloy,and the inferior high-temperature strength and poor high-temperature stability limit the wide application of Mg-Li *** present,the main methods to improve the mechanical properties of Mg-Li alloy are alloying,grain refinement,and compound *** domestic and overseas research progress in the strengthening and toughening methods and mechanisms of Mg-Li alloy are reviewed,and the future development of the high strength and high toughness Mg-Li alloy is prospected.

关键词： Mg-Li alloy Solution strengthening Precipitation strengthening Grain reflnement strengthening Compound strengthening

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Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi Mingjun wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou huang hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

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