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Analysis of crack opening stresses for center- and edge-crack tension specimens

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Chinese Journal of Aeronautics 2014年第2期27卷 291-298页

作者： Tong Di-hua wu Xue-Ren AVIC Beijing Institute of Aeronautical Materials

Accurate determination of crack opening stress is of central importance to fatigue crack growth analysis and life prediction based on the crack-closure model. This paper studies the crack opening behavior for center- and edge-crack tension specimens. It is found that the crack opening stress is affected by the crack tip element. By taking the crack tip element into account, a modified crack opening stress equation is given for the center-crack tension specimen. Crack surface displace- ment equations for an edge crack in a semi-infinite plate under remote uniform tension and partially distributed pressure are derived by using the weight function method. Based on these displacements, a crack opening stress equation for an edge crack in a semi-infinite plate under uniform tension has been developed. The study shows that the crack opening stress is geometry-dependent, and the weight function method provides an effective and reliable tool to deal with such geometry depen- dence.

关键词： Center- and edge-crack Crack closure Crack opening stresses Crack surface displacements Weight function method

Force-displacement characteristics of simply supported beam laminated with shape memory alloys

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Acta Mechanica Sinica 2011年第6期27卷 1065-1070页

作者： Zhi-Qiang wu Zhen-hua Zhang School of Mechanical Engineering Tianjin University 300072 Tianjin China Department of Electromechanical Engineering Nanyang Institute of Technology 473004 Nanyang China

As a preliminary step in the nonlinear design of shape memory alloy（SMA） composite structures,the force-displacement characteristics of the SMA layer are *** bilinear hysteretic model is adopted to describe the constitutive relationship of SMA *** the assumption that there is no point of SMA layer finishing martensitic phase transformation during the loading and unloading process,the generalized restoring force generated by SMA layer is deduced for the case that the simply supported beam vibrates in its first *** generalized force is expressed as piecewise-nonlinear hysteretic function of the beam transverse *** the energy dissipated by SMA layer during one period is obtained by integration,then its dependencies are discussed on the vibration amplitude and the SMA＇s strain（Ms-Strain） value at the beginning of martensitic phase *** is shown that SMA＇s energy dissipating capacity is proportional to the stiffness difference of bilinear model and nonlinearly dependent on *** increasing rate of the dissipating capacity gradually reduces with the amplitude *** condition corresponding to the maximum dissipating capacity is deduced for given value of the vibration *** obtained results are helpful for designing beams laminated with shape memory alloys.

关键词： Shape memory alloy Laminated beam Bilinear hysteretic model Force-displacement characteristics - Energy dissipation

Copper and amine free Sonogashira cross-coupling reaction catalyzed by efficient diphosphane-palladium catalyst

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Chinese Chemical Letters 2011年第10期22卷 1175-1178页

作者： Ting He Lei Lei wu Xing Li Fu Hai Yan Fu hua Chen Rui xiang Li Key lab of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 China Guangxi Vocational ＆ Technical Institute of Industry Nanning 530001 China

The commercially available diphosphane ligand MeO-BIPHEP was first investigated in the palladium-catalyzed Sonogashira reaction in the absence of copper and *** coupling of various aryl bromides and aryl chlorides wit... 详细信息

关键词： MeO-BIPHEP Sonogashira reaction Diphosphane ligand Palladium complex

Glomangiomatosis-immunohistochemical study:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5406-5413页

作者： Ruo-Chen wu Ying-hua Gao Wen-Wen Sun xiang-Yun Zhang Shu-Peng Zhang Department of Pathology The Second Affiliated Hospital of Shandong First Medical UniversityTaian 271000Shandong ProvinceChina Department of Pathology The First People’s Hospital of Jining CityJining 272000Shandong ProvinceChina

BACKGROUND Glomangiomatosis(also known as diffuse glomus tumor)is extremely rare,accounting for only 5%of glomus *** prevalence of glomus tumors is only 2%of soft tissue *** can recur after *** growth may be diffuse or infiltrating and invasive,definitive identifying standards for malignant glomus tumors are *** article describes a case of glomangiomatosis with many nodular masses in the soft tissues of the right foot and calf.A review of the Chinese and English-language literature is *** SUMMARY A case of glomangiomatosis in a 55-year-old Chinese woman who presented clinically with many nodular masses in the soft tissues of the right foot and *** tumor was examined histologically and immunostaining was *** Glomangiomatosis occurs most often in young people,in the distal extremities,but is *** nodules are even *** 15 clinicopathological analyses of glomangiomatosis have been reported in the combined Chinese-and Englishlanguage *** the present case,microscopically,nested vascular globular cells were observed around the blood vessel *** revealed diffuse immunoreactivity for smooth muscle actin,vimentin,type Ⅳ collagen,and ***,CD34,and calponin were weakly,partially,and slightly positive,*** was no recurrence 1 year after resection.

关键词： Glomangiomatosis Glomus tumor Foot and ankle Perivascular tumors Case report

6-DOF Motion Assessment of A Hydrodynamic Numerical Simulation of A Semisubmersible Platform Using Prototype Monitoring Data

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China Ocean Engineering 2022年第4期36卷 575-587页

作者： LI Song wu Wen-hua YAO Wei-an Faculty of Vehicle Engineering and Mechanics Dalian University of TechnologyDalian 116024China State Key Laboratory of Structural Analysis of Industrial Equipment Dalian University of TechnologyDalian 116024China Research Institute of Dalian University of Technology in Shenzhen Gaoxin South fourth Road Nanshan DistrictShenzhen 518057China

Hydrodynamic numerical simulations are used to conduct structural analyses and inform the design of engineered marine *** this paper,a hydrodynamic numerical model of“Nanhai Tiaozhan”(NHTZ)FPS platform was established according to its design *** model was assessed with two sets of field monitoring data representing harsh and conventional sea *** motion responses of the platform according to the measured data and the hydrodynamic simulation were compared by reviewing their statistical characteristics,distributions,and spectrum *** comparison showed that the hydrodynamic model could correctly simulate the frequency domain characteristics of the motion responses of the ***,the simulation underestimated the reciprocating motions of the floating body and the influence of slow drift on the motion of the ***,analysis of the monitoring data revealed that the translational degrees of freedom(DOF)and rotational DOF of the platform were coupled,but these coupled motion states were not apparent in the hydrodynamic simulation.

关键词： prototype monitoring hydrodynamic numerical simulation statistical characteristics semisubmersible platform reciprocating motions

Cytotoxic 7-Methoxylated Caged Xanthones from the Twigs of Garcinia oligantha

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Chinese Journal of Chemistry 2021年第10期39卷 2898-2910页

作者： Jin-Ling Yang Wen-Wei Fu Qian xiang Rong wu Yue-Xun Tang Chang-wu Zheng Yue Lu hua Zhou Hong-Xi Xu School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203 China

Main observation and conclusion Nineteen unprecedented 7-methoxylated caged xanthones(1—19)were isolated from the twigs of Garcinia oligantha under the guidance of NMR *** structures and absolute configurations were demonstrated by extensive spectroscopic data,single-crystal X-ray diffraction,electronic circular dichroism(ECD)calculations,and the modified Mosher's *** 1 is a rare scalemic 7-methoxylated neo-caged xanthone,which was resolved using HPLC with CD detection on a chiral-phase AD column,and compounds 2—3 are rare 7-methoxylated caged xanthones with the hydrogenatedΔ^(8(8a))double *** compounds exhibited promising inhibitory activities against four human cancer cell lines with IC50 values ranging from 1.9 to 14.3μmol/L.A cell apoptosis analysis using flow cytometry showed that compound 11 could induce apoptosis in a dose dependent ***,PARP,caspase-9,and Bcl-2 western blotting suggested that compound 11-induced apoptosis may be involved in caspase-dependent pathway.

关键词： Garcinio oligantha Caged Xanthones Structure elucidation X-ray diffraction Tumor cell apoptosis

OCT6 inhibits differentiation of porcine-induced pluripotent stem cells through MAPK and PI3K signaling regulation

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Zoological Research 2022年第6期43卷 911-922页

作者： Xin-Chun Yang Xiao-Long wu Wen-Hao Li Xiao-Jie wu Qiao-Yan Shen Yun-xiang Li Sha Peng Jin-Lian hua College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China

As a transcription factor of the Pit-Oct-Unc(POU)domain family,octamer-binding transcription factor 6(OCT6)participates in various aspects of stem cell development and *** present,however,its role in porcine-induced pluripotent stem cells(piPSCs)remains ***,we explored the function of OCT6 in *** found that piPSCs overexpressing OCT6 maintained colony morphology and pluripotency under differentiation conditions,with a similar gene expression pattern to that of non-differentiated *** analysis revealed that OCT6 attenuated the adverse effects of extracellular signal-regulated kinase(ERK)signaling pathway inhibition on piPSC pluripotency by activating phosphatidylinositol 3-kinase-protein kinase B(PI3K-AKT)signaling *** research sheds new light on the mechanism by which OCT6 promotes PSC maintenance.

关键词： OCT6 piPSCs MAPK/ERK PI3K/AKT Pluripotency

Comparative analysis of different cyclosporine A doses on protection after myocardial ischemia/reperfusion injury in rat

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 144-148页

作者： Kang huang Shi-Juan Lu Jiang-hua Zhong Qun xiang Liu Wang Miao wu Department of Cardiology Haikou People's Hospital

Objective:To investigate the protective effect of different cyclosporin A(CsA)doses on myocardial ischemia/reperfusion injury in rat ***:A rat model of myocardial ischemia/reperfusion injury was established in vivo and the rats were randomly divided into four groups:placebo(PBS;T1),low-dose(CsA dose:1.0 mg/kg:T2),medium-dose(CsA dose:2.5 mg/kg:T3),and high-dose(CsA dose:5.0 mg/kg;T4)*** function indexes were monitored at different time points,the extent of myocardial infarction was assessed by Evans Blue-TTC staining,and creatine kinase MB mass and cardiac troponin 1 values were measured by biochemical ***:Compared with the T1 and T2 groups,both the creatine kinase MB mass and cardiac troponin 1 were significantly lower in the T3 and T4 groups(P<0.05).The mean arterial pressure(MAP)and left ventricular systolic pressure(LVSP)decreased sequentially in each group,with the extending reperfusion *** decreases in LVSP and MAP were observed in the T3 and T4 groups as compared to the T1 and T2 group(P<0.05)and the T2 group showed a significantly lower LVSP and MAP decline than the T1 group(P<0.05).Compared with the Tl group,the rats from the T2.T3,and T4 groups suffered from a significantly lower extent of myocardial infarction(P<0.05).Also,the a animals in the T3 and T4 groups had a significantly smaller extent of myocardial infarction than those in the T2 group(P<0.05).Conclusions:Various CsA doses exert different degrees of protection against ischemia/reperfusion injury,and this protective effect peaks at approximately 2.5 mg/kg in rat models.

关键词： Cyclosporin A Myocardial ischemia/reperfusion injury Mitochondrial permeability transition pore

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青稞分蘖角度的QTL定位

作物学报 2025年第1期51卷 260-272页

作者：杨景发余鑫莲姚有华姚晓华王蕾吴昆仑李新青海大学农林科学院/青海省作物分子育种重点实验室/青海省青稞遗传育种重点实验室/青藏高原种质资源研究与利用实验室/青海大学省部共建三江源生态与高原农牧业国家重点实验室青海西宁810016

分蘖角度是青稞株型的主要构成因素,在提高青稞产量与抗倒伏性中发挥着极为重要的作用。为解析青稞分蘖角度的遗传机制,本研究以青稞品种‘达章紫’(株型松散)和‘昆仑10号’(株型紧凑)为亲本构建的RIL群体为材料,基于高密度遗传图谱,... 详细信息

分蘖角度是青稞株型的主要构成因素,在提高青稞产量与抗倒伏性中发挥着极为重要的作用。为解析青稞分蘖角度的遗传机制,本研究以青稞品种‘达章紫’(株型松散)和‘昆仑10号’(株型紧凑)为亲本构建的RIL群体为材料,基于高密度遗传图谱,在多环境中进行青稞分蘖角度的QTL定位,并利用RIL群体衍生的剩余杂合系,对鉴定到的主效QTLqTA7H-1进行精细定位。在青稞7条染色体上共检测到9个控制分蘖角度的QTL,解释表型变异为6.41%~33.57%,其中,qTA3H-1和qTA7H-1为多环境共检测的主效QTL,平均加性效应分别为5.42°(增效)和-3.87°(减效);在减效QTL qTA7H-1初定位区间筛选到4个剩余杂合体,自交衍生F8:9近等基因系,在置信区间内加密设计14对分子标记对RHL群体极端单株进行检测,利用获得的5种交换类型单株,将qTA7H-1进一步界定在PC08(32,252,397)与PA10(41,790,765)约9.54Mb的物理区间内。本研究初步揭示调控青稞分蘖角度的遗传因子,为开展分蘖角度性状的遗传改良与分子设计育种奠定了基础。

关键词：青稞分蘖角度 QTL定位主效位点

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