检索结果-南通市图书馆

State of China’s climate in 2023

在线全文

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2024年第5期17卷 54-60页

作者： Linhai Sun Xiaying Zhu Wei Li Wanxiu Ai xianyan Chen Yundi Jiang Ling Wang Xukai Zou Shanshan Zhao Hongling zeng Hailing zhong National Climate Center China Meteorological AdministrationBeijingChina

China witnessed a warm and dry climate in *** annual surface air temperature reached a new high of 10.71℃,with the hottest autumn and the second hottest summer since ***,the annual precipitation was the second lowest since 2012,at 615.0 *** was less than normal from winter to summer,but more in *** with the annual condition,precipitation in the flood season from May to September was also the second lowest since 2012,which was 4.3%less than normal,with the anomalies in the central and eastern parts of China being higher in central areas and lower in the north and *** the contrary,the West China Autumn Rain brought much more rainfall than normal,with an earlier start and later *** there was less annual precipitation in 2023,China suffered seriously from heavy precipitation events and *** particular,from the end of July to the beginning of August,a rare,extremely strong rainstorm caused by Typhoon Dussuri hit Beijing,Tianjin,and Hebei,causing an abrupt alteration from drought to flood conditions in North *** contrast,Southwest China experienced continuous drought from the previous autumn to current *** early summer,North China and the Huanghuai region experienced the strongest high-temperature process since ***,there were more cold-air processes than normal impacting China,with the most severe of the year occurring in ***,in spring,there were more sand and dust occurrences in northern China.

关键词： Climate in China Hottest year Extreme events Dussuri

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI Zhi-feng LI Meng-ya zhong Yue-long JIANG Li-ying FENG Jie ZHA Jing-wei YAO Yin LI xian-ming DENG Bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p53

Effective time, correction speed and termination time of hemiepiphysiodesis in children

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第1期15卷 1-10页

作者： Jian-Fa zeng Yu-Yin Xie Can Liu Zhen-Qi Song Zheng Xu zhong-Wen Tang Jie Wen Sheng Xiao Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Anatomy Hunan Normal University school of MedicineChangsha 410003Hunan ProvinceChina

In children with asymmetric growth on the medial and lateral side of limbs,if there still remains growth potential,the guided growth technique of hemiepiphysiodesis on one side of the epiphysis is recognized as a safe and effective ***,when the hemi-epiphysiodesis start to correct the deformities,how many degrees could hemi-epiphysiodesis bring every month and when to remove the hemi-epiphysiodesis implant without rebound phenomenon are still on *** article reviews the current studies focus on the effective time,correction speed and termination time of hemi-epiphysiodesis.

关键词： Hemi-epiphysiodesis Percutaneous epiphysiodesis Transphyseal screws Eight plate

Roles of combined femoral and acetabular anteversion in pathological changes of hip dysplasia and hip reconstructive surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第5期15卷 390-399页

作者： Can Liu Zheng Xu Jian-Fa zeng Zhen-Qi Song Yu-Yin Xie zhong-Wen Tang Jie Wen Sheng Xiao Department of Anatomy Hunan Normal University School of MedicineChangsha 410003Hunan ProvinceChina Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina

Combined femoral and acetabular anteversion is the sum of femoral and acetabular anteversion,representing their morphological relationship in the axial *** with the increasing understanding of hip dysplasia in recent years,numerous scholars have confirmed the role of combined femoral and acetabular anteversion in the pathological changes of hip *** present,the reconstructive surgery for hip dysplasia includes total hip replacement and redirectional hip preservation *** an important surgery index,combined femoral and acetabular anteversion have a crucial role in these ***,we discuss the role of combined femoral and acetabular anteversion in pathological changes of hip dysplasia,total hip replacement,and redirectional hip preservation surgery.

关键词： Combined anteversion Femoral anteversion Acetabular anteversion Hip dysplasia Hip preservation surgery Total hip replacement

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients:Hepatitis B virus infection and transaminases should be considered

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第7期16卷 1018-1028页

作者： Jia-Yao Huang Jian-Yun Peng Hai-Yi Long xian zhong Yu-Hua Xie Lu Yao Xiao-Yan Xie Man-Xia Lin Department of Medical Ultrasonics The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma(HCC),but a convenient and comprehensive method to assess liver condition is *** stiffness(LS)measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver *** hepatitis B(CHB)is an important risk factor for HCC progression,but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral *** hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver *** To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and *** A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus(HBV)-DNA levels[HBV-DNA≥100.00 IU/mL as Pos group(n=200)and40 U/L),the correlations between LS and liver condition indices were not significant(P>0.05).CONCLUSION LS was significantly correlated with most liver condition indices in patients with CHB and ***,these correlations varied according to differences in HBV-DNA and transaminase concentrations.

关键词： Liver function Liver stiffness Elastography Chronic hepatitis B Hepatocellular carcinoma

Assembling molybdenum-doped platinum clusters into a coral-like nanostructure for highly enhanced oxygen reduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

eScience 2024年第1期4卷 123-131页

作者： Linwei Zheng Mang Niu Tiantian zeng Xiaohang Ge Yanrui Wang Chun xian Guo Weiyong Yuan Dapeng Cao Lian Ying Zhang Chang Ming Li Institute of Materials for Energy and Environment Institute of Biochemical EngineeringCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China Institute for Materials Science and Devices School of Materials Science and EngineeringSuzhou University of Science and TechnologySuzhou 215011PR China Ningbo Research Institute Zhejiang UniversityNingbo 315100China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

Regulating the electronic and geometric structures of electrocatalysts is an effective strategy to boost their catalytic ***,a coral-like nanostructure is assembled with Mo-doped Pt clusters to form a highly active catalyst toward the oxygen reduction reaction(ORR).The advantages of a Mo-doped porous skeleton,grain boundaries,and MoOx species on the Pt cluster surfaces synergistically boost the electrocatalytic *** unique architecture delivers 3.5-and 2.8-fold higher mass and specific activities,respectively,than commercial Pt/*** functional theory calculations reveal that the Mo-doped Pt clusters have an optimized Pt–O bond length of 2.110Å,which weakens the adsorption energy of the intermediate O*to yield great ORR ***,the catalyst shows a decay in the half-wave potential of only 8 mV after 10,000 cycles of accelerated durability *** high stability arises from the increased dissociation energy of Pt atoms and the stable architecture of the coral-like structure of clusters.

关键词： Pt clusters Mo doping Porous structure Pt-O bond Oxygen reduction reaction

Effects of oral probiotics on inflammation and intestinal function in adult patients after appendectomy:Randomized controlled trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第5期16卷 1371-1376页

作者： Ke Lan Ke-Rui zeng Fu-Rui zhong Sheng-Jin Tu Jin-Long Luo Shi-Long Shu Xue-Feng Peng Hua Yang Kai Lu Department of General Surgery Zigong Fourth People's HospitalZigong 643000Sichuan ProvinceChina

BACKGROUND Appendectomy is an acute abdominal surgery that is often accompanied by severe abdominal *** probiotics are one of the postoperative treatments for rapid ***,there is a lack of prospective studies on this topic after *** To investigate whether the postoperative probiotics can modulate the inflammatory response and restore intestinal function in patients following *** This was a prospective,randomized trial.A total of 60 emergency patients were randomly divided into a control group(n=30)and a probiotic group(n=30).Patients in the control group started to drink some water the first day after surgery,and those in the probiotic group were given water supplemented with Bacillus licheniformis capsules for 5 consecutive days *** indices of inflammation and postoperative conditions were recorded,and the data were analyzed with RStudio 4.3.2 *** A total of 60 participants were *** with those in the control group,the C-reactive protein(CRP),interleukin 6 and procalcitonin(PCT)levels were significantly lower in the probiotic group at 2 d after surgery(P=2.224e-05,P=0.037,and P=0.002,respectively,all P<0.05).This trend persisted at day 5 post-surgery,with CRP and PCT levels remaining significantly lower in the probiotic group(P=0.001 and P=0.043,both P<0.05).Furthermore,probiotics0.028,both P<0.05).CONCLUSION Postoperative oral administration of probiotics may modulate the gut microbiota,benefit the recovery of the early inflammatory response,and subsequently enhance recovery after appendectomy.

关键词： Probiotics Gut microbiota Appendectomy Inflammatory markers Intestinal function Enhanced recovery after surgery Postsurgical infections

Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-Sheng LAN Shuo CHEN You-Yi HUANG Lan-Jin WU Zhi-Qing QIN Ying HUANG Wan-zhong HUANG Ting zeng Xin HAO Hua-Bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

在线全文

学校读者我要写书评

暂无评论

不同制备工艺的温拌橡胶沥青性能

公路交通科技 2024年第3期41卷 26-34页

作者：钟献科广东粤海珠三角供水有限公司广东广州511458

为了研究不同制备工艺的温拌橡胶沥青性能差异,分析温拌橡胶最佳的制备工艺,分别制备了3种不同制备工艺的温拌橡胶沥青,包括:先制备橡胶沥青,再与温拌剂混合;先混合温拌剂与橡胶颗粒,再制备温拌橡胶沥青;制备橡胶沥青过程中加入温拌剂... 详细信息

为了研究不同制备工艺的温拌橡胶沥青性能差异,分析温拌橡胶最佳的制备工艺,分别制备了3种不同制备工艺的温拌橡胶沥青,包括:先制备橡胶沥青,再与温拌剂混合;先混合温拌剂与橡胶颗粒,再制备温拌橡胶沥青;制备橡胶沥青过程中加入温拌剂。通过开展不同制备工艺的温拌橡胶沥青针入度试验、软化点试验、流变试验与红外光谱试验,分析不同制备工艺的温拌橡胶沥青针入度、软化点、车辙因子、相位角、疲劳因子、劲度模量与化学组成的指标差异,研究温拌剂以及不同制备工艺对橡胶沥青性能的影响。同时,采用不同制备工艺的温拌橡胶沥青进行沥青混合料试件成型,研究适宜的击实温度及路用性能,包括高温稳定性、低温抗裂性与水稳定性。结果表明:温拌剂的掺入将导致橡胶沥青针入度增大,软化点减小,抗车辙性能下降,但不会对橡胶沥青的低温抗裂性与抗疲劳性能产生影响;温拌剂可有效降低混合料的击实温度,不会对橡胶沥青混合料的低温抗裂性与水稳定性产生影响,但其将导致混合料的抗车辙性能下降;提前混合温拌剂与橡胶颗粒的制备工艺可以增加橡胶颗粒与沥青的溶合效应,将温拌剂对橡胶沥青抗车辙性能的影响减少到最低,同时可以降低橡胶沥青与橡胶沥青混合料的生产温度,在3种不同制备工艺中具有明显的优势。

关键词：道路工程制备工艺试验研究温拌橡胶沥青流变性能抗车辙性能