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Asian Journal of Andrology 2016年第3期18卷 485-491,I0012页

作者： Xing-Fa Han Jun-Li Li Yu-Qin Zhou Xiao-Hua Ren Gong-Cheng Liu Xiao-Han Cao Xiao-Gang Du xian-yin zeng Isotope Research Biological Engineering and Application Biology Department Laboratory Sichuan Agricultural University Ya'an 625014 People's Republic of China.

GnRH sterilization vaccines have been developed for various practical and clinical reasons. However, conjugation of GnRH peptide to carrier protein has many drawbacks, hampering the further commercialization of GnRH vaccines. In this study, a new nonconjugated GnRH vaccine, D-Lys6-GnRH-tandem-dimer peptide （TDK）, emulsified in Specol adjuvant was investigated for its immunocastration efficacy in young male rats. Prepubertal male rats were randomly allocated into three groups （n = 12）： control （no treatment）, surgically castrated or immunized against 100 μg TDK in Specol adjuvant at 6 weeks of age （with a booster 8 weeks later）. Blood samples （for antibody titers and hormone concentrations） were collected at 2-week intervals until rats were killed （18 weeks of age）. Compared to intact controls, active immunization against TDK reduced （P〈 0.05） serum concentrations of testosterone, inhibin B, LH and FSH, prevented the onset of spermatogenesis at puberty. Furthermore, mRNA expressions of GnRH receptor, LH-β and FSH-β in the pituitary, LH receptor, FSH receptor, inhibin α, βA and βB subunit in the testes were decreased in immunocastrated rats compared to intact controls （P 〈 0.05）. These results demonstrate for the first time that GnRH-tandem-dimer peptide emulsified in Specol is a promising veterinary sterilization medicine.

关键词： GnRH nonconjugation rat reproductive axis sterilization

Mucosal and systemic immunity in mice after intranasal immunization with recombinant Lactococcus lactis expressing ORF6 of PRRSV

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Mucosal and systemic immunity in mice after intranasal immun...

Flexible Strain Sensors with Ultra-High Sensitivity and Wide Range Enabled by Crack-Modulated Electrical Pathways

中国畜牧兽医学会动物微生态学分会第十一次全国学术研讨会暨第五届会员代表大会

作者： Zhen-hua Wang Xiao-han Cao Xiao-gang Du Hai-bo Feng Di-Wang He-Song xian-yin zeng Department of Animal and Veterinary Science Chengdu Vocational College of Agricultural Science and Technology Isotope Research Laboratory College of Life and Basic SciencesSichuan Agricultural University Department of Veterinary Medicine Southwest University

The purpose of the study was to construct mucosal vaccine of a recombinant *** expressing PRRSV ORF6 gene and evaluate mucosal and systemic immune response against PRRSV in mice after intranasal *** result show that the vaccine can stimulate mice to produce specific IgG in serum and remarkable special s-IgA in lung lavage fluid,at the same time,the contents of cytokines IL-2 and IFN-γ of the experimental group were significant higher than those of the control group(P<0.01),however,the contents of cytokines IL-4 was not different to the all *** summary,the constructed mucosal vaccine can significantly induce mucosal immune,humoral immunity and cellular immunity involved Th1 type cytokines,which will lay a theoretical foundation on immune mechanism and new efficient vaccines for PRRSV.

关键词： L.lactis Intranasal immunization mucosal immunity PRRSV-ORF6

来源： cnki会议评论

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NANO-MICRO LETTERS 2025年第1期17卷 1-19页

作者： Bai, Yunzhao Zhou, Yunlei Wu, Xuanyu yin, Mengfei yin, Liting Qu, Shiyuan Zhang, Fan Li, Kan Huang, Yongan Huazhong Univ Sci & Technol State Key Lab Intelligent Mfg Equipment & Technol Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Flexible Elect Res Ctr Wuhan 430074 Peoples R China Xidian Univ Hangzhou Inst Technol Hangzhou 311200 Peoples R China Xidian Univ Sch Mechanoelect Engn Xian 710071 Peoples R China Univ Southern Calif Dept Aerosp & Mech Engn Los Angeles CA 90089 USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultra-high sensitivity and wide-range sensor, addressing the critical challenge of reconciling sensitivity with measurement range. Inspired by the structure of bamboo slips, we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode. The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%. The integration of patterned liquid metal enables customisable tuning of the sensor's response, while the porous fabric structure ensures superior comfort and air permeability for the wearer. Our design not only optimises the sensor's performance but also enhances the electrical stability that is essential for practical applications. Through systematic investigation, we reveal the intrinsic mechanisms governing the sensor's response, offering valuable insights for the design of wearable strain sensors. The sensor's exceptional performance across a spectrum of applications, from micro-strain to large-strain detection, highlights its potential for a wide range of real-world uses, demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

Synthesis of Terpyridine Derivatives Containing β-Cyclodextrin

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Chinese Chemical Letters 2003年第5期14卷 445-447页

作者： xian Hong yin Department of Chemistry Guangxi University for NationalitiesNanning 530006

A novel b-cyclodextrin-based terpyridine derivatives has been prepared by the coupling of 4-(4-bromomethyl phenyl)- 2, 2:6, 2-terpyridine with mono-6-hydroxy permethylated b- cyclodextrin. The cyclodextrin dimmer appending a 4-phenyl-2,2:6,2- terpyridine spacer on the primary faces was synthesized by reaction of 4-phenyl-2,2:6,2-terpyridine-6,6-dicarbonitrile with an excess of 6-deoxy-6-O-tosyl-b-cyclodextrin.

关键词： Cyclodextrin terpyridine synthesis.

Ultrasound-guided needle release plus corticosteroid injection of superficial radial nerve:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1320-1325页

作者： zeng zeng Cong-xian Chen Department of Ultrasound Zhejiang Provincial People's HospitalHangzhou 310000Zhejiang ProvinceChina

BACKGROUND The radial nerve(RN)splits into two main branches at the elbow:The superficial branch of RN(SBRN)and the deep branch of *** SBRN can be easily damaged in acute trauma due to its superficial *** SUMMARY A 55-year-old male patient injured his right wrist 10 mo ***,suturing and bandaging were performed in the emergency *** months after the scar had healed,he felt numbness and tingling in the dorsal surface of the thumb of the right *** the surgery of resection and SBRN anastomosis were *** pathological findings showed it as traumatic *** months after surgery,the patient felt numbness and tingling in the right dorsal surface of the thumb *** tenderness was marked in the operated *** indicated that the SBRN was adhered to the surrounding *** patient refused further surgical treatment and underwent ultrasound-guided needle release plus corticosteroid injection of the *** weeks later,the tenderness in the surgical area was reduced by 70%,the numbness in the dorsal surface of the thumb of the right hand was reduced by 40%and the nerve swelling evaluated by ultrasound was *** months passed,he did not feel any numbness or tingling sensation of his right *** is the first report of ultrasound-guided needle release plus corticosteroid injection of the *** Ultrasound can evaluate the condition of the RN,and the relationship with surrounding ***-guided needle release plus corticosteroid injection is an effective and safe treatment for SBRN adhesion.

关键词： Ultrasound-guided Needle release Superficial radial nerve Traumatic neuroma Corticosteroid injection Case report

Clinicopathological factors associated with pathological upgrading from biopsy to prostatectomy in patients with ISUP grade group≤2 prostate cancer

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Asian Journal of Andrology 2022年第5期24卷 487-493页

作者： Xing Li Zhi-xian Wang Yun-Peng Zhu Jing Wang Yi-Sheng yin Xiao-Yong zeng Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

We performed this study to investigate pathological upgrading from biopsy to prostatectomy and clinicopathological factors associated with grade group(GG)upgrading in patients with International Society of Urological Pathology(ISUP)GG 1 and 2 prostate cancer(PCa)in a Chinese *** included patients diagnosed with PCa with ISUP GG 1 and 2 at biopsy,who underwent RP at our ***-and postoperative clinical variables were *** and multivariate logistic regression analyses were conducted to identify independent factors associated with GG *** in GG upgraded group had higher total prostatespecific antigen(tPSA;median:14.43 ng ml^(−1) vs 10.52 ng ml^(−1),P=0.001)and PSA density(PSAD;median:0.45 ng ml^(−2) vs 0.27 ng ml^(−2),P3(86.4%vs 67.9%,P3(odds ratio[OR]:2.471,95%confidence interval[CI]:1.132–5.393;P=0.023),higher PSAD(P=0.001),and GG in biopsy(OR:0.241,95%CI:0.123–0.471;P3,and PNI were independent factors of GG *** factors should be considered for patients with ISUP grade≤2 PCa.

关键词： biopsy grade group prostate cancer radical prostatectomy upgrading

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

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Acta Pharmaceutica Sinica B 2021年第3期11卷 609-620页

作者： Jinghui Zhang Jiajun Fan xian zeng Mingming Nie Jingyun Luan Yichen Wang Dianwen Ju Kai yin Department of Gastrointestinal Surgery Changhai HospitalSecond Military Medical UniversityShanghai 200433China Department of Biological Medicines Fudan University School of PharmacyShanghai 201203China Shanghai Engineering Research Center of Immunotherapeutics Shanghai 201203China

The Hedgehog(HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment(TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug *** interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6(IL-6) and interferon-g(IFN-g), macrophages, and T cell-dependent immune responses, play a vital role in tumor growth by affecting the HH signaling pathway. Moreover, inhibition of proliferating cancer-associated fibroblasts(CAFs) and inflammatory factors can normalize the TME by suppressing HH signaling. Furthermore, aberrant HH signaling activation is favorable to both the proliferation of cancer stem cells(CSCs) and the drug resistance of gastrointestinal tumors. This review discusses the current understanding of the role and mechanism of aberrant HH signaling activation in gastrointestinal carcinogenesis, the gastrointestinal TME,tumor immune tolerance and drug resistance and highlights the underlying therapeutic opportunities.

关键词： Hedgehog Carcinogenesis Tumor microenvironment Gastrointestinal cancer Cancer stem cells Drug resistance

Effects of soil properties on production and bioaccumulation of methylmercury in rice paddies at a mercury mining area,China

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Journal of Environmental Sciences 2018年第6期30卷 194-205页

作者： Deliang yin Tianrong He Runsheng yin Lingxia zeng The Key Laboratory of Karst Environment and Geohazard Prevention Guizhou University Guiyang 550003 China College of Resources and Environments Southwest University Chongqing 400715 China State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Department of Civil and Environmental Engineering Environmental Chemistry and Technology Program University of Wisconsin-Madison Madison WI 53706 USA

Rice paddy soil is recognized as the hotspot of mercury（Hg） methylation, which is mainly a biotic process mediated by many abiotic factors. In this study, effects of key soil properties on the production and bioaccumulation of Hg and methylmercury（MeHg） in Hg-contaminated rice paddies were investigated. Rice and soil samples were collected from the active Hg smelting site and abandoned Hg mining sites（a total of 124 paddy fields） in the Wanshan Mercury Mine, China. Total Hg（THg） and MeHg in soils and rice grains, together with sulfur（S）,selenium（Se）, organic matter（OM）, nitrogen（N）, phosphorus（P）, mineral compositions（e.g., SiO2, Al2O3 and Fe2O3） and pH in soils were quantified. The results showed that long-term Hg mining activities had resulted in THg and MeHg contaminations in soil-rice system. The newly-deposited atmospheric Hg was more readily methylated relative to the native Hg already in soils, which could be responsible for the elevated MeHg levels in soils and rice grains around the active artificial Hg smelting site. The MeHg concentrations in soils and rice grains showed a significantly negative relationship with soil N/Hg, S/Hg and OM/Hg ratio possibly due to the formation of low-bioavailability Hg–S（N）–OM complexes in rhizosphere. The Hg–Se antagonism undoubtedly occurred in soil-rice system, while its role in bioaccumulation of MeHg in the MeHg-contaminated rice paddies was minor. However, other soil properties showed less influence on the production and bioaccumulation of MeHg in rice paddies located at the Wanshan Mercury Mine zone.

关键词： Rice paddy Physicochemical property Mercury mining area Mercury Methylmercury Bioaccumulation factors

Fracture gradient prediction:an overview and an improved method

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Petroleum Science 2017年第4期14卷 720-730页

作者： Jincai Zhang Shang-xian yin Geomech Energy HoustonTXUSA North China Institute of Science and Technology YanjiaoBeijing 101601China Present Address:Sinopec Tech HoustonTXUSA

The fracture gradient is a critical parameter for drilling mud weight design in the energy industry. A new method in fracture gradient prediction is proposed based on analyzing worldwide leak-off test(LOT) data in offshore drilling. Current fracture gradient prediction methods are also reviewed and compared to the proposed method. We analyze more than 200 LOT data in several offshore petroleum basins and find that the fracture gradient depends not only on the overburden stress and pore pressure, but also on the depth. The data indicate that the effective stress coefficient is higher at a shallower depth than that at a deeper depth in the shale formations. Based on this finding,a depth-dependent effective stress coefficient is proposed and applied for fracture gradient prediction. In some petroleum basins, many wells need to be drilled through long sections of salt formations to reach hydrocarbon *** fracture gradient in salt formations is very different from that in other sedimentary rocks. Leak-off test data in the salt formations are investigated, and a fracture gradient prediction method is proposed. Case applications are examined to compare different fracture gradient methods and validate the proposed methods. The reasons why the LOT value is higher than its overburden gradient are also explained.

关键词： Fracture gradient prediction Leak-off test Breakdown pressure Mud loss Fracture gradient in salt

Recent advance in porous coordination polymers from the viewpoint of crystalline-state transformation

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Science China Chemistry 2011年第9期54卷 1371-1394页

作者： yin Zheng zeng MingHua Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Ministry of EducationSchool of Chemistry&Chemical EngineeringGuangxi Normal UniversityGuilin 541004China

Recently,research of crystalline-state transformation involving the removal/inclusion of guest molecules in porous coordination polymers(PCPs) was ***-state transformation,especially,single-crystal to single-crystal(SC-SC) transformation as new method for the direct observation of host-guest chemistry,can reveal the intrinsic relevance and interaction between the framework and guest *** review describes our work concerning PCPs and recent investigations of others,within the last four years,from the viewpoint of crystalline-state transformations of PCPs on guest removal or inclusion *** substitution reaction and postsynthetic modification of PCPs in SC-SC fashion which were distinguished from conventional crystalline-state transformation triggered by guest removal or exchange were highlighted in this *** research status of crystalline-state transformation in China was briefly introduced as *** of structure analysis techniques including single-crystal X-ray diffraction,powder X-ray diffraction,neutron diffraction,inelastic neutron scattering as well as the application of synchrotron radiation light source will inevitably promote the advance of study of crystalline-state *** as a hotspot,deep investigations of crystalline-state transformation also help us to overcome the challenge of achieving multifunction and the correlation among them,such as sorption,magnetism,optical or electrical properties simultaneously in PCPs and contribute to design stimulate-oriented porous intelligent materials in the future.

关键词： porous coordination polymer crystalline-state transformation ligand substitution reaction postsynthetic modification structure analysis techniques