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The effect of bladder function on the efficacy of transurethral prostatectomy in patients with benign prostatic hyperplasia:a retrospective,single-center study

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Asian Journal of Andrology 2024年第1期26卷 112-118页

作者： Jin Li xian-yan-ling yi Ze-Yu Chen Bo Chen yin Huang Da-Zhou Liao Pu-Ze Wang De-Hong Cao Jian-Zhong Ai Liang-Ren Liu West China School of Medicine Sichuan UniversityChengdu 610041China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China

We investigated the impact and predictive value of bladder function in patients with benign prostatic hyperplasia(BPH)on the efficacy of transurethral ***,imaging,and urodynamic data of patients who underwent transurethral prostatectomy at West China Hospital of Sichuan University(Chengdu,China)from July 2019 to December 2021 were ***-up data included the quality of life(QoL),International Prostate Symptom Score(IPSS),and IPSS storage and voiding(IPSS-s and IPSS-v).Moreover,urinary creatinine(Cr),nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),and prostaglandin estradiol(PGE2)were measured in 30 patients with BPH and 30 healthy *** indicators were determined by subgroup analyses and receiver operating characteristic(ROC)curve *** the 313 patients with BPH included,patients with severe micturition problems had more improvements but higher micturition grades postoperatively than those with moderate ***,good bladder sensation,compliance,and detrusor contractility(Dc)were predictors of low postoperative IPSS and *** urinary concentrations of BDNF/Cr,NGF/Cr,and PGE2/Cr in patients were significantly higher than those in healthy participants(all P<***1).After evaluation,only DC was significantly related to both urinary indicators and postoperative recovery of *** with good DC,as predicted by urinary indicators,had lower IPSS and IPSS-v than those with reduced DC at the 1st month postoperatively(both P<0.05).In summary,patients with impaired bladder function had poor *** combined levels of urinary BDNF/Cr,NGF/Cr,and PGE2/Cr in patients with BPH may be valid predictors of preoperative bladderfunction and postoperative recovery.

关键词： BPH function of bladder IPSS:urodynamics

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Neoadjuvant chemotherapy for patients with locally advanced penile cancer:an updated evidence

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Asian Journal of Andrology 2022年第2期24卷 180-185页

作者： xian-yan-ling yi De-Hong Cao Ping-Hong You Xing-Yu Xiong Xiao-Nan Zheng Ge Peng Da-Zhou Liao Hong Li Lu yang Jian-Zhong Ai Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Urology People’s Hospital of Deyang CityDeyang 618000China Department of Endocrinology and Metabolism West China Hospital of Sichuan UniversityChengdu 610041China

Neoadjuvant chemotherapy(NAC)has shown promising results in patients with locally advanced penile ***,no consensus exists on its applications for locally advanced penile ***,it is unclear which kind of chemotherapy regimen is the best ***,a systematic search of PubMed,Web of Science,and EMBASE was performed in March 2021 to assess the efficacy and safety of NAC for the treatment of patients with locally advanced penile *** Newcastle–Ottawa Scale was used to assess the risk of bias in each *** study synthesized 14 published *** study revealed that patients who achieved an objective response to NAC obtained a better survival outcome compared with those who did not achieve an objective *** addition,the objective response rates(ORRs)and pathological complete response(pCR)rates were 0.57 and 0.11,*** incidence of grade≥3 toxicity was *** analysis found that the ORR and pCR of the taxane–platinum(TP)regimen group performed better than those of the nontaxane–platinum(NTP)regimen group(0.57 vs 0.54 and 0.14 vs 0.07,respectively).Moreover,the TP regimen group had more frequent toxicity than the NTP regimen group(0.41 vs 0.26).However,further studies were warranted to confirm the findings.

关键词： chemotherapy regimen locally advanced penile cancer neoadjuvant chemotherapy response rate

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ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression

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Military Medical Research 2024年第5期11卷 643-662页

作者： Hang Xu yi-Fan Li xian-yan-ling yi Xiao-Nan Zheng yang yang yan Wang Da-Zhou Liao Jia-Peng Zhang Ping Tan Xing-Yu Xiong Xi Jin Li-Na Gong Shi Qiu De-Hong Cao Hong Li Qiang Wei Lu yang Jian-Zhong Ai Department of Urology West China HospitalSichuan UniversityChengdu610041China Institute of Urology West China HospitalSichuan UniversityChengdu610041China Animal Experimental Center West China HospitalSichuan UniversityChengdu610041China Research Core Facility West China HospitalSichuan UniversityChengdu610041China

Background Cell metabolism plays a pivotal role in tumor progression,and targeting cancer metabolism might effectively kill cancer *** aimed to investigate the role of hexokinases in prostate cancer(PCa)and identify a crucial target for PCa *** The Cancer Genome Atlas(TCGA)database,online tools and clinical samples were used to assess the expression and prognostic role of ADP-dependent glucokinase(ADPGK)in *** effect of ADPGK expression on PCa cell malignant phenotypes was validated in vitro and in *** proteomics,metabolomics,and extracellular acidification rate(ECAR)and oxygen consumption rate(OCR)tests were performed to evaluate the impact of ADPGK on PCa *** underlying mechanisms were explored through ADPGK overexpression and knockdown,co-immunoprecipitation(Co-IP),ECAR analysis and cell counting kit-8(CCK-8)*** ADPGK was the only glucokinase that was both upregulated and predicted worse overall survival(OS)in prostate adenocarcinoma(PRAD).Clinical sample analysis demonstrated that ADPGK was markedly upregulated in PCa tissues ***-PCa *** ADPGK expression indicates worse survival outcomes,and ADPGK serves as an independent factor of biochemical *** vitro and in vivo experiments showed that ADPGK overexpression promoted PCa cell proliferation and migration,and ADPGK inhibition suppressed malignant ***,proteomics,and ECAR and OCR tests revealed that ADPGK significantly accelerated glycolysis in ***,ADPGK binds aldolase C(ALDOC)to promote glycolysis via AMP-activated protein kinase(AMPK)*** was positively correlated with ADPGK,and high ALDOC expression was associated with worse survival outcomes in *** In summary,ADPGK is a driving factor in PCa progression,and its high expression contributes to a poor prognosis in PCa *** accelerates PCa glycolysis and progression by activating ALDOC-AMPK signaling,suggesting

关键词： Prostate cancer(PCa) ADP-dependent glucokinase(ADPGK) Aldolase C(ALDOC) AMPK Glycolysis

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Morphogenesis of Pistillate Flowers of Cercidiphyllum japonicum(Cercidiphyllaceae)

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Journal of Integrative Plant Biology 2007年第9期49卷 1400-1408页

作者： Xiao-ling yan yi Ren xian-Hua Tian Xiao-Hui Zhang College of Life Sciences Shaanxi Normal University Key Laboratory of Medicinal Plant Resource and Natural Pharmaceutical Chemistry of Ministry of Education Xi'an 710062 China

Floral morphogenesis and the development of Cercidiphyllumjaponicum Sieb. et Zucc. were observed by scanning electron microscopy （SEM）. The results showed that the pistillate inflorescences were congested spikes with the flowers arranged opposite. Great differences between the so-called ＂bract＂ and the vegetative leaf were observed both in morphogenesis and morphology. In morphogenesis, the ＂bract＂ primordium is crescent-shaped, truncated at the apex and not conduplicate, has no stipule primordium at the base but does have some inconspicuous teeth in the margin that are not glandular. The leaf primordium is triangular, cycloidal at the apex, conduplicate, has two stipule primordia at the base, has one gland-tooth at the apex occurring at first and some gland-teeth in the margin that occur later. In morphology, the ＂bract＂ is also different to the vegetative leaf in some characteristics that were also illustrated in the present paper. Based on the hypothesis that the bract is more similar to the vegetative leaf than the tepal, we considered that the so-called ＂bract＂ of *** might be the tepal of the pistillate flower in morphological nature. Therefore, each pistillate flower contains a tepal and a carpel. We did not find any trace of other floral organs in the morphogenesis of the pistillate flower. Therefore we considered that the unicarpellate status of extant Cercidiphyllum might be to highly reduce and advance characteristics that make the extant Cercidiphyllum isolated from both fossil Cercidiphyllum-like plants and its extant affinities.

关键词： Cercidiphyllumjaponicum leaf morphogenesis pistillate flower tepal.

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Clinical utility of two-dimensional shear-wave elastography in monitoring disease course in autoimmune hepatitis-primary biliary cholangitis overlap syndrome

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World Journal of Gastroenterology 2022年第18期28卷 2021-2033页

作者： Yu-ling yan xian Xing yi Wang Xiao-Ze Wang Zhi Wang Li yang Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Sichuan University University of Oxford Huaxi Joint for Gastrointestinal Cancer CentreChengdu 610207Sichuan ProvinceChina

BACKGROUND Autoimmune hepatitis-primary biliary cholangitis(AIH-PBC)overlap syndrome has a worse prognosis than AIH or PBC ***,accurately staging liver fibrosis and dynamically monitoring disease progression are *** To investigate the performance of two-dimensional shear-wave elastography(2DSWE)for noninvasively staging liver fibrosis and assessing the clinical utility of repeated 2D-SWE for monitoring treatment response in AIH-PBC overlap *** A total of 148 patients diagnosed with AIH-PBC overlap syndrome were retrospectively *** them,82 patients had a 2D-SWE follow-up time of more than 1 *** Scheuer scoring system was used to evaluate stages of hepatic inflammation and liver *** performance of 2D-SWE for staging liver fibrosis was evaluated with the liver *** in liver stiffness(LS)measured by 2D-SWE in patients with or without complete biochemical remission were *** LS value was strongly correlated with liver fibrosis stage(Spearman r=0.84,P<0.0001).The areas under the receiver operating characteristic curves of LS for diagnosing significant fibrosis(≥S2),severe fibrosis(≥S3),and cirrhosis(S4)were 0.91,0.97,and 0.96,*** with complete biochemical remission had a considerable decrease in LS values(P<0.0001).More importantly,the declined LS in patients with S0-S2 was significantly lower than that in patients with S3-S4(P=0.0002).In contrast,patients who failed to achieve biochemical remission had a slight but not significant decrease in LS(P=0.37).CONCLUSION LS measured by 2D-SWE is an accurate and reliable method in assessing liver fibrosis,especially for diagnosing severe fibrosis(≥3)and monitoring treatment response in patients with AIH-PBC overlap syndrome.

关键词： Liver fibrosis Liver biopsy Diagnostic tests Autoimmune hepatitis Primary biliary cholangitis Inflammation

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Identification of winter long-lasting regional extreme low-temperature events in Eurasia and their variation during 1948—2017

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Advances in Climate Change Research 2021年第3期12卷 353-362页

作者： ZHANG ying-xian LIU yan-Ju DING yi-Hui Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing100081China

Compared with short-duration events,long-lasting regional extreme low-temperature events(RELTEs)often have more severe impacts on human societies due to the induced persistence and large geographic area of related weather and climate ***,an improved objective technique was applied to identify all long-lasting RELTEs in Eurasia from the winter of 1948/1949 to 2017/2018,followed by an in-depth discussion of its variation in terms of the annual frequency,duration,impacted area,mean intensity,maximum intensity,and a comprehensive *** RELTE lasting for 52 d in the winter of 2007/2008 exhibited the longest duration,largest impacted area,and a greatest comprehensive index,which induced extremely low temperatures for more than 20 d in Western Asia,Central Asia,and *** the past 70 winters,the frequency of long-lasting RELTEs decreased,especially after the late ***,the mean and maximum intensities and comprehensive index exhibited distinctly increasing *** indicators of winter long-lasting RELTEs had a similar inter-decadal fluctuation featured by two noticeable peaks occurring around 1970 and 2007,and a remarkable recovery was discovered in the period of late 1990s to mid-2010s,especially for the occurrence of super long-lasting ***,winter long-lasting RELTEs in Eurasia showed distinct trends under various decadal climate backgrounds,i.e.,a strong negative or weak positive trend in the accelerated warming period and conversely,a strong positive or weak negative trend in the wanning slowdown *** findings indicate that we should be alert of the similar future recovery of winter long-lasting RELTEs in Eurasia,which are likely to occur in the slowdown period of global warming.

关键词： Regional extreme low-temperature events Winter Long-lasting Eurasia Climate variation

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Entanglement entropy of an annulus in holographic thermalization

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Chinese Physics C 2020年第2期44卷 24-32页

作者： yi ling Yuxuan Liu Zhuo-Yu xian Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049China School of Physics University of Chinese Academy of Sciences Beijing 100049China Institute of Theoretical Physics Chinese Academy of Science Beijing 100190China

The thermalization process of the holographic entanglement entropy(HEE)of an annular domain is investigated in the Vaidya-AdS *** determine numerically the Hubeny-Rangamani-Takayanagi(HRT)surface,which may be a hemi-torus or two disks,depending on the ratio of the inner radius to the outer radius of the *** importantly,for some fixed ratio of the two radii,the annulus undergoes a phase transition,or a double phase transition,during thermalization from a hemi-torus to a two-disk configuration,or vice *** occurrence of various phase transitions is determined by the ratio of the two radii of the *** rate of entanglement growth is also investigated during the thermal *** local maximal rate of entanglement growth occurs in the region with a double phase ***,if the quench process is sufficiently slow,which may be controlled by the thickness of the null shell,the region with a double phase transition vanishes.

关键词： holographic entanglement entropy thermal quench annulus

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Effect of Rare Earth and Cooling Process on Microstructure and Mechanical Properties of an Ultra-Cleaned X80 Pipeline Steel

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Acta Metallurgica Sinica(English Letters) 2021年第5期34卷 639-648页

作者： He Duan yi-yin Shan Ke yang xian-Bo Shi Wei yan yi Ren Institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China State Key Laboratory of Metal Materials and Application for Marine Equipment Anshan114009China

In order to explore the eff ect of a small amount of rare earth addition in ultra-cleaned pipeline steel and the influence of the cooling process on the tensile and impact properties,three API X80 pipeline steels were fabricated by varying RE addition and the cooling process at the same *** microstructures with different features for a low C high Nb microalloyed high-strength pipeline steel and the corresponding mechanical properties were *** results showed that even in the ultra-cleaned steel with O and S contents less than 10 ppm,the addition of RE would still cause an increase in the volume fraction of inclusions consisting of complicated RE oxysulfide and RE *** inclusions formed in the 112 ppm RE steel were harmful to the low temperature toughness,while few inclusions formed in the 47 ppm RE steel had almost no influence on the low temperature *** two RE additions had no effect on strength of the *** the finishing cooling temperature was increased and the cooling rate was decreased within a certain range,the volume fractions of polygonal ferrite and quasi-polygonal ferrite as well as the number density and size of martensite–austenite islands were *** such combined effect,the strength of the steels had almost no *** the finishing cooling temperature was increased from 481 to 584℃and the cooling rate was reduced from 20 to 13℃/s,for the steel with 112 ppm addition of RE,there was an obvious decrease in the low temperature *** reduced value(about 33 J)of the USE of steel consisted of two parts including the influence(about 18 J)of more inclusions formed due to 112 ppm addition of RE and the eff ect(about 15 J)of the lower high-angle grain boundaries.

关键词： Low temperature toughness Cooling process High-angle grain boundaries(HAGBs) Ductile–brittle transition temperature(DBTT) Rare earth Inclusions

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Informational uncertainties of risk assessment about accidents of chemicals

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Journal of Environmental Sciences 2001年第1期13卷 69-74页

作者： ZHANG yi-xian Suzhou Institute of Urban Construction and Environmental Protection Suzhou 215011China

An analysis system of informational uncertainties for accidental risk assessment of chemicals is introduced. Statistical test methods and fuzzy sets method can do the quantitative analysis of the input parameters. The uncerainties of the model can be used by quantitative compared method for the leakage accidents of chemicals. The estimation of the leaking time is important for discussing accidental source term. The uncertain analyses of the release accident for pipeline gas (CO) liquid chlorine and liquid propane gas (LPG) have been discussed.

关键词： uncertainty risk assessment accident chemicals pipeline gas liquid chlorine LPG

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A negative regulator of synaptic development:MDGA and its links to neurodevelopmental disorders

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World Journal of Pediatrics 2019年第5期15卷 415-421页

作者： Rui Wang Jia-xian Dong Lu Wang Xin-yan Dong Eitan Anenberg Pei-Fang Jiang ling-Hui Zeng yi-Cheng Xie Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Department of Clinical Medicine Zhejiang University City CollegeHangzhou 310015China

Background Formation of protein complexes across synapses is a critical process in neurodevelopment,having direct implications on brain function and animal ***,we present the understanding,importance,and potential impact of a newly found regulator of such a key *** sources A systematic search of the literature was conducted on PubMed(Medline),Embase,and Central-Cochrane *** Membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor proteins(MDGAs)were recently discovered to regulate synaptic development and transmission via suppression of neurexins-neuroligins transsynaptic complex *** also regulate axonal migration and *** the context of their physiological role,we begin to consider the potential links to the etiology of certain neurodevelopmental *** present the gene expression and protein structure of MDGAs and discuss recent progress in our understanding of the neurobiological role of MDGAs to explore its potential as a therapeutic *** MDGAs play a key role in neuron migration,axon guidance and synapse development,as well as in regulating brain excitation and inhibition balance.

关键词： Adhesion molecule E/I balance Neurodevelopmental disorders Synapse

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