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Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic

Asian Journal of Andrology 2024年第1期26卷 41-45页

作者： Shun Bai Ming-Zhen Li Yang-Yang Wan Xue-Chun Hu Yi-Xun Liu xian-hong tong tong-Hang Guo Lu Zong Ran Liu Yuan-Qi Zhao Ping xiang Bo Xu Xiao-Hua Jiang Department of Gynecology and Obstetrics Reproductive and Genetic HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China NHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital)Guangzhou 510600China Department of Urology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Wannan Medical College Wuhu 241002China

Genetic risk factors have been shown to contribute to the development of sexual ***,the role of methylenetetrahydrofolate reductase(MTHFR)gene variants in the risk of erectile dysfunction(ED)remains *** this study,we recruited 1254 participants who underwent ED assessed by the International Index of Erectile *** MTHFR c.677C>T variant was also measured by fluorescence polymerase chain reaction(PCR).No significant difference in the genotypic frequency of the MTHFR C677T polymorphism(CC,CT,and TT)was observed between men from the ED and non-ED *** addition,on binary logistic regression analysis,both crude and adjusted models showed that the risk of ED was not significantly associated with the C677T ***,a significantly higher frequency of the 677TT polymorphism was found in severe and moderate ED(P=O.02).The positive correlation between the MTHFR 677TT polymorphism and severe ED was confirmed by logistic regression analysis,even after adjusting for potential confounders(odds ratio[OR]=2.46,95%confidence interval[CI]:1.15-5.50,P=0.02).These findings suggest a positive correlation between the MTHFR 677TT polymorphism and the risk of severe *** of MTHFR gene polymorphisms may provide complementary information for ED patients during routineclinicaldiagnosis.

关键词： erectile dysfunction gene variant genetic risk factors methylenetetrahydrofolate reductase sexual function

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Association between semen collection time and semen parameters:an observational study

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Asian Journal of Andrology 2023年第3期25卷 339-344页

作者： Shun Bai xian-Chao Dou Hao-Lin Qi Yan-Song Zhu Yin-Tao Zhang Yi-Xun Liu Xue-Chun Hu Cheng Cao xian-hong tong Bo Xu Li-Min Wu Xiao-Hua Jiang Reproductive and Genetic Hospital The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China School of Medical Imaging Bengbu Medical UniversityBengbu 233030China The First Clinical Medical School Anhui Medical UniversityHefei 230022China School of Life Science Anhui Medical UniversityHefei 230022China Department of Biochemistry and Molecular Biology Anhui Medical UniversityHefei 230022China Department of Urology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

The process of semen collection plays a key role in the quality of semen ***,the association between semen collection time and semen quality is still *** this study,ejaculates by masturbation from 746 subfertile men or healthy men who underwent semen analysis were *** median(interquartile range)semen collection time for all participants was 7.0(5.0-11.0)min,and the median time taken for semen collection was lower in healthy men than that in subfertile men(6.0 min vs 7.0 min).An increase in the time required to produce semen samples was associated with poorer semen *** those undergoing assisted reproductive technology(ART),the miscarriage rate was positively correlated with the semen collection *** adjusting for confounders,the highest quartile(Q4)of collection time was negatively associated with semen volume and sperm concentration.A longer time to produce semen samples(Q3 and Q4)was negatively correlated with progressive and total sperm *** addition,there was a significant negative linear association between the semen collection time and the sperm *** risks of asthenozoospermia(adjusted odds ratio[OR]=2.06,95%confidence interval[CI]:1.31-3.25,P=0.002)and teratozoospermia(adjusted OR=1.98,95%CI:1.10-3.55,P=0.02)were observed in Q3 than those in *** results indicate that a higher risk of abnormal semen parameter values was associated with an increase in time for semen collection,which may be related to male fertility through its association with semen quality.

关键词： asthenozoospermia semen collection time semen quality teratozoospermia

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Association of sexually transmitted infection with semen quality in men from couples with primary and secondary infertility

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Asian Journal of Andrology 2022年第3期24卷 317-322页

作者： Shun Bai Yuan Li Mei-hong Hu Li Wu Li-Jun Shui Xiao-Han Wang Yi-Xun Liu Qiu-Ling Yue Li-Na Yu Kai-Qiang Fu xian-hong tong Xue-Chun Hu Bo Xu Reproductive and Genetic Hospital The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Dermatology Department The Fifth People’s Hospital of Hainan ProvinceHaikou 570100China Provincial Hospital Affiliated to Anhui Medical University Hefei 230001China Department of Urology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China College of Veterinary Medicine Qingdao Agricultural UniversityQingdao 266109China

This study aims to compare the prevalence of sexually transmitted infections(STIs)with semen quality in men from couples with primary and secondary *** samples were collected from 133 men who requested fertility *** tract infection with Ureaplasma spp.(UU),Mycoplasma hominis(MH),Mycoplasma genitalium(MG),Chlamydia trachomatis(CT),Neisseria gonorrhoeae(NG),and herpes simplex virus-2(HSV-2)was assessed by PCR-based diagnostic *** all patients,the prevalence of STIs was higher in men from couples with primary infertility than that in men from couples with secondary infertility(39.7%vs 21.7%,P=0.03).The prevalence of UU was 28.8%and 13.3%in men from couples with primary and secondary infertility,*** from couples with primary infertility were more likely to be positive for UU than men from couples with secondary infertility(P=0.04).Regarding the UU subtype,the prevalence of Ureaplasma urealyticum(Uuu)and Ureaplasma parvum(Uup;including Uup1,Uup3,Uup6,and Uup14)did not differ between the two *** associations between the prevalence rates of MH,MG,and CT were found in men from either infertility group.A lower sperm concentration was associated with STI pathogen positivity in men with primary infertility according to the crude model(P=0.04).The crude and adjusted models showed that semen volume(both P=0.03)and semen leukocyte count(both P=0.02)were independently associated with secondary *** findings suggest the importance of classifying the type of infertility during routine diagnosis of seminal tract infections.

关键词： primary infertility secondary infertility semen parameters sexually transmitted infections

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Extract lithium from clay-type lithium ore by mixed acid and its mechanism Author links open overlay panel

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Particuology 2024年第8期91卷 323-332页

作者： Wuchang Zhou Ruiqi Xie Xiong tong xian Xie Yang Liu Zhihui Zhao Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China Technology Innovation Center for Comprehensive Utilization of Strategic Mineral Resources Ministry of Natural ResourcesChengdu610041China National&Regional Engineering Research Center for Green comprehensive Utilization of Tailing Resources from Metal Minerals Kunming650093China

A roasting-leaching test was carried out for the efficient utilization of clay-type lithium ore in the central region of Yunnan *** test used the mixed acid of sulfuric acid and phosphoric acid as the leaching *** the conditions of roasting temperature of 600℃,roasting time of 1 h,liquid-solid ratio of 5:1,volume ratio of H_(2)SO_(4)solution to H_(3)PO_(4)solution of 45:5,leaching time of 2 h and leaching temperature of 80℃,the leaching rate of lithium was as high as 97.83%.The leaching mechanism was studied by SEM,pore property analysis,XRD and *** was found that the morphology of the ore changed obviously after roasting and leaching,and a certain degree of collapse and fragmentation occurred,which provided favorable spatial conditions for the leaching of *** porosity,total intrusion volume and total pore area also increased after roasting and leaching,thus promoting the leaching of Li^(+).The results showed that chemical reaction taken placed during the roasting and *** phase of the sample changed from chlorite,kaolinite and diaspore(boehmite)mainly to corundum,hematite,periclase and quartz after ***,after leaching,no new phase was produced in the ore sample,and no S and P elements were found on the surface of the ore sample,indicating that the leaching mechanism of lithium might be the ion exchange between H^(+)and Li^(+).

关键词： Clay-type lithium ore Lithium extraction Roasting Leaching

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Review of the research on the development and utilization of clay-type lithium resources

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Particuology 2024年第4期87卷 46-53页

作者： Ruiqi Xie Zhihui Zhao Xiong tong xian Xie Qiang Song Peiqiang Fan Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China Yunnan Engineering Research Center for Metal Tailings Resource Utilization Kunming650093China

Since the demands for lithium have been in explosive growth recently and several great clay lithium resources were founded in China,the development and utilization of clay-type lithium resources become a hot *** order to provide a guidance for the concentration and extracting lithium of clay-type lithium resources,this review systematically summarized the main types and characteristics of clay-type lithium resources and the research status of lithium extraction from clay lithium ***,the flotation research status of the main mineral of clay lithium ore was also ***,we discussed the difficulties in the development and utilization of clay-type lithium ore and put forward the subsequent research *** paper can provide a guidance for the con-centration and extracting lithium of clay-type lithium resources in the future.

关键词： Clay lithium Clay mineral flotation Lithium extraction Leaching

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Impact of scandium and terbium on the mechanical properties,corrosion behavior,and biocompatibility of biodegradable Mg-Zn-Zr-Mn alloys

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Journal of Magnesium and Alloys 2024年第2期12卷 546-572页

作者： Khurram Munir Jixing Lin xian tong Arne Biesiekierski Yuncang Li Cuie Wen School of Engineering RMIT UniversityMelbourneVictoria 3001Australia School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325027China

Magnesium(Mg)-based bone implants degrade rapidly in the physiological environment of the human body which affects their structural integrity and biocompatibility before adequate bone *** earth elements(REEs)have demonstrated their effectiveness in tailoring the corrosion and mechanical behavior of Mg *** study methodically investigated the impacts of scandium(Sc)and terbium(Tb)in tailoring the corrosion resistance,mechanical properties,and biocompatibility of Mg–0.5Zn–0.35Zr–0.15Mn(MZZM)alloys fabricated via casting and hot *** indicate that addition of Sc and Tb improved the strength of MZZM alloys via grain size reduction and solid solution strengthening *** extruded MZZM–(1–2)Sc–(1–2)Tb(wt.%)alloys exhibit compressive strengths within the range of 336–405 MPa,surpassing the minimum required strength of 200 MPa for bone implants by a significant *** polarization tests revealed low corrosion rates of as–cast MZZM(0.25 mm/y),MZZM–2Tb(0.45 mm/y),MZZM–1Sc–1Tb(0.18 mm/y),and MZZM–1Sc–2Tb(0.64 mm/y),and extruded MZZM(0.17 mm/y),MZZM–1Sc(0.15 mm/y),MZZM-2Sc(0.45 mm/y),MZZM-1Tb(0.17 mm/y),MZZM-2Tb(0.10 mm/y),MZZM–1Sc-1Tb(0.14 mm/y),MZZM-1Sc-2Tb(0.40 mm/y),and MZZM–2Sc–2Tb(0.51 mm/y)alloys,which were found lower compared to corrosion rate of high-purity Mg(~1.0 mm/y)reported in the ***,addition of Sc,or Tb,or Sc and Tb to MZZM alloys did not adversely affect the viability of SaOS2 cells,but enhanced their initial cell attachment,proliferation,and spreading shown via polygonal shapes and *** study emphasizes the benefits of incorporating Sc and Tb elements in MZZM alloys,as they effectively enhance corrosion resistance,mechanical properties,and biocompatibility simultaneously.

关键词： Corrosion property In vitro cytotoxicity Magnesium alloys Mechanical property Rare earth elements

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Exploring the Interplay between Local Chain Structure and Stress Distribution in Polymer Networks

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Chinese Journal of Polymer Science 2024年第6期42卷 874-885页

作者： Jin-tong Xue Yang Bai Li Peng xian-Bo Huang Zhao-Yan Sun School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China National-certified Enterprise Technology Center Kingfa Science and Technology Co.Ltd.Guangzhou510663China

The mechanical behavior of polymer networks is intrinsically correlated with the local chain topology and chain *** this study,we delve into this relationship through the lens of coarse-grained molecular dynamics(CG-MD)*** aim is to illuminate the intricate interplay between local topology and stress distribution within polymer monomers,cross-linkers,and various components with distinct cross-link connections,thereby elucidating their collective impact on the mechanical properties of polymer *** mainly focus on how specific local structures contribute to the overall mechanical response of the *** particular,we employ local stress analysis to unravel the mechanics of these *** findings reveal the diverse responses of individual components,such as junctions,strands,cross-linkers between junctions,and dangling chain ends,when subjected to ***,we observe that these components exhibit varying degrees of deformation tolerance,underscoring the significance of their roles in determining the mechanical characteristics of the *** investigations highlight junctions as primary contributors to stress accumulation,and particles with higher local stress showing a stronger correlation between stress and Voronoi ***,our results indicate that both strands and cross-linkers between junctions exhibit heightened stress levels as strand lengths *** study enhances our understanding of the multifaceted factors governing the mechanical attributes of cross-linked polymer systems at the microstructural level.

关键词： Local chain structure Local stress Molecular dynamics simulation

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Flexural behavior of textile reinforced mortar-autoclaved lightweight aerated concrete composite panels

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 776-787页

作者： Liying GUO Mingke DENG Wei ZHANG tong LI Yangxi ZHANG Mengyu CAO xian HU Department of Civil Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Key Lab of Structural Engineering and Earthquake Resistance Ministry of Education(XAUAT)Xi’an 710055China Scene engineering design institute Xi’an 710016China Dahua Group Shang hai 200062China

To improve the deficiencies of prefabricated autoclaved lightweight aerated concrete(ALC)panel such as susceptibility to cracking and low load-bearing capacity,a textile-reinforced mortar-autoclaved lightweight aerated concrete(TRM-ALC)composite panel was developed in this *** group of reference ALC panels and five groups of TRM-ALC panels were fabricated and subjected to four-point flexural *** was applied on the tensile side of the ALC panels to create *** variable parameters were the plies of textile(one or two),type of textile(basalt or carbon),and whether the matrix(without textile)was applied on the compression side of *** results showed that a bonding only 8-mm-thick TRM layer on the surface of the ALC panel could increase the cracking load by 180%−520%.The flexural capacity of the TRM-ALC panel increased as the number of textile layers *** reinforcement of the matrix on the compressive side could further enhance the stiffness and ultimate loadbearing capacity of the TRM-ALC *** panels with basalt textile failed in flexural mode,with the rupture of fabric *** with carbon textile failed in shear mode due to the ultra-high tensile strength of *** addition,analytical models related to the different failure modes were presented to estimate the ultimate load-carrying capacity of the TRM-ALC panels.

关键词： prefabricated autoclaved lightweight aerated concrete panel textile-reinforced mortar cracking load flexural capacity stiffness

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Video caching and scheduling with edge cooperation

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Digital Communications and Networks 2024年第2期10卷 450-460页

作者： Zhidu Li Fuxiang Li tong Tang hong Zhang Jin Yang School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China Advanced Network and Intelligent Connection Technology Key Laboratory of Chongqing Education Commission of China Chongqing400065China Key Laboratory of Ubiquitous Sensing and Networking in Chongqing Chongqing400065China

In this paper,we explore a distributed collaborative caching and computing model to support the distribution of adaptive bit rate video *** aim is to reduce the average initial buffer delay and improve the quality of user *** the difference between global and local video popularities and the time-varying characteristics of video popularity,a two-stage caching scheme is proposed to push popular videos closer to users and minimize the average initial buffer *** on both long-term content popularity and short-term content popularity,the proposed caching solution is decouple into the proactive cache stage and the cache update *** the proactive cache stage,we develop a proactive cache placement algorithm that can be executed in an off-peak *** the cache update stage,we propose a reactive cache update algorithm to update the existing cache policy to minimize the buffer *** results verify that the proposed caching algorithms can reduce the initial buffer delay efficiently.

关键词： Video service Distributed and collaborative caching Long-term popularity Short-term popularity

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Addressing chemoresistance with a lipid gemcitabine nanotherapeutic strategy for effective treatment of pancreatic cancer

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Nano Research 2024年第9期17卷 8377-8388页

作者： Jiawei hong Shiyun xian Shusen Zheng Hangxiang Wang Donghai Jiang The First Affiliated Hospital NHC Key Laboratory of Combined Multi-Organ TransplantationCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesState Key Laboratory for Diagnosis and Treatment of Infectious DiseasesSchool of MedicineZhejiang UniversityHangzhou 310003China Jinan Microecological Biomedicine Shandong Laboratory Jinan 250117China

Resistance to gemcitabine in pancreatic cancer poses a significant clinical *** investigation is warranted to assess whether nano-formulation strategy can be employed to enhance the sensitivity of resistant strains to gemcitabine *** this study,using gemcitabine-resistant pancreatic cancer cell lines,we examined the therapeutic potential of a gemcitabine nanodelivery platform and assessed the ability to overcome drug resistance against resistant *** of human equilibrative nucleoside transporter 1(hENT1)led to reduced cellular uptake of gemcitabine,resulting in chemoresistance in pancreatic *** nanoparticles circumvented the entry blockade caused by hENT1 silencing through *** entry via clathrin-mediated endocytosis increased intracellular gemcitabine accumulation in gemcitabine-resistant pancreatic cancer ***,gemcitabine nanoparticles are preferential in vivo delivery to tumor tissues,likely due to the enhanced permeability and retention *** comparison to free gemcitabine,gemcitabine nanoparticles demonstrate a more pronounced cytotoxic effect on gemcitabine-resistant pancreatic cancer cells,with favorable *** study improved the efficacy of gemcitabine through nanotechnology,providing a novel strategy to address gemcitabine-resistant pancreatic cancer.

关键词： pancreatic cancer gemcitabine resistance gemcitabine nanoparticle human equilibrative nucleoside transporter 1

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