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Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 592-598页

作者： Li-jiang TANG Jian-jun JIANG Xiao-feng CHEN Jian-an WANG xian-fang lin Yu-xi DU Cong-feng fang Zhao-xia PU Department of Cardiology Taizhou Hospital Wenzhou Medical College Taizhou 317000 China Department of Cardiology Hangzhou 310009 China Cardiovascular Key Lab of Zhejiang Province the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Echocardiography Taizhou Hospital Wenzhou Medical College Taizhou 317000 China

Objective:Uric acid(UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome(MS).This study aims to investigate the relation between UA levels and aortic root ***:A total of 348 hypertensive patients [age(67.5±9.8) years] with or without MS were included in the *** aortic root diameters at the aortic annulus,the sinuses of Valsalva,the sinotubular junction,and the proximal part of the ascending aorta were measured using a two-dimensional(2D) *** UA levels were also measured for all ***:A high UA level is independently associated with aortic root diameters at the sinuses of Valsalva(P=0.001) and the proximal ascending aorta(P<0.0001) in the hypertensive patients without *** contrast,aortic root diameters were not significantly related to UA levels in the hypertensive patients with ***,increased UA levels were associated with an increased risk for aortic root dilatation in the patients without MS(sex-adjusted hazard ratio 1.75,95% confidence intervals(CI) 1.27-2.41),but not in those with ***:This study demonstrated an independent relationship between the aortic root dimensions and increased levels of serum UA in the hypertensive patients without *** understanding of the mechanisms underlying these associations may allow a clearer interpretation of the potential value of specific urate-lowering treatment on cardiovascular disease.

关键词： Aortic root Uric acid Hypertension Metabolic syndrome

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Schistosoma japonicum: Isolation and Identification of Peptides Mimicking Ferritin Epitopes from Phage Display Library

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Acta Biochimica et Biophysica Sinica 2004年第3期36卷 206-210页

作者： Lian-Fei TANG, Xin-Yuan YI*, xian-fang ZENG, lin-Qian WANG, and Shun-Ke ZHANG Department of Parasitology, Central South University xiangya School of Medicine, Changsha 410078, China Department of Parasitology Central South University Xiangya School of Medicine Changsha 410078 China

In an attempt to isolate and identify the antigenic epitopes on ferritin of Schistosoma japonicum (SjFer) and to test their protective potentiality against Schistosoma japonicum (S.j), polyclonal antisera against SjFer was prepared to screen a 12-mer random peptide library. Three rounds of biopan- ning were performed and resulted in an enrichment. Six peptides selected randomly from the third elute were all found to be positive by evaluating the binding to anti-SjFer sera by ELISA and Western blot- ting. Three amino acid sequences were deduced from the six phage clones by sequencing. When they were used to vaccinate mice, the three peptides could induce significant reduction in adult worms (26.7%, 20.4%, and 25.9%) as well as in liver eggs per gram (LEPG) (40.0%, 38.2%, and 40.8%). This result showed that three mimotopes on SjFer were obtained and they could induce significant protective efficacy against S.j.

关键词： phage displayed peptide library epitope Schistosoma japonicum ferritin

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输尿管软镜下“粉末化碎石”治疗肾结石的疗效

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中外医疗 2016年第33期35卷 83-84,87页

作者：方先林南京鼓楼医院集团宿迁市人民医院泌尿外科江苏宿迁223800

目的探析"粉末化碎石"在输尿管软镜治疗肾结石中的疗效。方法整群选取该院2015年4月—2016年8月收治的64例肾结石患者,对其临床资料进行回顾性分析,两组均采取组合式输尿管软镜下钬激光碎石术,将其随机分为研究组(36例)和对照组(28例),... 详细信息

目的探析"粉末化碎石"在输尿管软镜治疗肾结石中的疗效。方法整群选取该院2015年4月—2016年8月收治的64例肾结石患者,对其临床资料进行回顾性分析,两组均采取组合式输尿管软镜下钬激光碎石术,将其随机分为研究组(36例)和对照组(28例),对照组结石直径均大于3 mm,未能完成粉末化碎石,研究组结石直径均小于2 mm,达到粉末化碎石,比较两组结石清除率及并发症的发生率。结果研究组结石清除率(35/36)97.22%,对照组结石清除率(14/28)50.00%,比较差异有统计学意义,P<0.05。研究组并发症发生率13.89%显著低于对照组92.86%(P<0.05)。结论组合式输尿管软镜下钬激光碎石术治疗肾结石安全有效,在"粉末化碎石"理论指导的基础上,患者结石清除率比较高,属于临床理想的治疗方案,值得临床推广。

关键词：粉末化碎石输尿管软镜钬激光碎石术肾结石

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen fang Huang Lijie Mao Zhimin Zhang Han lin Qixin Yan xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： fang, Lei lin, Xiaoqi Xu, Ruian Liu, Lu Zhang, Yu Tian, Feng Li, Jiao Jiao Xue, Jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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托毒生肌法结合隐动脉胫骨皮瓣修复小腿骨皮缺损23例

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世界中西医结合杂志 2010年第9期5卷 789-791页

作者：方先林赵祚恭河南省固始县人民医院河南固始465200 河南省洛阳正骨医院河南洛阳465200

目的探讨托毒生肌法结合隐动脉胫骨皮瓣修复小腿骨皮缺损的疗效。方法对23例小腿粉碎性骨折并严重软组织损伤后形成骨皮缺损、胫骨骨髓炎患者行托毒生肌方外洗加病灶清除隐动脉胫骨皮瓣修复术。术后镇痛、抗凝、血管活性、抗炎药物等对... 详细信息

目的探讨托毒生肌法结合隐动脉胫骨皮瓣修复小腿骨皮缺损的疗效。方法对23例小腿粉碎性骨折并严重软组织损伤后形成骨皮缺损、胫骨骨髓炎患者行托毒生肌方外洗加病灶清除隐动脉胫骨皮瓣修复术。术后镇痛、抗凝、血管活性、抗炎药物等对症治疗,内服中药补益气血、扶正祛邪,可见光照射,观察皮瓣血液循环。结果 23例骨皮瓣全部成活,断蒂后6个月～14个月在积极功能锻炼下,患者膝、踝关节功能基本恢复。3例术后出现静脉回流障碍,给予抬高患肢、消肿治疗后好转。4例术前缺损面积较大、感染程度较深,术后出现骨皮瓣周围渗出较多,给予抗生素、中药内服,换药后病情好转。结论托毒生肌法结合隐动脉胫骨皮瓣修复小腿骨皮缺损,疗效确切。

关键词：骨皮缺损隐动脉托毒生肌法胫骨皮瓣

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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li Bo Peng Hua Bai lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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“皮肤物理抗菌膜”专利技术在小鼠生殖道淋病奈瑟球菌感染中的预防作用

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中华医学杂志 2011年第6期91卷 405-408页

作者：方先林戴玉田尹跃平兰厚金周六化南京大学医学院附属鼓楼医院泌尿外科 210008 中国医学科学院皮肤性病研究所微生物实验室

目的探讨“皮肤物理抗菌膜”专利技术在小鼠淋病奈瑟球菌（简称淋球菌）感染中的预防作用，以寻求淋病预防新方法。方法（1）模拟雄鼠向雌鼠传播淋球菌：将淋球菌WHO-L菌株接种于经过苯甲酸雌二醇预处理的雌性BALB／c小鼠阴道。实验组... 详细信息

目的探讨“皮肤物理抗菌膜”专利技术在小鼠淋病奈瑟球菌（简称淋球菌）感染中的预防作用，以寻求淋病预防新方法。方法（1）模拟雄鼠向雌鼠传播淋球菌：将淋球菌WHO-L菌株接种于经过苯甲酸雌二醇预处理的雌性BALB／c小鼠阴道。实验组小鼠阴道使用“皮肤物理抗菌膜”长效抗菌材料，对照组小鼠阴道使用去离子水。接种后第2、4、5天取阴道分泌物做淋球菌培养，比较两组检出率；接种后2～10d 监N／,b鼠阴道分泌物涂片染色中多形核白细胞（PMN）平均数占总细胞百分数。（2）模拟雌鼠向雄鼠传播淋球菌：用玻璃棒代替小鼠阴茎，与已感染淋球菌的雌鼠模拟性交。实验组玻璃棒用长效抗菌材料浸泡，对照组用去离子水。洗脱玻璃棒头部分泌物，做淋球菌分离培养，比较两组检出率。结果（1）模拟雄鼠向雌鼠传播淋球菌实验中，实验组淋球菌培养阳性率低于对照组（第4天：10．0％比57．5％；第5天：7．5％比45．0％，均P〈0．01）；实验组小鼠在接种后5～8dPMN百分比显著低于对照组（均P〈0．05）。（2）模拟雌鼠向雄鼠传播淋球菌实验中，第1、2天实验组玻璃棒头部分泌物淋球菌培养阳性率分别为8．3％和0，显著低于对照组（72．7％和45．5％，均P〈0．01）。结论长效抗菌材料通过形成物理抗菌膜，可以预防雌性小鼠生殖道淋球菌的感染或定植，同时能对雄性小鼠能起到液态安全套的作用。

关键词：奈瑟球菌淋病材料试验长效抗菌材料

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei Liu Yantong Li Meng-xiang Wu Hao Kang Xiao-Li Zhao lin Xu linlin Liu Xiaodong Li Junfeng fang Zhiwei fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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