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新辅助免疫治疗联合化疗与手术治疗局部晚期可切除非小细胞肺癌的短期疗效比较

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中国肺癌杂志 2024年第6期27卷 421-430页

作者：李海天刘晴李斌陈玉珍蔺军平孟于琪冯海明郑智中惠一鸣兰州大学第二医院(第二临床医学院)胸外科兰州730030

背景与目的肺癌是中国发生率和死亡率均排名第一的癌症,非小细胞肺癌(non-small cell lung cancer,NSCLC)占所有肺恶性肿瘤的80%-85%。目前,手术治疗仍是肺癌主要的治疗方式。近年来,免疫检查点抑制剂在NSCLC中的疗效已成为共识,新辅... 详细信息

背景与目的肺癌是中国发生率和死亡率均排名第一的癌症,非小细胞肺癌(non-small cell lung cancer,NSCLC)占所有肺恶性肿瘤的80%-85%。目前,手术治疗仍是肺癌主要的治疗方式。近年来,免疫检查点抑制剂在NSCLC中的疗效已成为共识,新辅助免疫联合化疗(neoadjuvant immunochemotherapy, nICT)在早中期NSCLC中显示出来良好的疗效和安全性。然而,nICT治疗局部晚期NSCLC的相关研究较少。本研究旨在评估程序性死亡受体1(programmed cell death 1, PD-1)抑制剂联合含铂两药新辅助治疗治疗局部晚期可切除NSCLC的有效性和安全性。方法纳入2021年1月至2024年4月于兰州大学第二医院胸外科就诊的85例确诊可切除ⅢA、ⅢB期患者,分为nICT组(n=32)和单纯手术组(n=53),比较两组患者的临床基线资料、围手术期相关指标及术后并发症,并评估n ICT组的影像学缓解率、病理学缓解率、相关不良反应发生率、生活质量。结果两组患者临床基线资料差异均无统计学意义(P>0.05)。nICT组选择开胸方式比单纯手术组发生率高(P=0.002),两组手术时间、术中出血量、清扫淋巴结个数、带管时间、术后住院时间及R0切除率的差异无统计学意义(P>0.05)。nICT组与单纯手术组术后总并发症发生率分别为31.25%和22.64%,差异无统计学意义(P=0.380)。nICT组中客观缓解率(objective responserate,ORR)为84.38%,完全缓解(completeresponse,CR)5例(15.63%),部分缓解(partialresponse,PR)22例(68.75%),病理性完全缓解(pathologicalcompleteresponse,pCR)15例(46.88%),主要病理缓解(major pathologicalreaponse,MPR)11例(34.38%)。nICT治疗期间,3级治疗相关不良反应共12例(37.50%),无不良反应或免疫相关不良反应导致患者死亡。而且,n ICT治疗后患者相关症状有所改善。结论 nICT治疗局部晚期可切除NSCLC显示出良好的疗效,治疗相关不良事件可控,是局部晚期可切除NSCLC安全、可行的新辅助治疗模式。

关键词：肺肿瘤新辅助免疫化疗 PD-1抑制剂客观缓解率并发症

Ethylene Biology Blooms from Fundamenta Research to Postharvest Applications

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Molecular Plant 2016年第1期9卷 187-188页

作者： Ziqiang Zhu Ziqiang xian Hongwei Guo Zhengguo li College of life Sciences Nanjing Normal University Nanjing 210023 China Key Laboratory of Functional Gene and Regulation Technologies under Chongqing Municipal Education Commission School of Life SciencesChongqing University Chongqing 400044 China State Key Laboratory of Protein and Plant Gene Research School of Life Sciences and Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100875 China

The 10th International Conference on the Plant Hormone Ethylene, co-chaired by Zhengguo li （Chongqing University）, Hongwei Guo （Peking University）, Joseph Ecker （SALK, USA）, Mondher Bou- zayen （University of To... 详细信息

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重症急性胰腺炎继发胰腺坏死组织感染早期预警指标研究

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中国实用外科杂志 2024年第6期44卷 696-700页

作者：刘星黄鹂龙灵仙黄辉宇吴艳红李国光王湘英湖南省人民医院(湖南师范大学附属第一医院)重症医学科湖南长沙410005 湖南省人民医院(湖南师范大学附属第一医院)胰脾外科湖南长沙410005 湖南省澧县人民医院湖南澧县415500 湖南师范大学胰腺疾病转化医学研究所湖南长沙410005

目的探究重症急性胰腺炎(SAP)继发胰腺坏死组织感染(IPN)的早期预警指标。方法回顾性分析湖南省人民医院2012—2019年SAP病人临床资料,收集人口学特征、病因、发病后48 h内的临床数据和发病72 h后的急性胰腺炎严重指数(CTSI)评分,采... 详细信息

目的探究重症急性胰腺炎(SAP)继发胰腺坏死组织感染(IPN)的早期预警指标。方法回顾性分析湖南省人民医院2012—2019年SAP病人临床资料,收集人口学特征、病因、发病后48 h内的临床数据和发病72 h后的急性胰腺炎严重指数(CTSI)评分,采用多因素Logistic回归分析IPN的影响因素,用ROC曲线比较Logistic回归模型、CTSI、急性胰腺炎严重程度床边指数(BISAP)、急性生理与慢性健康状况评分系统Ⅱ(APACHEⅡ)、序贯器官衰竭评估(SOFA)评分的预测效能,并分析各评分预测IPN的cutoff值。结果 SAP病人共277例,IPN组74例,对照组203例。Logistic回归分析示:谵妄(OR=4.049,95%CI 1.058~15.500,P=0.041)是IPN的危险因素,血细胞比容(Hct)(OR=0.939,95%CI 0.897~0.983,P=0.007)是IPN的保护性因素。Logistic回归模型、CTSI、BISAP、APACHEⅡ、SOFA预测IPN的ROC曲线下面积依次为0.719、0.702、0.622、0.593和0.561;各评分预测IPN的cutoff值:CTSI≥7分、BISAP≥3分、APACHEⅡ≥14分,SOFA≥5分。结论早期谵妄和Hct下降可预警SAP后期继发IPN,建议及时转诊IPN高危病人。

关键词：重症急性胰腺炎谵妄血细胞比容胰腺坏死组织感染

Effects of specimen size on flow stress of micro rod specimen

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Transactions of Nonferrous Metals Society of China 2009年第S02期19卷 511-515页

作者： WANG Chun-ju GUO bin SHAN De-bin SUN li-ning School of Materials Science and Engineering Harbin Institute of technologyHarbin 150001China Robot Institute of Technology Harbin Institute of TechnologyHarbin 150001China

With the miniaturization of parts,size effects occur in the micro-forming *** investigate the effects of the specimen size on the flow stress,a series of upsetting deformation experiments were carried out at room temperature for specimens with different *** the grain size of billets was changed by anneal processes to analyze the grain size effects on the size dependence of flow *** deviation of stress was *** results show that the flow stress decreases with decreasing billet *** the dislocation accumulation in free surface layer is slight,the reduction degree of flow stress becomes larger when the plastic deformation goes *** flow stress is enlarged by grain size,which can be analyzed by the grain boundary length per *** deviation increases with decreasing specimen *** can be explained by the effects of grain orientation stochastic distribution according to the Schmid *** a result,the micro-forming process must be considered from the viewpoint of polycrystalline structure,and the single grains of micro-billet dominate the deformation.

关键词： micro-forming size effects free surface effects deviation flow stress

Development of a large nanocrystalline soft magnetic alloy core with highμ'_(p)Qf products for CSNS-Ⅱ

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Nuclear Science and Techniques 2022年第8期33卷 45-54页

作者： bin Wu Xiao li Zhun li Chun-lin Zhang Yang liu Wei Long xiang li Jian Wu Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China

A waterproof nanocrystalline soft magnetic alloy core with a size of O.D.850 mm×I.D.316 mm×H.25 mm for radio frequency acceleration was successfully developed by winding 18μm 1k107b MA ***μ'_(p)Qf products reached 7.5,10,and 12 GHz at 1,3,and 5 MHz,***μ'_(p)Qf products of the MA core(O.D.250 mm×I.D.100 mm×H.25 mm)manufactured using a 13μm MA ribbon further increased by 30%.Detailed improvements on the MA core manufacture process are discussed *** high-power tests on the new MA cores demonstrated its good performance of waterproofness,particularly its stability of highμ'_(p)Qf *** MA core with highμ'pQf product and large size can operate under a high average RF power,high electric field,and in deionized water,which will be used in the China Spallation Neutron Source PhaseⅡ(CSNS-Ⅱ).

关键词： Large size magnetic alloy core High insulation and low stress coating Waterproof structure Transverse magnetic field annealing High power MA-loaded cavity

The discovery of interfacial electronic interaction within cobalt boride@MXene for high performance lithium-sulfur batteries

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Chinese Chemical Letters 2021年第7期32卷 2249-2253页

作者： bin Guan Xun Sun Yu Zhang xian Wu Yue Qiu Maoxu Wang lishuang Fan Naiqing Zhang State Key Laboratory of Urban Water Resource and Environment School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Academy of Fundamental and Interdisciplinary Sciences Harbin Institute of TechnologyHarbin 150001China

lithium-sulfur battery is strongly considered as the most promising next-generation energy storage system because of the high theoretical specific *** serious"shuttle effect"and sluggish reaction kinetic limited the commercial application of lithium-sulfur *** hetero structure s were applied to accelerate polysulfides conversion and suppress their migration in lithium-sulfur ***,the effect of the interface in heterostructure was not ***,the Co_(2)B@MXene heterostructure is synthesized through chemical reactions at room temperature and employed as the interlayer material for li-S *** theoretical calculations and experimental results indicate that the interfacial electronic interaction of Co_(2)B@MXene induce the transfer of electrons from Co_(2)B to MXene,enhancing the catalytic ability and favoring fast redox kinetics of the polysulfides,and the theoretical calculations also reveal the underlying mechanisms for the electron transfer is that the two materials have different Fermi energy *** cell with Co_(2)B@MXene exhibits a high initial capacity of1577 mAh/g at 0.1 C and an ultralow capacity decay of 0.0088%per cycle over 2000 cycles at 2 *** at5.1 mg/cm^(2) of sulfur loading,the cell with Co_(2)B@MXene delivers 5.2 mAh/cm^(2) at 0.2 C.

关键词： Co_(2)B@MXene Separator Interfacial electronic interaction Catalytic activity lithium-sulfur batteries

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变电站综合自动化改造及安全管控分析

农村电气化 2024年第1期 11-13页

作者：李志强李晶邓显俊王斌许继电气股份有限公司河南许昌461000

随着科技的不断发展,自动化改造成为提高变电站运行效率和安全性的有效手段。文章介绍变电站综合自动化改造流程及安全管控措施,从而优化设备配置,减少人工操作,实现实时监测和调度功能,提高工作效率。

关键词：变电站综合自动化改造安全管控

Effect of SiO_(2) and B_(2)O_(3) on crystallization and structure of CaF2–CaO–Al_(2)O_(3)-based slag for electroslag remelting of ultra-supercritical rotor steel

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Journal of Iron and Steel Research International 2021年第12期28卷 1530-1540页

作者： Yi Huang Cheng-bin Shi Xiu-xiu Wan Jiang-ling li Ding-li Zheng Jing li State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China College of Materials Science and Engineering Chongqing UniversityChongqing400044China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina

Regarding development of the dedicated slag for electroslag remelting,crystallization characteristics of the slag exert a strong influence on the initial solidification of liquid metal in mold and surface quality of as-cast *** crystallization behavior of CaF_(2)-CaO-Al_(2)O_(3)-based slag with varying SiO_(2)and B_(2)O_(3)contents and their correlation with the slag structure were *** SiO_(2)(0.24-8.95 mass%)and B_(2)O_(3)(0-3.20 mass%)contents lowers the crystallization temperature and suppresses the crystallization of the slag melts,as well as decreases the sizes of the crystalline *** crystalline phases precipitated during continuous cooling of the slag melts are faceted 11CaO·7Al_(2)O_(3)·CaF_(2),faceted or spherical CaF_(2),and non-faceted MgO·Al_(2)O_(3)(or MgO)in sequence irrespective of the SiO_(2)and B_(2)O_(3)contents of the *** polymerization degree of slag melts increases with increasing either SiO_(2)or B_(2)O_(3)*** crystallization of the slag melts is increasingly retarded with increasing the SiO_(2)and B_(2)O_(3)contents of the slag caused by increased component diffusion resistance originating from increased polymerization degree of the slag melts.

关键词： Crystallization Slag structure Polymerization degree Electroslag remelting Ultra-supercritical rotor steel

Analysis of Genetic Diversity in Natural Populations of Psathyrostachys huashanica Keng Using Microsatellite (SSR) Markers

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Agricultural Sciences in China 2010年第4期9卷 463-471页

作者： liU Wen-xian liU Wei-hua WU Jun GAO Ai-nong li li-hui National Key Facility for Crop Gene Resources and Genetic Improvement （NFCRI） Institute of Crop Germplasm Resources Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China Institute of Botany Chinese Academy of Sciences Beijing 100093 P.R.China Graduate School Chinese Academy of Sciences Beijing 100049 P.R.China College of Agronomy Northwest A＆F University Yangling 712100 P.R.China

Psathyrostachys huashanica Keng is endemic to China and only distributed in Huashan Mountain in Shaanxi Province, China. In this study, 15 P. huashanica populations consisting of 450 individuals sampled across their main distribution were investigated by using the simple sequence repeats （SSRs） markers. A total of 184 alleles were detected on 24 SSR loci, and the number of alleles on each locus ranged from 2 to15, with an average of 7.667. The total gene diversity （HT= 0.683） and the coefficient of population differentiation （GST = 0.125） showed that P. huashanica had a relatively high level of genetic variation, and the genetic variation was mainly distributed within the populations. The gene flow among the populations of P. huashanica （Nm = 1.750） was much less than that of the common anemophytes （Nm = 5.24）. Correlation analysis demonstrated that the number of alleles as well as genetic diversity of the five populations of Huangpu valley decreased along with the increase of altitudes, but the correlation was not significant. Implications of these results for future P. huashanica collection, evaluation and conservation were discussed.

关键词： Psathyrostachys huashanica Keng SSR genetic diversity conservation implication