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Signal Transduction and Targeted Therapy 2024年第3期9卷 1165-1173页

作者： Wenxin luo Jiadi Gan Zhu luo Shuangqing Li Zhoufeng Wang Jiaxuan Wu Huohuo Zhang Jinghong xian Ruixin Cheng Xiumei Tang Yi Liu Ling Yang Qianqian Mou Xue Zhang Yi Chen Weiwen Wang Yantong Wang Lin Bai Xuan Wei Rui Zhang Lan Yang Yaxin Chen Li Yang Yalun Li Dan Liu Weimin Li Lei Chen Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduChina Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduChina Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Respiratory Health and Multimorbidity West China HospitalChengduChina Institute of Respiratory Health and Multimorbidity West China HospitalSichuan UniversityChengduChina Clinical Trial Center West China HospitalSichuan UniversityChengduChina General Practice Medical Center West China HospitalSichuan UniversityChengduChina Fangcao Community Health Service Center of Chengdu High-tech Zone ChengduChina The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengduChina West China School of Nursing Sichuan UniversityChengduChina Department of Infection Control West China HospitalSichuan UniversityChengduChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology West China HospitalSichuan UniversityChengduChina

Vaccines have proven effective in protecting populations against COVID-19,including the recombinant COVID-19 vaccine(Sf9 cells),the first approved recombinant protein vaccine in *** this positive-controlled trial with 85 adult participants(Sf9 cells group:n=44;CoronaVac group:n=41),we evaluated the safety,immunogenicity,and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine,and found a post-booster adverse events rate of 20.45%in the Sf9 cells group and 31.71%in the CoronaVac group(p=0.279),within 28 days after booster *** group reported any severe adverse *** the Sf9 cells vaccine booster,the geometric mean titer(GMT)of binding antibodies to the receptor-binding domain of prototype SARS-CoV-2 on day 28 post-booster was significantly higher than that induced by the CoronaVac vaccine booster(100,683.37 vs.9,451.69,p<0.001).In the Sf9 cells group,GMTs of neutralizing antibodies against pseudo SARS-CoV-2 viruses(prototype and diverse variants of concern[VOCs])increased by 22.23–75.93 folds from baseline to day 28 post-booster,while the CoronaVac group showed increases of only 3.29–10.70 ***,neutralizing antibodies against live SARS-CoV-2 viruses(prototype and diverse VOCs)increased by 68.18–192.67 folds on day 14 post-booster compared with the baseline level,significantly greater than the CoronaVac group(19.67–37.67 folds).A more robust Th1 cellular response was observed with the Sf9 cells booster on day 14 post-booster(mean IFN-γ+spot-forming cells per 2×105 peripheral blood mononuclear cells:26.66 vs.13.59).Protective effectiveness against symptomatic COVID-19 was approximately twice as high in the Sf9 cells group compared to the CoronaVac group(68.18%vs.36.59%,p=0.004).Our study findings support the high protective effectiveness of heterologous boosting with the recombinant COVID-19 vaccine(Sf9 cells)against symptomatic COVID-19 of dive

关键词： protective vaccine boost

PIF4 interacts with ABI4 to serve as a transcriptional activator complex to promote seed dormancy by enhancing ABA biosynthesis and signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 909-927页

作者： Xiaofeng luo Yujia Dai Baoshan xian Jiahui Xu Ranran Zhang Muhammad Saad Rehmani Chuan Zheng Xiaoting Zhao Kaitao Mao Xiaotong Ren Shaowei Wei Lei Wang Juan He Weiming Tan Junbo Du Weiguo Liu Shu Yuan Kai Shu Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi'an 710129China Research&Development Institute of Northwestern Polytechnical University in ShenzhenShenzhen 518057China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China Institute of Ecological Agriculture Sichuan Agricultural UniversityChengdu 611130China College of Resources Sichuan Agricultural UniversityChengdu 611130China

Transcriptional regulation plays a key role in the control of seed dormancy,and many transcription factors(TFs)have been ***,the mechanisms underlying the interactions between different TFs within a transcriptional complex regulating seed dormancy remain largely ***,we showed that TF PHYTOCHROME-INTERACTING FACTOR4(PIF4)physically interacted with the abscisic acid(ABA)signaling responsive TF ABSCISIC ACID INSENSITIVE4(ABI4)to act as a transcriptional complex to promote ABA biosynthesis and signaling,finally deepening primary seed *** pif4 and abi4 single mutants exhibited a decreased primary seed dormancy phenotype,with a synergistic effect in the pif4/abi4 double ***4 binds to ABI4 to form a heterodimer,and ABI4 stabilizes PIF4 at the protein level,whereas PIF4 does not affect the protein stabilization of ***,both TFs independently and synergistically promoted the expression of ABI4 and NCED6,a key gene for ABA *** genetic evidence is also consistent with the phenotypic,physiological and biochemical analysis ***,this study revealed a transcriptional regulatory cascade in which the PIF4–ABI4 transcriptional activator complex synergistically enhanced seed dormancy by facilitating ABA biosynthesis and signaling.

关键词： ABA ABI4 PIF4 seed dormancy and germination transcriptional complex

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超新星遗迹和脉冲星风云的X射线偏振成像

天文学进展 2024年第1期42卷 76-85页

作者：罗天贤周平南京大学天文与空间科学学院南京210046 现代天文与天体物理教育部重点实验室南京210046

年轻超新星遗迹和脉冲星风云中的高能粒子可以通过同步辐射产生X射线。对该辐射的偏振测量有助于揭示粒子加速区磁场的性质,进而研究粒子加速的机制。首颗X射线偏振成像卫星于2021年底发射升空,已揭示了数个年轻超新星遗迹和脉冲星风云... 详细信息

年轻超新星遗迹和脉冲星风云中的高能粒子可以通过同步辐射产生X射线。对该辐射的偏振测量有助于揭示粒子加速区磁场的性质,进而研究粒子加速的机制。首颗X射线偏振成像卫星于2021年底发射升空,已揭示了数个年轻超新星遗迹和脉冲星风云的X射线偏振图像。观测显示,仙后A和第谷超新星遗迹的偏振度较低,平均值分别约为2.5%和9%;而蟹状星云和船帆脉冲星风云的偏振度较高,平均值分别约为20%和45%。结果表明脉冲星风云的磁场较为有序,而两个年轻超新星遗迹的粒子加速区磁场是高度湍动的,且激波附近的磁场结构呈现径向分布。未来,随着对IXPE的使用越来越广泛,以及与我国建设中的增强型X射线时变与偏振探测器(eXTP)等更多望远镜投入使用,以上两类天体的磁场构型和粒子加速模型将得到进一步的限定。

关键词：超新星遗迹脉冲星风云偏振 X射线天文学粒子加速

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一种电力变压器短路累积机械损伤评价方法

电工技术学报 2024年第8期39卷 2578-2590页

作者：欧强罗隆福李勇杨贤周腊吾西南科技大学信息工程学院绵阳621010 湖南大学电气与信息工程学院长沙410082 广东电网有限责任公司电力科学研究院广州510080 长沙理工大学电气与信息工程学院长沙410114

多次短路会逐渐积累绕组机械损伤,最终导致电力变压器损坏。然而,目前缺乏一种量化评估方法来评估此类损伤,这对电网的安全运行构成了威胁。因此,该文提出一种考虑绕组的非线性特点和累积过程的电力变压器绕组短路累积机械损伤评价方法... 详细信息

多次短路会逐渐积累绕组机械损伤,最终导致电力变压器损坏。然而,目前缺乏一种量化评估方法来评估此类损伤,这对电网的安全运行构成了威胁。因此,该文提出一种考虑绕组的非线性特点和累积过程的电力变压器绕组短路累积机械损伤评价方法,为评估绕组短路对电力变压器的影响提供了新的途径。该方法采用阻尼比和可靠性损失系数作为特征量,通过指数型曲线来模拟绕组机械弱化过程。同时考虑变压器的初始承受短路的能力、短路电流幅值和故障次数等影响因素,量化了短路损伤与绕组动态机械寿命之间的关系。此外,通过对一台110 kV电力变压器进行多次短路破坏性试验,验证了该评价方法的正确性。最后,阐述了提出的评价方法适用于不同的校核控制方法,并强调了控制阻尼比在减少累积损伤方面的积极作用。

关键词：电力变压器短路累积损伤可靠性评价

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石墨炔在水系离子电池中的研究进展

新型炭材料（中英文） 2024年第3期39卷 388-406页

作者：徐显敏封文聪任静柯罗雯武汉理工大学材料科学与工程学院材料复合新技术国家重点实验室湖北武汉430070 武汉理工大学理学院物理系湖北武汉430070

石墨炔(Graphdiyne,GDY)是一种全新的炭材料,具有特殊的炭杂化排列方式、独特的化学性质和电子结构以及独特的孔隙结构等优点,在电化学储能领域具有良好的应用前景。新兴的水系离子电池具有低成本和高安全性等优点,然而,高性能电极材料... 详细信息

石墨炔(Graphdiyne,GDY)是一种全新的炭材料,具有特殊的炭杂化排列方式、独特的化学性质和电子结构以及独特的孔隙结构等优点,在电化学储能领域具有良好的应用前景。新兴的水系离子电池具有低成本和高安全性等优点,然而,高性能电极材料的开发、新型隔膜体系的设计以及稳定界面的策略等仍是水系离子电池面临的主要挑战。石墨炔在负极保护、正极包覆、隔膜设计以及稳定界面pH值等方面,可以改善离子传输与界面沉积行为、电解液不稳定等问题。特别是石墨炔自下而上的分子结构设计策略使其具有易修饰、掺杂的特点,改性的石墨炔类似物具有更加优异的性能,拓宽了其在水系离子电池中的应用。本文系统综述了石墨炔的结构与性质以及合成方法,特别对石墨炔在水系离子电池中的研究进行了总结。此外,对石墨炔在水系离子电池中应用时仍存在的问题与挑战进行了探讨,对石墨炔在水系离子电池中的发展进行了展望。

关键词：石墨炔炭材料电化学储能水系离子电池分子结构设计

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寿险公司代理人管理评价与公司经营目标实现——基于寿险公司“基本法”的视角

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保险研究 2024年第2期 31-44页

作者：罗婧文许闲南开大学金融学院复旦大学经济学院风险管理与保险学系

目前我国保险代理人(包括专属代理人和中介公司代理人)对寿险业保费收入的贡献超过50%。作为各公司保险代理人管理的基本纲要,保险代理人基本管理办法(基本法)通过对保险代理人的约束与管理,对公司经营目标的实现产生重要影响。本文对2... 详细信息

目前我国保险代理人(包括专属代理人和中介公司代理人)对寿险业保费收入的贡献超过50%。作为各公司保险代理人管理的基本纲要,保险代理人基本管理办法(基本法)通过对保险代理人的约束与管理,对公司经营目标的实现产生重要影响。本文对26家公司的基本法内容进行拆解整合,形成包含7个一级指标,30个二级指标,76个三级指标的基本法指标体系。运用层次分析法,在对保险公司管理人员、保险代理人和消费者调查的基础上,确定了指标体系权重,形成了基本法评估框架。基于这一框架,本文聚焦寿险公司经营中重点关注的业务规模、业务稳定性和保险投诉指标,阐述了基本法指标模块与寿险公司经营指标的传导机制,帮助寿险公司基于公司发展目标形成差异化且有针对性的基本法改革思路。

关键词：基本法改革保险代理人指标体系经营情况

Efficacy of percutaneous mechanical thrombus removal in acute lower extremity deep venous thrombosis

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World Journal of Clinical Cases 2024年第21期12卷 4590-4600页

作者： Jun-Qiang Xue Ping Yin Jian-Ping He Hui Wei Cui-Jie Geng Yu-xian luo Department of Vascular Surgery Shijiazhuang People's HospitalShijiazhuang 050011Hebei ProvinceChina Department of Laboratory Medicine Shijiazhuang Hospital of Traditional Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Catheter Room Shijiazhuang People's HospitalShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary *** treatments like catheter-directed thrombolysis(CDT)often result in variable success rates and *** To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute *** A retrospective analysis was performed to examine 58 hospitalised patients with acute LEDVT between August 2019 and August *** patients were categorised into the percutaneous mechanical thrombectomy(PMT)group(n=24)and CDT group(n=32).The follow-up,safety and treatment outcomes were compared between the two *** main observational indexes were venous patency score,thrombus removal effect,complications,hospitalisation duration and *** The venous patency score was 9.04±1.40 in the PMT group and 8.81±1.60 in the CDT group,and the thrombus clearance rate was 100%in both *** complication rate was 8.33%in the PMT group and 34.84%in the CDT group,and the difference was statistically significant(P<0.05).The average hospitalisation duration was 6.54±2.48 days in the PMT group and 8.14±3.56 days in the CDT *** incidence of PTS was lower in the PMT group than in the CDT group;however,the difference was not statistically significant(P<0.05).CONCLUSION Compared with CDT,treatment of LEDVT via PMT was associated with a better thrombus clearance rate,clinical therapeutic effect and PTS prevention function,but the difference was not statistically ***,PMT was associated with a reduced urokinase dosage,shortened hospitalisation duration and reduced incidence of complications,such as infections and small *** results indicate that PMT has substantial beneficial effects in the treatment of LEDVT.

关键词： Post-thrombotic syndrome Catheter-directed thrombolysis Percutaneous mechanical thrombectomy Acute lower extremity deep venous thrombosis

Effect of sintering temperature and holding time on structure and properties of Li_(1.5)Ga_(0.5)Ti_(1.5)(PO_4)_(3)electrolyte with fast ionic conductivity

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 2959-2971页

作者： Yin-yi luo Hao-zhang LIANG Ping ZHANG Lei HAN Qian ZHANG Li-dan LIU Zhi-wei luo Tian-xiang NING An-xian LU School of Materials Science and Engineering Central South UniversityChangsha 410083China School of Materials Science and Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

Li1.5Ga0.5Ti1.5(PO4)3(LGTP)is recognized as a promising solid electrolyte material for lithium *** this work,LGTP solid electrolyte materials were prepared under different process conditions to explore the effects of sintering temperature and holding time on relative density,phase composition,microstructure,bulk conductivity,and total *** the impedance test under frequency of 1-10~6 Hz,the bulk conductivity of the samples increased with increasing sintering temperature,and the total conductivity first increased and then *** results showed that the average grain size in the ceramics was controlled by the sintering temperature,which increased from(0.54±0.01)μm to(1.21±0.01)μm when the temperature changed from 750 to 950°*** relative density of the ceramics increased and then decreased with increasing temperature as the porosity *** holding time had little effect on the grain size growth or sample density,but an extended holding time resulted in crack generation that served to reduce the conductivity of the solid electrolyte.

关键词： sintering temperature holding time conductivity cracks solid-state electrolyte

Preparation of kakkatin derivatives and their anti-tumor activity

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World Journal of Clinical Oncology 2024年第8期15卷 1078-1091页

作者： Yu-Ying Jiang Hui-Hua Dong Wen-Ting Zhou Jia-Zi luo xian Wei Yan-Qiang Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Collaborative Innovation Center for Guangxi Ethnic Medicine The School of Chemistry and Pharmaceutical SciencesYoujiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Modern pharmacological studies have confirmed that plant-derived compounds from Puerariae flos(PF)has significant biological activities against liver damage,tumors and *** is an isoflavone polyphenolic compound isolated from PF ***,the effect of kakkatin and its derivatives on anti-tumor has not been well *** To design and synthesize a kakkatin derivative[6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one(HK)]to explore its anti-tumor biological *** Hept-6-yn-1-yl ethanesulfonate was introduced to replace hydrogen at the hydroxyl position of kakkatin phenol,and the derivative of kakkatin was prepared;the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide was used to detect cell viability,a clone formation assay was adopted to detect cell proliferation,apoptosis,necrosis,and cell cycles were analyzed by Annexin V/propidium iodide staining and flow *** migration and invasion ability were evaluated by cell scratch assay and transwell *** potential mechanism of HK on hepatocellular carcinoma(HCC)SMMC-7721 cells was explored through network pharmacology and molecular docking,and finally real-time PCR assays was used to verify the potential targets and evaluate the biological activity of *** Compared with kakkatin,the modified HK did not significantly increase the inhibitory activity of gastric cancer MGC803 cells,but the inhibitory activity of HCC SMMC-7721 cells was increased by about 30 times,with an IC50 value of 2.5μM,and the tumor inhibition effect was better than cisplatin,which could significantly inhibit the cloning,invasion and metastasis of HCC SMMC-7721 cells,and induce apoptosis and G2/M cycle *** mechanism of action is mainly related to the upregulation of PDE3B and NFKB1 target proteins in the cAMP *** HK have a significant inhibitory effect on HCC SMMC-7721 cells,and the targets of their action may be PDE3B and NFKB1 prote

关键词： Kakkatin Derivative Hepatocellular carcinoma Anti-tumor Biological activity