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Effects of Aphidius gifuensis on the feeding behavior and potato virus Y transmission ability of Myzus persicae

Insect Science 2018年第6期25卷 1025-1034页

作者： ying-Qin He Yong-Qiang Zhang Juan-Ni Chen Wen-Long Chen xian-yi zeng Hai-Tao Chen Wei Ding College of Plant Protection Southwest UniversityChongqingChina Guizhou Key Laboratory of Plant Disease and Pest Management for Mountain Agriculture Institute of EntomologyGuizhou UniversityGuiyangChina Chongqing Institute of Tobacco Science ChongqingChina

The stylet penetration behavior of aphids when feeding on plants is associated with virus acquisition and *** gifuensis (Ashmead)is a primary endoparasitoid of Myzuspersicae (Sulzer)which is the most efficient vector of plant viruses. Information about the effects ofparasitoid on aphid and virus transmission can provide an essential foundation for designing effective biological control *** study aimed to investigate the effects *** on the feeding behavior and potato virus Y (PVY) transmission ability of *** results showed that after *** was para-sitized by ***,the duration of the first probe significantly ***, *** exerted remarkable effects on aphid feeding in phloem *** contribution of the E1 waveform to the phloem phase was significantly higher in all parasitized aphids than in the control *** the time of infestation increased for parasitized aphids,the total duration of phloem sap ingestion ***,the percentage of time *** spent in the xylem and phloem phases only changed significantly on day *** percent transmission of PVY by the aphids parasitized on day 5 was lower than that in the control,but no significant differences were *** significance of this work is the demonstration that *** can impede the feeding behavior of ***,which sheds light on the biological basis *** as a natural enemy, but unfortunately does not provide an immediate solution for disrupting the transmission of PVY.

关键词： Braconidae electrical penetration graphs feedingbehavior Myzuspersicae parasitoids virus transmission

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Minimally invasive endoscopic repair of rectovaginal fistula

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 1049-1059页

作者： yi-xian zeng ying-Hua He Yun Jiang Fei Jia Zi-Ting Zhao Xiao-Feng Wang Department of Proctology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Surgical techniques for repair of rectovaginal fistula(RVF)have been continually developed,but the ideal procedure remains *** repair is a novel and minimally invasive technique for RVF repair with increasing *** To review the current applications and preliminary outcomes of this technique for RVF repair,aiming to give surgeons an alternative in clinical *** Available articles were searched according to the search *** the sample size,fistula etiology,fistula type,endoscopic repair approaches,operative time and hospital stay,follow-up period,complication and life quality assessment were selected for recording and further *** A total of 11 articles were eventually identified,involving 71 patients with RVFs who had undergone endoscopic *** principal causes of RVFs were surgery(n=51,71.8%),followed by obstetrics(n=7,9.8%),inflammatory bowel disease(n=5,7.0%),congenital(n=3,4.2%),trauma(n=2,2.8%),radiation(n=1,1.4%),and in two patients,the cause was *** fistulas were in a mid or low *** endoscopic repair methods were included,namely transanal endoscopic microsurgery,endoscopic clipping,and endoscopic *** patients underwent>1-year follow-up,and the success rate was 40%-93%,and all cases reported successful *** complications were mentioned,while postoperative quality of life assessment was only mentioned in one *** In conclusion,endoscopic repair of RVF is novel,minimally invasive and promising with acceptable preliminary *** its unique advantages,endoscopic repair can be an alternative technique for surgeons.

关键词： Endoscopic repair Minimal-invasive technique Rectovaginal fistula

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Schistosoma japonicum: Isolation and Identification of Peptides Mimicking Ferritin Epitopes from Phage Display Library

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Acta Biochimica et Biophysica Sinica 2004年第3期36卷 206-210页

作者： Lian-Fei TANG, Xin-Yuan yi*, xian-Fang zeng, Lin-Qian WANG, and Shun-Ke ZHANG Department of Parasitology, Central South University xiangya School of Medicine, Changsha 410078, China Department of Parasitology Central South University Xiangya School of Medicine Changsha 410078 China

In an attempt to isolate and identify the antigenic epitopes on ferritin of Schistosoma japonicum (SjFer) and to test their protective potentiality against Schistosoma japonicum (S.j), polyclonal antisera against SjFer was prepared to screen a 12-mer random peptide library. Three rounds of biopan- ning were performed and resulted in an enrichment. Six peptides selected randomly from the third elute were all found to be positive by evaluating the binding to anti-SjFer sera by ELISA and Western blot- ting. Three amino acid sequences were deduced from the six phage clones by sequencing. When they were used to vaccinate mice, the three peptides could induce significant reduction in adult worms (26.7%, 20.4%, and 25.9%) as well as in liver eggs per gram (LEPG) (40.0%, 38.2%, and 40.8%). This result showed that three mimotopes on SjFer were obtained and they could induce significant protective efficacy against S.j.

关键词： phage displayed peptide library epitope Schistosoma japonicum ferritin

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Machine learning model using immune indicators to predict outcomes in early liver cancer

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World Journal of Gastroenterology 2025年第5期31卷 43-56页

作者： yi Zhang Ke Shi ying Feng xian-Bo Wang Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Patients with early-stage hepatocellular carcinoma(HCC)generally have good survival rates following surgical ***,a subset of these patients experience recurrence within five years *** To develop predictive models utilizing machine learning(ML)methods to detect early-stage patients at a high risk of *** Eight hundred and eight patients with HCC at Beijing Ditan Hospital were randomly allocated to training and validation cohorts in a 2:1 *** models were generated using random survival forests and artificial neural networks(ANNs).These ML models were compared with other classic HCC scoring systems.A decision-tree model was established to validate the contri-bution of immune-inflammatory indicators to the long-term outlook of patients with early-stage *** Immune-inflammatory markers,albumin-bilirubin scores,alpha-fetoprotein,tumor size,and International Normalized Ratio were closely associated with the 5-year survival *** various predictive models,the ANN model gene-rated using these indicators through ML algorithms exhibited superior perfor-mance,with a 5-year area under the curve(AUC)of 0.85(95%CI:0.82-0.88).In the validation cohort,the 5-year AUC was 0.82(95%CI:0.74-0.85).According to the ANN model,patients were classified into high-risk and low-risk groups,with an overall survival hazard ratio of 7.98(95%CI:5.85-10.93,P<0.0001)between the two *** Hepatocellular carcinoma(HCC)is one of the six most prevalent cancers[1]and the third leading cause of cancer-related mortality[2].China has some of the highest incidence and mortality rates for liver cancer,accounting for half of global cases[3,4].The Barcelona Clinic Liver Cancer(BCLC)Staging System is the most widely used framework for diagnosing and treating HCC[5].The optimal candidates for surgical treatment are those with early-stage HCC,classified as BCLC stage 0 or *** with early-stage liver cancer typically hav

关键词： Hepatocellular carcinoma Inflammation Machine learning Prognosis Artificial neural networks Immune biomarkers

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Low-concentration atropine(0.01%)on quantitative contrast sensitivity function in Chinese children with myopia

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 117-124页

作者： Yu-Hao Ye yi-Yong xian Fang Liu Zhong-Lin Lyu Xing-Tao Zhou Jing Zhao Department of Ophthalmology and Optometry Eye&ENT Hospital of Fudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200000China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200000China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000).Shanghai 200030 China Division of Arts and Sciences NYU ShanghaiShanghai 200000China Center for Neural Science and Department of Psychology New York UniversityNew York 10012USA NYU-ECNU Institute of Brain and Cognitive Science NYU ShanghaiShanghai 200000China

AIM:To investigate the effect of 0.01%low-concentration atropine(LA)on quantitative contrast sensitivity function(qCSF)in children with ***:This paired case-control study included 90 eyes of 58 children who were sex-,age-,and refractionmatched and equally divided into two groups:the 0.01%LA group had undergone 6mo use of daily 0.01%atropine and control group was naïve to *** ophthalmic examinations and qCSF test without refractive correction were *** groups were compared in monocular and binocular qCSF parameters,including the area under logCSF,CSF acuity,and contrast sensitivity(CS)at 1.0-18.0 cycle per degree(cpd).RESULTS:In the monocular comparison,the CSF acuity of the LA group was significantly higher than that of the control group(7.58±5.51 vs 6.37±4.22 cpd,P<0.05).The subgroup analysis showed that in the 6-9y group,CSF acuity was significantly higher in the LA group than the control group(8.76±6.19 vs 6.54±4.25 cpd,P<0.05),and in the Female group,low refraction sphere group,and high refraction cylinder group,the CS at high spatial frequencies(12.0 and 18.0 cpd)were significantly higher in the LA group than in the control group(all P<0.05).In the binocular test,CSF acuity and CS at 12.0 cpd were significantly higher in the LA group than in the control group(10.95±7.00 vs 8.65±5.12 cpd;0.17±0.33 vs 0.06±0.16,respectively;both P<0.05).CONCLUSION:Use of LA may result in improved CS in children with early onset myopia.

关键词： low-concentration atropine myopia quantitative contrast sensitivity function Chinese children

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Assessing the possibility of using large language models in ocular surface diseases

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 1-8页

作者： Qian Ling Zi-Song Xu Yan-Mei zeng Qi Hong xian-Zhe Qian Jin-Yu Hu Chong-Gang Pei Hong Wei Jie Zou Cheng Chen Xiao-Yu Wang Xu Chen Zhen-Kai Wu yi Shao Department of Ophthalmology the First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburgNetherlands Changde Hospital Xiangya School of MedicineCentral South University(the First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To assess the possibility of using different large language models(LLMs)in ocular surface diseases by selecting five different LLMS to test their accuracy in answering specialized questions related to ocular surface diseases:ChatGPT-4,ChatGPT-3.5,Claude 2,PaLM2,and ***:A group of experienced ophthalmology professors were asked to develop a 100-question singlechoice question on ocular surface diseases designed to assess the performance of LLMs and human participants in answering ophthalmology specialty exam *** exam includes questions on the following topics:keratitis disease(20 questions),keratoconus,keratomalaciac,corneal dystrophy,corneal degeneration,erosive corneal ulcers,and corneal lesions associated with systemic diseases(20 questions),conjunctivitis disease(20 questions),trachoma,pterygoid and conjunctival tumor diseases(20 questions),and dry eye disease(20 questions).Then the total score of each LLMs and compared their mean score,mean correlation,variance,and confidence were ***:GPT-4 exhibited the highest performance in terms of *** the average scores of the LLMs group with the four human groups,chief physician,attending physician,regular trainee,and graduate student,it was found that except for ChatGPT-4,the total score of the rest of the LLMs is lower than that of the graduate student group,which had the lowest score in the human *** ChatGPT-4 and PaLM2 were more likely to give exact and correct answers,giving very little chance of an incorrect ***-4 showed higher credibility when answering questions,with a success rate of 59%,but gave the wrong answer to the question 28% of the ***:GPT-4 model exhibits excellent performance in both answer relevance and ***2 shows a positive correlation(up to 0.8)in terms of answer accuracy during the *** terms of answer confidence,PaLM2 is second only to GPT4 and surpasses Claude 2,SenseNova,and *** the fact t

关键词： ChatGPT-4.0 ChatGPT-3.5 large language models ocular surface diseases

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Impact of dietary nutrition regimens based on body composition analysis on bone metabolism in Alzheimer’s disease patients

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World Journal of Psychiatry 2025年第2期15卷 59-68页

作者： Xue-Lian Wang yi-Ran Zhao ying Yu Zhi-Fang Mao Su-xian Tan Shan-Shan Yu Department of Clinical Nutrition The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Rehabilitation Treatment Group The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Geriatrics The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Rehabilitation Medicine The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Psychiatry The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Geriatric Psychiatry The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine ***,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively *** To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD *** This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December *** on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human *** intervention period lasted for 12 *** mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the *** No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(P-1 compared to the RD group(P<0.05).The mini-mental state examination(MMSE)score was similar in both groups before the ***,12 weeks after the intervention,the MMSE score in the PN group was significantly higher than

关键词： Alzheimer’s disease Bone metabolism disorders Human body composition analysis Dietary nutrition Bone homeostasis Dietary management

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Retrospective analysis of delta hemoglobin and bleeding-related risk factors in pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 229-239页

作者： yi-Min Lin Chao Yu Guo-Zhe xian Department of Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Emergency Surgery Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250011Shandong ProvinceChina

BACKGROUND Objective and accurate assessment of blood loss during pancreaticoduodenectomy(PD)is crucial for ensuring the safety and efficacy of the *** the visual method remains the most common clinical metric,many scholars argue that it significantly differs from actual blood loss and is inherently *** To assess blood loss in PD via delta hemoglobin(ΔHb)and compare it with the visual method to predict bleeding-related risk *** In this retrospective analysis,1722 patients who underwent PD from 2017 to 2022 at Shandong Provincial Hospital were divided into three groups:Open PD(OPD),laparoscopic PD(LPD),and conversion to OPD(CTOPD).IntraoperativeΔHb(IΔHb)was calculated via preoperative and 72-hour-postoperative hemoglobin concentrations,and its association with visually obtained estimated blood loss(EBL)was ***ΔHb(PΔHb)was calculated via preoperative and predischarge hemoglobin *** compared the differences in IΔHb and PΔHb among the three groups,and performed univariate and multi-variate regression analyses of IΔHb and PΔ*** The preoperative general information of patients showed no statistically si-gnificant difference among the three groups(P>0.05).The IΔHb in the OPD,LPD,and CTOPD groups were 22.00(12.00,36.00),21.00(10.00,33.00),and 33.00(18.12,52.24)g/L,respectively;And the PΔHb in the OPD,LPD,and CTOPD groups were 25.87(13.51,42.00),25.00(14.00,45.00),and 37.48(21.64,59.65)g/L,respectively,values significantly differed(P200μmol/L(95%CI:2.805-8.673,P24 kg/m2(95%CI:1.285-9.890,P=0.011),

关键词： Pancreaticoduodenectomy Delta hemoglobin Estimated blood loss Postpancreatectomy hemorrhage Risk factor

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Accelerating homogenization kinetics and enhancing hot-workability of as-cast nickel-based superalloy via prior hot-deformation

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Journal of Iron and Steel Research International 2025年第1期32卷 215-226页

作者： Jia-jun Chen Yang Zhou Hao-ran Han xian-guang Zhang Goro Miyamoto Ping-mei Tang Dong-ping Xiao Jian-hui Fu Peng Shi yi-wu Pei Jian Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Chengdu Advanced Metal Materials Industrial Technology Institute Co. Ltd.Chengdu 610300SichuanChina Institute for Materials Research Tohoku UniversitySendai 980-8577Aoba-KuJapan

Enhancing homogenization efficiency and hot-workability is the key issue for wrought superalloys in the industry.A novel approach for simultaneous accelerating the homogenization kinetics and improving hot-workability via a simple way of prior hot-deformation was proposed,which was not widely accepted for wrought *** homogenization efficiency is increased by 40%-70%via performing 10%-20%prior *** theoretical and experimental analyses revealed that the increment in homogenization efficiency is mainly attributed to the decrease in interdendritic-segregation spacing,and thus the necessary diffusion distance,rather than that of *** addition,dynamic and static recrystallizations occurred during the prior hot-deformation and diffusion-annealing processes,and the grains were significantly refined even after the ***,the size of the precipitates was refined as *** enhanced the hot-workability of the homogenized ingot for the subsequent cogging process.

关键词： Nickel-based superalloy Homogenization kinetics Prior hot-deformation Grain size Hot workability

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Research landmarks on the 60th anniversary of Epstein-Barr virus

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Science China(Life Sciences) 2025年第2期68卷 354-380页

作者： Lan-yi Zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-Xin Zhao Guo-Long Bu xian-Shu Tian Zi-ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong Sun Mu-Sheng zeng State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Viral Immunobiology Institute of Experimental ImmunologyUniversity of ZürichZürich 8092Switzerland Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalBoston MA 02115USA Department of Microbiology Harvard Medical SchoolBoston MA 02115USA Harvard Program in Virology Boston MA 02115USA Broad Institute of Harvard and MIT Cambridge MA 02142USA

Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human *** we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex *** this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.

关键词： Epstein-Barr virus oncovirus immune response epidemiology vaccines antibodies

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