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Role of bone marrow-derived mesenchymal stem cells in a rat model of severe acute pancreatitis

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World Journal of Gastroenterology 2012年第18期18卷 2270-2279页

作者： Xiao-Huang Tu Jing-xiang Song Xiao-Jun Xue xian-wei guo Yun-Xia Ma Zhi-Yao Chen Zhong-Dong Zou Lie Wang Department of General Surgery Fuzhou General Hospital of Nanjing Military RegionFuzhou 350025Fujian ProvinceChina

AIM:To investigate the role and potential mechanisms of bone marrow mesenchymal stem cells(MSCs) in severe acute peritonitis(SAP).METHODS:Pancreatic acinar cells from Sprague Dawley rats were randomly divided into three groups:nonsodium deoxycholate(SDOC) group(non-SODC group),SDOC group,and a MSCs intervention group(i.e.,a co-culture system of MSCs and pancreatic acinar cells + SDOC).The cell survival rate,the concentration of malonaldehyde(MDA),the density of superoxide dismutase(SOD),serum amylase(AMS) secretion rate and lactate dehydrogenase(LDH) leakage rate were detected at various time *** a separate study,Sprague Dawley rats were randomly divided into either an SAP group or an SAP + MSCs *** AMS,MDA and SOD,interleukin(IL)-6,IL-10,and tumor necrosis factor(TNF)-α levels,intestinal mucosa injury scores and proliferating cells of small intestinal mucosa were measured at various time points after injecting either MSCs or saline into *** both studies,the protective effect of MSCs was ***:In vitro,The cell survival rate of pancreatic acinar cells and the density of SOD were significantly reduced,and the concentration of MDA,AMS secretion rate and LDH leakage rate were significantly increased in the SDOC group compared with the MSCs intervention group and the Non-SDOC group at each time *** vivo,Serum AMS,IL-6,TNF-α and MAD level in the SAP + MSCs group were lower than the SAP group;however serum IL-10 level was higher than the SAP *** SOD level was higher than the SAP group at each time point,whereas a significant betweengroup difference in SOD level was only noted after 24 *** mucosa injury scores was significantly reduced and the proliferating cells of small intestinal mucosa became obvious after injecting ***:MSCs can effectively relieve injury to pancreatic acinar cells and small intestinal epithelium,promote the proliferation of enteric epithelium and repair of the mucosa,attenuate systemic in

关键词： Bone marrow mesenchymal stem cells Severe acute pancreatitis Intestinal barricade function Pancreatic acinar cells

The model of taking electronic medical records as the core for information construction in hospitals＂

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Chinese Medical Journal 2013年第2期126卷 373-377页

作者： WU Tao XU Ke LI Ping LI xian-feng XU wei-guo Xinhua Hospital Shanghai Jiao Tong University School ofMedicine Shanghai 200092 China

The development of hospital information has been carried out for nearly 50 years, and originally started Le hospital information system （HIS）1 So far HIS isas the hospital information system （HIS）J So far HIS is the most widely and deeply used management system for hospitals in China.2 ＂General function standard for hospital information system＂ issued by China＇s Ministry of Health in 2002 defined that ＂The hospital information system refers to using of computer hardware and software technology, network communications technology, and other modem technology to comprehensively manage personnel, logistics, and finance in various departments in hospital. Gather, store, treat, extract, transport, aggregate,and process data in various stages of the medical activities, so that provide comprehensive and automatic information management and service to the hospital.＂

关键词： electronic medical record hospital information construction

TNF-α up-regulates Nav1.3 in dorsal root ganglion after nerve injury

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TNF-α up-regulates Nav1.3 in dorsal root ganglion after ne...

基于非线性振动的联轴器膜盘振动疲劳试验研究

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ying ZANG,Xu-Hong wei,xian-guo LIU Pain research Center of Sun Yat-sen University,Guangzhou,510080

＜正＞TTX-sensitive（TTX-S） Nav1.3 sodium channel is barely detectable in adult DRG or spinal *** nerve injury,however,the channel is up-regulated dramatically,which may contribute to neuropathic *** previous studies have shown TNF-a in DRG is increased after selective damage of motor fibers by L5 ventral root trancection（L5-VRT）.In the present work,we tested the hypothesis that TNF-a up-regulates Nav 1.3 after nerve *** found that Nav 1.3 in ipsilateral L4 and L5 DRG was increased following L5-VRT,starting on day 1,reached a peak on day 7 and persisted for at least 5 weeks after *** staining revealed that Nav 1.3 is mainly located in the C-type neurons and to a less extent in A-type neurons;More than 85%of neurons that express Nav 1.3 is TNF-α -*** confirm the relationship between TNF-α and Nav1.3,we applied TNF-α directly on to sciatic nerve without nerve injury and found that TNF-α alone produced mechanical allodynia and up-regulation of Navl.3 in DRG ***,we observed pretreatment with thalidomide,an inhibitor of TNF-α synthesis,significantly inhibited the expression of Nav 1.3 in DRG and the behavioral signs of neuropathic pain induced by *** conclude that apart from transient activation of sensory neurons as reported previously,TNF-α may produce long-lasing excitability change of neurons by up-regulation of Nav 1.3.

关键词： TNF-α Nav1.3 neuropathic pain dorsal root ganglion

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实验力学 2016年第6期31卷 763-768页

作者：杨宪峰许巍郭广平北京航空材料研究院材料检测与评价航空科技重点实验室航空材料检测与评价北京市重点实验室先进高温结构材料国防科技重点实验室北京100095

介绍了航空发动机联轴器TC4钛合金膜盘振动疲劳的试验研究。通过建立闭环控制下的振动疲劳试验系统,得到了该膜盘在不同激励条件下的频率-位移响应曲线,由此阐明了联轴器膜盘在大挠度条件下的非线性振动特性。基于该特性进一步开展膜盘... 详细信息

介绍了航空发动机联轴器TC4钛合金膜盘振动疲劳的试验研究。通过建立闭环控制下的振动疲劳试验系统,得到了该膜盘在不同激励条件下的频率-位移响应曲线,由此阐明了联轴器膜盘在大挠度条件下的非线性振动特性。基于该特性进一步开展膜盘在非线性振动条件下的振动疲劳试验研究,给出了该膜盘的径向应力-疲劳寿命曲线以及疲劳极限值。最后分析了膜盘振动疲劳的主要破坏形式。结果表明,膜盘疲劳极限值介于其母体材料的中值疲劳极限值和高可靠度疲劳极限值之间,而主要破坏形式包括可见表面裂纹和表面剥落。

关键词：联轴器膜盘非线性振动振动疲劳

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo guo Di Wang Zhao-xian Li wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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减阻增程弹道的射程估算与特性分析

宇航学报 2017年第10期38卷 1048-1056页

作者：凌王辉鲜勇郭玮林李杰张大巧火箭军工程大学七系西安710025

为实现弹道导弹射程的快速估算和减阻设计后弹道增程的定量分析,提出一种基于导弹基本参数的射程快速精确估算方法。通过建立减阻模型,仿真计算得到气动阻力系数表,并对速度计算公式进行逐项积分,利用高度近似值和气动系数拟合结果得到... 详细信息

为实现弹道导弹射程的快速估算和减阻设计后弹道增程的定量分析,提出一种基于导弹基本参数的射程快速精确估算方法。通过建立减阻模型,仿真计算得到气动阻力系数表,并对速度计算公式进行逐项积分,利用高度近似值和气动系数拟合结果得到关机点状态量和射程的初步值,最终通过迭代计算得到满足精度要求的射程结果。仿真结果表明,经过高度和气动系数的迭代计算能有效快速得到满足精度的计算结果,通过减阻设计,导弹射程提高了162.36 km,增程的效果明显。

关键词：减阻设计弹道增程射程快速估算气动拟合迭代计算

Activation of translocator protein（TSPO） reverses neuropathic pain behavior

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Activation of translocator protein（TSPO） reverses neuropat...

A novel active-passive protection strategy endows carbonyl iron with excellent intelligent anti-corrosion and microwave absorption dual functional characteristics

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xu-Hong wei,Li-Jun ZHOU,Cui-Cui LIU,Xiao wei,xian-guo LIU~* Pain Research Center of Sun Yat-sen University,Guangzhou 510080,China

＜正＞Neuropathic pain is characterized by a heightened painful response to noxious（hyperalgesia） or innocuous（allodynia） stimulation,and pain at rest（spontaneous pain）.At present no effective drug is available for the clinical symptom.A recent study has shown that the translocator protein（TSPO,18 kDa）,a peripheral receptor for benzodiazepine,modulates pain behaviors of rats induced by *** the present study,we evaluated the role of TSPO in neuropthic pain produced by L5 spinal nerve ligation（L5 SNL） with use of behavioral testing, immunohistochemistry and Western blot *** found that TSPO was up-regulated in spinal dorsal horn following L5 SNL and the change lasted until behavioral signs of neuropathic pain diminished（around 50 d）.Double immunofluorescence showed that in naive rats,TSPO was located mainly in astrocytes,to a lesser extent in neurons, but not in microglia,whereas following L5 SNL,TSPO was upregulated in astrocytes and microglia,but not in *** data showed that single intrathecal injection of TSPO agonist Ro5-4864 or FGIN-1-27 reversed established mechanical allodynia induced by L5 SNL *** and Western blot showed that intrathecal injection of Ro5-4864 reversed activation of astrocytes,and depressed p38 MAPK activation,which is exclusively activated in spinal microglial cells following peripheral nerve *** data suggested that activation of TSPO by agonists might reverse neuropathic pain by inhibition of activated glial cells.

关键词： TSPO neuropathic pain astrocyte

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Nano Research 2025年第1期18卷 487-500页

作者： wei Tian Quanyuan Feng Linbo Zhang Yinfan Liu xian Jian Longjiang Deng Institute of Microelectronics School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China National Engineering Researching Centre of Electromagnetic Radiation Control Materials Key Laboratory of Multi-Spectral Absorbing Materials and Structures of Ministry of EducationState Key Laboratory of Electronic Thin Films and Integrated DevicesSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China The Yangtze Delta Region Institute(Huzhou)&School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaHuzhou 313001China

Carbonyl iron absorbers(CI)face significant challenges in practical applications,such as corrosion,interface bonding failure,detachment,and high maintenance ***,we have developed intelligent self-healing technology based on proactive/passive mechanisms via in situ synthesis of self-healing factors(polydopamine/benzotriazole(PDA/BTA))and physical barrier layers(SiO_(2)/1,1,1,3,3,3-hexamethyl disilazane,SiO_(2)/HMDS)to enhance corrosion resistance,while also being compatible with efficient microwave absorption *** unique multiscale structure gives full play to the utilization of the roles of each functional layer,including the intelligent self-healing features of PDA/BTA,physical shielding and spatial confinement characteristics of SiO_(2)/HMDS,and magnetic-dielectric synergistic mechanism resulted from the good impedance matching characteristics,the conduction loss,the interfacial polarization loss and natural *** asfabricated composites achieved an exceptional minimum reflection loss value of-55.4 dB at 10.7 GHz and the effective absorption band of 7.6 ***,it still exhibits obvious self-healing and corrosion resistance characteristics after 360 h corrosion treatment,ascribed to the self-healing mechanism of PDA/BTA and the blocking intervention effect of SiO_(2)/*** work is considered to pave the way for the synthesis of high-performance magnetic absorbers,especially in enhancing their intelligent self-healing ability in corrosive environments.

关键词： microwave absorption intelligent self-healing technology carbonyl iron multiscale structure magneticdielectric synergistic mechanism

FTIR光谱结合系统聚类分析的甜橙树苗鉴别研究

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光谱学与光谱分析 2012年第11期32卷 3006-3009页

作者：易时来邓烈何绍兰时有明郑永强吕强谢让金韦献果李松伟简水仙西南大学中国农业科学院柑桔研究所重庆400712 曲靖师范学院物理与电子工程学院云南曲靖655011

利用傅里叶变换红外光谱技术研究了7个不同甜橙树苗春梢叶片样品的红外光谱特征,结果表明,7个甜橙品种叶片样品的傅里叶变换红外光谱主要由纤维素和多糖的吸收带组成,其特征吸收峰频率位置基本一致,但在峰形、峰相对吸收强度上存在一定... 详细信息

利用傅里叶变换红外光谱技术研究了7个不同甜橙树苗春梢叶片样品的红外光谱特征,结果表明,7个甜橙品种叶片样品的傅里叶变换红外光谱主要由纤维素和多糖的吸收带组成,其特征吸收峰频率位置基本一致,但在峰形、峰相对吸收强度上存在一定差异,尤其在1 500～700cm-1范围内的差异较为明显。通过对1 500～700cm-1范围内的二阶导数光谱进行系统聚类分析,结果显示系统聚类分析能把不同甜橙品种按亲缘关系远近进行聚类,实现对甜橙品种的快速鉴别与分类。因此,利用傅里叶变换红外光谱技术结合系统聚类分析对柑橘品种快速鉴别与分类具有一定的可行性,可作为甜橙苗早期品种鉴别的一种扩展手段。

关键词：傅里叶变换红外光谱甜橙系统聚类分析鉴别分类