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Dose-response relationship between risk factors and incidence of COVID-19 in 325 hospitalized patients:A multicenter retrospective cohort study

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World Journal of Clinical Cases 2022年第10期10卷 3047-3059页

作者： Sheng-Chao Zhao xian-qiang yu Xue-Feng Lai Rui Duan De-Liang Guo Qian Zhu Department of Radiology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina Department of Surgery Qingdao Women and Children's Hospital affiliated to Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Occupational and Environmental Health Key Laboratory of Environment and HealthMinistry of Education&Ministry of Environmental ProtectionState Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of General Surgery Jingmen First People’HospitalJingmen 448000Hubei ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Ancreatic Surgery CenterZhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Pancreatic Surgery CenterZhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

BACKGROUND The epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)patients have been widely reported,but the assessment of doseresponse relationships and risk factors for mortality and severe cases and clinical outcomes remain *** To determine the dose-response relationship between risk factors and incidence of *** In this retrospective,multicenter cohort study,we included patients with confirmed COVID-19 infection who had been discharged or had died by February 6,*** used multivariable logistic regression and Cox proportional hazard models to determine the dose-response relationship between risk factors and incidence of *** It clarified that increasing risk of in-hospital death were associated with older age(HR:1.04,95%CI:1.01-1.09),higher lactate dehydrogenase[HR:1.04,95%confidence interval(CI):1.01-1.10],C-reactive protein(HR:1.10,95%CI:1.01-1.23),and procalcitonin(natural log-transformed HR:1.88,95%CI:1.22-2.88),and D-dimer greater than 1μg/m L at admission(natural log transformed HR:1.63,95%CI:1.03-2.58)by multivariable regression.D-dimer and procalcitonin were logarithmically correlated with COVID-19 mortality risk,while there was a linear dose-response correlation between age,lactate dehydrogenase,D-dimer and procalcitonin,independent of established risk *** Higher lactate dehydrogenase,D-dimer,and procalcitonin levels were independently associated with a dose-response increased risk of COVID-19 mortality.

关键词： Coronavirus disease 2019 Dose-response relationship Risk factor Prognosis Incidence

Serum magnesium level as a predictor of acute kidney injury in patients with acute pancreatitis

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World Journal of Clinical Cases 2021年第35期9卷 10899-10908页

作者： xian-qiang yu Hong-Bin Deng Yang Liu Cheng Qu Ze-Hua Duan Zhi-Hui Tong yu-Xiu Liu Wei-Qin Li Medical School Southeast UniversityNanjing 210009Jiangsu ProvinceChina Department of Critical Care Medicine Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina Department of Critical Care Medicine Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Critical Care Medicine General Hospital of Eastern Theater CommandNanjing 210002Jiangsu ProvinceChina

BACKGROUND Decreased serum magnesium(Mg2+)is commonly seen in critically ill *** is significantly more frequent in patients with severe acute *** kidney injury(AKI)in patients with acute pancreatitis(AP)is associated with an extremely high *** association underlying serum Mg2+and AKI in AP has not been *** To explore the association between serum Mg2+on admission and AKI in patients with *** A retrospective observational study was conducted in a cohort of patients(n=233)with AP without any renal injury before admission to our center from August 2015 to February *** characteristics on admission,severity score,laboratory values and in-hospital mortality were compared between patients with and without *** A total of 233 patients were included for analysis,including 85 with *** to patients without AKI,serum Mg2+level was significantly lower in patients with AKI at admission[OR=6.070,95%CI:3.374-10.921,P<0.001].Multivariate logistic analysis showed that lower serum Mg2+was an independent risk factor for AKI[OR=8.47,95%CI:3.02-23.72,P<0.001].CONCLUSION Our analysis indicates that serum Mg2+level at admission is independently associated with the development of AKI in patients with AP and may be a potential prognostic factor.

关键词： Acute pancreatitis Acute kidney injury Magnesium(Mg2+) Kidney Predictor of acute kidney injury

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自卸汽车液压倾卸机构最优化运动分析方法

重庆建筑大学学报 2000年第3期22卷 74-76页

作者：罗伟鲜玉强重庆建筑大学机电工程学院重庆400045

以自卸汽车液压倾卸机构为例。

关键词：机构自卸汽车运动分析最优化方法

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耐磨堆焊层中化学成分对热裂纹倾向的影响

重庆建筑大学学报 2000年第1期22卷 53-57页

作者：鲜玉强周英俊罗伟重庆建筑大学机电工程学院重庆400045

介绍了耐磨堆焊熔敷层热袭纹的形成机理,并以15#钢为母材,研究了高C合金多层堆焊中化学成分对热裂纹倾向的影响。

关键词：耐磨堆焊层化学成分热裂纹倾向

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高脂血症性急性胰腺炎研究进展

世界华人消化杂志 2021年第14期29卷 804-808页

作者：于先强李维勤东南大学医学院江苏省南京市210009 东部战区总医院重症医学科江苏省南京市210002

随着人群饮食结构等因素的不断改变,高脂血症性急性胰腺炎(hyperlipidemia acute pancreatitis,HLAP)的发病率逐年增加.尤其HLAP具有区别于其他类型急性胰腺炎的机制特点,因此其临床诊疗存在本身的特殊性.本篇将结合HLAP的研究进展进行... 详细信息

随着人群饮食结构等因素的不断改变,高脂血症性急性胰腺炎(hyperlipidemia acute pancreatitis,HLAP)的发病率逐年增加.尤其HLAP具有区别于其他类型急性胰腺炎的机制特点,因此其临床诊疗存在本身的特殊性.本篇将结合HLAP的研究进展进行综述.

关键词：急性胰腺炎高脂血症甘油三酯治疗低分子肝素

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

碳纤维表面超声振荡辅助电镀镍涂层工艺及其参数的影响规律

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中国有色金属学报 2020年第3期30卷 571-579页

作者：吕钊钊沙建军祖宇飞林冠璋代吉祥鲜玉强张伟崔鼎严从林大连理工大学工业装备结构分析国家重点实验室大连116024 中国工程物理研究院应用电子学研究所绵阳621900

碳纤维增强铝基复合材料具有诸多优良性能,在航空航天以及民用领域有广阔的应用前景。在碳纤维表面电镀镍涂层,可有效改善碳纤维与铝基体的润湿性,并抑制基体对纤维的损伤。镍涂层的质量与改善效果密切相关。通过预氧化处理并结合超声... 详细信息

碳纤维增强铝基复合材料具有诸多优良性能,在航空航天以及民用领域有广阔的应用前景。在碳纤维表面电镀镍涂层,可有效改善碳纤维与铝基体的润湿性,并抑制基体对纤维的损伤。镍涂层的质量与改善效果密切相关。通过预氧化处理并结合超声振荡辅助电镀的方法在纤维表面沉积镍涂层,解决碳纤维在电镀过程中因纤维束丝难以分散而出现的"黑心"问题。在此基础上,研究电镀工艺参数对涂层质量的影响规律,并对优化工艺参数后制备的镍涂层与碳纤维的结合强度进行评价。结果表明:使用添加剂可提高镍涂层与碳纤维之间的结合力,当电镀液pH值调整到3~4、电流密度大于0.3 A/dm^2、电镀液温度控制在20~40℃时,所制备的镍涂层均匀致密。

关键词：碳纤维铝基复合材料电镀镍涂层微观结构

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Contribution of fungal biomass to persistent soil carbon across natural ecosystems

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Science China Earth Sciences 2025年

作者： xiang WANG Guang-Hui yu Yakov KUZYAKOV Bo-Hao YIN Andreas KAPPLER Cong-qiang LIU Bohai Coastal Critical Zone National Observation and Research Station Institute of Surface-Earth System Science School of Earth System Science Tianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai Rim Tianjin University Department of Soil Science of Temperate Ecosystems Department of Agricultural Soil Science University of G?ttingen Agro-Technological Institute Peoples Friendship University of Russia (RUDN University) Geomicrobiology Center for Applied Geosciences University of Tübingen Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infection University of Tübingen

Fungi are known to be crucial in the formation and stabilization of soil organic matter through their exudates and dead residues (necromass). Yet, it remains unclear how fungi contribute to the persistence of carbon in soils over millennial scales across biomes. Here, this study fills the knowledge gap by linking fungal carbon stocks with minerals-associated carbon stocks across major biomes. A strong correlation between fungal biomass and reactive mineral-associated carbon stocks in soils across six biomes supports the substantial role of fungi in soil carbon persistence at the global level. High spatial resolution nanoscale secondary ion mass spectrometry revealed that fungi may stabilize carbon by forming organo-mineral associations through their close physical connection to reactive minerals and weathered nanoparticles. We propose a conceptual model that emphasizes the dualistic role of hypha-mineral interactions:(i) fungi accelerate organic matter decomposition by producing reactive oxygen species on the hypha-mineral interfaces, and (ii) fungi stabilize their residues on mineral surfaces, leading to millennial scale persistence of soil C. Concluding, fungi play a fundamental role in ecosystems that extends beyond the decomposition of persistent carbon. They are crucial in stabilizing carbon on mineral surfaces, thereby facilitating the long-term removal of carbon from rapid biotic cycling.

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Mechanical properties and microstructures of Mg-6Si alloys fabricated using the tungsten-inert-gas arc additive manufacturing

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China Foundry 2025年

作者： Peng-cheng Zhou Guo-qiang You Jin-yu Feng Lei Wang Xiao Lin Bin Jiang College of Materials Science and Engineering Chongqing University National Engineering Research Center for Magnesium Alloys Chongqing University National Key Laboratory of Advanced Casting Technologies Chongqing University

Si-containing Mg alloys solidified at conventional rates often contain coarse and sharp Mg2Si phases,which can result in inferior material *** this study,Mg-6wt.%Si （Mg-6Si） alloy was prepared by wire arc additive manufacturing （WAAM）,employing the gas tungsten arc welding technique with rapid *** microstructures and mechanical properties of the WAAM alloy were investigated and compared with those of the as-cast samples produced using a metal *** results indicate that the WAAM Mg-6Si is harder and stronger than the as-cast *** microhardness of the WAAM Mg-6Si increases by 36.6%in comparison to that of as-cast Mg-6Si ***,the average tensile strengths at room temperature and 150°C increases by 63.4%and 21.3%,*** refines both the Mg2Si phase and the overall grains,resulting in a homogeneous morphology and improved mechanical *** granular Mg2Si phase,characterized by fine particles with a diffused distribution,shows a significant increase in *** acicular Mg2Si phase is distributed along the grain boundaries,and its concentration significantly *** average grain size of the Mg2Si phase is about 9.20μm,about 5 times *** refinement and distribution of the granular Mg2Si phase,as well as the reduction in the amount of needle-like Mg2Si particles,are the key factors for improving the mechanical properties of WAAM Mg-6Si alloy.

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