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Bedside cardiopulmonary ultrasonography evaluates lung water content in very low-weight preterm neonates with patent ductus arteriosus

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World Journal of Clinical Cases 2021年第8期9卷 1827-1834页

作者： Li-Fang Yu Chen-Ke Xu Min Zhao Lin Niu xian-mei huang Zhi-Qun Zhang Department of Ultrasound Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Department of Pediatrics Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Patent ductus arteriosus(PDA)is a common congenital heart abnormality in preterm neonates with a high incidence in neonates with very low birth *** PDA persists,interstitial lung water content increases,which could lead to abnormal circulation hemodynamics and pulmonary *** is important to perform early and reliable assessment of lung water content in very low-weight preterm neonates with persistent *** To evaluate the role of bedside cardiopulmonary ultrasonography in the lung water content assessment in very low-weight preterm neonates with persistent *** From January 2018 to March 2020,69 very low-weight preterm neonates with echocardiography-confirmed PDA were selected as the PDA *** the same time,89 very low-weight preterm neonates without PDA were randomly selected as the control *** neonates underwent echocardiography and 6-segment lung ultrasonography on the fourth day after *** clinical characteristics and main ultrasonography results were compared between the two ***’s analysis was used to analyze the correlation between lung ultrasonography score(LUS)and other related clinical and ultrasonography results in all *** the PDA group,PDA diameters were recorded,and the correlation with LUS and left atrium to aortic(LA/AO)dimension ratio were also ***/AO ratio is one of the ultrasonic diagnostic criteria for hemodynamically significant *** the ratio is≥1.5,it suggests the possibility of hemodynamic changes in persistent PDA.A receiver operating characteristic curve was established using the sensitivity of LUS to predict the hemodynamic changes in neonates with PDA as the ordinate and 1-specificity as the *** A total of 158 neonates were enrolled in this study,including 69 in the PDA group and 89 in the control *** were no statistical differences in sex,gestational age,birth weight,ventilator dependence,hospitalization length and left ventricular ejection f

关键词： Patent ductus arteriosus Cardiopulmonary Ultrasonography Lung ultrasound score Very low-weight neonates Preterm

早产儿支气管肺发育不良和红细胞输注间的关系(英文)

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早产儿支气管肺发育不良和红细胞输注间的关系(英文)

KL-6和Clara细胞蛋白作为早产儿支气管肺发育不良预测指标的比较(英文)

2014年浙江省医学会儿科学分会学术年会暨儿内科疾病诊治新进展国家级继续教育学习班

作者：张志群 xian-mei huang Hui LU Division of Neonatology Department of PediatricsHangzhou First People's Hospital Department of Pediatrics Hangzhou First People's Hospital

Background:Anemia of prematurity(AOP) and transfusion of packed red blood cells(PRBCs) are both common in preterm *** transfusion is used for the treatment of AOP to increase the oxygen carrying capacity of *** transfusion has been shown to result in higher rates of organ ***:To determine whether PRBC transfusion for AOP was associated with an incidence of bronchopulmonary dysplasia(BPD) in *** Design:This retrospective study was performed on all live-born neonates with birth weights ≤ 1,500 g or gestational age(GA) ≤ 32 weeks admitted from 2008 to *** who received PRBC transfusion and those who did not receive PRBC transfusion were compared for incidence of BPD and other ***:Of 209 patients,119 received PRBC transfusion before diagnosed BPD(group 1) and 90 did not receive PRBC or PRBC transfusion after diagnosed BPD(group 2).The incidence of BPD was higher in group 1 than group 2(37.8 vs.2.2%,p < 0.00001);after adjusting for significant risk factors,the adjusted odds ratio for BPD was 9.541(95% CI 2.031,44.806),p = ***:This study shows an association between PRBC transfusion and increased incidence of BPD in preterm infants.

关键词： prematurity bronchopulmonary dysplasia transfusion red blood cells anemia of prematurity

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KL-6和Clara细胞蛋白作为早产儿支气管肺发育不良预测指标的比较(...

Insights into spinal muscular atrophy from molecular biomarkers

2014年浙江省医学会儿科学分会学术年会暨儿内科疾病诊治新进展国家级继续教育学习班

作者： Ke-Yi Wang xian-mei huang Hui Lu Zhi-Qun Zhang Department of Central Laboratory Hangzhou First People's Hospital Department of Pediatrics Hangzhou First People's Hospital Division of Neonatology Department of PediatricsHangzhou First People's Hospital

Background:Circulating Krebs von den Lungen-6/mucin 1(KL-6/MUC1) and Clara cell secretory protein(CC16) are specific indicators of pulmonary injury involving the alveolar epithelium and ***:To evaluate the predictive characteristics of KL-6 and CC16 for bronchopulmonary dysplasia(BPD) in preterm infants,either independently or in combination,as well as to determine their reference *** design:This prospective cohort study was performed from 2011 to 2013 with preterm neonates of gestational age ≤32 weeks and birth weight ≤1500 *** KL-6 and CC16 levels were determined 7 and 14 days after ***:Seventy-three preterm infants were *** was identified in 24 of these infants(Gestational age:29.2 ± 1.7 weeks).After adjusting for potential confounders,serum KL-6 concentrations were found to be elevated in BPD infants at both time points relative to non-BPD infants,while serum CC16 concentrations were lower at 14 *** both 7 d and 14 d of life the predictive power of KL-6 levels exceeded that of CC16(area under receiver operating characteristic curve:at 7 d,0.91 cf.0.73,P = 0.02;at 14 d,0.95 cf.0.85,P = 0.05).The combination of these markers enhanced the sensitivity ***:Serum KL-6 level at 14 days of life in preterm infants predict the occurrence of *** serum levels of both KL-6 and CC16 together further enhanced the prediction *** biological markers could help the clinician plan early therapeutic interventions to minimize or avoid BPD in preterm infants.

关键词： Premature infants bronchopulmonary dysplasia Clara cell secretory protein KL-6 Mechanical ventilation

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian Wu Xiaohui huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Early amplitude-integrated EEG monitoring 6 h after birth predicts long-term neurodevelopment of asphyxiated late preterm infants

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Early amplitude-integrated EEG monitoring 6 h after birth pr...

第六届CAAE脑电图与神经电生理大会

作者： Chun-Ming Jiang Yi-Hua Yang Li-Qiong Chen xiang-Hua Shuai Hui Lu Jun-Hua xiang Zhan-Li Liu Yun-Xia Zhu Ren-Yan Xu Da-Rong Zhu xian-mei huang Hangzhou First People’s Hospital

＜正＞Purpose:The present study aimed to assess the prognostic value of early amplitude-integrated electroencephalogram（aEEG） in late preterm infants who were born at a gestational age between 340/7 and 366/7weeks for the prediction of neuro-behavioral ***:Late preterm infants（n=170） with normal,mild,and severe asphyxia underwent continuous recording of aEEC for 4～6h starting 6～8h after *** recordings were analyzed for background pattern,sleep-wake cycle（SWC）,and *** were assessed

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匈牙利方法在资源分配问题中的应用

山东科技大学学报（自然科学版） 2001年第2期20卷 18-20页

作者：赵茂先万贤美黄珍山东科技大学信息科学与工程学院泰安271019

通过对一维资源平行分配问题的讨论 ,给出了将该问题分解成若干个指派问题的方法 ,通过用匈牙利方法求解对应的指派问题。

关键词：资源分配问题指派问题匈牙利方法最优解

血清sTREM-1和降钙素原水平与多重耐药肺炎患者预后的相关性

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广东医科大学学报 2017年第5期35卷 500-503页

作者：余伟鹏冼美兰黄奕荣广东省汕头市潮阳区大峰医院呼吸内科广东汕头515154

目的探讨血清可溶性髓系细胞触发受体-1(sTREM-1)和降钙素原(PCT)水平对多重耐药肺炎患者预后的影响。方法收集60例多重耐药肺炎患者及60例正常对照者血清标本,ELISA和免疫荧光法分别检测PCT和sTREM-1水平,观察治疗前后变化,并分析其与... 详细信息

目的探讨血清可溶性髓系细胞触发受体-1(sTREM-1)和降钙素原(PCT)水平对多重耐药肺炎患者预后的影响。方法收集60例多重耐药肺炎患者及60例正常对照者血清标本,ELISA和免疫荧光法分别检测PCT和sTREM-1水平,观察治疗前后变化,并分析其与患者预后的相关性。结果治疗1、2周后,有效组血清sTREM-1、PCT水平明显低于无效组患者(P<0.01)。治疗后1周时患者血清sTREM-1和PCT水平对其预后判定具有较高价值,曲线下面积分别为0.88、0.91。COX回归分析显示sTREM-1、PCT水平与患者预后独立相关(P<0.05)。结论血清sTREM-1、PCT水平与多重耐药肺炎患者预后显著相关。

关键词：多重耐药肺炎可溶性髓系细胞触发受体-1 降钙素原

一起间接暴露引起狂犬病发病的流行病学调查报告

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中国病毒病杂志 2016年第2期6卷 159-160页

作者：任晓宾占仙梅黄仁杰杭州市疾病预防控制中心杭州310021 杭州市上城区疾病预防控制中心杭州310009

狂犬病是由狂犬病病毒感染引起的一种动物源性传染病。狂犬病病毒主要通过破损的皮肤或黏膜侵入人体,临床大多表现为特异性恐风、恐水、咽肌痉挛、进行性瘫痪等。近年来,狂犬病报告死亡数一直位居我国法定报告传染病前列,给人民群众生... 详细信息

狂犬病是由狂犬病病毒感染引起的一种动物源性传染病。狂犬病病毒主要通过破损的皮肤或黏膜侵入人体,临床大多表现为特异性恐风、恐水、咽肌痉挛、进行性瘫痪等。近年来,狂犬病报告死亡数一直位居我国法定报告传染病前列,给人民群众生命健康带来严重威胁。

关键词：间接暴露狂犬病病例报道

Antitumor activity of nervosine Ⅶ,and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells

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Chinese Journal of Natural Medicines 2020年第2期18卷 81-89页

作者： huang Shuai ZHAO Shuang-mei SHAN Lian-Hai ZHOU xian-Li School of Life Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

Nervosine Ⅶ is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis *** is first study to investigate the antitumor activity of nervosine Ⅶ in vitro,and the results indicated that nervosine Ⅶ induced autophagy and apoptosis in HCT116 human colorectal cancer *** studies showed that nervosine Ⅶ-induced apoptosis was associated with the intrinsic pathway by the activation of caspase-9,-3 *** induced by nervosine Ⅶ was characteristic with the regulation of autophagic markers including the increase of LC3-Ⅱ and beclin 1 proteins,and the decrease of p62 *** Ⅶ simultaneously induced autophagy and apoptosis by activated MAPKs signaling pathway including JNK,ERK1/2 and p38,suppressing the p53 signaling pathway.

关键词： Liparis nervosa Pyrrolizidine alkaloids NervosineⅦ Autophagy Apoptosis HCT116 cells