KL-6和Clara细胞蛋白作为早产儿支气管肺发育不良预测指标的比较(英文)
作者单位：Department of Central LaboratoryHangzhou First People's Hospital Department of PediatricsHangzhou First People's Hospital Division of NeonatologyDepartment of PediatricsHangzhou First People's Hospital
会议名称：《2014年浙江省医学会儿科学分会学术年会暨儿内科疾病诊治新进展国家级继续教育学习班》
会议日期：2014年
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
关 键 词：Premature infants bronchopulmonary dysplasia Clara cell secretory protein KL-6 Mechanical ventilation
摘 要：Background:Circulating Krebs von den Lungen-6/mucin 1(KL-6/MUC1) and Clara cell secretory protein(CC16) are specific indicators of pulmonary injury involving the alveolar epithelium and ***:To evaluate the predictive characteristics of KL-6 and CC16 for bronchopulmonary dysplasia(BPD) in preterm infants,either independently or in combination,as well as to determine their reference *** design:This prospective cohort study was performed from 2011 to 2013 with preterm neonates of gestational age ≤32 weeks and birth weight ≤1500 *** KL-6 and CC16 levels were determined 7 and 14 days after ***:Seventy-three preterm infants were *** was identified in 24 of these infants(Gestational age:29.2 ± 1.7 weeks).After adjusting for potential confounders,serum KL-6 concentrations were found to be elevated in BPD infants at both time points relative to non-BPD infants,while serum CC16 concentrations were lower at 14 *** both 7 d and 14 d of life the predictive power of KL-6 levels exceeded that of CC16(area under receiver operating characteristic curve:at 7 d,0.91 cf.0.73,P = 0.02;at 14 d,0.95 cf.0.85,P = 0.05).The combination of these markers enhanced the sensitivity ***:Serum KL-6 level at 14 days of life in preterm infants predict the occurrence of *** serum levels of both KL-6 and CC16 together further enhanced the prediction *** biological markers could help the clinician plan early therapeutic interventions to minimize or avoid BPD in preterm infants.