检索结果-南通市图书馆

Promotion effect of FOXCUT as a microRNA sponge for miR-24-3p on progression in triple-negative breast cancer through the p38 MAPK signaling pathway

引用

Chinese Medical Journal 2024年第1期137卷 105-114页

作者： Xiafei Yu Fangze Qian Xiaoqiang zhang Yanhui Zhu Gao He Junzhe Yang xian Wu Yi Zhou li Shen Xiaoyue Shi Hongfei zhang Xiao’an liu Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Background:Triple-negative breast cancer(TNBC)is a type of highly invasive breast cancer with a poor *** to new research,long noncoding RNAs(lncRNAs)play a significant role in the progression of *** the role of lncRNAs in breast cancer has been well reported,few studies have focused on *** study aimed to explore the biological function and clinical significance of forkhead box C1 promoter upstream transcript(FOXCUT)in triple-negative breast ***:Based on a bioinformatic analysis of the cancer genome atlas(TCGA)database,we detected that the lncRNA FOXCUT was overexpressed in TNBC tissues,which was further validated in an external cohort of tissues from the General Surgery Department of the First Affiliated Hospital of Nanjing Medical *** functions of FOXCUT in proliferation,migration,and invasion were detected in vitro or in *** assays and RNA immunoprecipitation(RIP)were performed to reveal that FOXCUT acted as a competitive endogenous RNA(ceRNA)for the microRNA miR-24-3p and consequently inhibited the degradation of ***:lncRNA FOXCUT was markedly highly expressed in breast cancer,which was associated with poor prognosis in some *** of FOXCUT significantly inhibited cancer growth and metastasis in vitro or in ***,FOXCUT competitively bounded to miR-24-3p to prevent the degradation of p38,which might act as an oncogene in breast ***:Collectively,this research revealed a novel FOXCUT/miR-24-3p/p38 axis that affected breast cancer progression and suggested that the lncRNA FOXCUT could be a diagnostic marker and therapeutic target for breast cancer.

关键词： Triple negative breast neoplasms RNA,long noncoding FOXCUT miR-24-3p p38 MAPK signaling pathway Disease progression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultrafast laser state active controlling based on anisotropic quasi-1D material

引用

light(Science & Applications) 2024年第4期13卷 717-726页

作者： Zixin Yang Qiang Yu Jian Wu Haiqin Deng Yan zhang Wenchao Wang Tianhao xian Luyi Huang Junrong zhang Shuai Yuan Jinyong Leng li Zhan Zongfu Jiang Junyong Wang Kai zhang Pu Zhou College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China. Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China. i-Lab&Key Laboratory of Nanodevices and Applications&Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China. School of Applied and Engineering Physics Cornell UniversityIthacaNY 14853USA. State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China. Shanghai Key Lab of Modern Optical System University of Shanghai for Science and TechnologyShanghai 200093China

Laser state active controlling is challenging under the influence of inherent loss and other nonlinear effects in ultrafast *** an extension of degree of freedom in optical devices based on low-dimensional materials may be a way ***,the anisotropic quasi-one-dimensional layered material Ta2PdS6 was utilized as a saturable absorber to modulate the nonlinear parameters effectively in an ultrafast system by polarization-dependent *** polarization-sensitive nonlinear optical response facilitates the Ta2PdS6-based mode-lock laser to sustain two types of laser states,i.e.,conventional soliton and noise-like *** laser state was switchable in the single fiber laser with a mechanism revealed by numerical *** coding was further demonstrated in this platform by employing the laser as a codable light *** work proposed an approach for ultrafast laser state active controlling with low-dimensional material,which offers a new avenue for constructing tunable on-fiber devices.

关键词： polarization fiber controlling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Self-assembly of perovskite nanocrystals:From driving forces to applications

引用

Journal of Energy Chemistry 2024年第1期88卷 561-578,I0013页

作者： Yi li Fei zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Self-assembly of metal halide perovskite nanocrystals(NCs)into superlattices can exhibit unique collective properties,which have significant application values in the display,detector,and solar cell *** review discusses the driving forces behind the self-assembly process of perovskite NCs,and the commonly used self-assembly methods and different self-assembly structures are ***,we summarize the collective optoelectronic properties and application areas of perovskite superlattice ***,we conclude with an outlook on the potential issues and future challenges in developing perovskite NCs.

关键词： Self-assembly Metal halide perovskite Nanocrystals Driving forces

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Guidance strategy of motion camouflage for spacecraft pursuit-evasion game

引用

Chinese Journal of Aeronautics 2024年第3期37卷 312-319页

作者： Jianqing li Chaoyong li Yonghe zhang Space Information Research Institute Hangzhou Dianzi UniversityHangzhou 310018China College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Key Lab of Microsatellites Chinese Academy of SciencesShanghai 201210China

This work is inspired by a stealth pursuit behavior called motion camouflage whereby a pursuer approaches an evader while the pursuer camouflages itself against a predetermined *** formulate the spacecraft pursuit-evasion problem as a stealth pursuit strategy of motion camouflage,in which the pursuer tries to minimize a motion camouflage index defined in this *** Euler-Hill reference frame whose origin is set on the circular reference orbit is used to describe the *** on the rule of motion camouflage,a guidance strategy in open-loop form to achieve motion camouflage index is derived in which the pursuer lies on the camouflage constraint line connecting the central spacecraft and *** order to dispose of the dependence on the evader acceleration in the open-loop guidance strategy,we further consider the motion camouflage pursuit problem within an infinite-horizon nonlinear quadratic differential *** saddle point solution to the game is derived by using the state-dependent Riccati equation method,and the resulting closed-loop guidance strategy is effective in achieving motion *** are performed to demonstrate the capabilities of the proposed guidance strategies for the pursuit–evasion game scenario.

关键词： Pursuit-evasion problem Motion camouflage Differential game Guidance strategy Orbit control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phosphorylation Promotes the Accumulation of PERIOD Protein Foci

引用

Research 2024年第1期2023卷 59-69页

作者： Mengna li Shujing li Luoying zhang Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanHubei 430074China Department of life Sciences Bengbu Medical CollegeBengbuAnhui 233030China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration WuhanHubei 430022China

Circadian clock drives the 24-h rhythm in our behavior and *** molecular clock consists of a series of transcriptional/translational feedback loops operated by a number of clock genes.A very recent study reported that the clock protein PERIOD(PER)is organized into discrete foci at the nuclear envelope in fly circadian neurons,which is believed to be important for controlling the subcellular localization of clock *** of inner nuclear membrane protein lamin B receptor(LBR)leads to disruption of these foci,but how they are regulated is yet ***,we found that PER foci are likely phase-separated condensates,the formation of which is mediated by intrinsically disordered region in *** promotes the accumulation of these *** phosphatase 2A,which is known to dephosphorylate PER,hampers the accumulation of the *** the other hand,the circadian kinase DOUBLETIME(DBT)which phosphorylates PER enhances the accumulation of the *** likely facilitates PER foci accumulation by destabilizing the catalytic subunit of protein phosphatase 2A,MICROTUBULE STAR(MTS).In conclusion,here,we demonstrate a key role for phosphorylation in promoting the accumulation of PER foci,while LBR modulates this process by impinging on the circadian phosphatase MTS.

关键词： conclusion separated translational

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic recrystallization mechanism, texture evolution development and mechanical characteristics of a Mg–8.7Gd–4.18Y–0.42Zr magnesium alloy by ECAP

引用

Progress in Natural Science:Materials International 2024年第2期34卷 376-388页

作者： ling zhang Yinglong li School of Materials Science and Engineering Northeastern University School of Mechanical and Engineering Ningxia Institute of Science and Technology

Equal channel angle pressing is recognized for its ability to refine alloy grains and alter grain orientation, thereby achieve better mechanical performance of the magnesium alloy. This study investigates the microstructures,dynamic recrystallization mechanism, texture development, and mechanical performance of GW94K(Mg–8.7Gd–4.18Y–0.42Zr wt. %) Mg alloy following ECAP-4 passes at 400°C and 3 mm/min. Results show that when high-temperature deformation is undertaken, twin formation is suppressed while dislocation slip is facilitated, increasing dislocation density during deformation. Following ECAP deformation, the sample displayed higher fracture elongation, TYS, and UTS than the as-solutioned GW94K alloy. In particular, the GW94K alloy performed well mechanically after ECAP-4 passes, with an ultimate TYS of 231 MPa, an UTS of 290 MPa, and an elongation of 14.8 %. DDRX and shear bands induce CDRX, both of which are important in plastic deformation. as well as in modifying microstructure and grain orientation during ECAP deformation.

关键词： Dynamic recrystallization mechanism Equal channel angular pressing Magnesium alloy Mechanical performance Mg-Gd-Y-Zr alloy Texture development

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Metal-organic framework-based single-atom electro-/ photocatalysts: Synthesis, energy applications, and opportunities

引用

Carbon Energy 2024年第1期6卷 1-43页

作者： Munir Ahmad Jiahui Chen Jianwen liu Yan zhang Zhongxin Song Shahzad Afzal Waseem Raza liaqat Zeb Andleeb Mehmood Arshad Hussain Jiujun zhang xian-Zhu Fu Jing-li Luo Shenzhen Key Laboratory of Energy Electrocatalytic Materials Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhenGuangdongChina College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhenGuangdongChina College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhenGuangdongChina Department of Environmental Engineering China Jiliang UniversityHangzhouZhejiangChina Institute for Advanced Study Shenzhen UniversityShenzhenGuangdongChina School of Bioengineering Dalian University of TechnologyDalianLiaoningChina College of Materials Science and Engineering Fuzhou UniversityFuzhouFujianChina Institute for Sustainable Energy Shanghai UniversityShanghaiChina

Single-atom catalysts(SACs)have gained substantial attention because of their exceptional catalytic ***,the high surface energy limits their synthesis,thus creating significant challenges for further *** the last few years,metal–organic frameworks(MOFs)have received significant consideration as ideal candidates for synthesizing SACs due to their tailorable chemistry,tunable morphologies,high porosity,and chemical/thermal *** this perspective,this review thoroughly summarizes the previously reported methods and possible future approaches for constructing MOF-based(MOF-derived-supported and MOF-supported)***,MOF-based SAC's identification techniques are briefly assessed to understand their coordination environments,local electronic structures,spatial distributions,and catalytic/electrochemical reaction *** review systematically highlights several photocatalytic and electrocatalytic applications of MOF-based SACs for energy conversion and storage,including hydrogen evolution reactions,oxygen evolution reactions,O_(2)/CO_(2)/N_(2) reduction reactions,fuel cells,and rechargeable *** light is also shed on the future development of this highly exciting field by highlighting the advantages and limitations of MOF-based SACs.

关键词： carbon energy generation MOF-derived-supported MOF-supported single atoms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Omics for deciphering oral microecology

引用

International Journal of Oral Science 2024年第2期16卷 197-207页

作者： Yongwang lin Xiaoyue liang Zhengyi li Tao Gong Biao Ren Yuqing li xian Peng State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduChina

The human oral microbiome harbors one of the most diverse microbial communities in the human body,playing critical roles in oral and systemic *** technological innovations are propelling the characterization and manipulation of oral ***-throughput sequencing enables comprehensive taxonomic and functional profiling of oral *** long-read platforms improve genome assembly from complex ***-cell genomics provides insights into uncultured *** imaging modalities including fluorescence,mass spectrometry,and Raman spectroscopy have enabled the visualization of the spatial organization and interactions of oral microbes with increasing *** techniques link phylogenetic identity with *** spectrometry imaging reveals metabolic niches and activities while Raman spectroscopy generates rapid biomolecular fingerprints for *** facilitates the isolation and cultivation of novel fastidious oral taxa using high-throughput *** integration of these technologies holds the promise of transforming our understanding of oral microbiome assembly,gene expression,metabolites,microenvironments,virulence mechanisms,and microbe-host interfaces in the context of health and ***,significant knowledge gaps persist regarding community origins,developmental trajectories,homeostasis versus dysbiosis triggers,functional biomarkers,and strategies to deliberately reshape the oral microbiome for therapeutic *** convergence of sequencing,imaging,cultureomics,synthetic systems,and biomimetic models will provide unprecedented insights into the oral microbiome and offer opportunities to predict,prevent,diagnose,and treat associated oral diseases.

关键词： insight holds oral

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selection of dialysis methods for end-stage kidney disease patients with diabetes

引用

World Journal of Diabetes 2024年第9期15卷 1862-1873页

作者： Yao-Hua Hu Ya-li liu ling-Fei Meng Yi-xian zhang Wen-Peng Cui Department of Nephrology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

The increasing prevalence of diabetes has led to a growing population of endstage kidney disease(ESKD)patients with ***,kidney transplantation is the best treatment option for ESKD patients;however,it is limited by the lack of ***,dialysis has become the standard treatment for ESKD ***,the optimal dialysis method for diabetic ESKD patients remains *** patients with diabetes often present with complex conditions and numerous ***,these patients face a high risk of infection and technical failure,are more susceptible to malnutrition,have difficulty establishing vascular access,and experience more frequent blood sugar fluctuations than the general ***,this article reviews nine critical aspects:Survival rate,glucose metabolism disorder,infectious complications,cardiovascular events,residual renal function,quality of life,economic benefits,malnutrition,and volume *** study aims to assist clinicians in selecting individualized treatment methods by comparing the advantages and disadvantages of hemodialysis and peritoneal dialysis,thereby improving patients’quality of life and survival rates.

关键词： Diabetes End-stage kidney disease Hemodialysis Peritoneal dialysis Dialysis methods selection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strategies of selective electroreduction of aqueous nitrate to N_(2) in chloride-free system:A critical review

引用

Green Energy & Environment 2024年第2期9卷 198-216页

作者： Fukuan li Weizhe zhang Peng zhang Ao Gong Kexun li College of Environmental Science and Engineering Nankai UniversityTianjin300350China MOE Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution ControlTianjin Key Laboratory of Environmental Technology for Complex Trans-Media PollutionNankai UniversityTianjin300350China

Electroreduction of nitrate has been gaining wide attention in recent years owing to it's beneficial for converting nitrate into benign N_(2) from the perspective of electrocatalytic denitrification or into value-added ammonia from the perspective of electrocatalytic NH_(3) *** reason of the undesired formation of ammonia is dominant during electroreduction of nitrate-containing wastewater,chloride has been widely used to improve N_(2) ***,selective electroreduction of nitrate to N2 gas in chloride-containing system poses several *** this review,we focus on the key strategies for efficiently enhancing N_(2) selectivity of electroreduction of nitrate in chloride-free system,including optimal selection of elements,combining an active metal catalyst with another metal,manipulating the crystalline morphology and facet orientation,constructing core–shell structure catalysts,*** summarizing the strategies,four possible reaction pathways of electro-reduction of nitrate to N_(2) are ***,this review attempts to provide practical strategies for enhancing N2 selectivity without the aid of electrochlorination and highlight directions for future research for designing appropriate electrocatalyst for final electrocatalytic denitrifi-cation.

关键词： Nitrate Chloride Electroreduction Selectivity Nitrogen

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：