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A hypothesis study on a four-period prevention model for high altitude disease

Military Medical Research 2018年第2期5卷 183-188页

作者： xian-Sheng Liu xiang-Rong Yang Lu Liu xian-kui qin Yu-Qi Gao Institute of Medicine and Hygienic Equipment for High Altitude Region College of High Altitude Military MedicineThird Military Medical UniversityNo.30 Gaotanyan StreetShapingba DistrictChongqing 400038China Department of Medical Affairs The 5th Hospital of the Chinese PLANo.893 Shengli StreetXingqing DistrictYinchuanNingxia 750003China Key Laboratory of High Altitude Environmental Medicine Third Military Medical UniversityMinistry of EducationNo.30 Gaotanyan StreetShapingba DistrictChongqing 400038China Key Laboratory of High Altitude Medicine of PLA No.30 Gaotanyan StreetShapingba DistrictChongqing 400038China Department of Health Service Training Base of Health ServiceThird Military Medical UniversityNo.30 Gaotanyan StreetShapingba DistrictChongqing 400038China Department of Outpatient PLA No.96819 UnitNo.2 Heping RoadChaoyang DistrictBeijing 100085China

Background:High altitude disease(HAD)can reduce combat effectiveness and damage the health of soldiers at high *** objective of this hypothesis study is to build a four-period prevention model for high altitude disease that can be applied at high altitudes of over 3000 *** of the hypothesis:We divided the time at high altitude into nine periods,with three stages from the ascent preparation to the descent to the plain,and applied a continuous dynamic and systematic four-period prevention model across the nine *** period of three stages has its own different measures and targets high altitude health care services for the prevention of high altitude disease.A standard four-period prevention model for high altitude disease was constructed for the high altitude health services at the population *** the hypothesis:Our hypothesized HAD prevention model represents a continuous dynamic and systematic four-period prevention model across the nine *** hypothesis can be tested from three *** first one is assessment of soldiers’operating *** second is comparison of the long-term high altitude population health basic data and development and utilization of big *** third is descent population health status comparative study and historical retrospective study on ***:As we know,it is necessary to protect soldiers’health through the ascent and *** the standard four-period model,we can protect soldiers’health by preventing high altitude diseases,screening the susceptible population,securely tracking their location and maintaining soldiers’health statuses;we also maintain their operational capabilities,eliminate their psychological fears and ease their family troubles.

关键词： High altitude disease High altitude health service Prevention model

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中药复方、中草药及其有效成分提取物治疗慢性丙型肝炎随机对照试验的系统综述和meta分析

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中西医结合学报 2009年第10期7卷 913-928页

作者：秦献魁韩梅刘建平解放军96819部队门诊部北京中医药大学循证医学中心挪威国家补充与替代医学研究中心特洛姆瑟大学

背景:干扰素联合利巴韦林是慢性丙型肝炎的常规治疗方法,然而,该疗法存在一定副作用,对部分患者疗效不佳,且治疗费用昂贵。中医药治疗慢性肝病包括丙型肝炎有大量报道,需要进行系统综述。目的:运用循证医学系统综述方法评价中草药治疗... 详细信息

背景:干扰素联合利巴韦林是慢性丙型肝炎的常规治疗方法,然而,该疗法存在一定副作用,对部分患者疗效不佳,且治疗费用昂贵。中医药治疗慢性肝病包括丙型肝炎有大量报道,需要进行系统综述。目的:运用循证医学系统综述方法评价中草药治疗慢性丙型肝炎的疗效和安全性。检索策略:MEDLINE、Cochrane图书馆(2009年第3期)、中国学术期刊全文数据库、中文科技期刊全文数据库、中国生物医学文献数据库、中文生物医学期刊数据库、中医药期刊文献数据库。检索日期截止2009年7月8日。纳入标准:收集比较中草药与安慰剂、非特异性治疗、干扰素治疗丙型肝炎的随机对照试验。中草药联用干扰素与单用干扰素比较的试验也予以纳入。资料提取与分析:两人独立提取资料,采用Cochrane协作网提供的软件RevMan 5.017进行资料分析。结局的效应指标为相对危险度或均数差,均以95%可信区间表示。结果:51篇随机对照试验满足纳入标准,共治疗3678名病人。所纳入的6篇英文文献质量较高,中文文献质量普遍偏低。在临床症状、肝功能及抗病毒效应的综合疗效分析中,中草药明显优于非特异性治疗,与干扰素疗效相当,中药联合干扰素与单用干扰素比较,差异无统计学意义。中药对血清丙型肝炎病毒(hepatitisC virus,HCV)RNA阴转的效果明显优于非特异性治疗,与干扰素抗病毒治疗比较,差异无统计学意义,而与干扰素合用的疗效优于单用干扰素;中药及其与抗病毒药物合用的抗HCV抗体阴转疗效均优于单用干扰素治疗。在改善肝功能指标上中药显著优于安慰剂、非特异性治疗,且与干扰素抗病毒治疗比较,差异无统计学意义,但与抗病毒治疗联合使用则优于单用抗病毒治疗。随访的疗效分析表明上述效应具有持续性。中药注射剂及抗病毒治疗均有一定的副作用,个别患者有较严重的副作用。结论:纳入本系统综述的部分中草药治疗慢性丙型肝炎具有改善症状、促进肝功能恢复和清除血清HCV标志物的作用。但是由于中文发表的临床试验质量较低,对那些疗效较好的中药制剂需要作进一步的验证,试验的设计及报告应按照国际规范执行。系统综述注册:http://***,注册号为380700081611301089。

关键词：中药慢性丙型肝炎系统综述 meta分析随机对照试验

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小柴胡汤治疗慢性乙型肝炎随机对照试验的系统评价

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中西医结合学报 2010年第4期8卷 312-320页

作者：秦献魁李萍韩梅刘建平解放军96819部队门诊部北京中医药大学循证医学中心挪威特洛姆瑟大学挪威国家补充与替代医学研究中心

小柴胡汤是《伤寒论》中的经典方,广泛用于慢性肝病的治疗,尤其在日本每年有超过100万的慢性肝病病人使用。目的:运用循证医学系统综述方法评价小柴胡汤治疗慢性乙型肝炎的抗病毒及保肝疗效和安全性。检索策略:文献检索包括电子与手工... 详细信息

小柴胡汤是《伤寒论》中的经典方,广泛用于慢性肝病的治疗,尤其在日本每年有超过100万的慢性肝病病人使用。目的:运用循证医学系统综述方法评价小柴胡汤治疗慢性乙型肝炎的抗病毒及保肝疗效和安全性。检索策略:文献检索包括电子与手工检索。电子检索MEDLINE数据库、中国学术期刊全文数据库(CNKI)、中文科技期刊全文数据库(重庆维普)、中国生物医学文献数据库(Chinese Biomedical LiteratureDatabase,CBM)、中文生物医学期刊数据库(Chinese Medical Current Contents,CMCC)、中医药期刊文献数据库。检索日期截止至2009年11月8日。纳入标准:收集比较小柴胡汤与安慰剂、非特异性治疗、抗病毒药物治疗慢性乙肝的随机对照试验。小柴胡汤联用抗病毒药物与抗病毒药物比较的试验也予以纳入。资料提取与分析:两人独立提取资料,采用Cochrane协作网提供的软件RevMan 5.017进行资料分析。结局的效应指标为危险比率(risk ratio,RR)或均数差(mean difference,MD),均以95%可信区间表示。结果:16篇随机对照试验共治疗1601名慢性乙肝病人满足纳入标准。所纳入的1篇英文文献质量较高,其余15篇中文文献质量普遍偏低。在肝功能及抗病毒效应的综合疗效评价分析中,小柴胡汤联合抗病毒药物治疗优于单用抗病毒药物,小柴胡汤与安慰剂在改善肝功能和抗病毒效应方面的差异无统计学意义,小柴胡汤与丹参注射液联用在肝功能恢复上优于非特异性治疗。纳入试验未报告小柴胡汤的副作用,抗病毒治疗对个别患者有较严重的副作用。结论:纳入本系统评价的部分试验表明小柴胡汤联合抗病毒药物治疗慢性乙肝具有改善肝功能和清除血清标志物的作用。但是由于用中文发表的临床试验质量较低,对那些疗效较好的中药制剂需要作进一步的验证,试验的设计及报告应按照国际规范执行。

关键词：小柴胡汤慢性乙型肝炎系统综述随机对照试验

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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu xian qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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Review:J-integral resistance curve testing and evaluation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第11期10卷 1541-1560页

作者： xian-kui ZHU Battelle Memorial Institute Columbus Ohio 43221 USA

In this paper a critical review is presented of the history and current state of the art of J-integral resistance curve testing and experimental evaluation methods in conjunction with a discussion of the development of the plane strain fracture toughness test standard ASTM E1820 developed by American Society for Testing and Materials (ASTM). Early research efforts on this topic are reviewed first. These include the J-integral concept, experimental estimates of the J-integral for stationary cracks, load line displacement (LLD) and crack mouth opening displacement (CMOD) based η factor equations, different formulations of J-integral incremental equations for growing cracks, crack growth corrected J-R curve determination, and experimental test methods. Recent developments in J-R curve testing and evaluation are then described, with emphasis on accurate J-integral incremental equations, a normalization method, a modified basic method, a CMOD direct method with use of incremental equations, relationships of plastic geometry factors, constraint-dependent J-R curve testing and correction approaches. An overview of the present fracture toughness test standard ASTM E1820-08a is then presented. The review shows that after more than 40 years of investigation and development, the J-integral resistance curve test methods in ASTM E1820 have become simpler, more cost-effective and more accurate.

关键词： J-integral J-R curve Fracture toughness Fracture testing Crack growth

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Improving the stability of metal halide perovskite solar cells from material to structure

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Journal of Energy Chemistry 2019年第6期28卷 90-99页

作者： kui qin Binghai Dong Shimin Wang Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials. Hubei University Wuhan 430062HubeiChina Key Laboratory for the Green Preparation and Application of Functional Materials Ministry of EducationFaculty of Materials Science and EngineeringHubei UniversityWuhan 430062HubeiChina

Metal halide perovskites(MHPs) are promising photovoltaic(PV) materials owing to their advantages such as high carrier mobility, excellent absorption coefficient, bandgap tenability, long diffusion length,and low material cost. These qualities have increased the efficiency of MHP solar cells to 23.3%. However,MHPs are hindered by a lack of stability. In addition, the applications of MHP solar cells are restricted by the instability of perovskite materials and devices. In this article, the most urgent stability problems faced by perovskite solar cells are identified, and recent progresses in MHPs are enumerated. The factors affecting the stability of perovskite materials and devices are also discussed. We analyzed the thermal and humid stability of perovskite materials in terms of transporting materials and their interface. In view of these recent advances, future works should focus on the large-scale application of MHP solar cells.

关键词： Perovskite solar cells Metal halide Stability Moisture Degradation

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Separation and enrichment mechanism of C54–TiSi_(2) from hypoeutectic Ti–65 wt.%Si alloy during directional solidification via alternating electromagnetic fields

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Journal of Iron and Steel Research International 2021年第1期28卷 29-37页

作者： kui‑song Zhu Jing‑fei Hu Wen‑hui Ma kui‑xian Wei Yong‑nian Dai The National Engineering Laboratory for Vacuum Metallurgy State Key Laboratory of Complex Nonferrous Metal Resources Clean UtilizationKunming University of Science and TechnologyKunming 650093YunnanChina College of Vanadium and Titanium Panzhihua UniversityPanzhihua 617000SichuanChina Key Laboratory for Nonferrous Vacuum Metallurgy of Yunnan Province Engineering Research Center for Silicon Metallurgy and Silicon Materials of Yunnan Provincial UniversitiesKunming University of Science and TechnologyKunming 650093YunnanChina

The effects of directional solidification parameters and the coupling of directional solidification parameters and alternating electromagnetic fields on separation and enrichment of the C54–TiSi2 phase were investigated in a directionally solidified hypoeutectic Ti–65 wt.%Si *** results indicated that by increasing the pull-down velocity at a given position within the ingot,the cooling rate,growth rate,and temperature gradient of ingot could be *** a pull-down velocity near 5μm/s,the temperature gradient,cooling rate,and growth rate decreased with increasing the thickness of the C54–TiSi2-rich *** fields enhanced mass transfer at pull-down velocities of 5,10,15,and 20μm/s,with resulting enriched layer thicknesses of 15,10,10,and 5 mm,*** increasing the percentage of Ti in the Ti–Si alloy from 25 to 35 wt.%,the thickness of the C54–TiSi2-rich layer was increased from 2.5 to 3.3 ***,the maximum C54–TiSi2 content obtained experimentally in this layer decreased from 92.06 to 79.49 mass%.

关键词： Ti–Si alloy Directional solidification Electromagnetic field Separation C54–TiSi2

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Intraoperative management and early post-operative outcomes of patients with coronary artery disease who underwent orthotopic liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 12-16页

作者： Hai-Ying Kong xian Zhao kui-Rong Wang Department of Anesthesiology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Anesthesiology International HospitalZhejiang UniversityHangzhou 310000China

Background: Coronary artery disease (CAD) is frequently observed in aging end-stage liver disease (ESLD) patients who require orthotopic liver transplantation (OLT). This situation is challenging for both the pa- tients and the medical staff. Methods: We retrospectively studied the case records of 26 ESLD patients with CAD who underwent OLT with total clamping of the inferior vena cava between 2014 and 2018. We analyzed the details of the pre-operative evaluation, intraoperative anesthetic management and post-operative prognosis of these patients. Results: All patients tolerated the anhepatic stage well. Post-reperfusion syndrome (PRS) was observed in 13 patients (50%) and 2 of them were severe but corrected well. ST-segment depression was frequently observed during the anhepatic stage and reperfusion stage. No mortality due to cardiac-related events occurred among the patients during hospitalization. OLT with the modi ed piggyback technique could successfully be performed in ESLD patients with mild and moderate CAD. Conclusions: A thorough evaluation and optimization of recipients, strict monitoring and optimized man-agement of circulation, knowledge of the complicated changes during OLT procedures, and strategies to ameliorate post-reperfusion syndrome favorite the outcomes.

关键词： Orthotopic liver transplantation Coronary artery disease Post-reperfusion syndrome

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Facile access to chiral 1-pyrrolines through Rh-catalyzed enantioselective partial hydrogenation of unprotected simple pyrroles

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Chinese Chemical Letters 2022年第12期33卷 5092-5095页

作者： kui Tian Gongyi Liu Xiu-qin Dong Engineering Research Centre of Organosilicon Compounds&Materials Ministry of EducationCollege of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China Suzhou Institute of Wuhan University Suzhou 215123China

Highly enantioselective Rh-catalyzed partial hydrogenation of unprotected simple 2-alkyl-5-aryl-disubstituted pyrroles has been successfully developed,generating a series of chiral 1-pyrroline derivatives generally with excellent results(95%-99%yields,91%-96%ee).Moreover,2,5-aryl-1H-pyrroles were hydrogenated well in high yields and good *** efficient protocol features easily accessible substrates,wide substrate scope,well functional group compatibility,commercially available rhodium precursor and chiral *** provides a versatile route to access chiral 1-pyrroline derivatives that are of great importance in organic synthesis and pharmaceutical chemistry.

关键词： Chiral 1-pyrrolines Partial hydrogenation Unprotected simple pyrroles Regioselectivity Enantioselectivity

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Adversarial Attacks and Defenses in Deep Learning

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Engineering 2020年第3期6卷 346-360页

作者： kui Ren Tianhang Zheng Zhan qin Xue Liu Institute of Cyberspace Research Zhejiang UniversityHangzhou 310027China College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China Department of Electrical and Computer Engineering University of TorontoTorontoON M5S 2E8Canada School of Computer Science McGill UniversityMontrealQC H3A 0E9Canada

With the rapid developments of artificial intelligence(AI)and deep learning(DL)techniques,it is critical to ensure the security and robustness of the deployed ***,the security vulnerability of DL algorithms to adversarial samples has been widely *** fabricated samples can lead to various misbehaviors of the DL models while being perceived as benign by *** implementations of adversarial attacks in real physical-world scenarios further demonstrate their ***,adversarial attack and defense techniques have attracted increasing attention from both machine learning and security communities and have become a hot research topic in recent *** this paper,we first introduce the theoretical foundations,algorithms,and applications of adversarial attack *** then describe a few research efforts on the defense techniques,which cover the broad frontier in the *** open problems and challenges are subsequently discussed,which we hope will provoke further research efforts in this critical area.

关键词： Machine learning Deep neural network Adversarial example Adversarial attack Adversarial defense

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