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Establishment of a prognosis predictive model for liver cancer based on expression of genes involved in the ubiquitin-proteasome pathway

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World Journal of Clinical Oncology 2024年第3期15卷 434-446页

作者： Hua Li Yi-Po Ma hai-Long Wang Cai-Juan Tian Yi-xian Guo Hong-Bo Zhang Xiao-Min liu Peng-Fei liu Department of Endoscopy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Critical Care Medicine Dingzhou City People’s HospitalDingzhou 073000Hebei ProvinceChina Department of Oncology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Tianjin Marvel Medical Laboratory Tianjin Marvelbio Technology Co.LtdTianjin 300180China Department of Intelligent Technology Tianjin Yunquan Intelligent Technology Co.LtdTianjin 300381China Department of Oncology Tianjin Huanhu HospitalTianjin 300350China

BACKGROUND The ubiquitin-proteasome pathway(UPP)has been proven to play important roles in *** To investigate the prognostic significance of genes involved in the UPP and develop a predictive model for liver cancer based on the expression of these *** In this study,UPP-related E1,E2,E3,deubiquitylating enzyme,and proteasome gene sets were obtained from the Kyoto Encyclopedia of Genes and Genomes(KEGG)database,aiming to screen the prognostic genes using univariate and multivariate regression analysis and develop a prognosis predictive model based RESULTS Five genes(including autophagy related 10,proteasome 20S subunit alpha 8,proteasome 20S subunit beta 2,ubiquitin specific peptidase 17 like family member 2,and ubiquitin specific peptidase 8)were proven significantly correlated with prognosis and used to develop a prognosis predictive model for liver *** training,validation,and Gene Expression Omnibus sets,the overall survival differed significantly between the high-risk and low-risk *** expression of the five genes was significantly associated with immunocyte infiltration,tumor stage,and postoperative recurrence.A total of 111 differentially expressed genes(DEGs)were identified between the high-risk and low-risk groups and they were enriched in 20 and 5 gene ontology and KEGG *** division cycle 20,Kelch repeat and BTB domain containing 11,and DDB1 and CUL4 associated factor 4 like 2 were the DEGs in the E3 gene set that correlated with *** We have constructed a prognosis predictive model in patients with liver cancer,which contains five genes that associate with immunocyte infiltration,tumor stage,and postoperative recurrence.

关键词： Liver cancer Ubiquitin-proteasome pathway Prognosis prediction Gene expression Immune infiltration

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High density iridium synergistic sites boosting CO-tolerate performance for PEMFC anode

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eScience 2024年第4期4卷 89-95页

作者： Tongtong Yang Xiaolong Yang Nanxing Gao Meijian Tang xian Wang Changpeng liu Wei Xing Junjie Ge State Key Laboratory of Electroanalytic Chemistry Jilin Province Key Laboratory of Low Carbon Chemistry PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

The usage of cheap crude H2 in proton-exchange membrane fuel cells(PEMFCs)is still unrealistic to date,due to the suffering of the current Pt based nano-catalysts from impurities such as CO in ***,synergistic active sites between single atom(SA)and nanoparticle(NP)have been found to be promising for overcoming the poisoning ***,lengthening the nanoparticle-single atom(SA–NP)interface,i.e.,constructing high density synergistic active sites,remains highly ***,we present a new strategy based on molecular fusion strategy to create abundant SA–NP interfaces,with high density SA–NP interfaces created on a two dimensional nitrogen doped carbon nanosheets(Ir-SACs&NPs/NC).Owing to the abundance of SA–NP interface sites,the catalyst was empowered with a high tolerance towards up to 1000ppm CO in H2 *** findings provide guidelines for the design and construction of active and anti-poisoning catalysts for PEMFC anode.

关键词： CO-tolerant electrocatalysts Hydrogen oxidation reaction Carbon monoxide oxidation reaction Synergistic effects

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Microwave-assisted exploration of the electron configuration-dependent electrocatalytic urea oxidation activity of 2D porous NiCo_(2)O_(4) spinel

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Journal of Energy Chemistry 2024年第4期91卷 226-235页

作者： Jun Wan Zhiao Wu Guangyu Fang Jinglin xian Jiao Dai Jiayue Guo Qingxiang Li Yongfei You Kaisi liu Huimin Yu Weilin Xu Huiyu Jiang Minggui Xia Huanyu Jin State Key Laboratory of New Textile Materials and Advanced Processing Technologies Hubei Key Laboratory of Biomass Fibers and Eco-Dyeing&FinishingWuhan Textile UniversityWuhan 430200HubeiChina Institute for Sustainability Energy and ResourcesThe University of AdelaideAdelaideSA 5005Australia Future Industries Institute University of South AustraliaMawson Lakes CampusAdelaideSA 5095Australia

Urea holds promise as an alternative water-oxidation substrate in electrolytic ***-valence nickelbased spinel,especially after heteroatom doping,excels in urea oxidation reactions(UOR).However,traditional spinel synthesis methods with prolonged high-temperature reactions lack kinetic precision,hindering the balance between controlled doping and highly active two-dimensional(2D)porous structures *** significantly impedes the identification of electron configuration-dependent active sites in doped 2D nickel-based ***,we present a microwave shock method for the preparation of 2D porous NiCo_(2)O_(4)*** the transient on-off property of microwave pulses for precise heteroatom doping and 2D porous structural design,non-metal doping(boron,phosphorus,and sulfur)with distinct extranuclear electron disparities serves as straightforward examples for *** tuning of lattice parameter reveals the impact of covalent bond strength on NiCo_(2)O_(4)structural *** introduced defect levels induce unpaired d-electrons in transition metals,enhancing the adsorption of electron-donating amino groups in urea ***,Bode plots confirm the impact mechanism of rapid electron migration caused by reduced band gaps on UOR *** prepared phosphorus-doped 2D porous NiCo_(2)O_(4),with optimal electron configuration control,outperforms most reported *** controlled modification strategy advances understanding theoretical structure-activity mechanisms of high-performance 2D spinels in UOR.

关键词： 2D materials Spinel Microwave Electrocatalysis Urea oxidation reaction

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Low-noise and low-power pixel sensor chip for gas pixel detectors

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Nuclear Science and Techniques 2024年第3期35卷 142-152页

作者： Zhuo Zhou Shi-Qiang Zhou Dong Wang xiang-Ming Sun Chao-Song Gao Peng-Zhen Zhu Wei-Ping Ren Jun liu Mu-xian Li Chen Lian Chun-Lai Dong PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China

Topmetal-M2 is a large-area pixel sensor chip fabricated using the GSMC 130 nm CMOS process in *** pixel array of Topmetal-M2 consists of pixels of 400 rows×512 columns with a pixel pitch of 45μm×45μ*** array is divided into 16 subarrays,with pixels of 400 rows×32 columns per *** pixel incorporates two charge sensors:a diode sensor and a Topmetal *** in-pixel circuit primarily consists of a charge-sensitive amplifier for energy measurements,a discriminator with a peak-holding circuit,and a time-to-amplitude converter for time-of-arrival *** pixel of Topmetal-M2 has a charge input range of~0-3 k e-,a voltage output range of~0-180 mV,and a charge-voltage conversion gain of~59.56μV∕e-.The average equivalent noise charge of Topmetal-M2,which includes the readout electronic system noise,is~43.45 e-.In the scanning mode,the time resolution of Topmetal-M2 is 1 LSB=1.25μs,and the precision is^()7.41μ*** an operating voltage of 1.5 V,Topmetal-M2 has a power consumption of~49 mW∕cm~*** this article,we provide a comprehensive overview of the chip architecture,pixel working principles,and functional behavior of ***,we present the results of preliminary tests conducted on Topmetal-M2,namely,alpha-particle and soft X-ray tests.

关键词： Charge collection Gas detectors Semiconductor detectors X-ray detectors

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Amorphous Iridium Oxide-Integrated Anode Electrodes with Ultrahigh Material Utilization for Hydrogen Production at Industrial Current Densities

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Nano-Micro Letters 2024年第10期16卷 225-239页

作者： Lei Ding Kui Li Weitian Wang Zhiqiang Xie Shule Yu Haoran Yu David ACullen Alex Keane Kathy Ayers Christopher BCapuano Fangyuan liu Pu-xian Gao Feng-Yuan Zhang Department of Mechanical Aerospace and Biomedical EngineeringUniversity of TennesseeKnoxvilleTN 37996USA Oak Ridge National Lab Center for Nanophase Materials SciencesOak RidgeTN 37831USA Nel Hydrogen WallingfordCT 06492USA Institute of Materials Science University of ConnecticutStorrsCT 06269USA Department of Materials Science and Engineering University of ConnecticutStorrsCT 06269USA

Herein,ionomer-free amorphous iridium oxide(IrO_(x))thin electrodes are first developed as highly active anodes for proton exchange membrane electrolyzer cells(PEMECs)via low-cost,environmentally friendly,and easily scalable electrodeposition at room *** with a Nafion 117 membrane,the IrO_(x)-integrated electrode with an ultralow loading of 0.075 mg cm^(-2)delivers a high cell efficiency of about 90%,achieving more than 96%catalyst savings and 42-fold higher catalyst utilization compared to commercial catalyst-coated membrane(2 mg cm^(-2)).Additionally,the IrO_(x)electrode demonstrates superior performance,higher catalyst utilization and significantly simplified fabrication with easy scalability compared with the most previously reported ***,the remarkable performance could be mainly due to the amorphous phase property,sufficient Ir^(3+)content,and rich surface hydroxide groups in ***,due to the high activity,high cell efficiency,an economical,greatly simplified and easily scalable fabrication process,and ultrahigh material utilization,the IrO_(x)electrode shows great potential to be applied in industry and accelerates the commercialization of PEMECs and renewable energy evolution.

关键词： Ionomer-free Amorphous IrOx electrodes Ultrahigh material utilization Scalable electrodeposition Hydrogen production

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu xiandeng Li Mi Li xian Wu Xiaohui Huang Ajing Xu Yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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Design of weak current measurement system and research on temperature impact

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Nuclear Science and Techniques 2024年第4期35卷 46-56页

作者： Chu-xiang Zhao San-Gang Li Rong-Rong Su Li Yang Ming-Zhe liu Qing-Yue Xue Shan Liao Zhi Zhou Qing-Shan Tan xian-Guo Tuo Yi Cheng College of Nuclear Technology and Automation Engineering Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China University of Science and Technology of China Hefei 230026China School of Physics and Electronic Engineering Sichuan University of Science and EngineeringZigong 643000China

A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization *** system incorporates a second-order low-pass filter circuit and the Kalman filtering algorithm to effectively filter out noise and minimize interference in the measurement *** conducted under normal temperature conditions has demonstrated the system's high precision ***,it was observed that temperature variations can affect the measurement *** were collected across temperatures ranging from -20 to 70℃,and a temperature correction model was established through linear regression fitting to address this *** feasibility of the temperature correction model was confirmed at temperatures of -5 and 40℃,where relative errors remained below 0.1% after applying the temperature *** research indicates that the designed measurement system exhibits excellent temperature adaptability and high precision,making it particularly suitable for measuring weak currents.

关键词： Weak current measurement system Neutron ionization chamber Kalman filter algorithm Temperature correction model

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Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic

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Asian Journal of Andrology 2024年第1期26卷 41-45页

作者： Shun Bai Ming-Zhen Li Yang-Yang Wan Xue-Chun Hu Yi-Xun liu xian-Hong Tong Tong-Hang Guo Lu Zong Ran liu Yuan-Qi Zhao Ping xiang Bo Xu Xiao-Hua Jiang Department of Gynecology and Obstetrics Reproductive and Genetic HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China NHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital)Guangzhou 510600China Department of Urology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Wannan Medical College Wuhu 241002China

Genetic risk factors have been shown to contribute to the development of sexual ***,the role of methylenetetrahydrofolate reductase(MTHFR)gene variants in the risk of erectile dysfunction(ED)remains *** this study,we recruited 1254 participants who underwent ED assessed by the International Index of Erectile *** MTHFR c.677C>T variant was also measured by fluorescence polymerase chain reaction(PCR).No significant difference in the genotypic frequency of the MTHFR C677T polymorphism(CC,CT,and TT)was observed between men from the ED and non-ED *** addition,on binary logistic regression analysis,both crude and adjusted models showed that the risk of ED was not significantly associated with the C677T ***,a significantly higher frequency of the 677TT polymorphism was found in severe and moderate ED(P=O.02).The positive correlation between the MTHFR 677TT polymorphism and severe ED was confirmed by logistic regression analysis,even after adjusting for potential confounders(odds ratio[OR]=2.46,95%confidence interval[CI]:1.15-5.50,P=0.02).These findings suggest a positive correlation between the MTHFR 677TT polymorphism and the risk of severe *** of MTHFR gene polymorphisms may provide complementary information for ED patients during routineclinicaldiagnosis.

关键词： erectile dysfunction gene variant genetic risk factors methylenetetrahydrofolate reductase sexual function

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The response of roots and the rhizosphere environment to integrative cultivation practices in paddy rice

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Journal of Integrative Agriculture 2024年第6期23卷 1879-1896页

作者： Hanzhu Gu xian Wang Minhao Zhang Wenjiang Jing Hao Wu Zhilin Xiao Weiyang Zhang Junfei Gu Lijun liu Zhiqin Wang Jianhua Zhang Jianchang Yang Hao Zhang Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology/Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops/Agricultural College Yangzhou UniversityYangzhou 225009China Taizhou Institute of Agricultural Science Jiangsu Academy of Agricultural SciencesTaizhou 225300China State Key Laboratory of Agrobiotechnology School of Life SciencesThe Chinese University of Hong KongShatinHong Kong 999077China Department of Biology Faculty of ScienceHong Kong Baptist UniversityKowloonHong Kong 999077China

Integrative cultivation practices(ICPs)are essential for enhancing cereal yield and resource use ***,the effects of ICP on the rhizosphere environment and roots of paddy rice are still poorly *** this study,four rice varieties were produced in the *** variety was treated with six different cultivation techniques,including zero nitrogen application(0 N),local farmers’practice(LFP),nitrogen reduction(NR),and three progressive ICP techniques comprised of enhanced fertilizer N practice and increased plant density(ICP1),a treatment similar to ICP1 but with alternate wetting and moderate drying instead of continuous flooding(ICP2),and the same practices as ICP2 with the application of organic fertilizer(ICP3).The ICPs had greater grain production and nitrogen use efficiency than the other three *** length,dry weight,root diameter,activity of root oxidation,root bleeding rate,zeatin and zeatin riboside compositions,and total organic acids in root exudates were elevated with the introduction of the successive cultivation *** enhanced nitrate nitrogen,the activities of urease and invertase,and the diversity of microbes(bacteria)in rhizosphere and non-rhizosphere soil,while reducing the ammonium nitrogen *** nutrient contents(ammonium nitrogen,total nitrogen,total potassium,total phosphorus,nitrate,and available phosphorus)and urease activity in rhizosphere soil were reduced in all treatments in comparison with the non-rhizosphere soil,but the invertase activity and bacterial diversity were *** main root morphology and physiology,and the ammonium nitrogen contents in rhizosphere soil at the primary stages were closely correlated with grain yield and internal nitrogen use *** findings suggest that the coordinated enhancement of the root system and the environment of the rhizosphere under integrative cultivation approaches may lead to higher rice production.

关键词： rice(Oryza sativa L.) nitrogen use efficiency grain yield integrative cultivation practices roots

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Phase-Based Optical Flow Method with Optimized Parameter Settings for Enhancing Displacement Measurement Adaptability

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Open Journal of Applied Sciences 2024年第5期14卷 1165-1184页

作者： Zhaoxin Peng Menglian liu Zhiliang Wang Wei liu xian Wang School of Mechanical Engineering Hunan University of Science and Technology Xiangtan China

To enhance the applicability and measurement accuracy of phase-based optical flow method using complex steerable pyramids in structural displacement measurement engineering applications, an improved method of optimizing parameter settings is proposed. The optimized parameters include the best measurement points of the Region of Interest (ROI) and the levels of pyramid filters. Additionally, to address the issue of updating reference frames in practical applications due to the difficulty in estimating the maximum effective measurement value, a mechanism for dynamically updating reference frames is introduced. Experimental results demonstrate that compared to representative image gradient-based displacement measurement methods, the proposed method exhibits higher measurement accuracy in engineering applications. This provides reliable data support for structural damage identification research based on vibration signals and is expected to broaden the engineering application prospects for structural health monitoring.

关键词： Displacement Measurement Phase-Based Optical Flow Optimized Parameter Setting

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