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Network pharmacology research of mechanism of Maxing Shigan Decoction in treating COVID-19

Quantitative Biology 2023年第1期11卷 94-103页

作者： xian-fang wang Zhi-Yong Du Qi-Meng Li Yi-Feng Liu Shao-Hui Ma Jui-Wei Cui School of Computer Science and Technology Henan Institute of TechnologyXinxiang 453003China School of Sanquan Xinxiang Medical UniversityXinxiang 453003China School of Computer and Information Engineering Henan Normal UniversityXinxiang 453003China School of the First Clinical Xinxiang Medical UniversityXinxiang 453003China

Background:The COVID-19 has a huge negative impact on people’s *** Chinese Medicine(TCM)has a good effect on viral *** is of great practical significance to study its ***:The ingredients and targets of each herb in Maxing Shigan Decoction which obtained from Traditional Chinese Medicine Systems Pharmacology(TCMSP)database,and the related targets of COVID-19 were screened by GeneCards database based on the network *** was used to analyze the intersection target between active ingredients and *** software was used to construct an active ingredient-disease target *** protein-protein interaction network was constructed by STRING database and Cytohubba was used to screen out the key *** Ontology(GO)functional enrichment analysis and KEGG pathway analysis were performed by DAVID ***:In this study,a total of 134 active ingredients and 229 related targets,198 targets of COVID-19 and 48 common targets of drug-disease were *** items and pathways were obtained through GO and KEGG pathway *** predicted active ingredients were quercetin,kaempferol,luteolin,naringenin,glycyrol,and the key targets involved IL6,MAPK3,MAPK8,CASP3,IL10,*** results showed that the active ingredients of Maxing Shigan Decoction acted on multiple targets which played roles in the treatment of COVID-19 by regulating inflammation,immune system and other ***:The main contribution of this paper is to use data to mine the principles of the treatment of COVID-19 from the pharmacology of these prescriptions,and the results can be provided theoretical reference for medical workers.

关键词： network pharmacology PPI Maxing Shigan Decoction COVID-19 target

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Detection of 100% oxygen induced changes in retina using magnetic resonance imaging： a human study

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Chinese Medical Journal 2010年第22期123卷 3277-3281页

作者： XU Qing-gang CHEN Qing-hua xian Jun-fang wang Zhen-chang Department of Radiology Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Background Inner retinal oxygenation response （△PO2） is a worldwide study focus. However, the relevant reports on its radiological measurments are limited. In this study, magnetic resonance imaging （MRI）, employing T1 weighted image （T1WI）, was used to detect changes in APO2 following 100% oxygen inhalation in human subjects. Methods MRI was performed on a 1.5-T GE scanner system. After obtaining ophthalmologic data, eleven healthy individuals were given room air and 100% oxygen inhalation in order with different intervals. The MRI TlWl data were collected for 50 minutes. Data were analyzed with NIH IMAGE software. Results APO2 was not panretinally uniform, and changes in oxygenation response were spatially inhomogeneous. During the initial phase （before 5 minutes） of 100% oxygen inhalation, preretinal vitreous water signals in the region of papilla optica increased rapidly. On the contrary, in other regions signals declined. In a later period （35 minutes）, APO2 was panretinally fluctuated and increased slowly and attained homeostasis. After hyperoxia （45 minutes）, delayed-enhancement of preretinal vitreous water signals in regions other than the papilla optica occurred, and then dropped down. There was no significant difference （P 〉0.05） at any consecutive time point during and after hyperoixa. Conclusions These results reveal that hyperoxia can induce region-specific signal changes in preretinal vitreous water. Regulatory activity of the retinal vessel network may be the mechanism during 100% oxygen inhalation. Moreover, MRI is a valuable tool for investigating APO2 and exploring the mechanism of retinal oxygenation response physiologically or pathologically in vivo.

关键词： hyperoxia retina retinal blood flow oxygen measurement magnetic resonance imaging

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Optimal Rapid Restart of Heuristic Methods of NP Hard Problems

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Transactions of Tianjin University 2004年第2期10卷 146-148页

作者：侯越先王芳 School of Electronic Information Engineering

Many heuristic search methods exhibit a remarkable variability in the time required to solve some particular problem instances. Their cost distributions are often heavy-tailed. It has been demonstrated that, in most cases, rapid restart (RR) method can prominently suppress the heavy-tailed nature of the instances and improve computation efficiency. However, it is usually time-consuming to check whether an algorithm on a specific instance is heavy-tailed or not. Moreover, if the heavy-tailed distribution is confirmed and the RR method is relevant, an optimal RR threshold should be chosen to facilitate the RR mechanism. In this paper, an approximate approach is proposed to quickly check whether an algorithm on a specific instance is heavy-tailed or not. The method is realized by means of calculating the maximal Lyapunov exponent of its generic running trace. Then a statistical formula to estimate the optimal RR threshold is educed. The method is based on common nonparametric estimation, e.g., Kernel estimation. Two heuristic methods are selected to verify our method. The experimental results are consistent with the theoretical consideration perfectly.

关键词： NP hard problems heavy-tailed rapid restart(RR) Lyapunov exponent optimal RR threshold

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World Journal of Gastroenterology 2011年第43期17卷 4779-4786页

作者： Gui-fang Guo Wen-Qi Jiang Bei Zhang Yu-Chen Cai Rui-Hua Xu Xu-xian Chen fang wang Liang-Ping Xia State Key Laboratory of Oncology Cancer Center Sun Yat-Sen University Guangzhou 510060 Guangdong Province China

AIM:To investigate the utility of Beclin-1 and LC3,two autophagy-related proteins,in predicting the cetuximab efficacy in advanced colorectal cancer(ACRC) . METHODS:The data of 85 patients with ACRC treated at the Sun Yat-sen University Cancer Center from March 1,2005 to December 31,2008 were studied,including 45 cases treated with cetuximab-containing chemotherapy and 40 cases treated with non-cetuximab-containing ***-1 and LC3 expression was evaluated by immunohistochemistry,and KRAS status was evaluated by polymerase chain reaction. RESULTS:Beclin-1 and LC3 expression in ACRC wassignificantly correlated(r=0.44,P<0.01);however,LC3 was more highly expressed in cancerous tissues than in normal tissues(Z=-2.63,P<0.01) .In the cetuximab-containing chemotherapy group,patients with low LC3 expression had higher objective response rates(ORRs) than those with high LC3 expression(52.9%vs 17.9%,P=0.01) ,and patients with low Beclin-1 expression had a longer median progressionfree survival(PFS) than their counterparts with higher Beclin-1 expression(9.0 mo vs 3.0 mo,P=0.01) . However,neither of these predictive relationships was detected in the group treated with non-cetuximabcontaining *** with wild-type KRAS had higher ORRs(42.3%vs 9.1%,P=0.049) and disease control rates(DCRs)(73.1%vs 36.4%,P= 0.035) ,and longer median PFS(5.5 mo vs 2.5 mo,P= 0.02) than those with mutant KRAS in the cetuximabcontaining chemotherapy *** Beclin-1(P= 0.52) nor LC3(P=0.32) expression was significantly correlated with KRAS status. CONCLUSION:Patients with low Beclin-1 expression had a longer PFS than those with high Beclin-1 expression,and patients with low LC3 expression had a higher ORR in ACRC patients treated with cetuximab-containing chemotherapy.

关键词： Beclin-1 Cetuximab Colorectal neoplasms Drug therapy LC3

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A Recurrent Ectopic Pregnancy within A Previous Caesarean Scar: A Case Report

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Journal of Reproduction and Contraception 2011年第1期22卷 45-49页

作者： Yu-xian wang fang-fang BAI Sheng-hui LU Department of Obstetrics and Gynecology The First Clinical Hospital Affiliated To Shanxi Medical University Taiyuan 030001 China

Objective To investigate the clinical diagnosis and treatment of caesarean scar pregnancy （CSP）. Methods We reported here a case of recurrent ectopic pregnancy within a previous cesarean scar and reviewed the literature. Results Surgical evacuation of a CSP was a small side effect and effective treatment of CSP. Conclusion Early and accurate diagnosis, timeliness and effective treatment were extremely important in saving patients＇ life and retaining their fertility.

关键词： cesarean scar pregnancy (CSP) ectopic pregnancy case report

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Detection of QTL for Cold Tolerance at Bud Bursting Stage Using Chromosome Segment Substitution Lines in Rice (Oryza sativa)

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Rice science 2011年第1期18卷 71-74页

作者： LIN Jing ZHU Wen-yin ZHANG Ya-dong ZHU Zhen ZHAO Ling CHEN Tao ZHAO Qing-yong ZHOU Li-hui fang xian-wen wang yan-ping wang Cai-lin Institute of Food Crops Jiangsu Academy of Agricultural Sciences Jiangsu High Quality Rice R ＆ D Center Nanjing Branch of China National Center for Rice Improvement Research Center for Protection and Utilization of Agricultural Germplasm Resource in Jiangsu Province Nanjing 210014 China

Ab The cold tolerance at the bud bursting stage （CTB） was evaluated at 5℃ by using a set of 95 chromosome segment substitution lines （CSSLs） derived from an indica rice 9311 and a japonica rice Nipponbare with a genetic background of 9311. The result showed that six CSSLs had slightly stronger effect on CTB than 9311. Total four quantitative trait loci （QTLs） for CTB were preliminary mapped on chromosomes 5 and 7 by substitution mapping, qCTB-5-1, qCTB-5-2 and qCTB-5-3 were mapped in the region of RM267-RM1237, RM2422-RM6054 and RM3321-RM1054, which were 21.3 cM, 27.4 cM and 12.7 cM in genetic distance on rice chromosome 5, respectively, qCTB-7 was mapped in a 6.8-cM region of RM11-RM2752 on rice chromosome 7.

关键词： chromosome segment substitution lines cold tolerance bud bursting stage substitution mapping rice

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慢加急性肝衰竭:东西方诊断和预后的差异

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世界华人消化杂志 2017年第21期25卷 1910-1920页

作者：王宪波高方媛首都医科大学附属北京地坛医院中西医结合中心北京市100015

慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)是以慢性肝病基础上发生的急性肝功能失代偿和短期高死亡率为主要临床特征的一种可逆的、复杂的临床综合征.由于不同区域ACLF的病因不同,且病理机制复杂,导致东西方对ACLF的定义及... 详细信息

慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)是以慢性肝病基础上发生的急性肝功能失代偿和短期高死亡率为主要临床特征的一种可逆的、复杂的临床综合征.由于不同区域ACLF的病因不同,且病理机制复杂,导致东西方对ACLF的定义及诊断标准仍存在争议,且缺乏公认的预后评估体系.近年来,ACLF引起了国内外学者的广泛关注,取得了一些重要的研究进展,本文将围绕国际上ACLF的最新进展,对ACLF的定义及预后评估等进行分析总结.

关键词：慢加急性肝衰竭定义预后

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双层类脂膜核酸传感器的研究进展

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分析测试学报 2003年第1期22卷 99-101页

作者：张彦莉高志贤房彦军王红勇军事医学科学院卫生学环境医学研究所天津300050

对近几年发展起来的双层类脂膜(BLM)核酸传感器的研究工作进行了讨论 ,详细论述了该传感器的特性、工作原理以及在核酸杂交、序列分析研究中的应用 ,并与其它核酸传感器的研究作了对比;展望了其发展方向。

关键词：研究进展双层类脂膜生物传感器核酸杂交序列分析

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基于Petri网带配置信息的酒店预订系统的优化分析

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佳木斯大学学报（自然科学版） 2016年第5期34卷 806-808页

作者：高雅楠方贤文王丽丽安徽理工大学理学院安徽淮南232001

业务流程的优化分析是业务流程管理的重要内容之一,对带相关约束的业务系统优化分析显得更为重要。这篇文章提出了一种带配置信息的业务系统优化分析方法,首先介绍了带配置信息的业务流程Petri网,在此基础上通过引进配置变迁对业务流程... 详细信息

业务流程的优化分析是业务流程管理的重要内容之一,对带相关约束的业务系统优化分析显得更为重要。这篇文章提出了一种带配置信息的业务系统优化分析方法,首先介绍了带配置信息的业务流程Petri网,在此基础上通过引进配置变迁对业务流程进行优化分析,最后通过具体的酒店预订系统的业务流程说明了该方法的可行性。

关键词：业务流程配置 Petri网酒店预订系统

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QCT Calculations of Reactions of F+LiH→LiF+H and F+LiD→LiF+D:Product Polarization and Isotope Effects

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Chinese Physics Letters 2011年第2期28卷 81-84页

作者： wang Tao YUE xian-fang School of Physics and Optoelectronic Technology Dalian University of TechnologyDalian 116024 Department of Physics and Information Engineering Jining UniversityJining 273155

Using the quasi-classical trajectory(QCT)method,the product polarization at the collision energy of 46 kcal/mol is investigated for the reactions of F+LiH(v=0,j=0)→LiF+H and F+LiD(v=0,j=0)→LiF+D on the 2A'ground state potential energy surface(PES)[***.106(1997)1013).The distribution of P(θr),which represents the K and J'correlation,the dihedral angle distribution of K-K'-J'P(φr),the angular distribution P(θr,φr)and the four PDDCSs[(2π/σ)(dσ00/dωt),(2πr/σ)(dσ20/dωt),(2π/σ)(dσ22+/dωt),(2π/σ)(dσ21-/dωt)]are presented and *** addition,isotope effects are *** results indicate that at the collision energy of 46 kcal/mol,with isotopic mass substitution,the orientation degree of LiF perpendicular to the scattering degree becomes stronger while the polarization degree of LiF perpendicular to K keeps almost *** addition,the angular distribution of LiF strongly prefers forward scattering.

关键词： scattering addition collision

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