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Borderline Case of Traces and Extensions for Weighted Sobolev Spaces

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Acta Mathematica Sinica,English Series 2023年第9期39卷 1817-1833页

作者： Man Zi Huang xian tao wang Zhuang wang Zhi Hao Xu MOE-LCSM School of Mathematics and StatisticsHunan Normal UniversityChangsha410081P.R.China

In this paper,we study the traces and the extensions for weighted Sobolev spaces on upper half spaces when the weights reach to the borderline *** first give a full characterization of the existence of trace spaces for these weighted Sobolev spaces,and then study the trace parts and the extension parts between the weighted Sobolev spaces and a new kind of Besov-type spaces(on hyperplanes)which are defined by using integral averages over selected layers of dyadic cubes.

关键词： Sobolev space borderline case trace theorem Besov-type space Muckenhoupt A_p weight

Linear Connectivity, Schwarz–Pick Lemma and Univalency Criteria for Planar Harmonic Mapping

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Acta Mathematica Sinica,English Series 2016年第3期32卷 297-308页

作者： Shao Lin CHEN Saminathan PONNUSAMY Antti RASILA xian tao wang Department of Mathematics and Computational Science Hengyang Normal University Indian Statistical Institute (ISI) Chennai CentreSETS (Society for Electronic Transactions and Security)MGR Knowledge CityCIT Campus Department of Mathematics and Systems Analysis Aalto University Department of Mathematics Shantou University

In this paper, we first establish a Schwarz-Pick lemma for higher-order derivatives of planar harmonic mappings, and apply it to obtain univalency criteria. Then we discuss distortion theorems, Lipschitz continuity an... 详细信息

关键词： Harmonic mapping linearly connected domain Schwarz-Pick lemma a-close-to-convex function John constant univalency

Expression of p53 in myocardium following coronary microembolization inrats and its significance

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Journal of Geriatric Cardiology 2017年第5期14卷 292-300页

作者： Yu-Han SUN Qiang SU Lang LI xian-tao wang Yuan-Xi LU Jia-Bao LIANG Department of Cardiology the First Affiliated Hospital of Guangxi Medical University Nanning China

Background Cardiomyocyte apoptosis is a primary cause for coronary microembolization （CME）-induced cardiac dysfunction, p53induces cell growth retardation and apoptosis through stress pathway. The present study investigated the mechanism of p53-induced myocar-dial apoptosis and cardiac dysfunction by activating the mitochondrion apoptotic pathway following CME. Methods Forty SD rats wereequally divided into microembolization （CME）, sham operation （sham）, CME＋siRNA-p53, and CME＋control-p53 groups. The CME ratmodel was established by injecting microembolization spheres via the left ventricle. Cardiac ultrasound, TUNEL, fluorescence quantitativePCR, and Western blot were used to assess the cardiac function indicators, cardiomyocyte apoptosis, and the expressions of mRNA and pro-tein in myocardial tissues, respectively. Results Echocardiography revealed a significantly reduced cardiac function of the CME group thanthe sham group while the CME-induced cardiac dysfunction was improved in the CME＋siRNA-p53 group. The indicators of myocardialapoptosis in the CME group increased significantly than the sham group; those of the CME＋siRNA-p53 group decreased significantly thanthe CME group. Fluorescence quantitative PCR and Western blot demonstrated that p53, Bbc3 （PUMA）, and cleaved caspase-3 expressionswere significantly increased, and BCL-2 expression was declined in myocardial tissues of the CME group compared to the sham group. Acontrasting result was observed in the CME＋siRNA-p53 group as compared to the CME group. Conclusions P53 is involved in theCME-induced cardiac dysfunction, which may up-regulate Bbc3 to activate BCL-2/caspase3 mitochondrial apoptotic pathway and inducemyocardial apoptosis. Inhibiting the p53 expression can effectively suppress this pathway, thereby reducing myocardial apoptosis and car-diac dysftmction.

关键词： Bbc3 BCL-2 Cardiac dysfunction Coronary microembolization Myocardial apoptosis p53

Nicorandil pretreatment inhibits myocardial apoptosis and improves cardiac function after coronary microembolization in rats

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Journal of Geriatric Cardiology 2018年第9期15卷 591-597页

作者： Wen-Kai HE Qiang SU Jiao-Bao LIANG xian-tao wang Yu-Han SUN Lang LI Department of Cardiology the First Affiliated Hospital of Guangxi Medical University Nanning China

Background Nicorandil （NIC） is a vasodilatory drug used to treat angina. However, its efficacy of cardioprotection in coronary mi- croembolization （CME） is largely unknown. This study was undertaken to determine whether nicorandil pretreatment could attenuate myo- cardial apoptosis and improve cardiac function after CME in rats. Methods Forty-five rats were randomly divided into a Sham group, a CME group and a CME ＋ NIC （NIC） group （n = 15 per group）. CME was established by injecting plastic microspheres （42 pm in diameter） into the left ventricle of the rats in all of the groups except the Sham group. The NIC group received nicorandil at 3 mg/kg per day for seven days before the operation. Cardiac fimction was assessed by echocardiography, the expression levels of cleaved caspase-9/8/3 were detected by Western blot, microinfarction area was measured by haematoxylin-basic fuchsin picric acid staining, and myocardial apoptosis was de- tected by TUNEL staining. Results Compared to that in the Sham group, cardiac fimction in the CME group was significantly decreased （P 〈 0.05）. However, compared to the CME group, the NIC group showed improved cardiac function （P 〈 0.05）. The expression levels of cleaved caspase-9/8/3 protein and myocardial apoptosis were dramatically increased in the CME group compared to those in the Sham group （P 〈 0.05）, while the NIC pretreatment group had significantly decreased expression levels of cleaved caspase-9/8/3 protein as well as a de- creased apoptotic rate （P 〈 0.05）. Conclusions NIC pretreatment inhibited CME-induced myocardial apoptosis and improved cardiac func- tion through blockade of the mitochondrial and death receptor-mediated apoptotic pathways.

关键词： Apoptosis Coronary microembolization Cardiac function Nicorandil

Ischemia/hypoxia inhibits cardiomyocyte autophagy and promotes apoptosis via the Egr-1/Bim/Beclin-1 pathway

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Journal of Geriatric Cardiology 2020年第5期17卷 284-293页

作者： Bo SU xian-tao wang Yu-Han SUN Man-Yun LONG Jing ZHENG Wen-Hao WU Lang LI Department of Cardiology the First Affiliated Hospital of Guangxi Medical UniversityNanningChina

Background Myocardial injury caused by microvascular obstruction(MVO)is characterized by persistent ischemia/hypoxia(IH)of cardiomyocytes after *** and Egr-1 were closely associated with various cardiovascular diseases,including *** and Beclin-1 are the important genes for autophagy and *** aimed to explore whether the Egr-1/Bim/Beclin-1 pathway is involved in regulating autophagy and apoptosis in IH-exposed *** Neonatal rat cardiomyocytes exposed to the IH environment in vitro were transfected with lentivirus expressing Egr-1 or Egr-1 sh RNA,or further treated with 3-methyladenine(3-MA).The expressions of autophagy and apoptosis-associated genes were evaluated using RT-q PCR and Western blots *** vacuoles and autophagic flux were detected by transmission electron microscopy(TEM)and confocal microscope,*** injury was assessed by lactate dehydrogenase(LDH)leakage,and apoptosis was determined by flow *** IH exposure elevated Egr-1 and Bim expressions,and decreased Beclin-1 expression in rat ***-1 overexpression in IH-exposed cardiomyocytes significantly up-regulated the levels of Egr-1 and Bim,and down-regulated the level of ***-1 knockdown resulted in down-regulated expressions of Egr-1 and Bim,as well as up-regulated expression of *** addition,Egr-1 knockdown induced autophagy was suppressed by 3-MA *** and autophagic flux experiments also confirmed that Egr-1 inhibited autophagy progression in IH-exposed ***-1 suppression protected cardiomyocytes from IH-induced injury,as evidenced by the positive correlations between Egr-1 expression and LDH leakage or apoptosis index in IH-exposed *** IH-induced cardiomyocyte autophagy and apoptosis are regulated by the Egr-1/Bim/Beclin-1 pathway,which is a potential target for treating cardiomyocyte injury caused by MVO in the IH environment.

关键词： Autophagy Apoptosis Cardiomyocyte Egr-1 Ischemia/hypoxia

China-France Culture Year Features Wealth of Events

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China & The World Cultural Exchange 2003年第3期69卷 22-24页

作者： Sheng xian, tao Hong and wang Feng

China and France have for centuries enjoyed friendly relations in the fields of politics, trade and culture. The China-France Culture Year, beginning this October, as the largest Sino-foreign event since the founding of New China, is expected to spark a new round of exchanges between the two *** two years of planning, the China Culture Year is to be inaugurated in France soon this September. With the theme of 'Ancient China, Colorful China, Modern China', the event aims to offer a comprehensive view of

关键词：中法文化年中国法国文化交流科技展览高等教育交流民族服装展览巴黎广州市艺术展览上海

具有分流叶片跨声速离心叶轮激波及能量损失分析

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航空动力学报 2016年第12期31卷 3010-3016页

作者：刘正先曹江涛王牧苏赵祎佳天津大学机械工程学院天津300072 天津大学化工学院天津300072

对具有分流叶片跨声速离心叶轮,采用激波基本关系式对数值信息进行分析和判定,理论证实了叶轮流道中激波的存在,并确定流道内高速气流易在主叶片前缘、分流叶片前缘以及主叶片的吸力面与分流叶片的压力面通道位置形成激波.进一步对比分... 详细信息

对具有分流叶片跨声速离心叶轮,采用激波基本关系式对数值信息进行分析和判定,理论证实了叶轮流道中激波的存在,并确定流道内高速气流易在主叶片前缘、分流叶片前缘以及主叶片的吸力面与分流叶片的压力面通道位置形成激波.进一步对比分析了叶顶间隙和运行工况对激波位置分布特征的影响及引起的能量损失.结果表明:固定叶顶间隙下,随着流量减小,激波位置向流道上游移动;叶顶间隙导致激波线位置向流道下游偏移;分流叶片前缘处有最强激波并引起较明显能量损失.

关键词：跨声速离心叶轮分流叶片叶顶间隙激波判定能量损失

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di wang Zhao-xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

一类随机干扰作用下的非线性系统的自适应控制

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信息与控制 2001年第S1期30卷 636-639页

作者：刘克显王玉涛王师东北大学信息学院 321信箱110006

利用随机干扰作用下的采样数据训练模糊神经网络可得到对象含噪声信息的统计辨识模型 ,通过预估及校正算法在线调整控制输入以弥补模型偏差的影响 ,实现系统的自适应控制 .仿真实验结果表明该控制方案具有较高的控制精度。

关键词：随机干扰控制统计模型模糊神经网络控制自适应控制