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Journal of Iron and Steel Research International 2010年第7期17卷 44-50页

作者： ZHANG Zi-cheng ZHU fu-xian li Yan-mei State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

The effect of thermomechanical control processing（TMCP）on microstructure and mechanical properties of Fe-0.2C-1.44Si-1.32Mn hot rolled TRIP steel was investigated through ***-induced transformation and transformation-induced plasticity behavior of retained austenite were *** results show that with multipass deformation,reduction per pass of more than critical deformation in austenite recrystallization region and total reduction of more than 58% in non-recrystallization region and high temperature section of two-phase region,austenite can be refined before γ→α *** is beneficial to obtain refined ferrite grain in final *** obtain fine and uniform microstructure and excellent strength-ductility balance,a three-stage cooling process（laminar cooling-air cooling-ultra-fast cooling）after hot rolling was *** ultimate tensile strength and elongation of the investigated steel can reach 663 MPa and 41%,respectively.

关键词： hot rolled TRIP steel TRIP effect retained austenite transformation-induced plasticity mechanical property

The thymic stromal cell line MTSC4 induced thymocyte apoptosis in a non-MHC-restricted manner

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Cell Research 2004年第2期14卷 125-133页

作者： Xue Ying HE~1, Juan li~1, Xiao Ping QIAN~1, Wen xian fu~1, Yan li~1, li WU~2, Wei Feng CHEN~1 ~1Department of Immunology, Peking University Health Science Center,38 Xueyuan Road, Beijing 100083, China. ~2The Walter and Eliza Hall Institute, PO Royal Melbourne Hospital, Victoria 3050, Australia. Department of Immunology Peking University Health Science Center Beijing China The Walter and Eliza Hall Institute PO Royal Melbourne Hospital Victoria Australia

Mouse thymic stromal cell line 4 （MTSC4） is one of the stromal cell lines established in our laboratory. While losing the characteristics of epithelial cells, they express some surface markers shared with thymic dendritic cells （TDCs）. To further study the biological functions of these cells, we compared the capability of MTSC4 with TDCs in the induction of thymocyte apoptosis, using thymic reaggregation culture system. Apoptosis of thymocytes induced by MTSC4 and TDCs was measured by Annexin V and PI staining and analyzed by flow cytometry. We found that MTSC4 selectively augmented the apoptosis of CD4+8+ （DP） thymocytes. This effect was Fas/FasL independent and could not be blocked by antibodies to MHC class Ⅰ and class Ⅱ molecules. In addition, MTSC4 enhanced the apoptosis of DP thymocytes from different strains of mice, which implies that MTSC4-induced thymocyte apoptosis is not mediated by the TCR recognition of self peptide/MHC molecules. In contrast to MTSC4, thymocyte apoptosis induced by TD

关键词： MHC thymic dendritic cells thymic stromal cell line thymocyte apoptosis.

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo li fu Tang Jingkai Zhang Yuetong Kang Hean Zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

The clinical observation of three-dimensional conformal radiotherapy combined with FOLFOX chemotherapy for rectal cancer of postoperative local recurrence

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The Chinese-German Journal of Clinical Oncology 2012年第8期11卷 465-468页

作者： Yeqin Zhou Mi liu Daiyuan Ma Tao Ren Xiaojie Ma xian fu li Bangxian Tan Department of Radiotherapy Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China

Objective The aim of this study was to explore the three-dimensional conformal radiotherapy combined with FOLFOX scheme chemotherapy in the treatment of postoperative recurrence of rectal cancer.

关键词： rectal neoplasm tumor recurrence conformal radiotherapy chemotherapy

Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

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Nano Research 2025年第1期18卷 520-544页

作者： Genping fu Yuting Weng Yunfan li Carl Ho Yiyu fu Wenxuan Wang Songbin fu Wenjing Sun Jie lin Xiaoyu Fan Binbin Jia Mengdi Cai linlin li Laboratory of Medical Genetics Harbin Medical UniversityHarbin 150081China Key Laboratory of Preservation of Human Genetics Resources and Disease Control in China(Harbin Medical University) Ministry of EducationHarbin 150081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School of Medicine in St.Louis St.LouisMO 63110USA Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseille College Wuhan University of TechnologyWuhan 430070China

Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration *** review firstly summarizes various types of nanoparticles in cancer ***,it offers a comprehensive overview of signalenhancing techniques for visualizing in situ tumors,along with multimodal diagnostic methods for detecting *** for tumor therapy,cutting-edge drug delivery methods that can cross biological barriers and the pinpoint targeting of tumor lesions for precise medical intervention are *** the domain of therapeutic diagnostics,we elucidate the theoretical underpinnings and structural paradigms that underlie a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publications delineating the clinical applications of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the clinical application of nanoparticles and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnology-based clinical practices.A deeper understanding of nanomaterials,together with intimate interdisciplinary collaborations,nano-wave will most probably guide human beings to win the battle against cancers.

关键词： nanoparticles drug delivery gastric cancer glioma glioblastoma

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu xiandeng li Mi li xian Wu Xiaohui Huang Ajing Xu Yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： xiang-Qun fu Hong-Wei li Jian-Hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

我国蔬菜生产技术效率变动及其影响因素分析——以黄瓜和茄子为例

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中国农业大学学报 2016年第12期21卷 133-143页

作者：张标张领先傅泽田李鑫星中国农业大学工学院北京100083 中国农业大学信息与电气工程学院北京100083

为探究我国蔬菜生产技术效率变动及其影响因素,基于技术效率理论基础,利用30个省市2011和2012年的164组样本数据,构建了超越对数生产函数模型,研究结果表明:我国蔬菜生产技术效率平均为0.809 9,存在显著的技术效率损失;各地区蔬菜生产... 详细信息

为探究我国蔬菜生产技术效率变动及其影响因素,基于技术效率理论基础,利用30个省市2011和2012年的164组样本数据,构建了超越对数生产函数模型,研究结果表明:我国蔬菜生产技术效率平均为0.809 9,存在显著的技术效率损失;各地区蔬菜生产技术效率水平有较大差异;平均技术效率从高到低依次为:中南>西北>华北>华东>西南>东北;物质与服务费用、化肥成本和劳动力成本3种投入要素存在不同程度的冗余。农业大省或较发达地区的蔬菜生产技术效率一般较高;无论黄瓜还是茄子,设施种植模式的平均技术效率均大于露地种植,且露地蔬菜生产的技术效率相对于设施蔬菜生产技术效率波动较大;农村人均纯收入和成灾面积比例对提高技术效率有负向影响,城镇化水平、农村劳动力受教育水平和有效灌溉率对技术效率提高有正向影响。

关键词：蔬菜设施蔬菜技术效率随机前沿生产函数影响因素

Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin fu Xiaoting Yang Ya Yu Kang Zhou Xiaoyang Ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen fuqiang Fan Yuhang li Yu fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-xian li Wei-Qi Zhang Yu-Ying Tan li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of liver Cancer Tianjin First Center HospitalTianjin 300192China Department of liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis