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Horticultural Plant Journal 2020年第5期6卷 335-342页

作者： Zhen He Tingting Dong Tielin Wang Wen Chen xian Liu Liangjun Li School of Horticulture and Plant Protection Yangzhou UniversityYangzhouJiangsu 225009China State Key Laboratory Breeding Base of Dao-di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China

Lotus(Nelumbo nucifera Gaertn.)is an economically important perennial aquatic herb plant in ***,viral diseases caused by Cucumber mosaic virus(CMV)and Dasheen mosaic virus(DsMV)are detected in *** this study,the putatively novel badnaviruses from lotus plants(LBVs)were identified using next-generation sequencing of siRNAs and conventional Sanger sequencing based on the RT/RNase H coding region *** plants infected by LBVs harbored virus quasispecies.A unique recombination event of LBVs was found in a single lotus *** inoculation showed that LBVs could actively replicate in the lotus plants,but without a wide host *** field survey of 43 lotus plants in Jiangsu Province showed a prevalence of 62.8%for LBVs,confirming that it is widely distributed in Jiangsu Province of China.

关键词： Nelumbo nucifera Badnaviruses mixed infection genetic variation

分析多层螺旋CT对急性阑尾炎患者的影像学特征及其诊断效果

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中国现代药物应用 2024年第6期18卷 79-82页

作者：黄苑君刘贤明张云光江西省遂川县人民医院 343900

目的针对急性阑尾炎患者行多层螺旋CT(MSCT)诊断,总结其影像学特征,分析其在急性阑尾炎中的诊断价值。方法80例疑似急性阑尾炎患者作为研究对象,所有患者分别行超声诊断与MSCT诊断,将手术病理结果作为金标准,分析诊断结果,比较超声与MSC... 详细信息

目的针对急性阑尾炎患者行多层螺旋CT(MSCT)诊断,总结其影像学特征,分析其在急性阑尾炎中的诊断价值。方法80例疑似急性阑尾炎患者作为研究对象,所有患者分别行超声诊断与MSCT诊断,将手术病理结果作为金标准,分析诊断结果,比较超声与MSCT诊断急性阑尾炎的诊断效能(敏感性、特异性、准确率、阳性预测值与阴性预测值),并比较不同类型阑尾炎患者的CT征象。结果病理诊断结果显示,80例患者中62例为阳性,18例为阴性;超声诊断真阳性51例,真阴性13例;MSCT诊断真阳性59例,真阴性16例。MSCT诊断敏感性、准确率以及阴性预测值分别为95.16%、93.75%、84.21%,高于超声诊断的82.26%、80.00%、54.17%,差异有统计学意义(P0.05)。MSCT诊断结果显示,59例真阳性病例中25例为单纯性阑尾炎,18例为化脓性阑尾炎,16例为穿孔坏疽性阑尾炎,不同类型阑尾炎患者的周围渗出占比比较,差异有统计学意义(P<0.05)。结论MSCT诊断急性阑尾炎敏感性、准确性高,通过CT征象观察有利于实现疾病类型鉴别,具有较高的临床价值。

关键词：多层螺旋CT 急性阑尾炎影像学特征诊断效能

Combination of CRISPR/Cas9 System and CAR-T Cell Therapy:A New Era for Refractory and Relapsed Hematological Malignancies

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Current Medical Science 2021年第3期41卷 420-430页

作者： Ke-jia HU Elaine Tan Su YIN Yong-xian HU He HUANG Bone Marrow Transplantation Center the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy Hangzhou 310003China Institute of Hematology Zhejiang UniversityHangzhou 310003China Zhejiang Laboratory for Systems&Precision Medicine Zhejiang University Medical CenterHangzhou 310003China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 311121China

Chimeric antigen receptor T(CAR-T)cell therapy is the novel treatment strategy for hematological malignancies such as acute lymphoblastic leukemia(ALL),lymphoma and multiple ***,treatment-related toxicities such as cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS)have become significant hurdles to CAR-T *** strategies were established to alter the CAR structure on the genomic level to improve efficacy and reduce ***,the innovative gene-editing technology-clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated nuclease9(Cas9)system,which particularly exhibits preponderance in knock-in and knockout at specific sites,is widely utilized to manufacture CAR-T *** application of CRISPR/Cas9 to CAR-T cell therapy has shown promising clinical results with minimal *** this review,we summarized the past achievements of CRISPR/Cas9 in CAR-T therapy and focused on the potential CAR-T targets.

关键词： chimeric antigen receptor T cell treatment clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated nuclease9 gene editing immunotherapy hematologic malignancy

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药用植物PAL基因及其功能研究进展

亚热带植物科学 2024年第2期53卷 181-190页

作者：王若娴朱瑞艳开国银时敏浙江中医药大学药学院/浙江省药食植物活性成分与健康国际科技合作基地浙江杭州311400

苯丙烷代谢途径是植物主要代谢途径之一,可产生黄酮、酚酸和木质素类等物质,这些物质不仅参与调控植物生长发育和抗逆等生理活动,还被用于预防和治疗疾病,是决定药用植物品质的关键因素之一。苯丙氨酸解氨酶(Phenylalanine ammonia-lyas... 详细信息

苯丙烷代谢途径是植物主要代谢途径之一,可产生黄酮、酚酸和木质素类等物质,这些物质不仅参与调控植物生长发育和抗逆等生理活动,还被用于预防和治疗疾病,是决定药用植物品质的关键因素之一。苯丙氨酸解氨酶(Phenylalanine ammonia-lyase,PAL)负责催化苯丙烷类代谢途径中第一个反应,是该途径的关键酶和限速酶。本文就药用植物中PAL基因的基本特性、表达调控机制等方面的研究进行综述,为进一步阐明药用植物中PAL的功能提供参考。

关键词：药用植物苯丙烷代谢途径苯丙氨酸解氨酶基因表达与调控

Equilibrium Segregation to Free Surface:Kinet ics and Experiment

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Chinese Physics Letters 1999年第5期16卷 364-366页

作者： CAO Ze-xian Ralf Mueller WANG En-ge NIE Yu-xin State Key Laboratory for Surface Physics Institute of PhysicsChinese Academy of SciencesBeijing 100080 Department of Physics University Kaiserslautern67653 KaiserslauternGermany

Fick's first law is modified with an additional term df(x)/dx to describe the segregation phenomenon,f(x)is a local,analytical function related to the depth profile at *** thus can be determined experimentally by depth profiling *** starting in an initially homogeneous solid is described by an inhomogeneous diffusion equation on the half-infinite *** with and without formation of overlayer suggests different boundary *** solution for the Ansatz f(x)=as exp(-x/d_(s))is in perfect agreement with experimental results on sulphur segregation to the surface of *** from the detailed kinetics,activation energy can be inferred from the surface concentration evolution under different *** sulphur segregation in titanium,E_(act)=718 meV/atom.

关键词： technique. titanium sulphur

基于高通量测序技术检测慢性髓性白血病患者ABL激酶区突变的临床价值

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中国实验血液学杂志 2024年第1期32卷 262-268页

作者：周玲王军亮王献伟李扬威邹喆张龑莉吕晓东郑州大学附属肿瘤医院河南省肿瘤医院中心实验室河南郑州450008 郑州大学附属肿瘤医院河南省肿瘤医院血液科河南郑州450008

目的:对比分析高通量测序法与Sanger测序法检测慢性髓性白血病(CML)患者ABL激酶区突变的效能及临床价值。方法:采集2017年7月至2021年3月于河南省肿瘤医院就诊的147例CML患者的198例次样本,同时进行高通量测序和Sanger测序,检测ABL激酶... 详细信息

目的:对比分析高通量测序法与Sanger测序法检测慢性髓性白血病(CML)患者ABL激酶区突变的效能及临床价值。方法:采集2017年7月至2021年3月于河南省肿瘤医院就诊的147例CML患者的198例次样本,同时进行高通量测序和Sanger测序,检测ABL激酶区突变,并收集相关临床数据进行对比分析。结果:高通量测序法检出总体突变比例和≥2个突变的比例明显高于Sanger测序法(P=0.01;P=0.046)。22例次检出≥2个突变,其中发现5例次(22.7%)复合突变。高通量测序法可检出Sanger法无法检出的低比例突变。198例次样本中检出低比例突变25例次(12.6%),高比例突变33例次(16.7%)和高低比例混合突变10例次(5.1%)。相关临床因素分析中,最佳反应期、失败期和警告期突变检出比例和发生低比例突变占比均逐渐升高(突变比例,P=0.016;低比例突变,P=0.005),伴随附加染色体异常出现突变的比例也明显升高(P=0.009)。接受一线、二线治疗的患者检出突变的比例明显低于接受三线及以上治疗的患者(P=0.006)。基于突变位点的VAF值分析有助于可视化评估耐药CML细胞的克隆演变状态。结论:高通量测序法较Sanger测序法检测突变更加敏感、准确,有助于临床精准、可视化评估TKI治疗反应和优化CML治疗策略。

关键词：慢性髓性白血病酪氨酸激酶抑制剂 ABL激酶区突变高通量测序 Sanger测序

基于既有盾构隧道区间暗挖施工的城市轨道交通车站结构力学行为研究

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城市轨道交通研究 2024年第8期27卷 129-136,142页

作者：张中安潘野郭振坤张姣龙高一民柳献深圳地铁建设集团有限公司深圳518026 中国铁路设计集团有限公司天津300142 同济大学土木工程学院上海200092

[目的]深圳轨道交通14号线肿瘤医院站采用大直径(8.5 m)盾构隧道扩挖的“先隧后站”方案,在暗挖车站主体结构与附属出入口连接时,需对隧道衬砌实施局部大尺寸开口施工。为保证隧道开口施工过程中的结构安全性,需对基于既有盾构隧道区间... 详细信息

[目的]深圳轨道交通14号线肿瘤医院站采用大直径(8.5 m)盾构隧道扩挖的“先隧后站”方案,在暗挖车站主体结构与附属出入口连接时,需对隧道衬砌实施局部大尺寸开口施工。为保证隧道开口施工过程中的结构安全性,需对基于既有盾构隧道区间暗挖的城市轨道交通车站结构力学行为进行研究。[方法]采用考虑衬砌结构环、纵缝影响的多环壳-刚性梁-接触衬砌计算模型,对车站暗挖过程进行分工况模拟,设置全开口衬砌环控制工况为开口工况,半开口衬砌环控制工况为拆撑工况;探究封顶块位置、内部支撑形式及隧道纵向开口尺寸等关键设计参数对车站结构的影响。[结果及结论]根据环梁受力特征,建议上、下部环梁在设计时选用钢材或内置钢构件。根据管片受力特性,确定开口区域内通缝拼装管片的排版形式;肿瘤医院站隧道开口区段通缝拼装管片封顶块建议设计在隧道顶部。开口衬砌环管片在施工全程中的弯矩分布与内部支撑有效约束点密切相关,而内部支撑形成有效约束的前提是拥有完整的轴向传力路径。隧道局部开口时开口衬砌环结构的整体性依赖于环缝侧部约束。

关键词：城市轨道交通车站结构力学行为既有盾构隧道区间暗挖施工

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Combined radiochemotherapy in patients with locally advanced pancreatic cancer: A meta-analysis

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World Journal of Gastroenterology 2013年第42期19卷 7461-7471页

作者： Yue Chen xian-Jun Sun Ting-Hui Jiang Ai-Wu Mao Department of Radiology Renji Hospital of Shanghai Jiaotong University School of Medicine Department of Combined Traditional Chinese and Western Medicine for Liver Gallbladder and Pancreas DiseasesMinhang BranchFudan University Shanghai Cancer Center Intervention Center Tongren BranchRenji Hospital of Shanghai Jiaotong University School of Medicine

AIM:To compare the long-term clinical efficacy of chemotherapy plus radiotherapy(CRT)with that of radiotherapy alone(RT)or chemotherapy alone(CT)for locally advanced pancreatic carcinoma(LAPC).METHODS:Using manual and computer-aided methods,we searched the data through the databases,including PubMed/EmBase/CNKI/CQVIP/China Journals Full Text Database and websites and proceedings of major annual meetings such as ASCO and *** methodological quality of the included studies was assessed using the Jadad scoring *** English and Chinese publications were *** collected data from controlled clinical trials on CRT vs RT or CT for LAPC,and conducted a meta-analysis of 15 included ***-analysis was performed using RevMan4.2Software according to the method recommended by Cochrane ***:Fifteen eligible randomized controlled trials including a total of 1128 patients were *** score was 2 in only one article,and 3-4 in the remaining 14 *** meta-analysis showed that CRT was superior in the 6-and 12-mo survivals to the RT alone group or CT alone group(P=0.0001 and P=0.02,respectively),whereas the 18-mo survival showed no significant difference(P=0.23).Subgroup analysis showed that the 6-,12-,and 18-mo survivals were not significantly different between the CRT group and CT group(P=0.07,P=0.23,and P=0.91,respectively).Notably,the CRT group had significantly better 6-,12-,and 18-mo survivals than the RT group(all P<0.01).CRT group had significantly more grade 3-4 treatmentrelated hematologic and non-hematologic toxicities than the CT group or RT group(all P<0.01).CONCLUSION:Compared with CT or RT,CRT can benefit the long-term survival of LAPC patients,although it may also increase treatment-related toxicities.

关键词： Pancreatic cancer Chemotherapy Radiotherapy Meta-analysis Survival

基于健康生态学理论的中国老年人超重/肥胖现状及影响因素分析

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现代预防医学 2024年第5期51卷 803-810页

作者：张宪琦李小菊赵莉樊荣董嘉鑫申小颖李依窈石河子大学医学院预防医学系新疆生产建设兵团重要新发传染病防控与公共卫生安全兵团重点实验室

目的了解中国老年人超重/肥胖的现状、影响因素及其城乡异质性，为制定相应的干预措施提供依据。方法利用2020年中国家庭追踪调查（CFPS）数据库中年龄≥60岁的样本数据。采用非条件二分类logistic回归分析老年人发生超重/肥胖的影响... 详细信息

目的了解中国老年人超重/肥胖的现状、影响因素及其城乡异质性，为制定相应的干预措施提供依据。方法利用2020年中国家庭追踪调查（CFPS）数据库中年龄≥60岁的样本数据。采用非条件二分类logistic回归分析老年人发生超重/肥胖的影响因素。结果本研究共纳入符合条件的样本4 870，其中超重/肥胖有1 903人，超重/肥胖率为39.08%，农村老年人超重/肥胖率为33.10%，城镇老年人超重/肥胖率为36.56%。60～69岁（OR=2.145,95%CI:1.559～2.951）、70～79岁（OR=1.752,95%CI:1.270～2.416）、患有慢性病（OR=1.215,95%CI:1.061～1.392）、吸烟（OR=0.651,95%CI:0.556～0.763）、生活在中部地区（OR=1.255,95%CI:1.052～1.498）、生活在东部地区（OR=1.378,95%CI:1.169～1.623）、居住在城镇（OR=1.366,95%CI:1.193～1.565）、小学及以下的受教育程度（OR=1.214,95%CI:1.034～1.427）、有离退休金（OR=1.342,95%CI:1.126～1.599）、有养老保险（OR=0.841,95%CI:0.739～0.956）是老年人超重/肥胖的影响因素。60～69岁（OR=2.333,95%CI:1.561～3.487）、70～79岁（OR=2.057,95%CI:1.372～3.084）、患有慢性病（OR=1.364,95%CI:1.132～1.645）、吸烟（OR=0.705,95%CI:0.563～0.881）、生活在东部地区（OR=1.278,95%CI:1.006～1.623）、小学及以下的受教育程度（OR=1.397,95%CI:1.104～1.768）、有离退休金（OR=1.284,95%CI:1.046～1.577）是城镇老年人超重/肥胖的影响因素；60～69岁（OR=1.779,95%CI:1.048～3.021）、吸烟（OR=0.594,95%CI:0.473～0.747）、生活在中部地区（OR=1.289,95%CI:1.010～1.647）、生活在东部地区（OR=1.481,95%CI:1.176～1.867）、有离退休金（OR=1.424,95%CI:1.003～2.022）、有新农合（OR=0.475,95%CI:0.261～0.862）、有城镇/城乡居民医保（OR=0.615,95%CI:0.380～0.995）是农村老年人超重/肥胖的影响因素。结论老年人超重/肥胖的影响因素是多层次、多维度的，且城乡间的影响因素不尽相同，应立足中国城乡差异现状，从个体到宏观不同的维度采取及时、有针对性的干预策略与防范措施。

关键词：超重/肥胖老年人健康生态学理论影响因素分析

Multi-task Learning of Semantic Segmentation and Height Estimation for Multi-modal Remote Sensing Images

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Journal of Geodesy and Geoinformation Science 2023年第4期6卷 27-39页

作者： Mengyu WANG Zhiyuan YAN Yingchao FENG Wenhui DIAO xian SUN Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100190China Key Laboratory of Network Information System Technology(NIST) Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China

Deep learning based methods have been successfully applied to semantic segmentation of optical remote sensing ***,as more and more remote sensing data is available,it is a new challenge to comprehensively utilize multi-modal remote sensing data to break through the performance bottleneck of single-modal *** addition,semantic segmentation and height estimation in remote sensing data are two tasks with strong correlation,but existing methods usually study individual tasks separately,which leads to high computational resource *** this end,we propose a Multi-Task learning framework for Multi-Modal remote sensing images(MM_MT).Specifically,we design a Cross-Modal Feature Fusion(CMFF)method,which aggregates complementary information of different modalities to improve the accuracy of semantic segmentation and height ***,a dual-stream multi-task learning method is introduced for Joint Semantic Segmentation and Height Estimation(JSSHE),extracting common features in a shared network to save time and resources,and then learning task-specific features in two task *** results on the public multi-modal remote sensing image dataset Potsdam show that compared to training two tasks independently,multi-task learning saves 20%of training time and achieves competitive performance with mIoU of 83.02%for semantic segmentation and accuracy of 95.26%for height estimation.

关键词： multi-modal multi-task semantic segmentation height estimation convolutional neural network