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Chinese Chemical Letters 2009年第12期20卷 1502-1505页

作者： Lei Feng Jian Yuan Hao Cheng Dong Xiong xian mo deng Chengdu Institute of Organic Chemistry Chinese Academy of Sciences P.O. Box 415 Chengdu 610041 China School of Microeletronics and Solid State Electronics University of Electronic Science and Technology of China Chengdu 610054 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

A novel poly（ethylene glycol）（PEG） analogue composed of aliphatic polyester backbone and pendant oligo（ethylene glycol） short chains is reported. The PEG analogue is a copolymer synthesized by ring-opening alternating copolymerization of succinic anhydride with 2-（（2-（2-metho xyethoxy）ethoxy）methyl）oxirane. The structure of the copolymer was confirmed by ^1H NMR spectrum. The effects of the monomer feed ratio on the copolymerization were studied and the polymerization mechanism was given. The PEG analogue disclosed is water-soluble and expected to have promising applications in biomedical fields as a substitute of PEG due to the existence of degradable ester bond in the backbone.

关键词： Water-soluble PEG analogue 2-((2-(2-Methoxyethoxy)ethoxy)methyl)oxirane Ring-opening alternating copolymerization Polyester

Different crystallinity of poly(d,l-lactide-co-p-dioxanone) copolymers acquired by control of chain microstructure

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Chinese Chemical Letters 2009年第12期20卷 1506-1509页

作者： Hui Zhen Zhao Jian Yuan Hao Cheng Dong Xiong xian mo deng Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China School of Microeletronics and Solid State Electronics University of Electronic Science and Technology of China Chengdu 610054 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

Poly（d,l-lactide-co-p-dioxanone）（P（LA-co-PDO）） copolymers with different chain microstructures were synthesized by onestep or two-step bulk ring-opening polymerizations of d,l-lactide （LA） and p-dioxanone （PDO） monomers using stannous octoate [Sn（Oct）2]/n-dodecanol as the initiating system. The average sequence lengths of the lactidyl （LLA） and dioxanyl （LpDo） units were calculated from the ^1H NMR spectra. It was found that both LLA and Lpoo values from the two-step syntheses were significantly longer than those from the corresponding one-step syntheses, indicating more blocky structure achieved for the twostep copolymers. Corresponding to this difference in microstructure, the two-step copolymers were semi-crystalline, while the one-step copolymers were completely amorphous. In conclusion, the crystallinity of P（LA-co-PDO） copolymers could be adjusted conveniently to meet specific applications by changing the microstructure of the copolymers via different polymerization routes.

关键词： Poly(d,l-lactide-co-p-dioxanone) Copolymerization Chain microstructure Crystallinity

MISCIBILITY AND moRPHOLOGICAL STRUCTURE OF BIODEGRADABLE BLEND OF POLY(β—HYDROXYBUTYRATE)AND POLY(D,L—LACTIDE)

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Chinese Chemical Letters 1993年第3期4卷 269-272页

作者： xian mo deng Lian Lai ZHANG Chengdu Institute of Organic Chemistry,Academia Sinica Chengdu 610041

The poly(β-hydroxybutyrate)/poly(d,1-lactide)(PHB/PLA)blend was found to be immiscible,the melting point and the phase crystallinity of PHB were independent of the blend *** with plain PHB,the blend exhibited the cry... 详细信息

关键词： PHB MISCIBILITY AND moRPHOLOGICAL STRUCTURE OF BIODEGRADABLE BLEND OF POLY HYDROXYBUTYRATE)AND POLY LACTIDE D,L

MISCIBILITY AND CRYSTALLIZATION BEHAVIOR OF BIODEGRADABLE BLEND OF POLY(β—HYDROXYBUTYRATE)AND POLY(D,L—LACTIDE)—CO—POLY(ETHYLENE GLYCOL)

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Chinese Chemical Letters 1993年第3期4卷 265-268页

作者： xian mo deng Lian Lai ZHANG Cheng Dong XIONG Chengdu Institute of Organic Chemistry,Academia Sinica,Chewgdu 610041

Studies on the miscibility of PHB/PELA blends showed that PHB and PELA were miscible in amorphous *** crystallization behavior of PHB in the blend was strongly de- pendent on the addition of PELA component.

关键词： PELA HYDROXYBUTYRATE)AND POLY LACTIDE MISCIBILITY AND CRYSTALLIZATION BEHAVIOR OF BIODEGRADABLE BLEND OF POLY PHB D,L CO

RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS

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Chinese Journal of Polymer Science 1999年第3期17卷 265-270页

作者： xian-mo deng Xiao-hong Li Ming-long Yuan Xiong-wei Li Cheng-dong Xiong Zhi-tang Huang Wen-xiang Jia Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China West China University of Medical Sciences, Chengdu, 610041, China Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China West China University of Medical Sciences Chengdu 610041 China

Poly-dl-lactide-poly(ethylene glycol) (PELA) triblock copolymers were synthesized with lanthanum acetate as the initiator. PELA microspheres with entrapped Vibrio Cholera antigen and outer membrane protein (OMP) were prepared by a double emulsion W/O/W based on solvent extraction methods. The obtained microspheres showed smooth and spherical surface and their size varied between 0.5 and 5.0 mu m, which are suitable for oral targeting delivery system. The distribution tests in rabbits and mice through scanning electronic micrography and fluorescence microscope indicated that microspheres have successfully reached the immunization-related tissues, such as the liver, spleen and intestinal peyer's patches, following oral administration. The PELA microspheres were also evaluated as an efficient antigen delivery system by enhancing a higher protective ratio against live Vibrios Cholera.

关键词： poly-dl-lactide-poly(ethylene glycol) Vibrio Cholera antigen lanthanum acetate microsphere protective ratio

Novel thermogelling poly(ε-caprolactone-co-lactide)-poly(ethylene glycol)-poly(ε-caprolactone-co-lactide) aqueous solutions

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Chinese Chemical Letters 2007年第6期18卷 747-749页

作者： Zhi Qiang Jiang, xian mo deng, Jian Yuan Hao Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, P.O. Box 415, Chengdu 610041, China Graduate School of Chinese Academy of Sciences, Beijing 100039, China Chengdu Institute of Organic Chemistry Chinese Academy of Sciences P.O. Box 415 Chengdu 610041 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

The aqueous solutions of poly(e-caprolactone-co-lactide)-poly(ethylene glycol)poly(e-caprolactone-co-lactide) undergoing sol-gel transition as the temperature increases from 20 to 50℃were successfully prepared. The thermogelling triblock copolymers were synthesized by subtle tuning of the chemical composition and the hydrophilicity/hydrophobicity balance. The sol-gel transition was studied focusing on structure-property relationship. The amphiphilic copolymer formed micelles in aqueous solutions. It is believed to have potential applications in drug delivery and tissue engineering.

关键词： Biomaterials Hydrogels Micelles Phase behavior

Rapid synthesis of biodegradable poly(epsilon-caprolactone-co-p-dioxanone) random copolymers under microwave irradiation

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Chinese Chemical Letters 2010年第2期21卷 249-252页

作者： Chen, Rui Hao, Jian Yuan Xiong, Cheng Dong deng, xian mo Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China Univ Elect Sci & Technol China Sch Microeletron & Solid State Elect Chengdu 610054 Peoples R China Chinese Acad Sci Grad Sch Beijing 100039 Peoples R China

Biodegradable poly(epsilon-caprolactone-co-p-dioxanone)(PCDO) random copolymers have been synthesized by ring-opening polymerization of epsilon-caprolactone(CL) and p-dioxanone(PDO) under microwave *** effects of irradiation time and different CL/PDO molar feed ratios on the microwave-assisted ring-opening polymerization(MROP) of PCDO have been *** resultant products were characterized by ~1H NMR,GPC and *** was found that the polymerization was completed within 20 min at 140℃.In th...

关键词： Biodegradable p-Dioxanone Microwave irradiation Random copolymer

Recent Advances in Microbial Production of Terpenoids from Biomass-derived Feedstocks

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Chemical Research in Chinese Universities 2024年第1期40卷 20-28页

作者： CAO Yujin xian mo CAS Key Laboratory of Biobased Materials Qingdao Institute of BioEnergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101P.R.China Shandong Energy Institute Qingdao 266101P.R.China Qingdao New Energy Shandong Laboratory Qingdao 266101P.R.China

Terpenoids are a diverse class of natural products widely used as pharmaceuticals,perfumes,flavors,and ***,terpenoids are obtained from natural sources,such as plants,but their production is limited by the insufficiency of resources and low yields of *** production of terpenoids has emerged as a promising alternative due to that it is sustainable and easy to scale *** review aims to summarize recent advances in microbial production of terpenoids from inexpensive biomass-derived *** pathways and key enzymes involved in terpenoid biosynthesis are *** that can utilize low-cost lignocellulosic feedstocks for terpenoid production are *** challenges and prospects faced by microbial terpenoid production are *** believe that continuous progress in the fields of biomass transformation and synthetic biology will ultimately achieve industrial production of microbial terpenoids.

关键词： Terpenoid Microbial production Biomass-derived feedstock Metabolic pathway

THS-GWNN:a deep learning framework for temporal network link prediction

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Frontiers of Computer Science 2022年第2期16卷 174-176页

作者： xian mo Jun PANG Zhiming LIU College of Computer&Information Science Southwest UniversityChongqing 400715China Faculty of Science Technology and Medicine&Interdisciplinary Centre for SecurityReliability and TrustUniversity of LuxembourgEsch-sur-Alzette L-4364Luxembourg

1 Introduction and main contributions Link prediction for temporal networks aims to evaluate the likelihood of the future linkage among nodes,which has significant applications in social networks,biological networks and traffic analysis[1],*** embedding[2]is an important analytical tool for temporal network link prediction,which helps us better understand network evolution[3].How to encode high-dimensional and non-Euclidean network information is a crucial problem for node embedding in temporal *** of the challenges is to reveal the spatial structure at each timestamp and the temporal property over time[4].Some existing work[5]shows that extracting the spatial relation of each node can be used as a valid feature representation for each ***,the emergence of deep learning techniques[4,5]brings new insights for learning temporal properties,but most models using deep learning still fail to achieve satisfying prediction accuracy.

关键词： network prediction networks

An Inherent Chiral Calix[4]arene Bearing Chiral Groups without Forming Sub-ring

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Chinese Chemical Letters 2006年第9期17卷 1169-1172页

作者： xian xian LIU Yan Song ZHENG Wan Ling mo Departmentof Chemistry Huazhong University of Science and Technology Wuhan 430074 Department of Chemistry Guilin Normal College Guilin 541001 不详

The NMR spectra revealed that the calixarene frame of 1, 3-disubstituted calix[4]arenes beating optically active groups is asymmetric, even without the formation of a sub-ring. This inherent chirality arises from the interaction of the two chiral groups, which hinder the substituents＇ free rotation. Thus, these chiral calix[4]arenes display good chiral recognition ability.

关键词： Calixarene inherent chirality chiral recognition.