Novel thermogelling poly(ε-caprolactone-co-lactide)-poly(ethylene glycol)-poly(ε-caprolactone-co-lactide) aqueous solutions

作     者：Zhi Qiang Jiang, Xian Mo Deng, Jian Yuan Hao Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, P.O. Box 415, Chengdu 610041, China Graduate School of Chinese Academy of Sciences, Beijing 100039, China 

作者机构：Chengdu Institute of Organic ChemistryChinese Academy of SciencesP.O.Box 415Chengdu 610041China Graduate School of Chinese Academy of SciencesBeijing 100039China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2007年第18卷第6期

页      面：747-749页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：National Natural Science Foundation of China,NSFC: 50603025 Chinese Academy of Sciences,CAS 

主　　题：Biomaterials Hydrogels Micelles Phase behavior 

摘      要：The aqueous solutions of poly(e-caprolactone-co-lactide)-poly(ethylene glycol)poly(e-caprolactone-co-lactide) undergoing sol-gel transition as the temperature increases from 20 to 50℃were successfully prepared. The thermogelling triblock copolymers were synthesized by subtle tuning of the chemical composition and the hydrophilicity/hydrophobicity balance. The sol-gel transition was studied focusing on structure-property relationship. The amphiphilic copolymer formed micelles in aqueous solutions. It is believed to have potential applications in drug delivery and tissue engineering.