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2016年全国植物生物学大会

作者： Fu-Yuan Zhu mo-xian Chen Jianhua Zhang Ying-Gao Liu State Key Laboratory of Crop Biology College of Life ScienceShandong Agricultural University School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kong

In eukaryotes,mechanisms such as alternative splicing(AS) and alternative translation initiation(ATI) contribute to organismal protein diversity. Specifically,splicing factors play crucial roles during stress,in responses to hormones and development cues. However,the underlying mechanisms are not well investigated in plants. Here,we report the parallel employment of RNA sequencing and proteomic identification by constructing specific libraries to unravel AS isoforms and novel proteins in response to abscisic acid(ABA) treatment. Our results suggest that approximately 78% of intron-containing genes were alternatively spliced. Amongst a total of 141,419 identified AS events,two newly defined AS types,which are referred to as alternative first exon(TSS) and alternative last exon(TTS),were more abundant than intron retention(IR) in Arabidopsis. However,by contrast to AS events detected under normal conditions,ABA-regulated AS isoforms were more likely to be translated into proteins. Subsequent bioinformatic and structural analysis indicates that the alternation of splicing factor AS isoforms was crucial in response to ABA treatment. ABA extensively regulates the AS pattern in Arabidopsis by increasing the number of non-conventional splicing sites. This work is also the first instance in which thousands of new proteins encoded from the same m RNA through ATI or 3′ to 5′ translation were detected using a self-constructed library on the sense and antisense strand of the Arabidopsis genome. The combined results thus enhance our understanding the regulation of AS and translation mechanisms under normal condition and in response to ABA treatment.

关键词： alternative spling alternative translation ABA proteogenomic

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小学生考试粗心现象的心理分析

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心理与行为研究 2008年第4期6卷 301-305页

作者：莫闲南通大学教育科学学院南通226007

对314名小学3～5年级学生考试粗心情况、神经活动特性,以及书写水平的测试,揭示了小学生考试粗心现象与神经活动特性与书写水平之间的关系。结果显示:(1)小学生考试粗心现象与其皮质神经的活动强度没有必然的联系,与其皮质神经活动的均... 详细信息

对314名小学3～5年级学生考试粗心情况、神经活动特性,以及书写水平的测试,揭示了小学生考试粗心现象与神经活动特性与书写水平之间的关系。结果显示:(1)小学生考试粗心现象与其皮质神经的活动强度没有必然的联系,与其皮质神经活动的均衡性也没有必然的联系;(2)小学生考试粗心程度与个体的书写水平呈中等程度的正相关。

关键词：考试粗心神经活动特性书写水平

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PMB/GO纳米复合材料的制备及阻燃性能

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高分子材料科学与工程 2009年第12期25卷 126-128,132页

作者：黄萍珍莫羡忠甘春芳苏州大学材料学院江苏苏州215021 广西师范学院化学系广西南宁530001

用共混法制备甲基丙烯酸甲酯-丙烯酸丁酯共聚物(PMB)/氧化石墨(GO)纳米复合材料。采用X射线衍射(XRD)和透射电镜(TEM)对复合材料结构进行了表征,并采用热重分析法(TGA)和锥形量热分析(CONE)研究了其阻燃性能变化。XRD和TEM分析结果表明... 详细信息

用共混法制备甲基丙烯酸甲酯-丙烯酸丁酯共聚物(PMB)/氧化石墨(GO)纳米复合材料。采用X射线衍射(XRD)和透射电镜(TEM)对复合材料结构进行了表征,并采用热重分析法(TGA)和锥形量热分析(CONE)研究了其阻燃性能变化。XRD和TEM分析结果表明,复合物中添加GO形成剥离型结构的纳米复合材料。TGA研究发现复合材料的热稳定性得到提高。CONE的测试结果表明,GO极大地改善了体系的燃烧性能,其中加5%GO体系的pk-HRR降低了62.2%。

关键词：氧化石墨甲基丙烯酸甲酯-丙烯酸丁酯共聚物纳米复合材料共混法

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Novel thermogelling poly(ε-caprolactone-co-lactide)-poly(ethylene glycol)-poly(ε-caprolactone-co-lactide) aqueous solutions

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Chinese Chemical Letters 2007年第6期18卷 747-749页

作者： Zhi Qiang Jiang, xian mo Deng, Jian Yuan Hao Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, P.O. Box 415, Chengdu 610041, China Graduate School of Chinese Academy of Sciences, Beijing 100039, China Chengdu Institute of Organic Chemistry Chinese Academy of SciencesP.O.Box 415Chengdu 610041China Graduate School of Chinese Academy of Sciences Beijing 100039China

The aqueous solutions of poly(e-caprolactone-co-lactide)-poly(ethylene glycol)poly(e-caprolactone-co-lactide) undergoing sol-gel transition as the temperature increases from 20 to 50℃were successfully prepared. The thermogelling triblock copolymers were synthesized by subtle tuning of the chemical composition and the hydrophilicity/hydrophobicity balance. The sol-gel transition was studied focusing on structure-property relationship. The amphiphilic copolymer formed micelles in aqueous solutions. It is believed to have potential applications in drug delivery and tissue engineering.

关键词： Biomaterials Hydrogels Micelles Phase behavior

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Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

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Chinese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun XIAO Shi-lin LIN Ru-kun LI Chan CHEN Zhi-jie CHEN Yi-fei LUO Chao-hua mo Zhi-xian LIN Ying-bo School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. Methods: B16F10 and 4T1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. The cell viability was detected by cell counting kit-8. The expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRT-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNT group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathological changes of tumor tissues were observed by hematoxylin-eosin staining. The cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P mote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

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聚氨酯的生物降解研究进展

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应用与环境生物学报 2018年第5期24卷 985-992页

作者：闫华张汝兵咸漠中国科学院青岛生物能源与过程研究所中国科学院生物基材料重点实验室

聚氨基甲酸酯（PU）因具有高强度、抗撕裂、耐磨损等诸多优势,广泛应用于各个领域,但是聚氨酯材料不易降解,给生态环境安全造成很大危害.使用生物方法降解聚氨酯成为当今的研究热点.概述聚氨酯的现状、生物降解机理和研究进展,并结合近... 详细信息

聚氨基甲酸酯（PU）因具有高强度、抗撕裂、耐磨损等诸多优势,广泛应用于各个领域,但是聚氨酯材料不易降解,给生态环境安全造成很大危害.使用生物方法降解聚氨酯成为当今的研究热点.概述聚氨酯的现状、生物降解机理和研究进展,并结合近年来开展的聚氨酯生物降解实例,重点阐述细菌和真菌降解聚氨酯的机理及进展情况.研究发现,真菌降解聚氨酯主要通过分泌酶进行作用,真菌附着在聚氨酯材料的表面,通过生物体的繁殖和菌丝的生长破坏聚氨酯材料的结构,同时分泌水解酶、尿素酶、蛋白酶等进一步作用,共同完成聚氨酯的生物降解;而细菌降解聚氨酯时,自身先产生一种水溶性胞内酶连接细菌的细胞膜和聚氨酯材料,然后分泌胞外酶破坏聚氨酯底物,将聚氨酯材料分解为小分子物质,而降解生成的小分子则可被细菌生物体直接代谢,最终完成聚氨酯的降解.最后探讨聚氨酯生物降解存在的问题,并展望发展趋势,指出未来应依据聚氨酯的种类、特点来筛选针对性的降解菌株,并开展生物降解作用机理研究,为聚氨酯生物降解工艺技术的研发提供理论支撑.

关键词：聚氨酯生物降解绿色降解生物酶解生物氧化

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Skyway:Accelerate Graph Applications with a Dual-Path Architecture and Fine-Grained Data Management

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Journal of Computer Science & Technology 2024年第4期39卷 871-894页

作者： mo Zou Ming-Zhe Zhang Ru-Jia Wang xian-He Sun Xiao-Chun Ye Dong-Rui Fan Zhi-Min Tang Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of Information Engineering Chinese Academy of SciencesBeijing 100045China Department of Computer Science Illinois Institute of TechnologyChicagoIL 60616U.S.A.

Graph processing is a vital component of many AI and big data ***,due to its poor locality and complex data access patterns,graph processing is also a known performance killer of AI and big data *** this work,we propose to enhance graph processing applications by leveraging fine-grained memory access patterns with a dual-path architecture on top of existing software-based graph *** first identify that memory accesses to the offset,edge,and state array have distinct locality and impact on *** then introduce the Skyway architecture,which consists of two primary components:1)a dedicated direct data path between the core and memory to transfer state array elements efficiently,and 2)a data-type aware fine-grained memory-side row buffer hardware for both the newly designed direct data path and the regular memory hierarchy data *** proposed Skyway architecture is able to improve the overall performance by reducing the memory access interference and improving data access efficiency with a minimal *** evaluate Skyway on a set of diverse algorithms using large real-world *** a simulated fourcore system,Skyway improves the performance by 23%on average over the best-performing graph-specialized hardware optimizations.

关键词： graph application computer architecture memory hierarchy

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学习动机整合理论的建构与研究展望

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心理科学 2008年第6期31卷 1517-1520页

作者：莫闲南通大学教育科学学院南通226007

动机整合理论为研究学习动机提供了新的视野,本文参照动机整合理论,建立学习动机整合的概念。学习动机整合是指在学习过程中,个体通过自我调节,逐步内化外部控制因素、增强学习自主性的过程。学习动机的整合状态是最理想的学习动机状态... 详细信息

动机整合理论为研究学习动机提供了新的视野,本文参照动机整合理论,建立学习动机整合的概念。学习动机整合是指在学习过程中,个体通过自我调节,逐步内化外部控制因素、增强学习自主性的过程。学习动机的整合状态是最理想的学习动机状态。学习动机整合水平评定工具的修订、学习动机整合水平及其相关因素的调查分析、促进学习动机整合的策略研究是研究学习动机整合问题中需要关注的三个方面。

关键词：学习动机自我决定动机整合动机内化

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WNT5A Regulated by miR154-5p is Associated with Angiopoiesis and Invasion of Placental Site Trophoblastic Tumor (PSTT)

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Biomedical and Environmental Sciences 2024年第4期37卷 423-427页

作者： ZHANG Sai CHEN Zhi xian ZHANG mo DU Yan ZHOU Jia Yi WU Jing YU Yin Hua CAO Qi ZHAO Hong Bo Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China

Placental site trophoblastic tumor(PSTT),a rare gestational trophoblastic neoplasm(GTN),exhibits slow growth,late-onset metastasis,and chemotherapy insensitivity[1,2].The invasive capacity of trophoblasts induces angiogenesis in PSTT,yet the specific mechanism remains unclear[3].PSTT is typically resistant to chemotherapy and hysterectomy stands as the primary therapeutic choice for patients with an overall cure rate of approximately 75%-80%[4,5].Therefore,investigating the precise emergence and progression of PSTT is crucial,aiming to identify novel targets for diagnosis and therapy.

关键词： chemotherapy diagnosis metastasis

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Theoretical Design of Defects as a Driving Force for Ion Transport in Li_(3)OBr Solid Electrolyte

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Energy & Environmental Materials 2024年第3期7卷 143-153页

作者： Xingyun Luo Yanlu Li xian Zhao State Key Lab of Crystal Materials and Institute of Crystal Materials Shandong UniversityJinan 250100China Center for Optics Research and Engineering Shandong UniversityQingdao 266237China

Due to ever-increasing concerns about safety issues in using Li ionic batteries,solid electrolytes have extensively *** Li-rich antiperovskite Li_(3)OBr has been considered as a promising solid electrolyte candidate,but it still suffers challenges to achieve a high ionic conductivity owing to the high intrinsic symmetry of the crystal ***,we presented a design strategy that introduces various point defects and grain boundaries to break the high lattice symmetry of Li_(3)OBr crystal,and their effect and microscopic mechanism of promoting the migration of Li-ion were explored *** has been found that Li_(i)are the dominant defects responsible for the fast Li-ion diffusion in bulk Li_(3)OBr and its surface,but they are easily trapped by the grain boundaries,leading to the annihilating of the Frenkel defect pair V'_(Li)+Li_(i),and thus limits the V'_(Li)diffusion at the grain *** V_(Br)defect near the grain boundaries can effectively drive V'_(Li)across the grain boundary,thereby converting the carrier of Li^(+)migration from Li,in the bulk and surface to V'_(Li)at the grain boundary,and thus improving the ionic conductivity in the whole Li_(3)OBr *** work provides a comprehensive insight into the Li^(+)transport and conduction mechanism in the Li_(3)OBr *** opens a new way of improving the conductivity for all-solid-state Li electrolyte material through the defect design.

关键词： defects density functional theory ionic migration solid electrolyte

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