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Attention-based network embedding with higher-order weights and node attributes

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 440-451页

作者： xian mo Binyuan Wan Rui Tang Junkai Ding Guangdi Liu School of Information Engineering Ningxia UniversityYinchuanChina School of Cyber Science and Engineering Sichuan UniversityChengduChina Computer Science and Information Technology University of MalayaKuala LumpurMalaysia Academy of Medical Sciences Zhengzhou UniversityZhengzhouChina

Network embedding aspires to learn a low-dimensional vector of each node in networks,which can apply to diverse data mining *** real-life,many networks include rich attributes and temporal ***,most existing embedding approaches ignore either temporal information or network attributes.A self-attention based architecture using higher-order weights and node attributes for both static and temporal attributed network embedding is presented in this article.A random walk sampling algorithm based on higher-order weights and node attributes to capture network topological features is *** static attributed networks,the algorithm incorporates first-order to k-order weights,and node attribute similarities into one weighted graph to preserve topological features of *** temporal attribute networks,the algorithm incorporates previous snapshots of networks containing first-order to k-order weights,and nodes attribute similarities into one weighted *** addition,the algorithm utilises a damping factor to ensure that the more recent snapshots allocate a greater *** features are then incorporated into topological ***,the authors adopt the most advanced architecture,Self-Attention Networks,to learn node *** results on node classification of static attributed networks and link prediction of temporal attributed networks reveal that our proposed approach is competitive against diverse state-of-the-art baseline approaches.

关键词： data mining deep neural networks social network

To explore the pathogenesis of anterior resection syndrome by magnetic resonance imaging rectal defecography

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 529-538页

作者： Ling-Hou Meng xian-Wei mo Bing-Yu Yang Hai-Quan Qin Qing-Zhou Song Xin-Xin He Qiang Li Zheng Wang Chang-Lin mo Guo-Hai Yang Department of Gastrointestinal Surgery Guangxi Clinical Research Center for Colorectal CancerGuangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal and Anal Surgery Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiology Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina First Department of Chemotherapy Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over 90%of rectal cancer patients develop low anterior resection syndrome(LARS)after sphincter-preserving *** current globally recognized evaluation method has many drawbacks and its subjectivity is too strong,which hinders the research and treatment of *** To evaluate the anorectal function after colorectal cancer surgery by quantifying the index of magnetic resonance imaging(MRI)defecography,and pathogenesis of *** We evaluated 34 patients using the standard LARS score,and a new LARS evaluation index was established using the dynamic images of MRI defecography to verify the LARS *** In the LARS score model,there were 10(29.41%)mild and 24(70.58%)severe cases of *** comparison of defecation rate between the two groups was 29.36±14.17%versus 46.83±18.62%(P=0.004);and MRI-rectal compliance(MRI-RC)score was 3.63±1.96 versus 7.0±3.21(P=0.001).Severe and mild LARS had significant differences using the two evaluation *** was a significant negative correlation between LARS and MRI-RC score(P<0.001),and they had a negative correlation with defecation rate(P=0.028).CONCLUSION MRI defecography and standard LARS score can both be used as an evaluation index to study the pathogenesis of LARS.

关键词： Anterior resection syndrome Colorectal cancer Diagnostic evaluation system Magnetic resonance imaging defecography Pathogenesis

急性胰腺炎发病机制及并发内脏静脉血栓研究进展

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陕西医学杂志 2024年第2期53卷 282-285页

作者：莫闲杨闯川北医学院四川南充637000 四川省精神卫生中心绵阳市第三人民医院四川绵阳621000

急性胰腺炎(AP)具有进展快、病死率高等特点,其发病因素较为复杂,是临床常见急腹症,临床上依据其器官功能衰竭和并发症发生情况可分为轻度、中度和重度AP。目前有关AP发生机制尚未完全阐明,主要存在胰酶自噬、胰泡细胞凋亡、炎症损伤、... 详细信息

急性胰腺炎(AP)具有进展快、病死率高等特点,其发病因素较为复杂,是临床常见急腹症,临床上依据其器官功能衰竭和并发症发生情况可分为轻度、中度和重度AP。目前有关AP发生机制尚未完全阐明,主要存在胰酶自噬、胰泡细胞凋亡、炎症损伤、钙离子超载等理论。内脏静脉血栓(SVT)是AP常见并发症,其中以脾静脉、门静脉血栓较为常见,SVT可导致AP患者出现胃底静脉大出血、肠缺血坏死等,增加AP患者死亡风险。早期预防SVT发生风险,是改善AP预后的有效手段,临床上常通过药物、液体复苏、营养支持、手术等方法来预防SVT发生。现就其发病机制以及合并SVT进行综述。

关键词：急性胰腺炎内脏静脉血栓钙离子胰泡细胞炎症研究现状

基于脑-小脑连接梯度的AD患者脑功能层级结构变化研究

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磁共振成像 2024年第5期15卷 1-7页

作者：何美荣莫贤游晚芳孙昂张俊然四川大学电气工程学院成都610065 西北民族大学电气工程学院兰州730030

目的采用基于梯度的方法分析阿尔茨海默病(Alzheimer’s disease,AD)大脑皮层组织沿脑-小脑连接梯度的功能层级结构及其与小脑相互作用的改变,以及与认知功能障碍之间的联系。材料与方法基于AD神经影像学计划(Alzheimer’s Disease Neur... 详细信息

目的采用基于梯度的方法分析阿尔茨海默病(Alzheimer’s disease,AD)大脑皮层组织沿脑-小脑连接梯度的功能层级结构及其与小脑相互作用的改变,以及与认知功能障碍之间的联系。材料与方法基于AD神经影像学计划(Alzheimer’s Disease Neuroimaging Initiative,ADNI)公开数据库,共纳入33名AD患者和46名年龄、性别相匹配的健康对照(healthy controls,HC)。采用梯度计算方法,通过对所有被试的脑-小脑静息态功能连接矩阵进行非线性分解,得到了每个被试的脑-小脑功能连接梯度。采用双样本t检验进行组间的脑-小脑梯度分数差异分析,以及梯度异常的脑区与小脑功能连接的组间比较,并采用相关分析评估了异常的梯度分数以及功能连接值与临床量表分数的相关性。结果与HC组相比,AD组在涉及高级认知功能区域右侧颞下回(right inferior temporal gyrus,RITG)(t=4.71,P<0.001)的梯度分数发生局部性改变,进一步基于梯度异常脑区为种子点的功能连接分析显示出RITG到小脑双侧CrusⅡ区域以及延伸到的ⅦB区(右侧:t=-4.89,P<0.001,左侧:t=-4.98,P<0.001)功能连接的降低。临床量表相关性分析显示,AD患者的梯度异常脑区的连接梯度分数与社会活动功能(Functional Activity Questionnaire,FAQ)评分密切相关(r=0.40,P=0.025)。结论AD患者参与高级认知功能的局部区域功能层级结构的异常变化及其与小脑双侧CrusⅡ和ⅦB脑区的功能连接降低可能是认知功能受损的潜在因素之一。

关键词：阿尔茨海默病脑-小脑连接梯度静息态功能连接磁共振成像功能层级结构

融合注意力的主动迭代优化白细胞图像分类模型

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中国生物医学工程学报 2024年第4期43卷 408-418页

作者：蒋舒颖李志明莫贤孙昂张俊然四川大学电气工程学院成都610065

白细胞的数量和结构特征蕴含了人类健康状况的重要信息。通过对不同种类的白细胞进行计数,可为多种疾病的早期治疗提供重要依据。但目前采集与标注白细胞数据集成本较高、现有的白细胞数据集数量较少,给计算机辅助白细胞自动分类带来了... 详细信息

白细胞的数量和结构特征蕴含了人类健康状况的重要信息。通过对不同种类的白细胞进行计数,可为多种疾病的早期治疗提供重要依据。但目前采集与标注白细胞数据集成本较高、现有的白细胞数据集数量较少,给计算机辅助白细胞自动分类带来了挑战。为此,本研究提出了一种融合注意力的主动迭代优化白细胞图像分类模型,通过在ResNet18主干网络上附加用于主动学习的LossNet网络,从大量未标注样本中挑选最具代表性的样本进行标注,减少了需要人工标注的样本量。同时,为了应对白细胞数据集类间不平衡对主动学习的影响,加入主动迭代扩增模块,挑选训练过程中的困难样本进行含有随机因子的数据扩增,自下而上形成了双向的信息交互,以增强模型对不平衡数据集的适应力。最终,在比较了3种注意力模块后,本研究选择加入CBAM注意力模块,以增强模型对白细胞特征区域的关注、提高模型的性能。采用包含14514张白细胞显微镜图像的Raabin-WBC数据集进行方法验证。实验结果表明,所提出的模型在使用训练集28%、37%、52%的样本时,分类准确率分别达到92.35%、93.64%、94.86%,相比原ResNet18分别提升了5.14%、9.24%、2.37%,模型有效降低了白细胞数据集的标注成本,在缺乏标注的医学数据集上具有较为广泛的应用前景。

关键词：主动学习白细胞主动迭代扩增 LossNet 医学图像分类

A Green and Efficient Trinitration System for Aromatic Compounds with Bi（NO3）3·5H2O/[HMIMICIO4 as Catalyst in HNO3/Ac2O

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Chemical Research in Chinese Universities 2015年第5期31卷 761-765页

作者： SUN Weizhi YU Shitao xian mo CAS Key Laboratory of Biobased Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China College of Chemical Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

To investigate the green trinitration method of aromatic compounds, with Lewis acid/ionic liquid as catalyst and HNOJAc2O as nitration reagent, a Lewis acid/ionic liquid/HNO3/Ac2O system was established. In various combinations of Lewis acids and ionic liquids, Bi（NO3）3-5H2O/[HMIM]CIO4 proved to be a very efficient catalyst for the trinitration of activated aromatic compounds and reusable for 3 times. Reaction conditions for the trinitration were optimized and yields of the trinitro products were from mild to excellent. This sulfuric acid-free system has the advantages of strong trinitration ability, low environment pollution, low toxicity, low cost and high potential for industrial application.

关键词： Green trinitration Aromatic compound Lewis acid Ionic liquid Acetyl nitrate

Synthesis of novel biodegradable poly(ethylene glycol) analogue:Water-soluble aliphatic polyester with pendant oligo(ethylene glycol) chains

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Chinese Chemical Letters 2009年第12期20卷 1502-1505页

作者： Lei Feng Jian Yuan Hao Cheng Dong Xiong xian mo Deng Chengdu Institute of Organic Chemistry Chinese Academy of Sciences P.O. Box 415 Chengdu 610041 China School of Microeletronics and Solid State Electronics University of Electronic Science and Technology of China Chengdu 610054 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

A novel poly（ethylene glycol）（PEG） analogue composed of aliphatic polyester backbone and pendant oligo（ethylene glycol） short chains is reported. The PEG analogue is a copolymer synthesized by ring-opening alternating copolymerization of succinic anhydride with 2-（（2-（2-metho xyethoxy）ethoxy）methyl）oxirane. The structure of the copolymer was confirmed by ^1H NMR spectrum. The effects of the monomer feed ratio on the copolymerization were studied and the polymerization mechanism was given. The PEG analogue disclosed is water-soluble and expected to have promising applications in biomedical fields as a substitute of PEG due to the existence of degradable ester bond in the backbone.

关键词： Water-soluble PEG analogue 2-((2-(2-Methoxyethoxy)ethoxy)methyl)oxirane Ring-opening alternating copolymerization Polyester

Rapid synthesis of biodegradable poly(epsilon-caprolactone-co-p-dioxanone) random copolymers under microwave irradiation

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Chinese Chemical Letters 2010年第2期21卷 249-252页

作者： Chen, Rui Hao, Jian Yuan Xiong, Cheng Dong Deng, xian mo Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China Univ Elect Sci & Technol China Sch Microeletron & Solid State Elect Chengdu 610054 Peoples R China Chinese Acad Sci Grad Sch Beijing 100039 Peoples R China

Biodegradable poly(epsilon-caprolactone-co-p-dioxanone)(PCDO) random copolymers have been synthesized by ring-opening polymerization of epsilon-caprolactone(CL) and p-dioxanone(PDO) under microwave *** effects of irradiation time and different CL/PDO molar feed ratios on the microwave-assisted ring-opening polymerization(MROP) of PCDO have been *** resultant products were characterized by ~1H NMR,GPC and *** was found that the polymerization was completed within 20 min at 140℃.In th...

关键词： Biodegradable p-Dioxanone Microwave irradiation Random copolymer

Different crystallinity of poly(d,l-lactide-co-p-dioxanone) copolymers acquired by control of chain microstructure

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Chinese Chemical Letters 2009年第12期20卷 1506-1509页

作者： Hui Zhen Zhao Jian Yuan Hao Cheng Dong Xiong xian mo Deng Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China School of Microeletronics and Solid State Electronics University of Electronic Science and Technology of China Chengdu 610054 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

Poly（d,l-lactide-co-p-dioxanone）（P（LA-co-PDO）） copolymers with different chain microstructures were synthesized by onestep or two-step bulk ring-opening polymerizations of d,l-lactide （LA） and p-dioxanone （PDO） monomers using stannous octoate [Sn（Oct）2]/n-dodecanol as the initiating system. The average sequence lengths of the lactidyl （LLA） and dioxanyl （LpDo） units were calculated from the ^1H NMR spectra. It was found that both LLA and Lpoo values from the two-step syntheses were significantly longer than those from the corresponding one-step syntheses, indicating more blocky structure achieved for the twostep copolymers. Corresponding to this difference in microstructure, the two-step copolymers were semi-crystalline, while the one-step copolymers were completely amorphous. In conclusion, the crystallinity of P（LA-co-PDO） copolymers could be adjusted conveniently to meet specific applications by changing the microstructure of the copolymers via different polymerization routes.

关键词： Poly(d,l-lactide-co-p-dioxanone) Copolymerization Chain microstructure Crystallinity