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Chinese Chemical Letters 2023年第12期34卷 215-219页

作者： Qian Feng Nan li Zeyuan Zhang kai Gao kai Wang Sanliang ling Hongye Yuan Yanmin Zhang Mingming Zhang State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXian Jiaotong UniversityXi'an 710049China School of Pharmacy Health Science CenterXi'an Jjiaotong UniversityXi'an 710061China State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China Advanced Materials Research Group Faculty of EngineeringUniversity of NottinghamNottingham NG72RDUnited Kingdom

Developing novel emissive supramolecular assemblies with elegant architectures and tunable perfor-mance remains highly desirable yet ***,we report the design and synthesis of several 9.10-bis(diphenylmethylene)-9.10-dihydroanthracene-based metal organic assembles with aggregation-induced emission *** assemblies feature intriguing thermochromic and mechanochromic properties,ie.,distinguishable fuorescence responses in terms of emission wavelength and intensity un-der variable temperatures and ***,these assemblies can serve as excellent fluorescent sensors for the detection of polysaccharide *** to the differentiated charge type and den-sity,the assembles display distinct sensing mechanisms toward different polysaccharide *** study provides novel perspectives for the synthesis of buttrfly-like platinum(I)supramolecular coordi-nation complexes with multistimuli-responsiveness for polysaccharide *** will facllitate the development of stimuli-responsive materials.

关键词： light-emitting materials Butterfly-like assembles Aggregation-induced emission Multiple sensing

Biological nano agent produced by hypoxic preconditioning stem cell for stroke treatment

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Nano Research 2023年第5期16卷 7413-7421页

作者： Xin-Chi Jiang Hong-Hui Wu Tianyuan Zhang Yun-Fei Dong Yao-Sheng li Ting Huang An-Hao Tian Peng-xiang Chen xian-Ming lin Ying-Zhi Huang Chong liu xiang-Nan Zhang Zhong Chen Yasuhiko Tabata Jian-Qing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China Department of Pathology and Pathophysiology and Department of Neurosurgery of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China The Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310058China SinoCell Biotechnology Ltd. Ningbo 315000China Key Laboratory of Medical Neurobiology of the Ministry of Health of China Institute of Pharmacology&ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Laboratory of Biomaterials Department of Regeneration Science and EngineeringInstitute for Frontier Life and Medical SciencesKyoto UniversityKyoto 606-8501Japan

Exosomes make a significant contribution during stem cell-based therapy due to the abundant *** evidence implies exosomes can act as potential biological nano *** herein propose hypoxic preconditioning for neural stem cells(NSCs)that could produce hypoxic exosomes for efficient treatment of ischemic *** preconditioning on NSCs significantly altered the miRNAs encapsulated in ***,hypoxic exosomes could target the injured brain to regulate the microenvironment to inhibit neuroinflammation and promote blood–brain barrier permeability ***,the autologous NSCs in Nestin-CreER mice could be activated by hypoxic exosomes to facilitate nerve *** hypoxic preconditioning,exosomes further exerted therapeutic effects on both survival(25%)and behavioral outcomes in ischemic stroke ***,hypoxic preconditioning NSCs can produce effective nano agent and may represent a promising strategy for clinical neurorestorative therapy.

关键词： exosomes hypoxia-preconditioning stem cells ischemic stroke microenvironment

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基于典型相关分析的多视图跨领域情感分类

计算机工程 2010年第24期36卷 186-188页

作者：黄贤立淮阴师范学院计算机科学与技术学院江苏淮安223300

跨领域的文本分类,是指利用有标记领域的知识去帮助另一个概率分布不同的,未标记领域的知识进行分类的问题。从多视图学习的视角提出一个新的跨领域文本分类的方法(MTV算法)。通过在核空间典型相关分析中引入与标记相关的信息,MTV算法... 详细信息

跨领域的文本分类,是指利用有标记领域的知识去帮助另一个概率分布不同的,未标记领域的知识进行分类的问题。从多视图学习的视角提出一个新的跨领域文本分类的方法(MTV算法)。通过在核空间典型相关分析中引入与标记相关的信息,MTV算法可以得到一个判别性能更优的公共子空间。在多个情感类文本数据上的实验表明,MTV算法可以大大提升传统监督式学习算法面对领域迁移时的分类性能,并且在引入判别式的核空间典型相关分析后,进一步优化性能。

关键词：跨领域学习迁移学习情感分类文本分类核空间典型相关分析

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强噪声背景红外微弱动目标集成检测

电波科学学报 2008年第3期23卷 438-442页

作者：鲜海滢傅志中李在铭电子科技大学通信与信息工程学院四川成都610054

微弱运动目标检测一直是红外成像识别、跟踪领域中的重要课题。我们提出了一种新的基于强复杂噪声背景的红外微弱运动目标集成检测算法。针对复杂噪声,提出一种新的基于邻域梯度累积平方误差最小原则的自适应滤波算法。该算法,对各种加... 详细信息

微弱运动目标检测一直是红外成像识别、跟踪领域中的重要课题。我们提出了一种新的基于强复杂噪声背景的红外微弱运动目标集成检测算法。针对复杂噪声,提出一种新的基于邻域梯度累积平方误差最小原则的自适应滤波算法。该算法,对各种加性、乘性噪声的滤波性能优异且均衡,适合对复杂噪声进行滤波。针对微小目标检测,我们提出一种基于运动平台的微小目标运动场集成检测算法。该算法,改变传统微小目标检测算法,要求提前对运动背景进行精确全域运动估计及补偿的模式,而只对图像运动场进行估计及补偿,提高了算法的可实现性。

关键词：强噪声复杂噪声微弱目标运动检测

Percutaneous extraction of leads from coronary sinus vein and branch by modified techniques

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Chinese Medical Journal 2012年第20期125卷 3707-3711页

作者： CHU xian-ming li Xue-bin ZHANG Ping, WANG Long li Ding li Bing AN Yi LENG Min DUAN Jiang-bo GUO Ji-hong Department of Cardiac Electrophysiology Peking University People's HospitalBeijing 100044China Department of Cardiology Affiliated Hospital of Medical CollegeQingdao UniversityQingdaoShandong 266100China Department of Biology Medical College of Qingdao UniversityQingdaoShandong 266021China

Background Cardiac resynchronization therapy （CRT） device and coronary sinus （CS） lead extraction are required due to the occurrence of systemic infection, malfunction, or upgrade. Relevant research of CS lead extraction is rare, especially in developing countries because of the high cost and lack of specialized tools. We aimed to evaluate percutaneous extraction of CS leads by modified conventional techniques. Methods Of 200 patients referred for lead extraction from January 2007 to June 2011, 24 （12.0%） involved CS leads （24 CS leads）. We prospectively analyzed clinical characteristics, optimized extraction techniques and feasibility of extraction. Results Complete procedural success was achieved in 23 patients （95.8%）, and the clinical success in 24 patients （100.0%）. The leading indication for CS lead extraction was infection （66.7%）. Mean implant duration was （29.5±20.2） months （range, 3-78 months）. Sixteen CS leads （66.6%） were removed with locking stylets plus manual traction by superior transvenous approach. Mechanical dilatation and counter-traction was required to free fibrotic adhesions and extract 4 CS leads （16.7%）, which had longer implant duration than other leads （（62.5±12.3） vs. （22.9±14.1） months, P〈0.05）. Another 4 CS （16.7%） leads were removed by modified and innovative snare techniques from femoral vein approach. Median extraction time was 11 minutes （range, 3-61 minutes） per CS lead, which had significant correlation with implant duration （r = 0.8, P 〈0.001）. Sixteen patients （66.6%） were reimplanted with new devices at a median of 7.5 days after extraction. Median followed-up was 23.5 months （range, 8-61 months）, three patients died due to sudden cardiac death （26 months）, heart failure （45 and 57 months, respectively）. Conclusion The modified procedure was proved to be practical for percutaneous extraction of CS leads, especially in developing countries lacking expensive powered sheaths.

关键词： lead " extraction " cardiac resynchronization therapy " coronary vessels " infection

Significant expansion and red-shifting of fluorescent protein chromophore determined through computational design and genetic code expansion

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Biophysics Reports 2018年第5期4卷 273-285页

作者： li Wang xian Chen Xuzhen Guo Jiasong li Qi liu Fuying Kang Xudong Wang Cheng Hu Haiping liu Weimin Gong Wei Zhuang Xiaohong liu Jiangyun Wang Institute of Biophysics Chinese Academy of Sciences College of life Sciences University of Chinese Academy of Sciences Key Laboratory of Physics and Technology for Advanced Batteries (Ministry of Education) Department of PhysicsJilin University State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Fluorescent proteins(FPs) with emission wavelengths in the far-red and infrared regions of the spectrum provide powerful tools for deep-tissue and super-resolution imaging. The development of red-shifted FPs has evoked widespread interest and continuous engineering efforts. In this article,based on a computational design and genetic code expansion, we report a rational approach to significantly expand and red-shift the chromophore of green fluorescent protein(GFP). We applied computational calculations to predict the excitation and emission wavelengths of a FP chromophore harboring unnatural amino acids(UAA) and identify in silico an appropriate UAA, 2-amino-3-(6-hydroxynaphthalen-2-yl)propanoic acid(naphthol-Ala). Our methodology allowed us to formulate a GFP variant(cpsf GFP-66-Naphthol-Ala) with red-shifted absorbance and emission spectral maxima exceeding 60 and 130 nm, respectively, compared to those of GFP. The GFP chromophore is formed through autocatalytic post-translational modification to generate a planar 4-(p-hydroxybenzylidene)-5-imidazolinone chromophore. We solved the crystal structure of cpsf GFP-66-naphthol-Ala at 1.3 ? resolution and demonstrated the formation of a much larger conjugated p-system when the phenol group is replaced by naphthol. These results explain the significant red-shifting of the excitation and emission spectra of cpsf GFP-66-naphthol-Ala.

关键词： Computational design Green fluorescent protein Red-shift Unnatural amino acids

基于虚拟嵌入块和量化器原点抖动的YASS改进算法

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华南理工大学学报（自然科学版） 2013年第1期41卷 38-46页

作者：马丽红李晓吕先明华南理工大学电子与信息学院∥近距离无线通信与网络教育部工程研究中心广东广州510640

为了提高YASS算法的隐写安全性,提出一种基于灵活次序的虚拟嵌入块和量化器原点随机抖动的YASS改进算法———VHD-YASS算法.为了增加嵌入位置的随机性,该改进算法在每个载体块内随机选取一个不规则区域,重新生成一个虚拟的8×8小块来取... 详细信息

为了提高YASS算法的隐写安全性,提出一种基于灵活次序的虚拟嵌入块和量化器原点随机抖动的YASS改进算法———VHD-YASS算法.为了增加嵌入位置的随机性,该改进算法在每个载体块内随机选取一个不规则区域,重新生成一个虚拟的8×8小块来取代传统YASS算法中规则的8×8嵌入块,用于消息的嵌入;然后,通过密钥控制量化索引调制(QIM)中奇/偶量化器的原点偏移,消除QIM量化步长较大时消息嵌入造成的DCT系数聚集效应.将文中改进算法与传统YASS算法和两种不同的改进YASS算法进行了对比实验,结果表明:在同一嵌入容量下,文中改进算法的检测概率最高为0.614,而传统YASS算法的检测概率最高为0.983.从抗隐写分析能力、可视性及算法复杂度方面综合分析可知,文中算法是一种有效的隐写算法.

关键词： YASS算法虚拟嵌入块量化器原点抖动观测域隐写分析

The 15N NMR study of silatranes

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Chinese Journal of Chemistry 1986年第2期4卷 140-143页

作者： ZHU Jin-Chang* SUN xian-Yu WU Hua-Ju JIANG li-Jin, Institute of Photographic Chemistry, Academia Sinica, Beijing CHEN Bang-Qin WU Guan-li, Institute of Chemistry, Academia Sinica, Beijing Institute of Photographic Chemistry Academia Sinica Beijing Institute of Chemistry Academia Sinica Beijing

Various silatrane compounds were studied by means of15N NMR spectroscopy. Thequantum chemical calculations of some of the compounds were carried out using CNDO/2 *** following correlations were obtained, i. e.,15N chemical shifts vary linearly with Taft's polar sub-stituent constants σ*（s） of the substituents R on the silicon atoms, and also with the net charge den-sities on the nitrogen atoms. From both experimental and theoretical aspects, it could be concluded thatthe Si←N dative bonds in a series of silatrane compounds actually exist.

关键词： N NMR study of silatranes The NMR

Multi-Sensor Image Fusion: A Survey of the State of the Art

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Journal of Computer and Communications 2021年第6期9卷 73-108页

作者： Bing li Yong xian Daqiao Zhang Juan Su Xiaoxiang Hu Weilin Guo Xi’an High-Tech Research Institute Xi’an China School of Automation Northwestern Polytechnical University Xi’an China Xi’an Satellite Control Center Xi’an China

Image fusion has been developing into an important area of research. In remote sensing, the use of the same image sensor in different working modes, or different image sensors, can provide reinforcing or complementary information. Therefore, it is highly valuable to fuse outputs from multiple sensors (or the same sensor in different working modes) to improve the overall performance of the remote images, which are very useful for human visual perception and image processing task. Accordingly, in this paper, we first provide a comprehensive survey of the state of the art of multi-sensor image fusion methods in terms of three aspects: pixel-level fusion, feature-level fusion and decision-level fusion. An overview of existing fusion strategies is then introduced, after which the existing fusion quality measures are summarized. Finally, this review analyzes the development trends in fusion algorithms that may attract researchers to further explore the research in this field.

关键词： Multi-Sensor Image Fusion Fusion Strategy Feature Enhancement Fusion Performance Assessment

冯契美学观的逻辑进路和理论品格——兼与实践美学的比较

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华东师范大学学报（哲学社会科学版） 2007年第2期39卷 15-19页

作者：李丕显徐州师范大学文学院江苏徐州221116

冯契美学观在国内美学界独树一帜,首先在于它的哲学品位和理论深度,具体表现于从抽象上升到具体的逻辑进路,具有巨大的历史感。考索20世纪中国美学流派的此消彼长,我们不难发现冯契美学与实践美学之间存有深刻的思想关联,这两种美学观... 详细信息

冯契美学观在国内美学界独树一帜,首先在于它的哲学品位和理论深度,具体表现于从抽象上升到具体的逻辑进路,具有巨大的历史感。考索20世纪中国美学流派的此消彼长,我们不难发现冯契美学与实践美学之间存有深刻的思想关联,这两种美学观可以互相印证其合理性。

关键词：冯契美学观逻辑进路实践美学